Search Results - "Scott, William L."

Animal‐borne wireless network: Remote imaging of community ecology by Park, Shinkyu, Aschenbach, Konrad H., Ahmed, Manjur, Scott, William L., Leonard, Naomi E., Abernathy, Kyler, Marshall, Greg, Shepard, Mike, Martins, Nuno C.

“…This article describes the design, construction, and field‐testing of a standalone networked animal‐borne monitoring system conceived to study community…”
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Preparation and Use of a General Solid-Phase Intermediate to Biomimetic Scaffolds and Peptide Condensations by Samaritoni, J Geno, Martynow, Jacek G, O'Donnell, Martin J, Scott, William L

“…The Distributed Drug Discovery (D3) program develops simple, powerful, and reproducible procedures to enable the distributed synthesis of large numbers of…”
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Unexpected Hydrolytic Instability of N‑Acylated Amino Acid Amides and Peptides by Samaritoni, J. Geno, Copes, Alexus T, Crews, DeMarcus K, Glos, Courtney, Thompson, Andre L, Wilson, Corydon, O’Donnell, Martin J, Scott, William L

“…Remote amide bonds in simple N-acyl amino acid amide or peptide derivatives 1 can be surprisingly unstable hydrolytically, affording, in solution, variable…”
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Solid-Phase Synthesis of Amine/Carboxyl Substituted Prolines and Proline Homologues: Scope and Limitations by Zhou, Ziniu, Scott, William L, O'Donnell, Martin J

“…A solid-phase procedure is used to synthesize racemic peptidomimetics based on the fundamental peptide unit. The peptidomimetics are constructed around proline…”
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Solid-phase synthetic route to multiple derivatives of a fundamental peptide unit by Scott, William L, Zhou, Ziniu, Zajdel, Paweł, Pawłowski, Maciej, O'Donnell, Martin J

“…Amino acids are Nature's combinatorial building blocks. When substituted on both the amino and carboxyl sides they become the basic scaffold present in all…”
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Discovery of potent and selective inhibitors of the Escherichia coli M1-aminopeptidase via multicomponent solid-phase synthesis of tetrazole-peptidomimetics by Méndez, Yanira, De Armas, German, Pérez, Idalia, Rojas, Tamara, Valdés-Tresanco, Mario E., Izquierdo, Maikel, Alonso del Rivero, Maday, Álvarez-Ginarte, Yoanna María, Valiente, Pedro A., Soto, Carmen, de León, Lena, Vasco, Aldrin V., Scott, William L., Westermann, Bernhard, González-Bacerio, Jorge, Rivera, Daniel G.

“…The Escherichia coli neutral M1-aminopeptidase (ePepN) is a novel target identified for the development of antimicrobials. Here we describe a solid-phase…”
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Ecological and behavioral mechanisms of density-dependent habitat expansion in a recovering African ungulate population by Becker, Justine A., Hutchinson, Matthew C., Potter, Arjun B., Park, Shinkyu, Guyton, Jennifer A., Abernathy, Kyler, Americo, Victor F., da Conceicao, Anagledis, Kartzinel, Tyler R., Kuziel, Luca, Leonard, Naomi E., Lorenzi, Eli, Martins, Nuno C., Pansu, Johan, Scott, William L., Stahl, Maria K., Torrens, Kai R., Stalmans, Marc E., Long, Ryan A., Pringle, Robert M.

“…Major disturbances can temporarily remove factors that otherwise constrain population abundance and distribution. During such windows of relaxed top-down…”
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Solid-Phase Synthesis of Arylpiperazine Derivatives and Implementation of the Distributed Drug Discovery (D3) Project in the Search for CNS Agents by Zajdel, Paweł, Król, Joanna, Grychowska, Katarzyna, Pawłowski, Maciej, Subra, Gilles, Nomezine, Gaël, Martinez, Jean, Satała, Grzegorz, Bojarski, Andrzej J., Zhou, Ziniu, O’Donnell, Martin J., Scott, William L.

“…We have successfully implemented the concept of Distributed Drug Discovery (D3) in the search for CNS agents. Herein, we demonstrate, for the first time,…”
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Geometric Gait Design for a Starfish‐Inspired Robot Using a Planar Discrete Elastic Rod Model by Scott, William L., Paley, Derek A.

