Search Results - "Scott, Kenneth"

The Genomic Landscape and Clinical Relevance of A-to-I RNA Editing in Human Cancers by Han, Leng, Diao, Lixia, Yu, Shuangxing, Xu, Xiaoyan, Li, Jie, Zhang, Rui, Yang, Yang, Werner, Henrica M.J., Eterovic, A. Karina, Yuan, Yuan, Li, Jun, Nair, Nikitha, Minelli, Rosalba, Tsang, Yiu Huen, Cheung, Lydia W.T., Jeong, Kang Jin, Roszik, Jason, Ju, Zhenlin, Woodman, Scott E., Lu, Yiling, Scott, Kenneth L., Li, Jin Billy, Mills, Gordon B., Liang, Han

“…Adenosine-to-inosine (A-to-I) RNA editing is a widespread post-transcriptional mechanism, but its genomic landscape and clinical relevance in cancer have not…”
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Design thinking: Critical analysis and future evolution by Verganti, Roberto, Dell’Era, Claudio, Swan, Kenneth Scott

“…The importance of design as a source of value creation has been studied for decades. In the late 90s, however, a specific approach in the practice of design…”
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A Pan-Cancer Proteogenomic Atlas of PI3K/AKT/mTOR Pathway Alterations by Zhang, Yiqun, Kwok-Shing Ng, Patrick, Kucherlapati, Melanie, Chen, Fengju, Liu, Yuexin, Tsang, Yiu Huen, de Velasco, Guillermo, Jeong, Kang Jin, Akbani, Rehan, Hadjipanayis, Angela, Pantazi, Angeliki, Bristow, Christopher A., Lee, Eunjung, Mahadeshwar, Harshad S., Tang, Jiabin, Zhang, Jianhua, Yang, Lixing, Seth, Sahil, Lee, Semin, Ren, Xiaojia, Song, Xingzhi, Sun, Huandong, Seidman, Jonathan, Luquette, Lovelace J., Xi, Ruibin, Chin, Lynda, Protopopov, Alexei, Westbrook, Thomas F., Shelley, Carl Simon, Choueiri, Toni K., Ittmann, Michael, Van Waes, Carter, Weinstein, John N., Liang, Han, Henske, Elizabeth P., Godwin, Andrew K., Park, Peter J., Kucherlapati, Raju, Scott, Kenneth L., Mills, Gordon B., Kwiatkowski, David J., Creighton, Chad J.

“…Molecular alterations involving the PI3K/AKT/mTOR pathway (including mutation, copy number, protein, or RNA) were examined across 11,219 human cancers…”
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The RNA-binding protein AKAP8 suppresses tumor metastasis by antagonizing EMT-associated alternative splicing by Hu, Xiaohui, Harvey, Samuel E., Zheng, Rong, Lyu, Jingyi, Grzeskowiak, Caitlin L., Powell, Emily, Piwnica-Worms, Helen, Scott, Kenneth L., Cheng, Chonghui

“…Alternative splicing has been shown to causally contribute to the epithelial–mesenchymal transition (EMT) and tumor metastasis. However, the scope of splicing…”
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PIK3CA variants selectively initiate brain hyperactivity during gliomagenesis by Yu, Kwanha, Lin, Chia-Ching John, Hatcher, Asante, Lozzi, Brittney, Kong, Kathleen, Huang-Hobbs, Emmet, Cheng, Yi-Ting, Beechar, Vivek B., Zhu, Wenyi, Zhang, Yiqun, Chen, Fengju, Mills, Gordon B., Mohila, Carrie A., Creighton, Chad J., Noebels, Jeffrey L., Scott, Kenneth L., Deneen, Benjamin

“…Glioblastoma is a universally lethal form of brain cancer that exhibits an array of pathophysiological phenotypes, many of which are mediated by interactions…”
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A-to-I RNA Editing Contributes to Proteomic Diversity in Cancer by Peng, Xinxin, Xu, Xiaoyan, Wang, Yumeng, Hawke, David H., Yu, Shuangxing, Han, Leng, Zhou, Zhicheng, Mojumdar, Kamalika, Jeong, Kang Jin, Labrie, Marilyne, Tsang, Yiu Huen, Zhang, Minying, Lu, Yiling, Hwu, Patrick, Scott, Kenneth L., Liang, Han, Mills, Gordon B.

