Search Results - "Scott, Lesley"

Givosiran: First Approval by Scott, Lesley J.

“…Givosiran (Givlaari™) is an aminolevulinate synthase 1 (ALAS1)-directed small interfering RNA (siRNA) covalently linked to a ligand to enable specific delivery…”
Get full text

Tocilizumab: A Review in Rheumatoid Arthritis by Scott, Lesley J.

“…Intravenous (IV) and subcutaneous (SC) tocilizumab (RoActemra ® ), an IL-6 receptor antagonist, are approved (± methotrexate) in numerous countries throughout…”
Get full text

Niraparib: First Global Approval by Scott, Lesley J.

“…Oral niraparib, a highly-selective, potent poly(ADP-ribose) polymerase (PARP)-1 and PARP-2 inhibitor, is approved in the USA for the maintenance treatment of…”
Get full text

Larotrectinib: First Global Approval by Scott, Lesley J.

“…Larotrectinib (VITRAKVI ® ) is an orally administered, small molecule, highly-selective, tropomyosin receptor kinase (TRK) inhibitor that was developed by Loxo…”
Get full text

Apatinib: A Review in Advanced Gastric Cancer and Other Advanced Cancers by Scott, Lesley J.

“…Apatinib [Aitan ® (brand name in China)], also known as rivoceranib, is a novel, small molecule, selective vascular endothelial growth factor receptor-2…”
Get full text

Ubrogepant: First Approval by Scott, Lesley J.

“…Ubrogepant (Ubrelvy™) is an orally administered, small molecule, highly-selective, calcitonin gene-related peptide (CGRP) antagonist that was developed by…”
Get full text

Eravacycline: A Review in Complicated Intra-Abdominal Infections by Scott, Lesley J.

“…Eravacycline (Xerava™), a novel fully synthetic fluorocycline, consists of the tetracyclic core scaffold with unique modifications in the tetracyclic D ring;…”
Get full text

Sitagliptin: A Review in Type 2 Diabetes by Scott, Lesley J.

“…The dipeptidyl peptidase-4 inhibitor sitagliptin (Januvia ® ; Glactiv ® ; Tesavel ® ; Xelevia™) is approved in more than 130 countries worldwide as monotherapy…”
Get full text

Lemborexant: First Approval by Scott, Lesley J.

“…Lemborexant (DAYVIGO™) is an orally administered, dual orexin receptor (OXR) antagonist that exhibits reversible competitive antagonism at OXR1 and OXR2 (>…”
Get full text

Rimegepant: First Approval by Scott, Lesley J.

“…The orally disintegrating tablet (ODT) formulation of rimegepant (NURTEC ODT ® ) is a small molecule, highly-selective, calcitonin gene-related peptide…”
Get full text

Enzalutamide: A Review in Castration-Resistant Prostate Cancer by Scott, Lesley J.

“…Oral enzalutamide (Xtandi ® ), a second generation androgen receptor inhibitor, is indicated for the treatment of castration-resistant prostate cancer (CRPC)…”
Get full text

Siponimod: A Review in Secondary Progressive Multiple Sclerosis by Scott, Lesley J.

“…Oral siponimod (Mayzent ® ), a next-generation, selective sphingosine 1-phosphate receptor (S1PR) 1 and 5 modulator, is approved in several countries for the…”
Get full text

Lumasiran: First Approval by Scott, Lesley J., Keam, Susan J.

“…Lumasiran (Oxlumo™) is a subcutaneously administered small interfering RNA (siRNA) targeting the mRNA for hydroxyacid oxidase 1 gene ( HAO1 ; encodes glycolate…”
Get full text

Alipogene Tiparvovec: A Review of Its Use in Adults with Familial Lipoprotein Lipase Deficiency by Scott, Lesley J.

“…Alipogene tiparvovec (Glybera ® ; AMT-011, AAV1-LPL S447X ) is an adeno-associated virus serotype 1-based gene therapy for adult patients with familial…”
Get full text

Brexanolone: First Global Approval by Scott, Lesley J.

“…Brexanolone (ZULRESSO™) is an intravenously administered, small molecule, neuroactive steroid GABA A receptor positive allosteric modulator that was developed…”
Get full text

Ferric Carboxymaltose: A Review in Iron Deficiency by Scott, Lesley J.

“…Intravenous ferric carboxymaltose (Ferinject ® ; Injectafer ® ) is a colloidal solution of nanoparticles which consist of a polynuclear iron…”
Get full text

Dulaglutide: A Review in Type 2 Diabetes by Scott, Lesley J.

“…Subcutaneous dulaglutide (Trulicity ® ) is a once-weekly glucagon-like peptide-1 receptor agonist that is approved in numerous countries as an adjunct to diet…”
Get full text

Dolutegravir/Lamivudine Single-Tablet Regimen: A Review in HIV-1 Infection by Scott, Lesley J.

“…The oral once-daily, fixed-dose single-tablet regimen (STR) of dolutegravir/lamivudine (Dovato ® ), combining a second generation integrase single-strand…”
Get full text

Teriflunomide: A Review in Relapsing–Remitting Multiple Sclerosis by Scott, Lesley J.

“…Teriflunomide (Aubagio ® ) is a disease-modifying immunomodulatory drug with anti-inflammatory properties that selectively and reversibly inhibits the…”
Get full text

Peramivir: A Review in Uncomplicated Influenza by Scott, Lesley J.

“…Intravenous peramivir (Alpivab™; Rapivab ® ; Rapiacta ® ; PeramiFlu ® ), the most recent globally approved inhibitor of influenza neuraminidase, is indicated…”
Get full text