“…A starfish‐inspired robotic platform consisting of multiple soft fluidic bending actuator arms arranged with radial symmetry about a rigid hub is described…”
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Solid-Phase Unnatural Peptide Synthesis (UPS) by O'Donnell, Martin J, Zhou, Changyou, Scott, William L

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Globally Distributed Drug Discovery of New Antibiotics: Design and Combinatorial Synthesis of Amino Acid Derivatives in the Organic Chemistry Laboratory by Dounay, Amy B, O’Donnell, Martin J, Samaritoni, J. Geno, Popiolek, Lukasz, Schirch, Douglas, Biernasiuk, Anna, Malm, Anna, Lamb, Isaac W, Mudrack, Kristen, Rivera, Daniel G, Ojeda, Gerardo M, Scott, William L

“…An experiment for the synthesis of N-acyl derivatives of natural amino acids has been developed as part of the Distributed Drug Discovery (D3) program…”
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Multi-Institution Research and Education Collaboration Identifies New Antimicrobial Compounds by Fuller, Amelia A, Dounay, Amy B, Schirch, Douglas, Rivera, Daniel G, Hansford, Karl A, Elliott, Alysha G, Zuegg, Johannes, Cooper, Matthew A, Blaskovich, Mark A. T, Hitchens, Jacob R, Burris-Hiday, Sarah, Tenorio, Kristiana, Mendez, Yanira, Samaritoni, J. Geno, O’Donnell, Martin J, Scott, William L

“…New antibiotics are urgently needed to address increasing rates of multidrug resistant infections. Seventy-six diversely functionalized compounds, comprising…”
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Documenting and harnessing the biological potential of molecules in Distributed Drug Discovery (D3) virtual catalogs by Abraham, Milata M., Denton, Ryan E., Harper, Richard W., Scott, William L., O'Donnell, Martin J., Durrant, Jacob D.

“…Virtual molecular catalogs have limited utility if member compounds are (i) difficult to synthesize or (ii) unlikely to have biological activity. The…”
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Distributed Drug Discovery: Advancing Chemical Education through Contextualized Combinatorial Solid-Phase Organic Laboratories by Scott, William L, Denton, Ryan E, Marrs, Kathleen A, Durrant, Jacob D, Samaritoni, J. Geno, Abraham, Milata M, Brown, Stephen P, Carnahan, Jon M, Fischer, Lindsey G, Glos, Courtney E, Sempsrott, Peter J, O’Donnell, Martin J

“…The Distributed Drug Discovery (D3) program trains students in three drug discovery disciplines (synthesis, computational analysis, and biological screening)…”
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Solid-Phase Synthesis of Multiple Classes of Peptidomimetics from Versatile Resin-Bound Aldehyde Intermediates by Scott, William L, Martynow, Jacek G, Huffman, John C, O'Donnell, Martin J

“…A wide variety of highly substituted lactam containing peptidomimetic scaffolds are prepared by solid-phase synthesis from a single, versatile class of…”
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Effect of single agent high-dose methotrexate-related acute kidney injury on length of hospitalization and relative dose intensity in adult patients with central nervous system lymphoma by Steward, Jennifer S, Bullard, Heather M, O’Rourke, Timothy J, Campbell, Alan D, Brinker, Brett T, Yost, Kathleen J, Vanderwoude, Amy C, Scott, William L, Kintzel, Polly E

“…Purpose Grade ≥3 adverse effects prolong hospitalization and reduce chemotherapy dose intensity. The purpose of this study was to evaluate the rate and…”
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Solid-Phase Synthesis of Amino- and Carboxyl-Functionalized Unnatural α-Amino Acid Amides by Scott, William L, Zhou, Ziniu, Martynow, Jacek G, O’Donnell, Martin J

“…A new solid-phase synthesis efficiently incorporates three different substituents (from R1-X, R2-CO2H, and R3-NH2) into a glycine-based peptidomimetic…”
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Pseudohyperkalemia in a patient with chronic lymphoblastic leukemia and tumor lysis syndrome by Kintzel, Polly E, Scott, William L

“…Purpose:Recognition of pseudohyperkalemia is essential to prevent medical mismanagement of erroneous hyperkalemia. The purpose of this case is to describe…”
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Crawling Gait Design for a Caterpillar-Inspired Robot with Tendon-Driven Flexible Bending Segments by Shi, Hanlin, Scott, William L.

“…Soft crawling robots can potentially access locations that are unreachable by humans and traditional rigid robots, playing a crucial role in conducting…”
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Interest Rate Risk and Equity Values of Life Insurance Companies: A GARCH-M Model by Brewer, Elijah, Carson, James M., Elyasiani, Elyas, Mansur, Iqbal, Scott, William L.

“…The importance of managerial decisions related to interest-sensitive cash flows has received considerable attention in the insurance literature. Consistent…”
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