Search Results - "Scott, Timothy L"

Collagen prolyl 4-hydroxylase 1 is essential for HIF-1α stabilization and TNBC chemoresistance by Xiong, Gaofeng, Stewart, Rachel L., Chen, Jie, Gao, Tianyan, Scott, Timothy L., Samayoa, Luis M., O’Connor, Kathleen, Lane, Andrew N., Xu, Ren

“…Collagen prolyl 4-hydroxylase (P4H) expression and collagen hydroxylation in cancer cells are necessary for breast cancer progression. Here, we show that P4H…”
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Noninvasive liquid diet delivery of stable isotopes into mouse models for deep metabolic network tracing by Sun, Ramon C., Fan, Teresa W.-M., Deng, Pan, Higashi, Richard M., Lane, Andrew N., Le, Anh-Thu, Scott, Timothy L., Sun, Qiushi, Warmoes, Marc O., Yang, Ye

“…Delivering isotopic tracers for metabolic studies in rodents without overt stress is challenging. Current methods achieve low label enrichment in proteins and…”
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Preclinical evaluation of novel fatty acid synthase inhibitors in primary colorectal cancer cells and a patient-derived xenograft model of colorectal cancer by Zaytseva, Yekaterina Y, Rychahou, Piotr G, Le, Anh-Thu, Scott, Timothy L, Flight, Robert M, Kim, Ji Tae, Harris, Jennifer, Liu, Jinpeng, Wang, Chi, Morris, Andrew J, Sivakumaran, Theru A, Fan, Teresa, Moseley, Hunter, Gao, Tianyan, Lee, Eun Y, Weiss, Heidi L, Heuer, Timothy S, Kemble, George, Evers, Mark

“…Fatty Acid Synthase (FASN), a key enzyme of lipogenesis, is upregulated in many cancers including colorectal cancer (CRC); increased FASN expression is…”
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Tissue-Specific Downregulation of Fatty Acid Synthase Suppresses Intestinal Adenoma Formation via Coordinated Reprograming of Transcriptome and Metabolism in the Mouse Model of Apc-Driven Colorectal Cancer by Drury, James, Young, Lyndsay E A, Scott, Timothy L, Kelson, Courtney O, He, Daheng, Liu, Jinpeng, Wu, Yuanyan, Wang, Chi, Weiss, Heidi L, Fan, Teresa, Gentry, Matthew S, Sun, Ramon, Zaytseva, Yekaterina Y

“…Altered lipid metabolism is a potential target for therapeutic intervention in cancer. Overexpression of Fatty Acid Synthase (FASN) correlates with poor…”
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A Micro-Scale Analytical Method for Determining Glycogen Turnover by NMR and FTMS by Scott, Timothy L, Zhu, Juan, Cassel, Teresa A, Vicente-Muñoz, Sara, Lin, Penghui, Higashi, Richard M, Lane, Andrew N, Fan, Teresa W-M

“…Glycogen is a readily deployed intracellular energy storage macromolecule composed of branched chains of glucose anchored to the protein glycogenin. Although…”
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Repair of oxidative DNA damage and cancer: recent progress in DNA base excision repair by Scott, Timothy L, Rangaswamy, Suganya, Wicker, Christina A, Izumi, Tadahide

“…Reactive oxygen species (ROS) are generated by exogenous and environmental genotoxins, but also arise from mitochondria as byproducts of respiration in the…”
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The PLOD2/succinate axis regulates the epithelial-mesenchymal plasticity and cancer cell stemness by Tong, Yuxin, Qi, Yifei, Xiong, Gaofeng, Li, Junyan, Scott, Timothy L, Chen, Jie, He, Daheng, Li, Linzhang, Wang, Chi, Lane, Andrew N, Xu, Ren

“…Aberrant accumulation of succinate has been detected in many cancers. However, the cellular function and regulation of succinate in cancer progression is not…”
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Polyubiquitination of apurinic/apyrimidinic endonuclease 1 by Parkin by Scott, Timothy L., Wicker, Christina A., Suganya, Rangaswamy, Dhar, Bithika, Pittman, Thomas, Horbinski, Craig, Izumi, Tadahide

“…Apurinic/apyrimidinic endonuclease 1 (APE1) is an essential protein crucial for repair of oxidized DNA damage not only in genomic DNA but also in mitochondrial…”
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Purification and Growth of Melanocortin 1 Receptor (Mc1r)-Defective Primary Murine Melanocytes Is Dependent on Stem Cell Factor (SFC) from Keratinocyte-Conditioned Media by Scott, Timothy L., Wakamatsu, Kazumasa, Ito, Shosuke, D'Orazio, John A.

