Search Results - "Scott, John E."

Alleviating Cancer Drug Toxicity by Inhibiting a Bacterial Enzyme by Wallace, Bret D, Wang, Hongwei, Lane, Kimberly T, Scott, John E, Orans, Jillian, Koo, Ja Seol, Venkatesh, Madhukumar, Jobin, Christian, Yeh, Li-An, Mani, Sridhar, Redinbo, Matthew R

“…The dose-limiting side effect of the common colon cancer chemotherapeutic CPT-11 is severe diarrhea caused by symbiotic bacterial β-glucuronidases that…”
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Decorin core protein (decoron) shape complements collagen fibril surface structure and mediates its binding by Orgel, Joseph P R O, Eid, Aya, Antipova, Olga, Bella, Jordi, Scott, John E

“…Decorin is the archetypal small leucine rich repeat proteoglycan of the vertebrate extracellular matrix (ECM). With its glycosaminoglycuronan chain, it is…”
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MEKK2 mediates aberrant ERK activation in neurofibromatosis type I by Bok, Seoyeon, Shin, Dong Yeon, Yallowitz, Alisha R., Eiseman, Mark, Cung, Michelle, Xu, Ren, Li, Na, Sun, Jun, Williams, Alfred L., Scott, John E., Su, Bing, Shim, Jae-Hyuck, Greenblatt, Matthew B.

“…Neurofibromatosis type I (NF1) is characterized by prominent skeletal manifestations caused by NF1 loss. While inhibitors of the ERK activating kinases MEK1/2…”
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Estradiol enhances cell-associated paraoxonase 1 (PON1) activity in vitro without altering PON1 expression by Ahmad, Syed, Scott, John E.

“…PON1 is a high density lipoprotein-associated enzyme that plays an important role in organophosphate detoxification and prevention of atherosclerosis. In vivo…”
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A high throughput proliferation and cytotoxicity assay for co-cultured isogenic cell lines by Ahmad, Syed, Wood, Kris C., Scott, John E.

“…PTEN is a well-known tumor suppressor that is inactivated or suppressed at a high frequency in cancer. We sought an assay to screen compounds for ones that…”
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Cartilage elasticity resides in shape module decoran and aggrecan sumps of damping fluid: implications in osteoarthrosis by Scott, John E., Stockwell, Robin A.

“…Cartilage ultrastructure is based on collagen fibrils tied together by proteoglycans (PGs). Interfibrillar orthogonal PG bridges (‘shape modules’) were…”
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Cartilage is held together by elastic glycan strings. Physiological and pathological implications by Scott, John E

“…Animal shapes are maintained by connective tissue extracellular matrices (ECMs). ECM shapes depend on keeping collagen fibrils in the right places, held by…”
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Proteodermatan and Proteokeratan Sulfate (Decorin, Lumican/Fibromodulin) Proteins Are Horseshoe Shaped. Implications for Their Interactions with Collagen by Scott, John. E

“…The small proteoglycans proteodermatan and proteokeratan sulfates organize collagen fibrils in extracellular matrix [Scott, J. E. (1992) FASEB J. 6,…”
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Development and validation of a high-throughput intrinsic ATPase activity assay for the discovery of MEKK2 inhibitors by Ahmad, Syed, Hughes, Mark A, Johnson, Gary L, Scott, John E

“…The kinase MEKK2 (MAP3K2) has recently been implicated in tumor growth and metastasis. Thus, selective inhibition of MEKK2 may be a novel strategy for cancer…”
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Diagnosis and outcome of fetal lower urinary tract obstruction in the northern region of England by Anumba, Dilly O., Scott, John E., Plant, Nick D., Robson, Stephen C.

“…Objective We reviewed the prenatal and postnatal management of fetal lower urinary tract obstruction (LUTO) in a large geographically defined population…”
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CoAsy knockdown in TNBC cell lines resulted in no overt effect on cell proliferation in vitro by Kharabsheh, Hamzah A., Scott, John E.

