Search Results - "Screaton, Gavin R."

Evidence of escape of SARS-CoV-2 variant B.1.351 from natural and vaccine-induced sera by Zhou, Daming, Dejnirattisai, Wanwisa, Supasa, Piyada, Liu, Chang, Mentzer, Alexander J., Ginn, Helen M., Zhao, Yuguang, Duyvesteyn, Helen M.E., Tuekprakhon, Aekkachai, Nutalai, Rungtiwa, Wang, Beibei, Paesen, Guido C., Lopez-Camacho, Cesar, Slon-Campos, Jose, Hallis, Bassam, Coombes, Naomi, Bewley, Kevin, Charlton, Sue, Walter, Thomas S., Skelly, Donal, Lumley, Sheila F., Dold, Christina, Levin, Robert, Dong, Tao, Pollard, Andrew J., Knight, Julian C., Crook, Derrick, Lambe, Teresa, Clutterbuck, Elizabeth, Bibi, Sagida, Flaxman, Amy, Bittaye, Mustapha, Belij-Rammerstorfer, Sandra, Gilbert, Sarah, James, William, Carroll, Miles W., Klenerman, Paul, Barnes, Eleanor, Dunachie, Susanna J., Fry, Elizabeth E., Mongkolsapaya, Juthathip, Ren, Jingshan, Stuart, David I., Screaton, Gavin R.

“…The race to produce vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) began when the first sequence was published, and this forms…”
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Structural basis of potent Zika–dengue virus antibody cross-neutralization by Barba-Spaeth, Giovanna, Dejnirattisai, Wanwisa, Rouvinski, Alexander, Vaney, Marie-Christine, Medits, Iris, Sharma, Arvind, Simon-Lorière, Etienne, Sakuntabhai, Anavaj, Cao-Lormeau, Van-Mai, Haouz, Ahmed, England, Patrick, Stiasny, Karin, Mongkolsapaya, Juthathip, Heinz, Franz X., Screaton, Gavin R., Rey, Félix A.

“…Zika virus is a member of the Flavivirus genus that had not been associated with severe disease in humans until the recent outbreaks, when it was linked to…”
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Neutralization of SARS-CoV-2 by Destruction of the Prefusion Spike by Huo, Jiandong, Zhao, Yuguang, Ren, Jingshan, Zhou, Daming, Duyvesteyn, Helen M.E., Ginn, Helen M., Carrique, Loic, Malinauskas, Tomas, Ruza, Reinis R., Shah, Pranav N.M., Tan, Tiong Kit, Rijal, Pramila, Coombes, Naomi, Bewley, Kevin R., Tree, Julia A., Radecke, Julika, Paterson, Neil G., Supasa, Piyada, Mongkolsapaya, Juthathip, Screaton, Gavin R., Carroll, Miles, Townsend, Alain, Fry, Elizabeth E., Owens, Raymond J., Stuart, David I.

“…There are as yet no licensed therapeutics for the COVID-19 pandemic. The causal coronavirus (SARS-CoV-2) binds host cells via a trimeric spike whose receptor…”
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MAIT cells are activated during human viral infections by van Wilgenburg, Bonnie, Scherwitzl, Iris, Hutchinson, Edward C., Leng, Tianqi, Kurioka, Ayako, Kulicke, Corinna, de Lara, Catherine, Cole, Suzanne, Vasanawathana, Sirijitt, Limpitikul, Wannee, Malasit, Prida, Young, Duncan, Denney, Laura, Moore, Michael D., Fabris, Paolo, Giordani, Maria Teresa, Oo, Ye Htun, Laidlaw, Stephen M., Dustin, Lynn B., Ho, Ling-Pei, Thompson, Fiona M., Ramamurthy, Narayan, Mongkolsapaya, Juthathip, Willberg, Christian B., Screaton, Gavin R., Klenerman, Paul

