Search Results - "Scott, Kathryn A"

Iminosugar antivirals: the therapeutic sweet spot by Alonzi, Dominic S, Scott, Kathryn A, Dwek, Raymond A, Zitzmann, Nicole

“…Many viruses require the host endoplasmic reticulum protein-folding machinery in order to correctly fold one or more of their glycoproteins. Iminosugars with…”
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Coarse-Grained MD Simulations of Membrane Protein-Bilayer Self-Assembly by Scott, Kathryn A., Bond, Peter J., Ivetac, Anthony, Chetwynd, Alan P., Khalid, Syma, Sansom, Mark S.P.

“…Complete determination of a membrane protein structure requires knowledge of the protein position within the lipid bilayer. As the number of determined…”
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Effectiveness of the Med Safety mobile application in improving adverse drug reaction reporting by healthcare professionals in Uganda: a protocol for a pragmatic cluster-randomised controlled trial by Kiguba, Ronald, Mwebaza, Norah, Ssenyonga, Ronald, Ndagije, Helen Byomire, Nambasa, Victoria, Katureebe, Cordelia, Katumba, Kenneth, Tregunno, Phil, Harrison, Kendal, Karamagi, Charles, Scott, Kathryn A, Pirmohamed, Munir

“…IntroductionCombination antiretroviral therapy (cART) has massively reduced HIV mortality. However, long-term cART increases the risk of adverse drug reactions…”
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Factors Affecting Patient and Physician Engagement in Remote Health Care for Heart Failure: Systematic Review by Al-Naher, Ahmed, Downing, Jennifer, Scott, Kathryn A, Pirmohamed, Munir

“…Adult chronic heart failure mainly affects an elderly population with multiple comorbidities that often require frequent medical visits to prevent poor health…”
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Coarse-grained simulation: a high-throughput computational approach to membrane proteins by Sansom, Mark S P, Scott, Kathryn A, Bond, Peter J

“…An understanding of the interactions of membrane proteins with a lipid bilayer environment is central to relating their structure to their function and…”
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Essential chemistry for biochemists by Jonsson, Amanda L, Roberts, Mark A J, Kiappes, J L, Scott, Kathryn A

“…Within every living organism, countless reactions occur every second. These reactions typically occur more rapidly and with greater efficiency than would be…”
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Gating at Both Ends and Breathing in the Middle: Conformational Dynamics of TolC by Vaccaro, Loredana, Scott, Kathryn A., Sansom, Mark S.P.

“…Drug extrusion via efflux through a tripartite complex (an inner membrane pump, an outer membrane protein, and a periplasmic protein) is a widely used…”
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Conformational entropy of alanine versus glycine in protein denatured states by Scott, Kathryn A, Alonso, Darwin O.V, Sato, Satoshi, Fersht, Alan R, Daggett, Valerie

“…The presence of a solvent-exposed alanine residue stabilizes a helix by 0.4-2 kcal·mol⁻¹ relative to glycine. Various factors have been suggested to account…”
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Complex Folding Kinetics of a Multidomain Protein by Batey, Sarah, Scott, Kathryn A., Clarke, Jane

“…Spectrin domains are three-helix bundles, commonly found in large tandem arrays. Equilibrium studies have shown that spectrin domains are significantly…”
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Quinol Oxidation by c-Type Cytochromes: Structural Characterization of the Menaquinol Binding Site of NrfHA by Rodrigues, Maria Luisa, Scott, Kathryn A., Sansom, Mark S.P., Pereira, Inês A.C., Archer, Margarida

“…Membrane-bound cytochrome c quinol dehydrogenases play a crucial role in bacterial respiration by oxidizing menaquinol and transferring electrons to various…”
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The Folding of Spectrin Domains I: Wild-type Domains Have the Same Stability but very Different Kinetic Properties by Scott, Kathryn A., Batey, Sarah, Hooton, Karen A., Clarke, Jane

“…The study of proteins with the same architecture, but different sequence has proven to be a valuable tool in the protein folding field. As a prelude to studies…”
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The Folding of Spectrin Domains II: Phi-value Analysis of R16 by Scott, Kathryn A., Randles, Lucy G., Clarke, Jane

“…Studies on the folding of helical proteins have shown a wide range of different mechanisms and highlighted the importance of helical propensity as a factor in…”
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Predicting inter-species cross-talk in two-component signalling systems by Pawelczyk, Sonja, Scott, Kathryn A, Hamer, Rebecca, Blades, Gareth, Deane, Charlotte M, Wadhams, George H

“…Phosphosignalling pathways are an attractive option for the synthetic biologist looking for a wide repertoire of modular components from which to build. We…”
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Preparation of a Resin-Bound Arene−Ruthenium Complex and Assessment of Its Use in Enol Formate Synthesis and Olefin Cyclopropanation by Leadbeater, Nicholas E, Scott, Kathryn A, Scott, Lucy J

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Liquid buccal mucosa graft endoscopic urethroplasty: a validation animal study by Scott, Kathryn A., Li, Guanqun, Manwaring, Jared, Nikolavsky, Daniela A., Fudym, Yelena, Caza, Tiffany, Badar, Zain, Taylor, Nicole, Bratslavsky, Gennady, Kotula, Leszek, Nikolavsky, Dmitriy

“…Purpose To validate a novel method of urethral stricture treatment using liquid buccal mucosal grafts (LBMG) to augment direct vision internal urethrotomy…”
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Dynameomics: A Consensus View of the Protein Unfolding/Folding Transition State Ensemble across a Diverse Set of Protein Folds by Jonsson, Amanda L., Scott, Kathryn A., Daggett, Valerie

“…The Dynameomics project aims to simulate a representative sample of all globular protein metafolds under both native and unfolding conditions. We have…”
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Folding Mechanisms of Proteins with High Sequence Identity but Different Folds by Scott, Kathryn A, Daggett, Valerie

“…The problem of how a protein folds from a linear chain of amino acids to the three-dimensional structure necessary for function is often investigated using…”
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Hidden complexity in the mechanical properties of titin by Clarke, Jane, Williams, Philip M, Fowler, Susan B, Best, Robert B, Luis Toca-Herrera, José, Scott, Kathryn A, Steward, Annette

“…Individual molecules of the giant protein titin span the A-bands and I-bands that make up striated muscle. The I-band region of titin is responsible for…”
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A surgical “sewing machine” for rapid graft quilting and suturing in challenging spaces by Schardein, Jessica, Scott, Kathryn A., Bratslavsky, Gennady, Blakley, Stephen, Nikolavsky, Dmitriy

“…The use of grafts is commonly employed in urologic reconstructive surgery. In poorly accessible surgical areas, graft fixation can be difficult. To improve the…”
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Spectrin R16: Broad energy barrier or sequential transition states? by Scott, Kathryn A., Clarke, Jane

“…A number of models have been proposed to account for nonlinearity in the relation between observed rate constants for folding and/or unfolding and denaturant…”
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