Search Results - "Screaton, Robert A."

Of Mice and Men, Redux: Modern Challenges in β Cell Gene Targeting by Estall, Jennifer L, Screaton, Robert A

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The Keap1-Nrf2 Stress Response Pathway Promotes Mitochondrial Hyperfusion Through Degradation of the Mitochondrial Fission Protein Drp1 by Sabouny, Rasha, Fraunberger, Erik, Geoffrion, Michèle, Ng, Andy Cheuk-Him, Baird, Stephen D, Screaton, Robert A, Milne, Ross, McBride, Heidi M, Shutt, Timothy E

“…Mitochondrial function is coupled to metabolic and survival pathways through both direct signaling cascades and dynamic changes in mitochondrial morphology…”
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Mutant GNAS drives pancreatic tumourigenesis by inducing PKA-mediated SIK suppression and reprogramming lipid metabolism by Patra, Krushna C., Kato, Yasutaka, Mizukami, Yusuke, Widholz, Sebastian, Boukhali, Myriam, Revenco, Iulia, Grossman, Elizabeth A., Ji, Fei, Sadreyev, Ruslan I., Liss, Andrew S., Screaton, Robert A., Sakamoto, Kei, Ryan, David P., Mino-Kenudson, Mari, Castillo, Carlos Fernandez-del, Nomura, Daniel K., Haas, Wilhelm, Bardeesy, Nabeel

“…G protein α s (GNAS) mediates receptor-stimulated cAMP signalling, which integrates diverse environmental cues with intracellular responses. GNAS is…”
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Glycoprotein 2 is a specific cell surface marker of human pancreatic progenitors by Cogger, Kathryn F., Sinha, Ankit, Sarangi, Farida, McGaugh, Emily C., Saunders, Diane, Dorrell, Craig, Mejia-Guerrero, Salvador, Aghazadeh, Yasaman, Rourke, Jillian L., Screaton, Robert A., Grompe, Markus, Streeter, Philip R., Powers, Alvin C., Brissova, Marcela, Kislinger, Thomas, Nostro, M. Cristina

“…PDX1 + /NKX6-1 + pancreatic progenitors (PPs) give rise to endocrine cells both in vitro and in vivo. This cell population can be successfully differentiated…”
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Role of AMPK in pancreatic beta cell function by Fu, Accalia, Eberhard, Chandra E., Screaton, Robert A.

“…► Role of AMPK in insulin secretion by the pancreatic beta cell has been controversial. ► Animal modeling and RNAi approaches should help clarify the role of…”
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The AMPK-Related Kinases SIK1 and SIK3 Mediate Key Tumor-Suppressive Effects of LKB1 in NSCLC by Hollstein, Pablo E, Eichner, Lillian J, Brun, Sonja N, Kamireddy, Anwesh, Svensson, Robert U, Vera, Liliana I, Ross, Debbie S, Rymoff, T J, Hutchins, Amanda, Galvez, Hector M, Williams, April E, Shokhirev, Maxim N, Screaton, Robert A, Berdeaux, Rebecca, Shaw, Reuben J

“…Mutations in the LKB1 (also known as ) tumor suppressor are the third most frequent genetic alteration in non-small cell lung cancer (NSCLC). encodes a…”
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ROMO1 is an essential redox-dependent regulator of mitochondrial dynamics by Norton, Matthew, Ng, Andy Cheuk-Him, Baird, Stephen, Dumoulin, Ariane, Shutt, Timothy, Mah, Nancy, Andrade-Navarro, Miguel A, McBride, Heidi M, Screaton, Robert A

“…The dynamics of mitochondria undergoing fusion and fragmentation govern many mitochondrial functions, including the regulation of cell survival. Although the…”
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CREB coactivator TORC2 is a key regulator of fasting glucose metabolism by Koo, S.H, Flechner, L, Qi, L, Zhang, X, Screaton, R.A, Jeffries, S, Hedrick, S, Xu, W, Boussouar, F, Brindle, P

“…Glucose homeostasis is regulated systemically by hormones such as insulin and glucagon, and at the cellular level by energy status. Glucagon enhances glucose…”
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Axl Phosphorylates Elmo Scaffold Proteins To Promote Rac Activation and Cell Invasion by Abu-Thuraia, Afnan, Gauthier, Rosemarie, Chidiac, Rony, Fukui, Yoshinori, Screaton, Robert A., Gratton, Jean-Philippe, Côté, Jean-François

“…The receptor tyrosine kinase Axl contributes to cell migration and invasion. Expression of Axl correlates with metastatic progression in cancer patients, yet…”
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High-throughput Functional Genomics Identifies Regulators of Primary Human Beta Cell Proliferation by Robitaille, Karine, Rourke, Jillian L., McBane, Joanne E., Fu, Accalia, Baird, Stephen, Du, Qiujiang, Kin, Tatsuya, Shapiro, A.M. Jame, Screaton, Robert A.

