Search Results - "Scott, Sasinya N"

Recurrent SMARCA4 mutations in small cell carcinoma of the ovary by Jelinic, Petar, Mueller, Jennifer J, Olvera, Narciso, Dao, Fanny, Scott, Sasinya N, Shah, Ronak, Gao, JianJiong, Schultz, Nikolaus, Gonen, Mithat, Soslow, Robert A, Berger, Michael F, Levine, Douglas A

“…Douglas Levine and colleagues identify recurrent inactivating mutations in the SWI/SNF complex member SMARCA4 in 12 of 12 samples of small cell carcinoma of…”
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The genetic landscape of endometrial clear cell carcinomas by DeLair, Deborah F, Burke, Kathleen A, Selenica, Pier, Lim, Raymond S, Scott, Sasinya N, Middha, Sumit, Mohanty, Abhinita S, Cheng, Donavan T, Berger, Michael F, Soslow, Robert A, Weigelt, Britta

“…Clear cell carcinoma of the endometrium is a rare type of endometrial cancer that is generally associated with an aggressive clinical behaviour. Here, we…”
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GNAS and KRAS Mutations Define Separate Progression Pathways in Intraductal Papillary Mucinous Neoplasm-Associated Carcinoma by Tan, Marcus C., MBBS (Hons), Basturk, Olca, MD, Brannon, A. Rose, PhD, Bhanot, Umesh, MD, PhD, Scott, Sasinya N., MS, Bouvier, Nancy, BS, LaFemina, Jennifer, MD, FACS, Jarnagin, William R., MD, FACS, Berger, Michael F., PhD, Klimstra, David, MD, Allen, Peter J., MD, FACS

“…Background Intraductal papillary mucinous neoplasms (IPMN) are being increasingly recognized as important precursors to pancreatic adenocarcinoma. Elucidation…”
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Comparative sequencing analysis reveals high genomic concordance between matched primary and metastatic colorectal cancer lesions by Brannon, A Rose, Vakiani, Efsevia, Sylvester, Brooke E, Scott, Sasinya N, McDermott, Gregory, Shah, Ronak H, Kania, Krishan, Viale, Agnes, Oschwald, Dayna M, Vacic, Vladimir, Emde, Anne-Katrin, Cercek, Andrea, Yaeger, Rona, Kemeny, Nancy E, Saltz, Leonard B, Shia, Jinru, D'Angelica, Michael I, Weiser, Martin R, Solit, David B, Berger, Michael F

“…Colorectal cancer is the second leading cause of cancer death in the United States, with over 50,000 deaths estimated in 2014. Molecular profiling for somatic…”
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The oncocytic subtype is genetically distinct from other pancreatic intraductal papillary mucinous neoplasm subtypes by Basturk, Olca, Tan, Marcus, Bhanot, Umesh, Allen, Peter, Adsay, Volkan, Scott, Sasinya N, Shah, Ronak, Berger, Michael F, Askan, Gokce, Dikoglu, Esra, Jobanputra, Vaidehi, Wrzeszczynski, Kazimierz O, Sigel, Carlie, Iacobuzio-Donahue, Christine, Klimstra, David S

“…In 2010, the World Health Organization reclassified the entity originally described as intraductal oncocytic papillary neoplasm as the ‘oncocytic subtype' of…”
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The repertoire of genetic alterations in salivary duct carcinoma including a novel HNRNPH3-ALK rearrangement by Dogan, Snjezana, Ng, Charlotte K.Y., Xu, Bin, Kumar, Rahul, Wang, Lu, Edelweiss, Marcia, Scott, Sasinya N., Zehir, Ahmet, Drilon, Alexander, Morris, Luc G.T., Lee, Nancy Y., Antonescu, Cristina R., Ho, Alan L., Katabi, Nora, Berger, Michael F., Reis-Filho, Jorge S.

“…Salivary duct carcinoma (SDC) is a rare, aggressive malignancy with limited treatment options and poor outcome. Twenty-nine primary resected SDC, including 15…”
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Genomic characterization of response to chemoradiation in urothelial bladder cancer by Desai, Neil B., Scott, Sasinya N., Zabor, Emily C., Cha, Eugene K., Hreiki, Joseph, Sfakianos, John P., Ramirez, Ricardo, Bagrodia, Aditya, Rosenberg, Jonathan E., Bajorin, Dean F., Berger, Michael F., Bochner, Bernard H., Zelefsky, Michael J., Kollmeier, Marisa A., Ostrovnaya, Irina, Al‐Ahmadie, Hikmat A., Solit, David B., Iyer, Gopa

“…BACKGROUND The authors characterized the genetic landscape of chemoradiation‐treated urothelial carcinoma of the bladder (UCB) with the objective of…”
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Targeted exome sequencing profiles genetic alterations in leiomyosarcoma by Agaram, Narasimhan P., Zhang, Lei, LeLoarer, Francois, Silk, Tarik, Sung, Yun-Shao, Scott, Sasinya N., Kuk, Deborah, Qin, Li-Xuan, Berger, Michael F., Antonescu, Cristina R., Singer, Samuel