“…Adenosine (A) to inosine (I) RNA editing introduces many nucleotide changes in cancer transcriptomes. However, due to the complexity of post-transcriptional…”
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Systematic characterization of A-to-I RNA editing hotspots in microRNAs across human cancers by Wang, Yumeng, Xu, Xiaoyan, Yu, Shuangxing, Jeong, Kang Jin, Zhou, Zhicheng, Han, Leng, Tsang, Yiu Huen, Li, Jun, Chen, Hu, Mangala, Lingegowda S, Yuan, Yuan, Eterovic, A Karina, Lu, Yiling, Sood, Anil K, Scott, Kenneth L, Mills, Gordon B, Liang, Han

“…RNA editing, a widespread post-transcriptional mechanism, has emerged as a new player in cancer biology. Recent studies have reported key roles for individual…”
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Identification of Variant-Specific Functions of PIK3CA by Rapid Phenotyping of Rare Mutations by Dogruluk, Turgut, Tsang, Yiu Huen, Espitia, Maribel, Chen, Fengju, Chen, Tenghui, Chong, Zechen, Appadurai, Vivek, Dogruluk, Armel, Eterovic, Agna Karina, Bonnen, Penelope E, Creighton, Chad J, Chen, Ken, Mills, Gordon B, Scott, Kenneth L

“…Large-scale sequencing efforts are uncovering the complexity of cancer genomes, which are composed of causal "driver" mutations that promote tumor progression…”
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Signaling from the Golgi: mechanisms and models for Golgi phosphoprotein 3-mediated oncogenesis by Scott, Kenneth L, Chin, Lynda

“…Golgi phosphoprotein 3 (GOLPH3; also known as GPP34/GMx33/MIDAS) represents an exciting new class of oncoproteins involved in vesicular trafficking. Encoded by…”
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TMEM106B drives lung cancer metastasis by inducing TFEB-dependent lysosome synthesis and secretion of cathepsins by Kundu, Samrat T., Grzeskowiak, Caitlin L., Fradette, Jared J., Gibson, Laura A., Rodriguez, Leticia B., Creighton, Chad J., Scott, Kenneth L., Gibbons, Don L.

“…Metastatic lung cancer is the leading cause of cancer-associated mortality worldwide, therefore necessitating novel approaches to identify specific genetic…”
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RNA editing derived epitopes function as cancer antigens to elicit immune responses by Zhang, Minying, Fritsche, Jens, Roszik, Jason, Williams, Leila J., Peng, Xinxin, Chiu, Yulun, Tsou, Chih-Chiang, Hoffgaard, Franziska, Goldfinger, Valentina, Schoor, Oliver, Talukder, Amjad, Forget, Marie A., Haymaker, Cara, Bernatchez, Chantale, Han, Leng, Tsang, Yiu-Huen, Kong, Kathleen, Xu, Xiaoyan, Scott, Kenneth L., Singh-Jasuja, Harpreet, Lizee, Greg, Liang, Han, Weinschenk, Toni, Mills, Gordon B., Hwu, Patrick

“…In addition to genomic mutations, RNA editing is another major mechanism creating sequence variations in proteins by introducing nucleotide changes in mRNA…”
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Integrative genome comparison of primary and metastatic melanomas by Kabbarah, Omar, Nogueira, Cristina, Feng, Bin, Nazarian, Rosalynn M, Bosenberg, Marcus, Wu, Min, Scott, Kenneth L, Kwong, Lawrence N, Xiao, Yonghong, Cordon-Cardo, Carlos, Granter, Scott R, Ramaswamy, Sridhar, Golub, Todd, Duncan, Lyn M, Wagner, Stephan N, Brennan, Cameron, Chin, Lynda

“…A cardinal feature of malignant melanoma is its metastatic propensity. An incomplete view of the genetic events driving metastatic progression has been a major…”
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Fatalities Involving Substance Use Among US Oil and Gas Extraction Workers Identified Through an Industry Specific Surveillance System (2014–2019) by Ramirez-Cardenas, Alejandra, Wingate, Kaitlin C., Pompei, Richard, King, Bradley, Scott, Kenneth A., Hagan-Haynes, Kyla, Chosewood, L. Casey

“…Characteristics of oil and gas extraction (OGE) work, including long hours, shiftwork, fatigue, physically demanding work, and job insecurity are risk factors…”
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Cancer driver mutation prediction through Bayesian integration of multi-omic data by Wang, Zixing, Ng, Kwok-Shing, Chen, Tenghui, Kim, Tae-Beom, Wang, Fang, Shaw, Kenna, Scott, Kenneth L, Meric-Bernstam, Funda, Mills, Gordon B, Chen, Ken

“…Identification of cancer driver mutations is critical for advancing cancer research and personalized medicine. Due to inter-tumor genetic heterogeneity, many…”
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Mutations in FBXL4 Cause Mitochondrial Encephalopathy and a Disorder of Mitochondrial DNA Maintenance by Bonnen, Penelope E., Yarham, John W., Besse, Arnaud, Wu, Ping, Faqeih, Eissa A., Al-Asmari, Ali Mohammad, Saleh, Mohammad A.M., Eyaid, Wafaa, Hadeel, Alrukban, He, Langping, Smith, Frances, Yau, Shu, Simcox, Eve M., Miwa, Satomi, Donti, Taraka, Abu-Amero, Khaled K., Wong, Lee-Jun, Craigen, William J., Graham, Brett H., Scott, Kenneth L., McFarland, Robert, Taylor, Robert W.

