Search Results - "Scott, Mark G.H."

An escort for GPCRs: implications for regulation of receptor density at the cell surface by Achour, Lamia, Labbé-Jullié, Catherine, Scott, Mark G.H, Marullo, Stefano

“…G-protein-coupled receptors (GPCRs) are dynamically regulated by various mechanisms that tune their response to external stimuli. Modulation of their plasma…”
Get full text

Rapid Detection of Dynamic PTEN Regulation in Living Cells Using Intramolecular BRET by Misticone, Stanislas, Lima-Fernandes, Evelyne, Scott, Mark G H

“…Tumor suppressor PTEN phosphatase acts to inhibit the PI3K/AKT pathway and thus regulates cell proliferation, survival, and migration. Dysregulation of PTEN…”
Get more information

Strength of Neisseria meningitidis binding to endothelial cells requires highly-ordered CD147/β2-adrenoceptor clusters assembled by alpha-actinin-4 by Maïssa, Nawal, Covarelli, Valentina, Janel, Sébastien, Durel, Beatrice, Simpson, Nandi, Bernard, Sandra C., Pardo-Lopez, Liliana, Bouzinba-Ségard, Haniaa, Faure, Camille, Scott, Mark G.H., Coureuil, Mathieu, Morand, Philippe C., Lafont, Frank, Nassif, Xavier, Marullo, Stefano, Bourdoulous, Sandrine

“…Neisseria meningitidis (meningococcus) is an invasive bacterial pathogen that colonizes human vessels, causing thrombotic lesions and meningitis. Establishment…”
Get full text

β-arrestin 2 oligomerization controls the Mdm2-dependent inhibition of p53 by Boularan, Cédric, Scott, Mark G.H, Bourougaa, Karima, Bellal, Myriam, Esteve, Emmanuel, Thuret, Alain, Benmerah, Alexandre, Tramier, Marc, Coppey-Moisan, Maité, Labbé-Jullié, Catherine, Fåhraeus, Robin, Marullo, Stefano

“…β-arrestins (β-arrs), two ubiquitous proteins involved in serpentine heptahelical receptor regulation and signaling, form constitutive homo- and…”
Get full text

Targeting of beta-arrestin2 to the centrosome and primary cilium: role in cell proliferation control by Molla-Herman, Anahi, Boularan, Cedric, Ghossoub, Rania, Scott, Mark G H, Burtey, Anne, Zarka, Marion, Saunier, Sophie, Concordet, Jean-Paul, Marullo, Stefano, Benmerah, Alexandre

“…The primary cilium is a sensory organelle generated from the centrosome in quiescent cells and found at the surface of most cell types, from where it controls…”
Get full text

Recruitment of Activated G Protein-coupled Receptors to Pre-existing Clathrin-coated Pits in Living Cells by Scott, Mark G.H., Benmerah, Alexandre, Muntaner, Olivier, Marullo, Stefano

“…The process of clathrin-mediated endocytosis tightly regulates signaling of the superfamily of seven-transmembrane G protein-coupled receptors (GPCRs). A…”
Get full text

Control of the Mdm2-p53 signal loop by β-arrestin 2: the ins and outs by Blondel-Tepaz, Elodie, Enslen, Hervé, Scott, Mark G.H.

Get full text

Posttranslational Regulation and Conformational Plasticity of PTEN by Kotelevets, Larissa, Trifault, Barbara, Chastre, Eric, Scott, Mark G H

“…Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) is a tumor suppressor that is frequently down-modulated in human cancer. PTEN inhibits the…”
Get full text

Meningococcus Hijacks a β2-Adrenoceptor/β-Arrestin Pathway to Cross Brain Microvasculature Endothelium by Coureuil, Mathieu, Lécuyer, Hervé, Scott, Mark G.H., Boularan, Cédric, Enslen, Hervé, Soyer, Magali, Mikaty, Guillain, Bourdoulous, Sandrine, Nassif, Xavier, Marullo, Stefano

“…Following pilus-mediated adhesion to human brain endothelial cells, meningococcus (N. meningitidis), the bacterium causing cerebrospinal meningitis, initiates…”
Get full text

Control of the Mdm2-p53 signal loop by β-arrestin 2: The ins and outs by Blondel-Tepaz, Elodie, Enslen, Hervé, Scott, Mark G H

Get full text

Phosphorylation and Chronic Agonist Treatment Atypically Modulate GABAB Receptor Cell Surface Stability by Fairfax, Benjamin P., Pitcher, Julie A., Scott, Mark G.H., Calver, Andrew R., Pangalos, Menelas N., Moss, Stephen J., Couve, Andrés

“…GABAB receptors are heterodimeric G protein-coupled receptors that mediate slow synaptic inhibition in the central nervous system. The dynamic control of the…”
Get full text

Control of CCR5 Cell-Surface Targeting by the PRAF2 Gatekeeper by Da Silva, Elisa, Scott, Mark G H, Enslen, Hervé, Marullo, Stefano