“…Mucosal-associated invariant T (MAIT) cells are abundant in humans and recognize bacterial ligands. Here, we demonstrate that MAIT cells are also activated…”
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Recognition determinants of broadly neutralizing human antibodies against dengue viruses by Rouvinski, Alexander, Guardado-Calvo, Pablo, Barba-Spaeth, Giovanna, Duquerroy, Stéphane, Vaney, Marie-Christine, Kikuti, Carlos M., Navarro Sanchez, M. Erika, Dejnirattisai, Wanwisa, Wongwiwat, Wiyada, Haouz, Ahmed, Girard-Blanc, Christine, Petres, Stéphane, Shepard, William E., Desprès, Philippe, Arenzana-Seisdedos, Fernando, Dussart, Philippe, Mongkolsapaya, Juthathip, Screaton, Gavin R., Rey, Félix A.

“…Human antibodies in complex with the soluble dimeric form of the dengue virus envelope protein E recognize a quaternary epitope and exhibit strong neutralizing…”
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A protective Zika virus E-dimer-based subunit vaccine engineered to abrogate antibody-dependent enhancement of dengue infection by Slon-Campos, Jose Luis, Dejnirattisai, Wanwisa, Jagger, Brett W., López-Camacho, César, Wongwiwat, Wiyada, Durnell, Lorellin A., Winkler, Emma S., Chen, Rita E., Reyes-Sandoval, Arturo, Rey, Felix A., Diamond, Michael S., Mongkolsapaya, Juthathip, Screaton, Gavin R.

“…Infections with dengue virus (DENV) and Zika virus (ZIKV) can induce cross-reactive antibody responses. Two immunodominant epitopes—one to precursor membrane…”
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Flavivirus maturation leads to the formation of an occupied lipid pocket in the surface glycoproteins by Renner, Max, Dejnirattisai, Wanwisa, Carrique, Loïc, Martin, Itziar Serna, Karia, Dimple, Ilca, Serban L., Ho, Shu F., Kotecha, Abhay, Keown, Jeremy R., Mongkolsapaya, Juthathip, Screaton, Gavin R., Grimes, Jonathan M.

“…Flaviviruses such as Dengue (DENV) or Zika virus (ZIKV) assemble into an immature form within the endoplasmatic reticulum (ER), and are then processed by furin…”
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CryoEM structures of the multimeric secreted NS1, a major factor for dengue hemorrhagic fever by Shu, Bo, Ooi, Justin S. G., Tan, Aaron W. K., Ng, Thiam-Seng, Dejnirattisai, Wanwisa, Mongkolsapaya, Juthathip, Fibriansah, Guntur, Shi, Jian, Kostyuchenko, Victor A., Screaton, Gavin R., Lok, Shee-Mei

“…Dengue virus infection can cause dengue hemorrhagic fever (DHF). Dengue NS1 is multifunctional. The intracellular dimeric NS1 (iNS1) forms part of the viral…”
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Covalently linked dengue virus envelope glycoprotein dimers reduce exposure of the immunodominant fusion loop epitope by Rouvinski, Alexander, Dejnirattisai, Wanwisa, Guardado-Calvo, Pablo, Vaney, Marie-Christine, Sharma, Arvind, Duquerroy, Stéphane, Supasa, Piyada, Wongwiwat, Wiyada, Haouz, Ahmed, Barba-Spaeth, Giovanna, Mongkolsapaya, Juthathip, Rey, Félix A., Screaton, Gavin R.

