Search Results - "Scott, Mark G H"

CD4-CCR5 interaction in intracellular compartments contributes to receptor expression at the cell surface by Achour, Lamia, Scott, Mark G.H., Shirvani, Hamasseh, Thuret, Alain, Bismuth, Georges, Labbé-Jullié, Catherine, Marullo, Stefano

“…The association of CD4, a glycoprotein involved in T-cell development and antigen recognition, and CC chemokine receptor 5 (CCR5), a chemotactic G…”
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Control of CCR5 Cell-Surface Targeting by the PRAF2 Gatekeeper by Da Silva, Elisa, Scott, Mark G H, Enslen, Hervé, Marullo, Stefano

“…The cell-surface targeting of neo-synthesized G protein-coupled receptors (GPCRs) involves the recruitment of receptors into COPII vesicles budding at…”
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Pharmacological chaperone-rescued cystic fibrosis CFTR-F508del mutant overcomes PRAF2-gated access to endoplasmic reticulum exit sites by Saha, Kusumika, Chevalier, Benoit, Doly, Stéphane, Baatallah, Nesrine, Guilbert, Thomas, Pranke, Iwona, Scott, Mark G. H., Enslen, Hervé, Guerrera, Chiara, Chuon, Cérina, Edelman, Aleksander, Sermet-Gaudelus, Isabelle, Hinzpeter, Alexandre, Marullo, Stefano

“…The endoplasmic reticulum exit of some polytopic plasma membrane proteins (PMPs) is controlled by arginin-based retention motifs. PRAF2, a gatekeeper which…”
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The RanBP2/RanGAP1-SUMO complex gates β-arrestin2 nuclear entry to regulate the Mdm2-p53 signaling axis by Blondel-Tepaz, Elodie, Leverve, Marie, Sokrat, Badr, Paradis, Justine S., Kosic, Milena, Saha, Kusumika, Auffray, Cédric, Lima-Fernandes, Evelyne, Zamborlini, Alessia, Poupon, Anne, Gaboury, Louis, Findlay, Jane, Baillie, George S., Enslen, Hervé, Bouvier, Michel, Angers, Stéphane, Marullo, Stefano, Scott, Mark G. H.

“…Mdm2 antagonizes the tumor suppressor p53. Targeting the Mdm2-p53 interaction represents an attractive approach for the treatment of cancers with functional…”
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G Protein-Coupled Receptor Kinase 5 Contains a DNA-Binding Nuclear Localization Sequence by Johnson, Laura R., Scott, Mark G. H., Pitcher, Julie A.

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Beta-arrestins operate an on/off control switch for focal adhesion kinase activity by Alexander, Revu Ann, Lot, Isaure, Saha, Kusumika, Abadie, Guillaume, Lambert, Mireille, Decosta, Eleonore, Kobayashi, Hiroyuki, Beautrait, Alexandre, Borrull, Aurélie, Asnacios, Atef, Bouvier, Michel, Scott, Mark G. H., Marullo, Stefano, Enslen, Hervé

“…Focal adhesion kinase (FAK) regulates key biological processes downstream of G protein-coupled receptors (GPCRs) in normal and cancer cells, but the modes of…”
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Mechanical Activation of the β2-Adrenergic Receptor by Meningococcus: A Historical and Future Perspective Analysis of How a Bacterial Probe Can Reveal Signalling Pathways in Endothelial Cells, and a Unique Mode of Receptor Activation Involving Its N-Terminal Glycan Chains by Marullo, Stefano, Scott, Mark G. H., Enslen, Hervé, Coureuil, Mathieu

“…More than 12 years have passed since the seminal observation that meningococcus, a pathogen causing epidemic meningitis in humans, occasionally associated with…”
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Receptor sequestration in response to β-arrestin-2 phosphorylation by ERK1/2 governs steady-state levels of GPCR cell-surface expression by Paradis, Justine S., Ly, Stevenson, Blondel-Tepaz, Élodie, Galan, Jacob A., Beautrait, Alexandre, Scott, Mark G. H., Enslen, Hervé, Marullo, Stefano, Roux, Philippe P., Bouvier, Michel

“…MAPKs are activated in response to G protein-coupled receptor (GPCR) stimulation and play essential roles in regulating cellular processes downstream of these…”
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Secreted factors from brain endothelial cells maintain glioblastoma stem-like cell expansion through the mTOR pathway by Galan-Moya, Eva Maria, Le Guelte, Armelle, Lima-Fernandes, Evelyne, Thirant, Cécile, Dwyer, Julie, Bidere, Nicolas, Couraud, Pierre-Olivier, Scott, Mark G H, Junier, Marie-Pierre, Chneiweiss, Hervé, Gavard, Julie

“…Glioma stem‐cells are associated with the brain vasculature. However, the way in which this vascular niche regulates stem‐cell renewal and fate remains…”
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TRPV1 Activation Promotes β-arrestin2 Interaction with the Ribosomal Biogenesis Machinery in the Nucleolus:Implications for p53 Regulation and Neurite Outgrowth by Hassan, Ahmed, Iftinca, Mircea, Young, Daniel, Flynn, Robyn, Agosti, Francina, Abdullah, Nasser, Defaye, Manon, Scott, Mark G H, Dufour, Antoine, Altier, Christophe

