Search Results - "Scott, Madeline R"
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Abnormal expression of ER quality control and ER associated degradation proteins in the dorsolateral prefrontal cortex in schizophrenia
Published in Schizophrenia research (01-07-2018)“…Abnormalities in posttranslational protein modifications (PTMs) that regulate protein targeting, trafficking, synthesis, and function have been implicated in…”
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Twelve-hour rhythms in transcript expression within the human dorsolateral prefrontal cortex are altered in schizophrenia
Published in PLoS biology (24-01-2023)“…Twelve-hour (12 h) ultradian rhythms are a well-known phenomenon in coastal marine organisms. While 12 h cycles are observed in human behavior and physiology,…”
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3
Diurnal rhythms across the human dorsal and ventral striatum
Published in Proceedings of the National Academy of Sciences - PNAS (12-01-2021)“…The human striatum can be subdivided into the caudate, putamen, and nucleus accumbens (NAc). Each of these structures have some overlapping and some distinct…”
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4
Dysregulation of the unfolded protein response (UPR) in the dorsolateral prefrontal cortex in elderly patients with schizophrenia
Published in Molecular psychiatry (01-04-2021)“…Abnormalities in protein localization, function, and posttranslational modifications are targets of schizophrenia (SCZ) research. As a major contributor to the…”
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5
Bipolar disorder
Published in Current opinion in neurobiology (01-12-2023)“…This review focuses on recent advances made towards understanding the neurobiology of bipolar disorder (BD), a chronic neuropsychiatric illness characterized…”
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Intracellular compartment-specific proteasome dysfunction in postmortem cortex in schizophrenia subjects
Published in Molecular psychiatry (01-04-2020)“…Protein homeostasis is an emerging component of schizophrenia (SZ) pathophysiology. Proteomic alterations in SZ are well-documented and changes in transcript…”
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DiffCircaPipeline: a framework for multifaceted characterization of differential rhythmicity
Published in Bioinformatics (Oxford, England) (01-01-2023)“…Abstract Summary Circadian oscillations of gene expression regulate daily physiological processes, and their disruption is linked to many diseases. Circadian…”
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Cell-type and sex-specific rhythmic gene expression in the nucleus accumbens
Published in Molecular psychiatry (01-10-2024)“…Circadian rhythms are critical for human health and are highly conserved across species. Disruptions in these rhythms contribute to many diseases, including…”
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Diurnal Alterations in Gene Expression Across Striatal Subregions in Psychosis
Published in Biological psychiatry (1969) (15-01-2023)“…Psychosis is a defining feature of schizophrenia and highly prevalent in bipolar disorder. Notably, individuals with these illnesses also have major…”
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Comparative rhythmic transcriptome profiling of human and mouse striatal subregions
Published in Neuropsychopharmacology (New York, N.Y.) (01-04-2024)“…The human striatum can be subdivided into the caudate, putamen, and nucleus accumbens (NAc). In mice, this roughly corresponds to the dorsal medial striatum…”
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Abnormal ER quality control of neural GPI-anchored proteins via dysfunction in ER export processing in the frontal cortex of elderly subjects with schizophrenia
Published in Translational psychiatry (16-01-2019)“…Abnormalities of posttranslational protein modifications (PTMs) have recently been implicated in the pathophysiology of schizophrenia…”
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Protein Expression of Proteasome Subunits in Elderly Patients with Schizophrenia
Published in Neuropsychopharmacology (New York, N.Y.) (01-02-2016)“…The ubiquitin proteasome system (UPS) is a major regulator of protein processing, trafficking, and degradation. While protein ubiquitination is utilized for…”
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Neural activity in catecholaminergic populations following sexual and aggressive interactions in the brown anole, Anolis sagrei
Published in Brain research (17-03-2014)“…Abstract Social behaviors in vertebrates are modulated by catecholamine (CA; dopamine, norepinephrine, epinephrine) release within the social behavior neural…”
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14
Twelve-hour rhythms in transcript expression within the human dorsolateral prefrontal cortex are altered in schizophrenia
Published in PLoS biology (01-01-2023)“…Twelve-hour (12 h) ultradian rhythms are a well-known phenomenon in coastal marine organisms. While 12 h cycles are observed in human behavior and physiology,…”
Get full text
Journal Article -
15
Intracellular Compartment-Specific Abnormalities in Proteasome Expression and Activity in the Superior Temporal Gyrus in Schizophrenia
Published 01-01-2019“…Protein homeostasis is an emerging component of schizophrenia (SZ) pathophysiology. Proteomic alterations in SZ are well-documented; however the underlying…”
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