Search Results - "Scott, Donald K"

Nrf2: The Master and Captain of Beta Cell Fate by Baumel-Alterzon, Sharon, Katz, Liora S., Brill, Gabriel, Garcia-Ocaña, Adolfo, Scott, Donald K.

“…Prolonged hyperglycemia is toxic to pancreatic β cells, generating excessive reactive oxygen species, defective glucose-stimulated insulin secretion, decreased…”
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Replication confers β cell immaturity by Puri, Sapna, Roy, Nilotpal, Russ, Holger A., Leonhardt, Laura, French, Esra K., Roy, Ritu, Bengtsson, Henrik, Scott, Donald K., Stewart, Andrew F., Hebrok, Matthias

“…Pancreatic β cells are highly specialized to regulate systemic glucose levels by secreting insulin. In adults, increase in β-cell mass is limited due to brakes…”
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Regulation of Pdx1 by oxidative stress and Nrf2 in pancreatic beta-cells by Baumel-Alterzon, Sharon, Scott, Donald K

“…The beta-cell identity gene, pancreatic duodenal homeobox 1 ( ), plays critical roles in many aspects of the life of beta-cells including differentiation,…”
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Combined Inhibition of DYRK1A, SMAD, and Trithorax Pathways Synergizes to Induce Robust Replication in Adult Human Beta Cells by Wang, Peng, Karakose, Esra, Liu, Hongtao, Swartz, Ethan, Ackeifi, Courtney, Zlatanic, Viktor, Wilson, Jessica, González, Bryan J., Bender, Aaron, Takane, Karen K., Ye, Lillian, Harb, George, Pagliuca, Felicia, Homann, Dirk, Egli, Dieter, Argmann, Carmen, Scott, Donald K., Garcia-Ocaña, Adolfo, Stewart, Andrew F.

“…Small-molecule inhibitors of dual-specificity tyrosine-regulated kinase 1A (DYRK1A) induce human beta cells to proliferate, generating a labeling index of…”
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Depletion of Liver Kupffer Cells Prevents the Development of Diet-Induced Hepatic Steatosis and Insulin Resistance by WAN HUANG, METLAKUNTA, Anantha, DEDOUSIS, Nikolaos, PILI ZHANG, SIPULA, Ian, DUBE, John J, SCOTT, Donald K, O'DOHERTY, Robert M

“…Depletion of Liver Kupffer Cells Prevents the Development of Diet-Induced Hepatic Steatosis and Insulin Resistance Wan Huang 1 , Anantha Metlakunta 1 ,…”
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Insights into beta cell regeneration for diabetes via integration of molecular landscapes in human insulinomas by Wang, Huan, Bender, Aaron, Wang, Peng, Karakose, Esra, Inabnet, William B., Libutti, Steven K., Arnold, Andrew, Lambertini, Luca, Stang, Micheal, Chen, Herbert, Kasai, Yumi, Mahajan, Milind, Kinoshita, Yayoi, Fernandez-Ranvier, Gustavo, Becker, Thomas C., Takane, Karen K., Walker, Laura A., Saul, Shira, Chen, Rong, Scott, Donald K., Ferrer, Jorge, Antipin, Yevgeniy, Donovan, Michael, Uzilov, Andrew V., Reva, Boris, Schadt, Eric E., Losic, Bojan, Argmann, Carmen, Stewart, Andrew F.

“…Although diabetes results in part from a deficiency of normal pancreatic beta cells, inducing human beta cells to regenerate is difficult. Reasoning that…”
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T3 and Glucose Coordinately Stimulate ChREBP-Mediated Ucp1 Expression in Brown Adipocytes From Male Mice by Katz, Liora S, Xu, Shiliyang, Ge, Kai, Scott, Donald K, Gershengorn, Marvin C