“…Transient receptor potential vanilloids TRPV1) are non-selective cation channels that sense and transduce inflammatory pain signals. We previously reported…”
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Mechanical GPCR Activation by Traction Forces Exerted on Receptor N‑Glycans by Marullo, Stefano, Doly, Stephane, Saha, Kusumika, Enslen, Hervé, Scott, Mark G. H, Coureuil, Mathieu

“…Cells are sensitive to chemical stimulation which is converted into intracellular biochemical signals by the activation of specific receptors. Mechanical…”
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Cooperative Regulation of Extracellular Signal-Regulated Kinase Activation and Cell Shape Change by Filamin A and β-Arrestins by Scott, Mark G. H., Pierotti, Vincenzo, Storez, Hélène, Lindberg, Erika, Thuret, Alain, Muntaner, Olivier, Labbé-Jullié, Catherine, Pitcher, Julie A., Marullo, Stefano

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β-arrestin 2 oligomerization controls the Mdm2-dependent inhibition of p53 by Boularan, Cédric, Scott, Mark G.H, Bourougaa, Karima, Bellal, Myriam, Esteve, Emmanuel, Thuret, Alain, Benmerah, Alexandre, Tramier, Marc, Coppey-Moisan, Maité, Labbé-Jullié, Catherine, Fåhraeus, Robin, Marullo, Stefano

“…β-arrestins (β-arrs), two ubiquitous proteins involved in serpentine heptahelical receptor regulation and signaling, form constitutive homo- and…”
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Targeting of beta-arrestin2 to the centrosome and primary cilium: role in cell proliferation control by Molla-Herman, Anahi, Boularan, Cedric, Ghossoub, Rania, Scott, Mark G H, Burtey, Anne, Zarka, Marion, Saunier, Sophie, Concordet, Jean-Paul, Marullo, Stefano, Benmerah, Alexandre

“…The primary cilium is a sensory organelle generated from the centrosome in quiescent cells and found at the surface of most cell types, from where it controls…”
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Posttranslational Regulation and Conformational Plasticity of PTEN by Kotelevets, Larissa, Trifault, Barbara, Chastre, Eric, Scott, Mark G H

“…Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) is a tumor suppressor that is frequently down-modulated in human cancer. PTEN inhibits the…”
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Meningococcus Hijacks a beta 2-Adrenoceptor/ beta -Arrestin Pathway to Cross Brain Microvasculature Endothelium [inline image] by Coureuil, Mathieu, Lecuyer, Herve, Scott, Mark GH, Boularan, Cedric, Enslen, Herve, Soyer, Magali, Mikaty, Guillain, Bourdoulous, Sandrine, Nassif, Xavier, Marullo, Stefano

“…Following pilus-mediated adhesion to human brain endothelial cells, meningococcus (N. meningitidis), the bacterium causing cerebrospinal meningitis, initiates…”
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Targeting PTEN in Colorectal Cancers by Kotelevets, Larissa, Scott, Mark G H, Chastre, Eric

“…Phosphatase and tensin homolog (PTEN) is a tumour suppressor that represents one of the most common targets for genetic defect in human cancer. PTEN controls…”
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An escort for GPCRs: implications for regulation of receptor density at the cell surface by Achour, Lamia, Labbé-Jullié, Catherine, Scott, Mark G.H, Marullo, Stefano

“…G-protein-coupled receptors (GPCRs) are dynamically regulated by various mechanisms that tune their response to external stimuli. Modulation of their plasma…”
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CXCR7 participates in CXCL12-induced CD34+ cell cycling through β-arrestin–dependent Akt activation by Torossian, Frédéric, Anginot, Adrienne, Chabanon, Aurélie, Clay, Denis, Guerton, Bernadette, Desterke, Christophe, Boutin, Laetitia, Marullo, Stefano, Scott, Mark G.H., Lataillade, Jean-Jacques, Le Bousse-Kerdilès, Marie-Caroline

“…In addition to its well-known effect on migration and homing of hematopoietic stem/progenitor cells (HSPCs), CXCL12 chemokine also exhibits a cell cycle and…”
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Targeting Spare CC Chemokine Receptor 5 (CCR5) as a Principle to Inhibit HIV-1 Entry by Jin, Jun, Colin, Philippe, Staropoli, Isabelle, Lima-Fernandes, Evelyne, Ferret, Cécile, Demir, Arzu, Rogée, Sophie, Hartley, Oliver, Randriamampita, Clotilde, Scott, Mark G.H., Marullo, Stefano, Sauvonnet, Nathalie, Arenzana-Seisdedos, Fernando, Lagane, Bernard, Brelot, Anne

“…CCR5 binds the chemokines CCL3, CCL4, and CCL5 and is the major coreceptor for HIV-1 entry into target cells. Chemokines are supposed to form a natural barrier…”
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