Search Results - "Scott, Karen J."

Cell carriage, delivery, and selective replication of an oncolytic virus in tumor in patients by Adair, Robert A, Roulstone, Victoria, Scott, Karen J, Morgan, Ruth, Nuovo, Gerard J, Fuller, Martin, Beirne, Deborah, West, Emma J, Jennings, Victoria A, Rose, Ailsa, Kyula, Joan, Fraser, Sheila, Dave, Rajiv, Anthoney, David A, Merrick, Alison, Prestwich, Robin, Aldouri, Amer, Donnelly, Oliver, Pandha, Hardev, Coffey, Matt, Selby, Peter, Vile, Richard, Toogood, Giles, Harrington, Kevin, Melcher, Alan A

“…Oncolytic viruses, which preferentially lyse cancer cells and stimulate an antitumor immune response, represent a promising approach to the treatment of…”
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Tumor Infection by Oncolytic Reovirus Primes Adaptive Antitumor Immunity by PRESTWICH, Robin J, ERRINGTON, Fiona, SELBY, Peter J, VILE, Richard G, MELCHER, Alan A, ILETT, Elizabeth J, MORGAN, Ruth S. M, SCOTT, Karen J, KOTTKE, Timothy, THOMPSON, Jill, MORRISON, Ewan E, HARRINGTON, Kevin J, PANDHA, Hardev S

“…Purpose: Early clinical trials are under way exploring the direct oncolytic potential of reovirus. This study addresses whether tumor infection by reovirus is…”
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Cytotoxic and immune‐mediated killing of human colorectal cancer by reovirus‐loaded blood and liver mononuclear cells by Adair, Robert A., Scott, Karen J., Fraser, Sheila, Errington‐Mais, Fiona, Pandha, Hardev, Coffey, Matt, Selby, Peter, Cook, Graham P., Vile, Richard, Harrington, Kevin J., Toogood, Giles, Melcher, Alan A.

“…Reovirus is a promising oncolytic virus, acting by both direct and immune‐mediated mechanisms, although its potential may be limited by inactivation after…”
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Evidence for Oncolytic Virotherapy: Where Have We Got to and Where Are We Going? by Turnbull, Samantha, West, Emma J, Scott, Karen J, Appleton, Elizabeth, Melcher, Alan, Ralph, Christy

“…The last few years have seen an increased interest in immunotherapy in the treatment of malignant disease. In particular, there has been significant enthusiasm…”
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Dynamic Oxidation of Gaseous Mercury in the Arctic Troposphere at Polar Sunrise by Lindberg, Steve E, Brooks, Steve, Lin, C.-J, Scott, Karen J, Landis, Matthew S, Stevens, Robert K, Goodsite, Mike, Richter, Andreas

“…Gaseous elemental mercury (Hg0) is a globally distributed air toxin with a long atmospheric residence time. Any process that reduces its atmospheric lifetime…”
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Plasmacytoid dendritic cells orchestrate innate and adaptive anti-tumor immunity induced by oncolytic coxsackievirus A21 by Müller, Louise M E, Holmes, Matthew, Michael, Joanne L, Scott, Gina B, West, Emma J, Scott, Karen J, Parrish, Christopher, Hall, Kathryn, Stäble, Sina, Jennings, Victoria A, Cullen, Matthew, McConnell, Stewart, Langton, Catherine, Tidswell, Emma L, Shafren, Darren, Samson, Adel, Harrington, Kevin J, Pandha, Hardev, Ralph, Christy, Kelly, Richard J, Cook, Gordon, Melcher, Alan A, Errington-Mais, Fiona

“…The oncolytic virus, coxsackievirus A21 (CVA21), has shown promise as a single agent in several clinical trials and is now being tested in combination with…”
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Anti–PD-1/anti–CTLA-4 efficacy in melanoma brain metastases depends on extracranial disease and augmentation of CD8⁺ T cell trafficking by Taggart, David, Andreou, Tereza, Scott, Karen J., Williams, Jennifer, Rippaus, Nora, Brownlie, Rebecca J., Ilett, Elizabeth J., Salmond, Robert J., Melcher, Alan, Lorger, Mihaela

“…Inhibition of immune checkpoints programmed death 1 (PD-1) and cytotoxic T lymphocyte-associated protein 4 (CTLA-4) on T cells results in durable antitumor…”
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Reactivity and Mobility of New and Old Mercury Deposition in a Boreal Forest Ecosystem during the First Year of the METAALICUS Study by Hintelmann, Holger, Harris, Reed, Heyes, Andrew, Hurley, James P, Kelly, Carol A, Krabbenhoft, David P, Lindberg, Steve, Rudd, John W. M, Scott, Karen J, St.Louis, Vincent L

“…The METAALICUS (Mercury Experiment To Assess Atmospheric Loading In Canada and the US) project is a whole ecosystem experiment designed to study the activity,…”
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Importance of the Forest Canopy to Fluxes of Methyl Mercury and Total Mercury to Boreal Ecosystems by St. Louis, Vincent L, Rudd, John W. M, Kelly, Carol A, Hall, Britt D, Rolfhus, Kristofer R, Scott, Karen J, Lindberg, Steve E, Dong, Weijin

“…The forest canopy was an important contributor to fluxes of methyl mercury (MeHg) and total mercury (THg) to the forest floor of boreal uplands and wetlands…”
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Oncolytic Herpes Simplex Virus Inhibits Pediatric Brain Tumor Migration and Invasion by Cockle, Julia V., Brüning-Richardson, Anke, Scott, Karen J., Thompson, Jill, Kottke, Timothy, Morrison, Ewan, Ismail, Azam, Carcaboso, Angel M., Rose, Ailsa, Selby, Peter, Conner, Joe, Picton, Susan, Short, Susan, Vile, Richard, Melcher, Alan, Ilett, Elizabeth

