Search Results - "Scott, Peter JH"
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Highlight selection of radiochemistry and radiopharmacy developments by editorial board
Published in EJNMMI radiopharmacy and chemistry (16-09-2024)“…Background The Editorial Board of EJNMMI Radiopharmacy and Chemistry releases a biannual highlight commentary to update the readership on trends in the field…”
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Nuclear Medicine and Artificial Intelligence: Best Practices for Algorithm Development
Published in Journal of Nuclear Medicine (01-04-2022)“…The nuclear medicine field has seen a rapid expansion of academic and commercial interest in developing artificial intelligence (AI) algorithms. Users and…”
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Gait speed in Parkinson disease correlates with cholinergic degeneration
Published in Neurology (29-10-2013)“…OBJECTIVE:We investigated dopaminergic and cholinergic correlates of gait speed in Parkinson disease (PD) and non-PD control subjects to test the hypothesis…”
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Ethical Considerations for Artificial Intelligence in Medical Imaging: Data Collection, Development, and Evaluation
Published in Journal of Nuclear Medicine (01-12-2023)“…The development of artificial intelligence (AI) within nuclear imaging involves several ethically fraught components at different stages of the machine…”
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Ethical Considerations for Artificial Intelligence in Medical Imaging: Deployment and Governance
Published in Journal of Nuclear Medicine (01-10-2023)“…The deployment of artificial intelligence (AI) has the potential to make nuclear medicine and medical imaging faster, cheaper, and both more effective and more…”
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Artificial Intelligence in Nuclear Medicine: Opportunities, Challenges, and Responsibilities Toward a Trustworthy Ecosystem
Published in Journal of Nuclear Medicine (01-02-2023)“…Trustworthiness is a core tenet of medicine. The patient-physician relationship is evolving from a dyad to a broader ecosystem of health care. With the…”
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Proceedings: PET Drugs-A Workshop on Inspections Management and Regulatory Considerations
Published in Journal of Nuclear Medicine (01-07-2022)“…Recent advances in the development of new molecular imaging agents for PET have led to the approval of several new molecular entities for PET imaging by the…”
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Frequency of cholinergic and caudate nucleus dopaminergic deficits across the predemented cognitive spectrum of Parkinson disease and evidence of interaction effects
Published in JAMA neurology (01-02-2015)“…Little is known about the relative contributions of multisystem degenerative processes across the spectrum of predemented cognitive decline in Parkinson…”
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On the consensus nomenclature rules for radiopharmaceutical chemistry – Reconsideration of radiochemical conversion
Published in Nuclear medicine and biology (01-02-2021)“…Radiochemical conversion is an important term to be included in the “Consensus nomenclature rules for radiopharmaceutical chemistry”. Radiochemical conversion…”
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Development of Fluorinated NP-59: A Revival of Cholesterol Use Imaging with PET
Published in Journal of Nuclear Medicine (01-12-2022)“…Imaging of cholesterol use is possible with the I scintiscanning/SPECT agent NP-59. This agent provided a noninvasive measure of adrenal function and steroid…”
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Extra-nigral pathological conditions are common in Parkinson's disease with freezing of gait: An in vivo positron emission tomography study
Published in Movement disorders (01-08-2014)“…Cholinergic denervation has been associated with falls and slower gait speed and β‐amyloid deposition with greater severity of axial motor impairments in…”
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Thalamic cholinergic innervation and postural sensory integration function in Parkinson's disease
Published in Brain (London, England : 1878) (01-11-2013)“…The pathophysiology of postural instability in Parkinson's disease remains poorly understood. Normal postural function depends in part on the ability of the…”
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Striatal and Cortical β-Amyloidopathy and Cognition in Parkinson's Disease
Published in Movement disorders (01-01-2016)“…ABSTRACT Introduction Although most previous cognitive studies of β‐amyloidopathy in PD focused on cortical plaque deposition, recent postmortem studies point…”
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Striatal and Cortical [beta]-Amyloidopathy and Cognition in Parkinson's Disease
Published in Movement disorders (01-01-2016)“…Introduction Although most previous cognitive studies of [beta]-amyloidopathy in PD focused on cortical plaque deposition, recent postmortem studies point to…”
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Diabetes mellitus is independently associated with more severe cognitive impairment in Parkinson disease
Published in Parkinsonism & related disorders (01-12-2014)“…Abstract Background There is increasing interest in interactions between metabolic syndromes and neurodegeneration. Diabetes mellitus (DM) contributes to…”
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A Comprehensive Assessment of 68Ga-PSMA-11 PET in Biochemically Recurrent Prostate Cancer: Results from a Prospective Multicenter Study on 2,005 Patients
Published in The Journal of nuclear medicine (1978) (01-04-2022)“…We prospectively investigated the performance of the prostate-specific membrane antigen (PSMA) ligand 68Ga-PSMA-11 for detecting prostate adenocarcinoma in…”
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Clinical markers for identifying cholinergic deficits in Parkinson's disease
Published in Movement disorders (01-02-2015)“…ABSTRACT Background Cholinergic projection systems degeneration is associated with dopamine nonresponsive features of Parkinson's disease (PD). Cholinergic…”
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Radiosynthesis and initial preclinical evaluation of [11C]AZD1283 as a potential P2Y12R PET radiotracer
Published in Nuclear medicine and biology (01-11-2022)“…Chronic neuroinflammation and microglial dysfunction are key features of many neurological diseases, including Alzheimer's Disease and multiple sclerosis…”
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Issues in preclinical radiopharmaceutical research: Significance, relevance and reproducibility
Published in Nuclear medicine and biology (01-12-2018)“…Kilbourn and Scott discuss the three critical factors that they believe should be applied to every preclinical study in radiopharmaceutical research. The…”
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Is logP truly dead?
Published in Nuclear medicine and biology (01-11-2017)“…More than 100 years ago, the importance of lipophilicity to the passive permeability of molecules through the blood brain barrier was recognized. In the…”
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