“…Leiomyosarcoma (LMS) belongs to the class of genetically complex sarcomas and shows numerous, often non‐recurrent chromosomal imbalances and aberrations. We…”
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Cutaneous squamous and neuroendocrine carcinoma: genetically and immunohistochemically different from Merkel cell carcinoma by Pulitzer, Melissa P, Brannon, A Rose, Berger, Michael F, Louis, Peter, Scott, Sasinya N, Jungbluth, Achim A, Coit, Daniel G, Brownell, Isaac, Busam, Klaus J

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Memorial Sloan Kettering-Integrated Mutation Profiling of Actionable Cancer Targets (MSK-IMPACT): A Hybridization Capture-Based Next-Generation Sequencing Clinical Assay for Solid Tumor Molecular Oncology by Cheng, Donavan T, Mitchell, Talia N, Zehir, Ahmet, Shah, Ronak H, Benayed, Ryma, Syed, Aijazuddin, Chandramohan, Raghu, Liu, Zhen Yu, Won, Helen H, Scott, Sasinya N, Brannon, A Rose, O'Reilly, Catherine, Sadowska, Justyna, Casanova, Jacklyn, Yannes, Angela, Hechtman, Jaclyn F, Yao, Jinjuan, Song, Wei, Ross, Dara S, Oultache, Alifya, Dogan, Snjezana, Borsu, Laetitia, Hameed, Meera, Nafa, Khedoudja, Arcila, Maria E, Ladanyi, Marc, Berger, Michael F

“…The identification of specific genetic alterations as key oncogenic drivers and the development of targeted therapies are together transforming clinical…”
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Genome Sequencing Identifies a Basis for Everolimus Sensitivity by Iyer, Gopa, Hanrahan, Aphrothiti J., Milowsky, Matthew I., Al-Ahmadie, Hikmat, Scott, Sasinya N., Janakiraman, Manickam, Pirun, Mono, Sander, Chris, Socci, Nicholas D., Ostrovnaya, Irina, Viale, Agnes, Heguy, Adriana, Peng, Luke, Chan, Timothy A., Bochner, Bernard, Bajorin, Dean F., Berger, Michael F., Taylor, Barry S., Solit, David B.

“…Cancer drugs often induce dramatic responses in a small minority of patients. We used whole-genome sequencing to investigate the genetic basis of a durable…”
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NF1 Mutations Are Common in Desmoplastic Melanoma by Wiesner, Thomas, Kiuru, Maija, Scott, Sasinya N, Arcila, Maria, Halpern, Allan C, Hollmann, Travis, Berger, Michael F, Busam, Klaus J

“…Desmoplastic melanoma (DM) is a rare variant of melanoma with distinct clinical, histopathologic, and immunohistochemical features. Clinically, DM differs from…”
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Memorial Sloan Kettering-Integrated Mutation Profiling of Actionable Cancer Targets (MSK-IMPACT) by Cheng, Donavan T, Mitchell, Talia N, Zehir, Ahmet, Shah, Ronak H, Benayed, Ryma, Syed, Aijazuddin, Chandramohan, Raghu, Liu, Zhen Yu, Won, Helen H, Scott, Sasinya N, Brannon, A. Rose, O'Reilly, Catherine, Sadowska, Justyna, Casanova, Jacklyn, Yannes, Angela, Hechtman, Jaclyn F, Yao, Jinjuan, Song, Wei, Ross, Dara S, Oultache, Alifya, Dogan, Snjezana, Borsu, Laetitia, Hameed, Meera, Nafa, Khedoudja, Arcila, Maria E, Ladanyi, Marc, Berger, Michael F

“…The identification of specific genetic alterations as key oncogenic drivers and the development of targeted therapies are together transforming clinical…”
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Tumor Genetic Analyses of Patients with Metastatic Renal Cell Carcinoma and Extended Benefit from mTOR Inhibitor Therapy by VOSS, Martin H, HAKIMI, A. Ari, SOCCI, Nicholas D, VIALE, Agnes, SCHULTZ, Nikolaus, SANDER, Chris, REUTER, Victor E, RUSSO, Paul, CHENG, Emily H, MOTZER, Robert J, BERGER, Michael F, HSIEH, James J, PHAM, Can G, BRANNON, A. Rose, CHEN, Ying-Bei, CUNHA, Luis F, AKIN, Oguz, HAN LIU, TAKEDA, Shugaku, SCOTT, Sasinya N

