Search Results - "Scott Simonet, W"

Bench to bedside: elucidation of the OPG–RANK–RANKL pathway and the development of denosumab by Lacey, David L., Boyle, William J., Simonet, W. Scott, Kostenuik, Paul J., Dougall, William C., Sullivan, John K., Martin, Javier San, Dansey, Roger

“…Key Points This Review chronicles the events that led to an increased understanding of osteoclast biology, the identification of osteoprotegerin (OPG) and the…”
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Reversal of Cancer Cachexia and Muscle Wasting by ActRIIB Antagonism Leads to Prolonged Survival by Zhou, Xiaolan, Wang, Jin Lin, Lu, John, Song, Yanping, Kwak, Keith S., Jiao, Qingsheng, Rosenfeld, Robert, Chen, Qing, Boone, Thomas, Simonet, W. Scott, Lacey, David L., Goldberg, Alfred L., Han, H.Q.

“…Muscle wasting and cachexia have long been postulated to be key determinants of cancer-related death, but there has been no direct experimental evidence to…”
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Sclerostin Antibody Treatment Increases Bone Formation, Bone Mass, and Bone Strength in a Rat Model of Postmenopausal Osteoporosis by Li, Xiaodong, Ominsky, Michael S, Warmington, Kelly S, Morony, Sean, Gong, Jianhua, Cao, Jin, Gao, Yongming, Shalhoub, Victoria, Tipton, Barbara, Haldankar, Raj, Chen, Qing, Winters, Aaron, Boone, Tom, Geng, Zhaopo, Niu, Qing‐Tian, Ke, Hua Zhu, Kostenuik, Paul J, Simonet, W Scott, Lacey, David L, Paszty, Chris

“…The development of bone‐rebuilding anabolic agents for potential use in the treatment of bone loss conditions, such as osteoporosis, has been a long‐standing…”
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Two doses of sclerostin antibody in cynomolgus monkeys increases bone formation, bone mineral density, and bone strength by Ominsky, Michael S, Vlasseros, Fay, Jolette, Jacquelin, Smith, Susan Y, Stouch, Brian, Doellgast, George, Gong, Jianhua, Gao, Yongming, Cao, Jin, Graham, Kevin, Tipton, Barbara, Cai, Jill, Deshpande, Rohini, Zhou, Lei, Hale, Michael D, Lightwood, Daniel J, Henry, Alistair J, Popplewell, Andrew G, Moore, Adrian R, Robinson, Martyn K, Lacey, David L, Simonet, W Scott, Paszty, Chris

“…The development of bone‐rebuilding anabolic agents for treating bone‐related conditions has been a long‐standing goal. Genetic studies in humans and mice have…”
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Targeted Deletion of the Sclerostin Gene in Mice Results in Increased Bone Formation and Bone Strength by Li, Xiaodong, Ominsky, Michael S, Niu, Qing‐Tian, Sun, Ning, Daugherty, Betsy, D'Agostin, Diane, Kurahara, Carole, Gao, Yongming, Cao, Jin, Gong, Jianhua, Asuncion, Frank, Barrero, Mauricio, Warmington, Kelly, Dwyer, Denise, Stolina, Marina, Morony, Sean, Sarosi, Ildiko, Kostenuik, Paul J, Lacey, David L, Simonet, W Scott, Ke, Hua Zhu, Paszty, Chris

“…Introduction: Sclerosteosis is a rare high bone mass genetic disorder in humans caused by inactivating mutations in SOST, the gene encoding sclerostin. Based…”
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Sclerostin Antibody Reverses Bone Loss by Increasing Bone Formation and Decreasing Bone Resorption in a Rat Model of Male Osteoporosis by Li, Xiaodong, Ominsky, Michael S, Villasenor, Kelly S, Niu, Qing-Tian, Asuncion, Frank J, Xia, Xuechun, Grisanti, Mario, Wronski, Thomas J, Simonet, W Scott, Ke, Hua Zhu