“…Nuclear genetic disorders causing mitochondrial DNA (mtDNA) depletion are clinically and genetically heterogeneous, and the molecular etiology remains…”
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Rational combination therapy with PARP and MEK inhibitors capitalizes on therapeutic liabilities in RAS mutant cancers by Sun, Chaoyang, Fang, Yong, Yin, Jun, Chen, Jian, Ju, Zhenlin, Zhang, Dong, Chen, Xiaohua, Vellano, Christopher P, Jeong, Kang Jin, Ng, Patrick Kwok-Shing, Eterovic, Agda Karina B, Bhola, Neil H, Lu, Yiling, Westin, Shannon N, Grandis, Jennifer R, Lin, Shiaw-Yih, Scott, Kenneth L, Peng, Guang, Brugge, Joan, Mills, Gordon B

“…Mutant has remained recalcitrant to targeted therapy efforts. We demonstrate that combined treatment with poly(adenosine diphosphate-ribose) polymerase (PARP)…”
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Systematic Functional Annotation of Somatic Mutations in Cancer by Ng, Patrick Kwok-Shing, Li, Jun, Jeong, Kang Jin, Shao, Shan, Chen, Hu, Tsang, Yiu Huen, Sengupta, Sohini, Wang, Zixing, Bhavana, Venkata Hemanjani, Tran, Richard, Soewito, Stephanie, Minussi, Darlan Conterno, Moreno, Daniela, Kong, Kathleen, Dogruluk, Turgut, Lu, Hengyu, Gao, Jianjiong, Tokheim, Collin, Zhou, Daniel Cui, Johnson, Amber M., Zeng, Jia, Ip, Carman Ka Man, Ju, Zhenlin, Wester, Matthew, Yu, Shuangxing, Li, Yongsheng, Vellano, Christopher P., Schultz, Nikolaus, Karchin, Rachel, Ding, Li, Lu, Yiling, Cheung, Lydia Wai Ting, Chen, Ken, Shaw, Kenna R., Meric-Bernstam, Funda, Scott, Kenneth L., Yi, Song, Sahni, Nidhi, Liang, Han, Mills, Gordon B.

“…The functional impact of the vast majority of cancer somatic mutations remains unknown, representing a critical knowledge gap for implementing precision…”
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Simultaneous screening of overexpressed genes in breast cancer for oncogenic drivers and tumor dependencies by Mofunanya, Adaobi, Cameron, Eleanor R., Braun, Christian J., Celeste, Frank, Zhao, Xiaoyu, Hemann, Michael T., Scott, Kenneth L., Li, Jinyu, Powers, Scott

“…There are hundreds of genes typically overexpressed in breast cancer cells and it's often assumed that their overexpression contributes to cancer progression…”
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Neomorphic PDGFRA extracellular domain driver mutations are resistant to PDGFRA targeted therapies by Ip, Carman K. M., Ng, Patrick K. S., Jeong, Kang Jin, Shao, S. H., Ju, Zhenlin, Leonard, P. G., Hua, Xu, Vellano, Christopher P., Woessner, Richard, Sahni, Nidhi, Scott, Kenneth L., Mills, Gordon B.

“…Activation of platelet-derived growth factor receptor alpha (PDGFRA) by genomic aberrations contributes to tumor progression in several tumor types. In this…”
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Intronic miR-211 Assumes the Tumor Suppressive Function of Its Host Gene in Melanoma by Levy, Carmit, Khaled, Mehdi, Iliopoulos, Dimitrios, Janas, Maja M., Schubert, Steffen, Pinner, Sophie, Chen, Po-Hao, Li, Shuqiang, Fletcher, Anne L., Yokoyama, Satoru, Scott, Kenneth L., Garraway, Levi A., Song, Jun S., Granter, Scott R., Turley, Shannon J., Fisher, David E., Novina, Carl D.

“…When it escapes early detection, malignant melanoma becomes a highly lethal and treatment-refractory cancer. Melastatin is greatly downregulated in metastatic…”
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