“…The expansion of cells for regenerative therapy will require the genetic dissection of complex regulatory mechanisms governing the proliferation of…”
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Subcutaneous white adipose tissue independently regulates burn-induced hypermetabolism via immune-adipose crosstalk by Knuth, Carly M., Barayan, Dalia, Lee, Ju Hee, Auger, Christopher, de Brito Monteiro, Lauar, Ricciuti, Zachary, Metko, Dea, Wells, Lisa, Sung, Hoon-Ki, Screaton, Robert A., Jeschke, Marc G.

“…Severe burns induce a chronic hypermetabolic state that persists well past wound closure, indicating that additional internal mechanisms must be involved…”
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The CREB Coactivator TORC2 Functions as a Calcium- and cAMP-Sensitive Coincidence Detector by Screaton, Robert A., Conkright, Michael D., Katoh, Yoshiko, Best, Jennifer L., Canettieri, Gianluca, Jeffries, Shawn, Guzman, Ernesto, Niessen, Sherry, Yates, John R., Takemori, Hiroshi, Okamoto, Mitsuhiro, Montminy, Marc

“…Elevations in circulating glucose and gut hormones during feeding promote pancreatic islet cell viability in part via the calcium- and cAMP-dependent…”
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Essential Role of TID1 in Maintaining Mitochondrial Membrane Potential Homogeneity and Mitochondrial DNA Integrity by Ng, Andy Cheuk-Him, Baird, Stephen D., Screaton, Robert A.

“…The tumorous imaginal disc 1 (TID1) protein localizes mainly to the mitochondrial compartment, wherein its function remains largely unknown. Here we report…”
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Glucose controls CREB activity in islet cells via regulated phosphorylation of TORC2 by Jansson, Deidre, Ng, Andy Cheuk-Him, Fu, Accalia, Depatie, Chantal, Al Azzabi, Mufida, Screaton, Robert A

“…CREB is a cAMP- and calcium-responsive transcriptional activator that is required for islet beta cell proliferation and survival. Glucose and incretin hormones…”
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Beyond Genetics: The Role of Metabolism in Photoreceptor Survival, Development and Repair by Hanna, Joseph, David, Luke Ajay, Touahri, Yacine, Fleming, Taylor, Screaton, Robert A, Schuurmans, Carol

“…Vision commences in the retina with rod and cone photoreceptors that detect and convert light to electrical signals. The irreversible loss of photoreceptors…”
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Silencing the G-protein coupled receptor 3-salt inducible kinase 2 pathway promotes human β cell proliferation by Iorio, Caterina, Rourke, Jillian L., Wells, Lisa, Sakamaki, Jun-Ichi, Moon, Emily, Hu, Queenie, Kin, Tatsuya, Screaton, Robert A.

“…Loss of pancreatic β cells is the hallmark of type 1 diabetes, for which provision of insulin is the standard of care. While regenerative and stem cell…”
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Using kinomics to delineate signaling pathways: Control of crtc2/torc2 by the ampk family by Fu, Accalia, Screaton, Robert A.

“…The classical role of AMP-activated protein kinase (AMPK) as an energy status sensor is expanding to include other members of the AMPK family. Recent genetic…”
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AMPK and Friends: Central Regulators of β Cell Biology by Rourke, Jillian L., Hu, Queenie, Screaton, Robert A.

“…If left unchecked, prediabetic hyperglycemia can progress to diabetes and often life-threatening attendant secondary complications. Central to the process of…”
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Deregulated Expression of the Human Tumor Marker CEA and CEA Family Member CEACAM6 Disrupts Tissue Architecture and Blocks Colonocyte Differentiation by Ilantzis, Christian, Demarte, Luisa, Screaton, Robert A., Stanners, Clifford P.

“…Human carcinoembryonic antigen (CEA) and the CEA family member CEACAM6 (formerly nonspecific crossreacting antigen [NCA]) function in vitro, at least, as…”
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Fas-Associated Death Domain Protein Interacts with Methyl-CpG Binding Domain Protein 4: A Potential Link between Genome Surveillance and Apoptosis by Screaton, Robert A., Kiessling, Stephan, Sansom, Owen J., Millar, Catherine B., Maddison, Kathryn, Bird, Adrian, Clarke, Alan R., Frisch, Steven M.

“…Fas-associated death domain protein (FADD) is an adaptor protein bridging death receptors with initiator caspases. Thus, its function and localization are…”
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