“…Abstract Increasing brown adipose tissue (BAT) activity is regarded as a potential treatment of obese, hyperglycemic patients with metabolic syndrome…”
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Disrupting the DREAM complex enables proliferation of adult human pancreatic β cells by Wang, Peng, Karakose, Esra, Argmann, Carmen, Wang, Huan, Balev, Metodi, Brody, Rachel I, Rivas, Hembly G, Liu, Xinyue, Wood, Olivia, Liu, Hongtao, Choleva, Lauryn, Hasson, Dan, Bernstein, Emily, Paulo, Joao A, Scott, Donald K, Lambertini, Luca, DeCaprio, James A, Stewart, Andrew F

“…Resistance to regeneration of insulin-producing pancreatic β cells is a fundamental challenge for type 1 and type 2 diabetes. Recently, small molecule…”
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Dendritic Cells Promote Macrophage Infiltration and Comprise a Substantial Proportion of Obesity-Associated Increases in CD11c+ Cells in Adipose Tissue and Liver by STEFANOVIC-RACIC, Maja, XIAO YANG, THOMSON, Angus W, O'DOHERTY, Robert M, TURNER, Michael S, MANTELL, Benjamin S, STOLZ, Donna B, SUMPTER, Tina L, SIPULA, Ian J, DEDOUSIS, Nikolaos, SCOTT, Donald K, MOREL, Penelope A

“…Obesity-associated increases in adipose tissue (AT) CD11c(+) cells suggest that dendritic cells (DC), which are involved in the tissue recruitment and…”
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Single-nucleus RNA sequencing of human pancreatic islets identifies novel gene sets and distinguishes β-cell subpopulations with dynamic transcriptome profiles by Kang, Randy B, Li, Yansui, Rosselot, Carolina, Zhang, Tuo, Siddiq, Mustafa, Rajbhandari, Prashant, Stewart, Andrew F, Scott, Donald K, Garcia-Ocana, Adolfo, Lu, Geming

“…Single-cell RNA sequencing (scRNA-seq) provides valuable insights into human islet cell types and their corresponding stable gene expression profiles. However,…”
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T3 and glucose increase expression of phosphoenolpyruvate carboxykinase (PCK1) leading to increased β-cell proliferation by Katz, Liora S., Argmann, Carmen, Lambertini, Luca, Scott, Donald K.

“…Thyroid hormone (T3) and high glucose concentrations are critical components of β-cell maturation and function. In the present study, we asked whether T3 and…”
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Transcriptional regulation of human dual specificity protein phosphatase 1 (DUSP1) gene by glucocorticoids by Shipp, Lauren E, Lee, Joyce V, Yu, Chi-Yi, Pufall, Miles, Zhang, Pili, Scott, Donald K, Wang, Jen-Chywan

“…Glucocorticoids are potent anti-inflammatory agents commonly used to treat inflammatory diseases. They convey signals through the intracellular glucocorticoid…”
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Maladaptive positive feedback production of ChREBPβ underlies glucotoxic β-cell failure by Katz, Liora S., Brill, Gabriel, Zhang, Pili, Kumar, Anil, Baumel-Alterzon, Sharon, Honig, Lee B., Gómez-Banoy, Nicolás, Karakose, Esra, Tanase, Marius, Doridot, Ludivine, Alvarsson, Alexandra, Davenport, Bennett, Wang, Peng, Lambertini, Luca, Stanley, Sarah A., Homann, Dirk, Stewart, Andrew F., Lo, James C., Herman, Mark A., Garcia-Ocaña, Adolfo, Scott, Donald K.

“…Preservation and expansion of β-cell mass is a therapeutic goal for diabetes. Here we show that the hyperactive isoform of carbohydrate response-element…”
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Aberrant methylation underlies insulin gene expression in human insulinoma by Karakose, Esra, Wang, Huan, Inabnet, William, Thakker, Rajesh V., Libutti, Steven, Fernandez-Ranvier, Gustavo, Suh, Hyunsuk, Stevenson, Mark, Kinoshita, Yayoi, Donovan, Michael, Antipin, Yevgeniy, Li, Yan, Liu, Xiaoxiao, Jin, Fulai, Wang, Peng, Uzilov, Andrew, Argmann, Carmen, Schadt, Eric E., Stewart, Andrew F., Scott, Donald K., Lambertini, Luca