“…Sclerostin antibody (Scl-Ab) restored bone mass and strength in the ovariectomized rat model of postmenopausal osteoporosis. Increased bone mineral density…”
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Inhibition of WISE Preserves Renal Allograft Function by XUEMING QIAN, XIAODONG YUAN, VALENTE, Eliane G, PRETORIUS, Jim, STENVENS, Jennitte L, TIPTON, Barbara, WINTERS, Aaron G, GRAHAM, Kevin, HARRISS, Lindsey, BAKER, Daniel M, DAMORE, Michael, SALIMI-MOOSAVI, Hossein, VONDERFECHT, Steven, YONGMING GAO, ELKHAL, Abdallah, PASZTY, Chris, SCOTT SIMONET, W, RICHARDS, William G, TULLIUS, Stefan G, XUPENG GE, LEE, Jae, JURISCH, Anke, LI ZHANG, YOU, Andrew, FITZPATRICK, Vincent D, WILLIAM, Alexia

“…Wnt-modulator in surface ectoderm (WISE) is a secreted modulator of Wnt signaling expressed in the adult kidney. Activation of Wnt signaling has been observed…”
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Novel Neurotrophin-1/B Cell-Stimulating Factor-3: A Cytokine of the IL-6 Family by Senaldi, G, Varnum, B C, Sarmiento, U, Starnes, C, Lile, J, Scully, S, Guo, J, Elliott, G, McNinch, J, Shaklee, C L, Freeman, D, Manu, F, Simonet, W S, Boone, T, Chang, M S

“…We have identified a cytokine of the IL-6 family and named it novel neurotrophin-1/B cell-stimulating factor-3 (NNT-1/BSF-3). NNT-1/BSF-3 cDNA was cloned from…”
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Osteoclast differentiation and activation by Boyle, William J, Simonet, W. Scott, Lacey, David L

“…Osteoclasts are specialized cells derived from the monocyte/macrophage haematopoietic lineage that develop and adhere to bone matrix, then secrete acid and…”
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Dkk1-mediated inhibition of Wnt signaling in bone results in osteopenia by Li, Ji, Sarosi, Ildiko, Cattley, Russell C., Pretorius, James, Asuncion, Frank, Grisanti, Mario, Morony, Sean, Adamu, Stephen, Geng, Zhaopo, Qiu, Wanrong, Kostenuik, Paul, Lacey, David L., Simonet, W. Scott, Bolon, Brad, Qian, Xueming, Shalhoub, Victoria, Ominsky, Michael S., Zhu Ke, Hua, Li, Xiaodong, Richards, William G.

“…Mutations affecting the activity of the Wnt co-receptors LRP5 and LRP6 that cause alterations in skeletal biology confirmed the involvement of Wnt signaling in…”
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Dickkopf‐1 regulates bone formation in young growing rodents and upon traumatic injury by Li, Xiaodong, Grisanti, Mario, Fan, Wei, Asuncion, Frank J, Tan, Hong‐Lin, Dwyer, Denise, Han, Chun‐Ya, Yu, Longchuan, Lee, Jae, Lee, Edward, Barrero, Mauricio, Kurimoto, Pam, Niu, Qing‐Tian, Geng, Zhaopo, Winters, Aaron, Horan, Tom, Steavenson, Shirley, Jacobsen, Frederick, Chen, Qing, Haldankar, Raj, Lavallee, Jennifer, Tipton, Barbara, Daris, Mark, Sheng, Jackie, Lu, Hsieng S, Daris, Kristi, Deshpande, Rohini, Valente, Eliane G, Salimi‐Moosavi, Hossein, Kostenuik, Paul J, Li, Ji, Liu, Min, Li, Chaoyang, Lacey, David L, Simonet, W Scott, Ke, Hua Zhu, Babij, Philip, Stolina, Marina, Ominsky, Michael S, Richards, William G