“…A problem in the search for an efficient vaccine against dengue virus is the immunodominance of the fusion loop epitope (FLE), a segment of the envelope…”
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Generation of SARS-CoV-2 escape mutations by monoclonal antibody therapy by Ragonnet-Cronin, Manon, Nutalai, Rungtiwa, Huo, Jiandong, Dijokaite-Guraliuc, Aiste, Das, Raksha, Tuekprakhon, Aekkachai, Supasa, Piyada, Liu, Chang, Selvaraj, Muneeswaran, Groves, Natalie, Hartman, Hassan, Ellaby, Nicholas, Mark Sutton, J., Bahar, Mohammad W., Zhou, Daming, Fry, Elizabeth, Ren, Jingshan, Brown, Colin, Klenerman, Paul, Dunachie, Susanna J., Mongkolsapaya, Juthathip, Hopkins, Susan, Chand, Meera, Stuart, David I., Screaton, Gavin R., Rokadiya, Sakib

“…COVID-19 patients at risk of severe disease may be treated with neutralising monoclonal antibodies (mAbs). To minimise virus escape from neutralisation these…”
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Antibodies targeting epitopes on the cell-surface form of NS1 protect against Zika virus infection during pregnancy by Wessel, Alex W., Kose, Nurgun, Bombardi, Robin G., Roy, Vicky, Chantima, Warangkana, Mongkolsapaya, Juthathip, Edeling, Melissa A., Nelson, Christopher A., Bosch, Irene, Alter, Galit, Screaton, Gavin R., Fremont, David H., Crowe, James E., Diamond, Michael S.

“…There are no licensed therapeutics or vaccines available against Zika virus (ZIKV) to counteract its potential for congenital disease. Antibody-based…”
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Rational Zika vaccine design via the modulation of antigen membrane anchors in chimpanzee adenoviral vectors by López-Camacho, César, Abbink, Peter, Larocca, Rafael A., Dejnirattisai, Wanwisa, Boyd, Michael, Badamchi-Zadeh, Alex, Wallace, Zoë R., Doig, Jennifer, Velazquez, Ricardo Sanchez, Neto, Roberto Dias Lins, Coelho, Danilo F., Kim, Young Chan, Donald, Claire L., Owsianka, Ania, De Lorenzo, Giuditta, Kohl, Alain, Gilbert, Sarah C., Dorrell, Lucy, Mongkolsapaya, Juthathip, Patel, Arvind H., Screaton, Gavin R., Barouch, Dan H., Hill, Adrian V. S., Reyes-Sandoval, Arturo

“…Zika virus (ZIKV) emerged on a global scale and no licensed vaccine ensures long-lasting anti-ZIKV immunity. Here we report the design and comparative…”
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Sensing of immature particles produced by dengue virus infected cells induces an antiviral response by plasmacytoid dendritic cells by Décembre, Elodie, Assil, Sonia, Hillaire, Marine L B, Dejnirattisai, Wanwisa, Mongkolsapaya, Juthathip, Screaton, Gavin R, Davidson, Andrew D, Dreux, Marlène

“…Dengue virus (DENV) is the leading cause of mosquito-borne viral illness and death in humans. Like many viruses, DENV has evolved potent mechanisms that…”
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The alteration of NK cells phenotypes related to the functions and dengue disease outcomes by Taechasan, Napas, Scherwitzl, Iris, Supasa, Piyada, Dejnirattisai, Wanwisa, Sriruksa, Kanokwan, Limpitikul, Wannee, Malasit, Prida, Screaton, Gavin R, Mongkolsapaya, Juthathip, Duangchinda, Thaneeya

“…•The NKp30 receptor's expression on activated NK cells is more pronounced in DF patients than in DHF patients, suggesting a potential role of this receptor in…”
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The SARS-CoV-2 neutralizing antibody response to SD1 and its evasion by BA.2.86 by Zhou, Daming, Supasa, Piyada, Liu, Chang, Dijokaite-Guraliuc, Aiste, Duyvesteyn, Helen M. E., Selvaraj, Muneeswaran, Mentzer, Alexander J., Das, Raksha, Dejnirattisai, Wanwisa, Temperton, Nigel, Klenerman, Paul, Dunachie, Susanna J., Fry, Elizabeth E., Mongkolsapaya, Juthathip, Ren, Jingshan, Stuart, David I., Screaton, Gavin R.