“…The cell-surface targeting of neo-synthesized G protein-coupled receptors (GPCRs) involves the recruitment of receptors into COPII vesicles budding at…”
Get full text

Pharmacological chaperone-rescued cystic fibrosis CFTR-F508del mutant overcomes PRAF2-gated access to endoplasmic reticulum exit sites by Saha, Kusumika, Chevalier, Benoit, Doly, Stéphane, Baatallah, Nesrine, Guilbert, Thomas, Pranke, Iwona, Scott, Mark G. H., Enslen, Hervé, Guerrera, Chiara, Chuon, Cérina, Edelman, Aleksander, Sermet-Gaudelus, Isabelle, Hinzpeter, Alexandre, Marullo, Stefano

“…The endoplasmic reticulum exit of some polytopic plasma membrane proteins (PMPs) is controlled by arginin-based retention motifs. PRAF2, a gatekeeper which…”
Get full text

The RanBP2/RanGAP1-SUMO complex gates β-arrestin2 nuclear entry to regulate the Mdm2-p53 signaling axis by Blondel-Tepaz, Elodie, Leverve, Marie, Sokrat, Badr, Paradis, Justine S., Kosic, Milena, Saha, Kusumika, Auffray, Cédric, Lima-Fernandes, Evelyne, Zamborlini, Alessia, Poupon, Anne, Gaboury, Louis, Findlay, Jane, Baillie, George S., Enslen, Hervé, Bouvier, Michel, Angers, Stéphane, Marullo, Stefano, Scott, Mark G. H.

“…Mdm2 antagonizes the tumor suppressor p53. Targeting the Mdm2-p53 interaction represents an attractive approach for the treatment of cancers with functional…”
Get full text

Strength of Neisseria meningitidis binding to endothelial cells requires highly-ordered CD147/β 2 -adrenoceptor clusters assembled by alpha-actinin-4 by Maïssa, Nawal, Covarelli, Valentina, Janel, Sébastien, Durel, Beatrice, Simpson, Nandi, Bernard, Sandra C, Pardo-Lopez, Liliana, Bouzinba-Ségard, Haniaa, Faure, Camille, Scott, Mark G H, Coureuil, Mathieu, Morand, Philippe C, Lafont, Frank, Nassif, Xavier, Marullo, Stefano, Bourdoulous, Sandrine

“…Neisseria meningitidis (meningococcus) is an invasive bacterial pathogen that colonizes human vessels, causing thrombotic lesions and meningitis. Establishment…”
Get full text

Beta-arrestins operate an on/off control switch for focal adhesion kinase activity by Alexander, Revu Ann, Lot, Isaure, Saha, Kusumika, Abadie, Guillaume, Lambert, Mireille, Decosta, Eleonore, Kobayashi, Hiroyuki, Beautrait, Alexandre, Borrull, Aurélie, Asnacios, Atef, Bouvier, Michel, Scott, Mark G. H., Marullo, Stefano, Enslen, Hervé

“…Focal adhesion kinase (FAK) regulates key biological processes downstream of G protein-coupled receptors (GPCRs) in normal and cancer cells, but the modes of…”
Get full text

Mechanical Activation of the β2-Adrenergic Receptor by Meningococcus: A Historical and Future Perspective Analysis of How a Bacterial Probe Can Reveal Signalling Pathways in Endothelial Cells, and a Unique Mode of Receptor Activation Involving Its N-Terminal Glycan Chains by Marullo, Stefano, Scott, Mark G. H., Enslen, Hervé, Coureuil, Mathieu

“…More than 12 years have passed since the seminal observation that meningococcus, a pathogen causing epidemic meningitis in humans, occasionally associated with…”
Get full text

Receptor sequestration in response to β-arrestin-2 phosphorylation by ERK1/2 governs steady-state levels of GPCR cell-surface expression by Paradis, Justine S., Ly, Stevenson, Blondel-Tepaz, Élodie, Galan, Jacob A., Beautrait, Alexandre, Scott, Mark G. H., Enslen, Hervé, Marullo, Stefano, Roux, Philippe P., Bouvier, Michel

“…MAPKs are activated in response to G protein-coupled receptor (GPCR) stimulation and play essential roles in regulating cellular processes downstream of these…”
Get full text

Targeting PTEN in Colorectal Cancers by Kotelevets, Larissa, Scott, Mark G H, Chastre, Eric

“…Phosphatase and tensin homolog (PTEN) is a tumour suppressor that represents one of the most common targets for genetic defect in human cancer. PTEN controls…”
Get more information

Secreted factors from brain endothelial cells maintain glioblastoma stem-like cell expansion through the mTOR pathway by Galan-Moya, Eva Maria, Le Guelte, Armelle, Lima-Fernandes, Evelyne, Thirant, Cécile, Dwyer, Julie, Bidere, Nicolas, Couraud, Pierre-Olivier, Scott, Mark G H, Junier, Marie-Pierre, Chneiweiss, Hervé, Gavard, Julie

“…Glioma stem‐cells are associated with the brain vasculature. However, the way in which this vascular niche regulates stem‐cell renewal and fate remains…”
Get full text