“…The physiological role of Dickkopf‐1 (Dkk1) during postnatal bone growth in rodents and in adult rodents was examined utilizing an antibody to Dkk1 (Dkk1‐Ab)…”
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Pulmonary Malformation in Transgenic Mice Expressing Human Keratinocyte Growth Factor in the Lung by Simonet, W S, DeRose, M L, Bucay, N, Nguyen, H Q, Wert, S E, Zhou, L, Ulich, T R, Thomason, A, Danilenko, D M, Whitsett, J A

“…Expression of human keratinocyte growth factor (KGF/FGF-7) was directed to epithelial cells of the developing embryonic lung of transgenic mice disrupting…”
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Genetics of primary generalized osteoarthritis by Scott Simonet, W

“…Osteoarthritis (OA) is a common joint disease with complex etiology, including biomechanical, biochemical, and genetic components. The genetics of primary…”
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Osteoprotegerin reverses osteoporosis by inhibiting endosteal osteoclasts and prevents vascular calcification by blocking a process resembling osteoclastogenesis by Min, H, Morony, S, Sarosi, I, Dunstan, C R, Capparelli, C, Scully, S, Van, G, Kaufman, S, Kostenuik, P J, Lacey, D L, Boyle, W J, Simonet, W S

“…High systemic levels of osteoprotegerin (OPG) in OPG transgenic mice cause osteopetrosis with normal tooth eruption and bone elongation and inhibit the…”
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The Candidate Neuroprotective Agent Artemin Induces Autonomic Neural Dysplasia without Preventing Peripheral Nerve Dysfunction by Bolon, Brad, Jing, Shuqian, Asuncion, Frank, Scully, Sheila, Pisegna, Marlese, Van, Gwyneth Y., Zheng Hu, Yan Bin Yu, Min, Hosung, Wild, Ken, Rosenfeld, Robert D., Tarpley, John, Carnahan, Josette, Duryea, Diane, Hill, Dave, Kaufman, Steve, Yan, Xiao-Qiang, Juan, Todd, Christensen, Kathy, Mccabe, James, Simonet, W. Scott

“…Artemin (ART) signals through the GFRα—3/RET receptor complex to support sympathetic neuron development. Here we show that ART also influences autonomic…”
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Fgf-10 is required for both limb and lung development and exhibits striking functional similarity to Drosophila branchless by Min, H, Danilenko, D M, Scully, S A, Bolon, B, Ring, B D, Tarpley, J E, DeRose, M, Simonet, W S

“…Fgf-10-deficient mice (Fgf-10(-/-)) were generated to determine the role(s) of Fgf-10 in vertebrate development. Limb bud initiation was abolished in…”
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Increased RANK ligand in bone marrow of orchiectomized rats and prevention of their bone loss by the RANK ligand inhibitor osteoprotegerin by Li, Xiaodong, Ominsky, Michael S, Stolina, Marina, Warmington, Kelly S, Geng, Zhaopo, Niu, Qing-Tian, Asuncion, Frank J, Tan, Hong-Lin, Grisanti, Mario, Dwyer, Denise, Adamu, Steven, Ke, Hua Zhu, Simonet, W. Scott, Kostenuik, Paul J

“…Abstract Orchiectomized (ORX) rats were used to examine the extent to which their increased bone resorption and decreased bone density might relate to…”
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FGF-18, a Novel Member of the Fibroblast Growth Factor Family, Stimulates Hepatic and Intestinal Proliferation by Hu, Mickey C.-T., Qiu, Wan R., Wang, You-ping, Hill, Dave, Ring, Brian D., Scully, Sheila, Bolon, Brad, DeRose, Margaret, Luethy, Roland, Simonet, W. Scott, Arakawa, Tsutomu, Danilenko, Dimitry M.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Keratinocyte growth factor reduces lung damage due to acid instillation in rats by Yano, T, Deterding, R R, Simonet, W S, Shannon, J M, Mason, R J

“…Acid aspiration is a serious complication of anesthesia and other forms of unconsciousness that can result in the adult respiratory distress syndrome (ARDS),…”
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Systemic inhibition of sclerostin for treatment of osteoporosis and bone healing by Simonet, W. Scott

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