“…Rapalogs are allosteric mTOR inhibitors and approved agents for advanced kidney cancer. Reports of clonal heterogeneity in this disease challenge the concept…”
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Genomic Characterization of Upper Tract Urothelial Carcinoma by Sfakianos, John P, Cha, Eugene K, Iyer, Gopa, Scott, Sasinya N, Zabor, Emily C, Shah, Ronak H, Ren, Qinghu, Bagrodia, Aditya, Kim, Philip H, Hakimi, A. Ari, Ostrovnaya, Irina, Ramirez, Ricardo, Hanrahan, Aphrothiti J, Desai, Neil B, Sun, Arony, Pinciroli, Patrizia, Rosenberg, Jonathan E, Dalbagni, Guido, Schultz, Nikolaus, Bajorin, Dean F, Reuter, Victor E, Berger, Michael F, Bochner, Bernard H, Al-Ahmadie, Hikmat A, Solit, David B, Coleman, Jonathan A

“…Abstract Background Despite a similar histologic appearance, upper tract urothelial carcinoma (UTUC) and urothelial carcinoma of the bladder (UCB) tumors have…”
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Alternative transcription initiation leads to expression of a novel ALK isoform in cancer by Wiesner, Thomas, Lee, William, Obenauf, Anna C., Ran, Leili, Murali, Rajmohan, Zhang, Qi Fan, Wong, Elissa W. P., Hu, Wenhuo, Scott, Sasinya N., Shah, Ronak H., Landa, Iñigo, Button, Julia, Lailler, Nathalie, Sboner, Andrea, Gao, Dong, Murphy, Devan A., Cao, Zhen, Shukla, Shipra, Hollmann, Travis J., Wang, Lu, Borsu, Laetitia, Merghoub, Taha, Schwartz, Gary K., Postow, Michael A., Ariyan, Charlotte E., Fagin, James A., Zheng, Deyou, Ladanyi, Marc, Busam, Klaus J., Berger, Michael F., Chen, Yu, Chi, Ping

“…A novel ALK transcript expressed in a subset of human cancers, arising from a de novo alternative transcription initiation site within the ALK gene, is…”
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Frequent somatic CDH1 loss-of-function mutations in plasmacytoid variant bladder cancer by Al-Ahmadie, Hikmat A, Iyer, Gopa, Lee, Byron H, Scott, Sasinya N, Mehra, Rohit, Bagrodia, Aditya, Jordan, Emmet J, Gao, Sizhi Paul, Ramirez, Ricardo, Cha, Eugene K, Desai, Neil B, Zabor, Emily C, Ostrovnaya, Irina, Gopalan, Anuradha, Chen, Ying-Bei, Fine, Samson W, Tickoo, Satish K, Gandhi, Anupama, Hreiki, Joseph, Viale, Agnès, Arcila, Maria E, Dalbagni, Guido, Rosenberg, Jonathan E, Bochner, Bernard H, Bajorin, Dean F, Berger, Michael F, Reuter, Victor E, Taylor, Barry S, Solit, David B

“…David Solit and colleagues report that inactivating CDH1 mutations are found in 84% of plasmacytoid bladder cancer samples tested and are not found in other…”
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Genomic Predictors of Survival in Patients with High-grade Urothelial Carcinoma of the Bladder by Kim, Philip H, Cha, Eugene K, Sfakianos, John P, Iyer, Gopa, Zabor, Emily C, Scott, Sasinya N, Ostrovnaya, Irina, Ramirez, Ricardo, Sun, Arony, Shah, Ronak, Yee, Alyssa M, Reuter, Victor E, Bajorin, Dean F, Rosenberg, Jonathan E, Schultz, Nikolaus, Berger, Michael F, Al-Ahmadie, Hikmat A, Solit, David B, Bochner, Bernard H

“…Abstract Urothelial carcinoma of the bladder (UCB) is genomically heterogeneous, with frequent alterations in genes regulating chromatin state, cell cycle…”
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A phase 2 trial of buparlisib in patients with platinum‐resistant metastatic urothelial carcinoma by McPherson, Victor, Reardon, Brendan, Bhayankara, Aravind, Scott, Sasinya N., Boyd, Mariel E., Garcia‐Grossman, Ilana R., Regazzi, Ashley M., McCoy, Asia S., Kim, Philip H., Al‐Ahmadie, Hikmat, Ostrovnaya, Irina, Roth, Andrew J., Farooki, Azeez, Berger, Michael F., Rosenberg, Jonathan E., Solit, David B., Van Allen, Eliezer, Milowsky, Matthew I., Bajorin, Dean F., Iyer, Gopa

“…Background The phosphatidyl 3‐inositol kinase (PI3K)/Akt/mechanistic target of rapamycin (mTOR) pathway frequently is activated in patients with urothelial…”
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Cutaneous squamous and neuroendocrine carcinoma: genetically and immunohistochemically different from Merkel cell carcinoma by Pulitzer, Melissa P, Brannon, A Rose, Berger, Michael F, Louis, Peter, Scott, Sasinya N, Jungbluth, Achim A, Coit, Daniel G, Brownell, Isaac, Busam, Klaus J

“…Cutaneous neuroendocrine (Merkel cell) carcinoma most often arises de novo in the background of a clonally integrated virus, the Merkel cell polyomavirus, and…”
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