Search Results - "Scott, Peter J H"
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Synthesis of [18F]Arenes via the Copper-Mediated [18F]Fluorination of Boronic Acids
Published in Organic letters (04-12-2015)“…A copper-mediated radiofluorination of aryl- and vinylboronic acids with K18F is described. This method exhibits high functional group tolerance and is…”
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Copper-Catalyzed [18F]Fluorination of (Mesityl)(aryl)iodonium Salts
Published in Organic letters (20-06-2014)“…A practical, rapid, and highly regioselective Cu-catalyzed radiofluorination of (mesityl)(aryl)iodonium salts is described. This protocol utilizes [18F]KF…”
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Late-stage [18F]fluorination: new solutions to old problems
Published in Chemical science (Cambridge) (01-01-2014)“…The last 2-3 years have seen numerous relationships develop between organometallic chemists, fluorine chemists and PET Centers around the world. These…”
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Frequency of cholinergic and caudate nucleus dopaminergic deficits across the predemented cognitive spectrum of Parkinson disease and evidence of interaction effects
Published in JAMA neurology (01-02-2015)“…Little is known about the relative contributions of multisystem degenerative processes across the spectrum of predemented cognitive decline in Parkinson…”
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DARK Classics in Chemical Neuroscience: Cocaine
Published in ACS chemical neuroscience (17-10-2018)“…In this Review, we consider the story of cocaine from its humble origins in South America to its status as one of the most abused substances in 21st century…”
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Copper(II)-Mediated [11C]Cyanation of Arylboronic Acids and Arylstannanes
Published in Organic letters (16-03-2018)“…A copper-mediated method for the transformation of diverse arylboron compounds and arylstannanes to aryl-[11C]-nitriles is reported. This method is…”
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Gait speed in Parkinson disease correlates with cholinergic degeneration
Published in Neurology (29-10-2013)“…OBJECTIVE:We investigated dopaminergic and cholinergic correlates of gait speed in Parkinson disease (PD) and non-PD control subjects to test the hypothesis…”
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Ring opening of epoxides with [ 18 F]FeF species to produce [ 18 F]fluorohydrin PET imaging agents
Published in Chemical communications (Cambridge, England) (30-05-2019)“…A simple technique for the preparation of [18F]HF has been developed and applied to the generation of an [18F]FeF species for opening sterically hindered…”
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Classics in Neuroimaging: Development of PET Tracers for Imaging Monoamine Oxidases
Published in ACS chemical neuroscience (17-04-2019)“…In this Viewpoint, we highlight the history of positron emission tomography (PET) radiotracer development to quantify changes in monoamine oxidase (MAO)-A and…”
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Thalamic cholinergic innervation and postural sensory integration function in Parkinson's disease
Published in Brain (London, England : 1878) (01-11-2013)“…The pathophysiology of postural instability in Parkinson's disease remains poorly understood. Normal postural function depends in part on the ability of the…”
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Identification of [18F]TRACK, a Fluorine-18-Labeled Tropomyosin Receptor Kinase (Trk) Inhibitor for PET Imaging
Published in Journal of medicinal chemistry (22-02-2018)“…Changes in expression and dysfunctional signaling of TrkA/B/C receptors and oncogenic Trk fusion proteins are found in neurological diseases and cancers. Here,…”
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Production of radiometals in liquid targets
Published in EJNMMI radiopharmacy and chemistry (10-01-2020)“…Over the last several years, the use of radiometals has gained increasing relevance in supporting the continuous development of new, complementary and more…”
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Methods for the Incorporation of Carbon-11 To Generate Radiopharmaceuticals for PET Imaging
Published in Angewandte Chemie International Edition (01-01-2009)“…Diversification to meet demand: The growing demand for novel radiopharmaceuticals can only be met through the development of new approaches to isotopic…”
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Radionuclide Imaging for Neuroscience: Current Opinion and Future Directions
Published in Molecular imaging (2020)“…This meeting report summarizes a Consultants Meeting that was held at International Atomic Energy Agency headquarters in Vienna to provide an update on…”
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Proceedings of international symposium of trends in radiopharmaceuticals 2023 (ISTR-2023)
Published in EJNMMI radiopharmacy and chemistry (10-11-2023)“…The International Atomic Energy Agency (IAEA) held the 3rd International Symposium on Trends in Radiopharmaceuticals, (ISTR-2023) at IAEA Headquarters in…”
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Copper-Mediated Radiofluorination of Arylstannanes with [18F]KF
Published in Organic letters (21-10-2016)“…A copper-mediated nucleophilic radiofluorination of aryl- and vinylstannanes with [18F]KF is described. This method is fast, uses commercially available…”
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High Affinity Radiopharmaceuticals Based Upon Lansoprazole for PET Imaging of Aggregated Tau in Alzheimer’s Disease and Progressive Supranuclear Palsy: Synthesis, Preclinical Evaluation, and Lead Selection
Published in ACS chemical neuroscience (20-08-2014)“…Abnormally aggregated tau is the hallmark pathology of tauopathy neurodegenerative disorders and is a target for development of both diagnostic tools and…”
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Highlight selection of radiochemistry and radiopharmacy developments by editorial board
Published in EJNMMI radiopharmacy and chemistry (23-03-2023)“…Background The Editorial Board of EJNMMI Radiopharmacy and Chemistry releases a biannual highlight commentary to update the readership on trends in the field…”
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