“…The melanocortin 1 receptor (MC1R) is a transmembrane$\text{G}_{\text{s}}$-coupled surface protein found on melanocytes that binds melanocyte-stimulating…”
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Pigment-independent cAMP-mediated epidermal thickening protects against cutaneous UV injury by keratinocyte proliferation by Scott, Timothy L., Christian, Perry A., Kesler, Melissa V., Donohue, Kevin M., Shelton, Brent, Wakamatsu, Kazumasa, Ito, Shosuke, D'Orazio, John

“…The epidermis increases pigmentation and epidermal thickness in response to ultraviolet exposure to protect against UV‐associated carcinogenesis; however, the…”
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Pharmacologic induction of epidermal melanin and protection against sunburn in a humanized mouse model by Amaro-Ortiz, Alexandra, Vanover, Jillian C, Scott, Timothy L, D'Orazio, John A

“…Fairness of skin, UV sensitivity and skin cancer risk all correlate with the physiologic function of the melanocortin 1 receptor, a Gs-coupled signaling…”
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Induction of Calcitonin and Calcitonin Receptor Expression in Rat Mammary Tissue during Pregnancy by Tverberg, Lois A., Gustafson, Margaret F., Scott, Timothy L., Arzumanova, Irina V., Provost, Elayne R., Yan, Arthur W., Rawie, Sonja A.

“…Abstract Human breast milk samples at early time points after parturition contain high levels of calcitonin (CT) in both normal and thyroidectomized mothers,…”
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Abstract 4142: Regulation of tumor suppressor decorin by APE1 in head and neck squamous cell carcinoma by Wicker, Christina A., Scott, Timothy L., Suganya, Rangaswamy, Arnold, Susan M., Brill, Yolanda M., Horbinski, Craig M., Napier, Dana, Valentino, Joseph, Kudrimoti, Mahesh R., Yu, Guoqiang, Izumi, Tadahide

“…Oral cancers have a high rate of recurrence, and a tendency to develop treatment resistance. From 2009 to 2013, Kentucky had a disproportionately higher…”
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Induction of Calcitonin and Calcitonin Receptor Expression in Rat Mammary Tissue during Pregnancy1 by Tverberg, Lois A, Gustafson, Margaret F, Scott, Timothy L, Arzumanova, Irina V, Provost, Elayne R, Yan, Arthur W, Rawie, Sonja A

“…Human breast milk samples at early time points after parturition contain high levels of calcitonin (CT) in both normal and thyroidectomized mothers, suggesting…”
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Abstract 2324: Small-scale microwave-assisted acid hydrolysis method for glycogen determination and turnover in tumors using Stable Isotope Resolved Metabolomics by Lane, Andrew N., Scott, Timothy L., Zhu, Juan, Cassel, Teresa A., Vicente-Munoz, Sara, Lin, Penghui, Higashi, Richard M., Fan, Teresa W-M

“…Introduction: Glycogen is a readily deployed intracellular energy storage macromolecule composed of branched chains of glucose. Although glycogen primarily…”
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Abstract 622: Degradation of APE1 by the E3 ubiquitin ligase Parkin by Scott, Timothy L., Rangaswamy, Suganya, Dhar, Bithika, Zhi, LianTeng, Bueler, Hansruedi, Izumi, Tadahide

“…The mammalian apurinic/apyrimidinic endonuclease 1 (APE1/Ref1) is a DNA repair/redox regulator protein of which cytoplasmic accumulation has been associated…”
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Abstract 452: Activation of Akt pathway and autophagy promotes resistance to FASN inhibition in colorectal cancer patient-derived xenograft models by Zaytseva, Yekaterina Y., Rychahou, Piotr G., Le, Anh-Thu, Flight, Robert M., Scott, Timothy L., Harris, Jennifer W., Hodges, Sally, Hallahan, Brent J., Napier, Dana L., Liu, Jinpeng, Wang, Chi, Sunkara, Manjula, Morris, Andrew, Kim, Ji Tae, Arumugam, Sivakumaran Theru, Lane, Andrew, Fan, Teresa W., Moseley, Hunter, Gao, Tianyan, Lee, Eun Y., Weiss, Heidi L., Heuer, Timothy S., Kemble, George, Evers, B Mark

“…Fatty Acid Synthase (FASN), a key enzyme of de novo lipogenesis, is upregulated in many cancers including colorectal cancer (CRC); increased FASN expression is…”
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Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model by Amaro-Ortiz, Alexandra, Vanover, Jillian C., Scott, Timothy L., D'Orazio, John A.

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Induction of Calcitonin and Calcitonin Receptor Expression in Rat Mammary Tissue during Pregnancy 1 by Tverberg, Lois A., Gustafson, Margaret F., Scott, Timothy L., Arzumanova, Irina V., Provost, Elayne R., Yan, Arthur W., Rawie, Sonja A.

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