“…Pediatric high-grade glioma (pHGG) and diffuse intrinsic pontine glioma (DIPG) are invasive tumors with poor survival. Oncolytic virotherapy, initially devised…”
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Potentiating Oncolytic Virus-Induced Immune-Mediated Tumor Cell Killing Using Histone Deacetylase Inhibition by Jennings, Victoria A., Scott, Gina B., Rose, Ailsa M.S., Scott, Karen J., Migneco, Gemma, Keller, Brian, Reilly, Katrina, Donnelly, Oliver, Peach, Howard, Dewar, Donald, Harrington, Kevin J., Pandha, Hardev, Samson, Adel, Vile, Richard G., Melcher, Alan A., Errington-Mais, Fiona

“…A clinical oncolytic herpes simplex virus (HSV) encoding granulocyte-macrophage colony-stimulating factor (GM-CSF), talimogene laherparepvec, causes regression…”
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Reovirus-mediated cytotoxicity and enhancement of innate immune responses against acute myeloid leukemia by Hall, Kathryn, Scott, Karen J, Rose, Ailsa, Desborough, Michael, Harrington, Kevin, Pandha, Hardev, Parrish, Christopher, Vile, Richard, Coffey, Matt, Bowen, David, Errington-Mais, Fiona, Melcher, Alan A

“…Reovirus is a naturally occurring oncolytic virus that has shown preclinical efficacy in the treatment of a wide range of tumor types and has now reached phase…”
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Neoadjuvant Intravenous Oncolytic Vaccinia Virus Therapy Promotes Anticancer Immunity in Patients by Samson, Adel, West, Emma J, Carmichael, Jonathan, Scott, Karen J, Turnbull, Samantha, Kuszlewicz, Bethany, Dave, Rajiv V, Peckham-Cooper, Adam, Tidswell, Emma, Kingston, Jennifer, Johnpulle, Michelle, da Silva, Barbara, Jennings, Victoria A, Bendjama, Kaidre, Stojkowitz, Nicolas, Lusky, Monika, Prasad, K R, Toogood, Giles J, Auer, Rebecca, Bell, John, Twelves, Chris J, Harrington, Kevin J, Vile, Richard G, Pandha, Hardev, Errington-Mais, Fiona, Ralph, Christy, Newton, Darren J, Anthoney, Alan, Melcher, Alan A, Collinson, Fiona

“…Improving the chances of curing patients with cancer who have had surgery to remove metastatic sites of disease is a priority area for cancer research…”
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Nurse manager perspective of staff participation in unit level shared governance by Cox Sullivan, Sheila, Norris, Mitzi R., Brown, Lana M., Scott, Karen J.

“…Aim To examine the nurse manager perspective surrounding implementation of unit level shared governance in one Veterans Health Administration facility…”
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Perioperative Influenza Vaccination Reduces Postoperative Metastatic Disease by Reversing Surgery-Induced Dysfunction in Natural Killer Cells by TAI, Lee-Hwa, JIQING ZHANG, BELL, John C, MAKRIGIANNIS, Andrew P, MELCHER, Alan A, AUER, Rebecca C, SCOTT, Karen J, DE SOUZA, Christiano Tanese, ALKAYYAL, Almohanad A, ANU ABHIRAMI ANANTH, SAHI, Shalini, ADAIR, Robert A, MAHMOUD, Ahmad B, SAD, Subash

“…Surgical removal of solid primary tumors is an essential component of cancer treatment. Surgery-induced dysfunction in natural killer (NK) cells has been…”
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Intravenous Oncolytic Vaccinia Virus Therapy Results in a Differential Immune Response between Cancer Patients by West, Emma J, Scott, Karen J, Tidswell, Emma, Bendjama, Kaidre, Stojkowitz, Nicolas, Lusky, Monika, Kurzawa, Marta, Prasad, Raj, Toogood, Giles, Ralph, Christy, Anthoney, D Alan, Melcher, Alan A, Collinson, Fiona J, Samson, Adel

“…is an engineered Wyeth-strain vaccinia oncolytic virus (OV), which has been tested extensively in clinical trials, demonstrating enhanced cytotoxic T cell…”
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What is oncolytic virotherapy? by Cockle, Julia V, Scott, Karen J

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Mercury Biogeochemistry in the Idrija River, Slovenia, from above the Mine into the Gulf of Trieste by Hines, Mark E, Horvat, Milena, Faganeli, Jadran, Bonzongo, Jean-Claude J, Barkay, Tamar, Major, Elaine B, Scott, Karen J, Bailey, Elizabeth A, Warwick, John J, Lyons, W.Berry

“…The Idrija Mine is the second largest Hg mine in the world which operated for 500 years. Mercury (Hg)-laden tailings still line the banks, and the system is a…”
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The feasibility of establishing a programme of adjuvant autologous vaccination for renal cell carcinoma by Prestwich, Robin J., Scott, Karen J., Brown, Joanne, Harnden, Patricia, Whelan, Peter, Cartledge, Jon, O’Donnell, Dearbhaile, Pandha, Hardev S., Selby, Peter J., Banks, Rosamund E., Merrick, Alison E., Melcher, Alan A.

“…OBJECTIVE To report the results of a programme aimed at determining the feasibility of autologous renal cell carcinoma (RCC) tissue collection and vaccine…”
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Bioavailable Mercury in Arctic Snow Determined by a Light-Emitting Mer-Lux Bioreporter by Scott, Karen J.

“…The pervasive nature of Hg is due to its predominance ([Symbol Not Transcribed] [greater or equal to] 80%) in the atmosphere as elemental Hg (Hg[Symbol Not…”
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