“…Under pressure from neutralising antibodies induced by vaccination or infection the SARS-CoV-2 spike gene has become a hotspot for evolutionary change, leading…”
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Emerging variants develop total escape from potent monoclonal antibodies induced by BA.4/5 infection by Liu, Chang, Das, Raksha, Dijokaite-Guraliuc, Aiste, Zhou, Daming, Mentzer, Alexander J., Supasa, Piyada, Selvaraj, Muneeswaran, Duyvesteyn, Helen M. E., Ritter, Thomas G., Temperton, Nigel, Klenerman, Paul, Dunachie, Susanna J., Paterson, Neil G., Williams, Mark A., Hall, David R., Fry, Elizabeth E., Mongkolsapaya, Juthathip, Ren, Jingshan, Stuart, David I., Screaton, Gavin R.

“…The rapid evolution of SARS-CoV-2 is driven in part by a need to evade the antibody response in the face of high levels of immunity. Here, we isolate spike (S)…”
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Characterization of a potent and highly unusual minimally enhancing antibody directed against dengue virus by Renner, Max, Flanagan, Aleksandra, Dejnirattisai, Wanwisa, Puttikhunt, Chunya, Kasinrerk, Watchara, Supasa, Piyada, Wongwiwat, Wiyada, Chawansuntati, Kriangkrai, Duangchinda, Thaneeya, Cowper, Alison, Midgley, Claire M., Malasit, Prida, Huiskonen, Juha T., Mongkolsapaya, Juthathip, Screaton, Gavin R., Grimes, Jonathan M.

“…Dengue virus is a major pathogen, and severe infections can lead to life-threatening dengue hemorrhagic fever. Dengue virus exists as four serotypes, and…”
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Native-like SARS-CoV-2 Spike Glycoprotein Expressed by ChAdOx1 nCoV-19/AZD1222 Vaccine by Watanabe, Yasunori, Mendonça, Luiza, Allen, Elizabeth R, Howe, Andrew, Lee, Mercede, Allen, Joel D, Chawla, Himanshi, Pulido, David, Donnellan, Francesca, Davies, Hannah, Ulaszewska, Marta, Belij-Rammerstorfer, Sandra, Morris, Susan, Krebs, Anna-Sophia, Dejnirattisai, Wanwisa, Mongkolsapaya, Juthathip, Supasa, Piyada, Screaton, Gavin R, Green, Catherine M, Lambe, Teresa, Zhang, Peijun, Gilbert, Sarah C, Crispin, Max

“…Vaccine development against the SARS-CoV-2 virus focuses on the principal target of the neutralizing immune response, the spike (S) glycoprotein…”
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High-Avidity and Potently Neutralizing Cross-Reactive Human Monoclonal Antibodies Derived from Secondary Dengue Virus Infection by Tsai, Wen-Yang, Lai, Chih-Yun, Wu, Yi-Chieh, Lin, Hong-En, Edwards, Carolyn, Jumnainsong, Amonrat, Kliks, Srisakul, Halstead, Scott, Mongkolsapaya, Juthathip, Screaton, Gavin R, Wang, Wei-Kung

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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An In-Depth Analysis of Original Antigenic Sin in Dengue Virus Infection by MIDGLEY, Claire M, BAJWA-JOSEPH, Martha, GRIMES, Jonathan M, YOKSAN, Sutee, MALASIT, Prida, SIMMONS, Cameron P, MONGKOLSAPAYA, Juthathip, SCREATON, Gavin R, VASANAWATHANA, Sirijitt, LIMPITIKUT, Wannee, WILLS, Bridget, FLANAGAN, Aleksandra, WAIYAIYA, Emily, HAI BAC TRAN, COWPER, Alison E, CHOTIYARNWON, Pojchong

“…Erratum ( vol. 85 , p. 12100 ) Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious…”
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