“…Triple-negative breast cancer (TNBC) remains the most challenging breast cancer subtype to treat. CoA synthase (CoAsy) is a bifunctional enzyme, encoded by the…”
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Toward the Effective Surveillance of Hypospadias by Dolk, Helen, Vrijheid, Martine, John E. S. Scott, Addor, Marie-Claude, Botting, Bev, de Vigan, Catherine, de Walle, Hermien, Garne, Ester, Loane, Maria, Pierini, Anna, Garcia-Minaur, Sixto, Physick, Nigel, Tenconi, Romano, Wiesel, Awi, Calzolari, Elisa, Stone, David

“…Concern about apparent increases in the prevalence of hypospadias-a congenital male reproductive-tract abnormality-in the 1960s to 1980s and the possible…”
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Identification of ponatinib and other known kinase inhibitors with potent MEKK2 inhibitory activity by Ahmad, Syed, Johnson, Gary L., Scott, John E.

“…The kinase MEKK2 (MAP3K2) may play an important role in tumor growth and metastasis for several cancer types. Thus, targeting MEKK2 may represent a novel…”
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Discovery of Cercosporamide, a Known Antifungal Natural Product, as a Selective Pkc1 Kinase Inhibitor through High-Throughput Screening by Sussman, Andrea, Huss, Karen, Chio, Li-Chun, Heidler, Steve, Shaw, Margaret, Ma, Doreen, Zhu, Guoxin, Campbell, Robert M, Park, Tae-Sik, Kulanthaivel, Palaniappan, Scott, John E, Carpenter, John W, Strege, Mark A, Belvo, Matthew D, Swartling, James R, Fischl, Anthony, Yeh, Wu-Kuang, Shih, Chuan, Ye, Xiang S

“…Classifications Services EC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Old Drug New Use―Amoxapine and Its Metabolites as Potent Bacterial β-Glucuronidase Inhibitors for Alleviating Cancer Drug Toxicity by REN KONG, LIU, Timothy, XIAOPING ZHU, AHMAD, Syed, WILLIAMS, Alfred L, PHAN, Alexandria T, HONG ZHAO, SCOTT, John E, YEH, Li-An, WONG, Stephen T. C

“…Irinotecan (CPT-11) induced diarrhea occurs frequently in patients with cancer and limits its usage. Bacteria β-glucuronidase (GUS) enzymes in intestines…”
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Discovery and characterization of an iminocoumarin scaffold as an inhibitor of MEKK2 (MAP3K2) by Ahmad, Syed, St. Hilaire, Valentine R., Dandepally, Srinivasa R., Johnson, Gary L., Williams, Alfred L., Scott, John E.

“…The kinase MEKK2 (MAP3K2) activates the MEK5/ERK5 cell signaling pathway and may play an important role in tumor growth and metastasis. Thus, MEKK2 may…”
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Potential repurposing of known drugs as potent bacterial β-glucuronidase inhibitors by Ahmad, Syed, Hughes, Mark A, Yeh, Li-An, Scott, John E

“…The active metabolite of the chemotherapeutic irinotecan, SN-38, is detoxified through glucuronidation and then excreted into the gastrointestinal tract…”
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A universal competitive fluorescence polarization activity assay for S-adenosylmethionine utilizing methyltransferases by Graves, Tiffany L., Zhang, Yi, Scott, John E.

“…A high-throughput, competitive fluorescence polarization immunoassay has been developed for the detection of methyltransferase activity. The assay was designed…”
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Bosutinib reduces the efficacy of Dasatinib in triple-negative breast cancer cell lines by Tarpley, Mike, Abdissa, Temesgen T, Johnson, Gary L, Scott, John E

“…Triple-negative breast cancer (TNBC) is an aggressive sub-type of breast cancer. Dasatinib and bosutinib are FDA-approved Src/Abl kinase inhibitor drugs…”
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A homogeneous cell-based assay for measurement of endogenous paraoxonase 1 activity by Ahmad, Syed, Carter, Jade J., Scott, John E.

“…Paraoxonase 1 (PON1) is a high-density lipoprotein-associated enzyme that plays an important role in organophosphate detoxification and prevention of…”
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