“…Human insulinomas are rare, benign, slowly proliferating, insulin-producing beta cell tumors that provide a molecular “recipe” or “roadmap” for pathways that…”
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Author Correction: Maladaptive positive feedback production of ChREBPβ underlies glucotoxic β-cell failure by Katz, Liora S., Brill, Gabriel, Zhang, Pili, Kumar, Anil, Baumel-Alterzon, Sharon, Honig, Lee B., Gómez-Banoy, Nicolás, Karakose, Esra, Tanase, Marius, Doridot, Ludivine, Alvarsson, Alexandra, Davenport, Bennett, Wang, Peng, Lambertini, Luca, Stanley, Sarah A., Homann, Dirk, Stewart, Andrew F., Lo, James C., Herman, Mark A., Garcia-Ocaña, Adolfo, Scott, Donald K.

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Transcriptional activation of the Myc gene by glucose in β-cells requires a ChREBP-dependent 3-D chromatin interaction between the Myc and Pvt1 genes by Katz, Liora S, Brill, Gabriel, Wang, Peng, Lambertini, Luca, Zhang, Pili, Haldeman, Jonathan M, Liu, Hongtao, Newgard, Christopher B, Stewart, Andrew F, Garcia-Ocaña, Adolfo, Scott, Donald K

“…All forms of diabetes result from insufficient functional β-cell mass. Thus, achieving the therapeutic goal of expanding β-cell mass requires a better…”
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Pharmacological blockade of the EP3 prostaglandin E2 receptor in the setting of type 2 diabetes enhances β-cell proliferation and identity and relieves oxidative damage by Bosma, Karin J., Andrei, Spencer R., Katz, Liora S., Smith, Ashley A., Dunn, Jennifer C., Ricciardi, Valerie F., Ramirez, Marisol A., Baumel-Alterzon, Sharon, Pace, William A., Carroll, Darian T., Overway, Emily M., Wolf, Elysa M., Kimple, Michelle E., Sheng, Quanhu, Scott, Donald K., Breyer, Richard M., Gannon, Maureen

“…Type 2 diabetes is characterized by hyperglycemia and inflammation. Prostaglandin E2, which signals through four G protein-coupled receptors (EP1-4), is a…”
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MPI depletion enhances O-GlcNAcylation of p53 and suppresses the Warburg effect by Shtraizent, Nataly, DeRossi, Charles, Nayar, Shikha, Sachidanandam, Ravi, Katz, Liora S, Prince, Adam, Koh, Anna P, Vincek, Adam, Hadas, Yoav, Hoshida, Yujin, Scott, Donald K, Eliyahu, Efrat, Freeze, Hudson H, Sadler, Kirsten C, Chu, Jaime

“…Rapid cellular proliferation in early development and cancer depends on glucose metabolism to fuel macromolecule biosynthesis. Metabolic enzymes are presumed…”
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Mechanisms by which the thiazolidinedione troglitazone protects against sucrose‐induced hepatic fat accumulation and hyperinsulinaemia by Martins, Fátima O, Delgado, Teresa C, Viegas, Joana, Gaspar, Joana M, Scott, Donald K, O'Doherty, Robert M, Paula Macedo, M, Jones, John G

“…Background and Purpose Thiazolidinediones (TZD) are known to ameliorate fatty liver in type 2 diabetes. To date, the underlying mechanisms of their hepatic…”
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DNA methylation alters transcriptional rates of differentially expressed genes and contributes to pathophysiology in mice fed a high fat diet by Zhang, Pili, Chu, Tianjiao, Dedousis, N, Mantell, Benjamin S, Sipula, Ian, Li, Lucy, Bunce, Kimberly D, Shaw, Patricia A, Katz, Liora S, Zhu, Jun, Argmann, Carmen, O'Doherty, Robert M, Peters, David G, Scott, Donald K

“…Abstract Objective Overnutrition can alter gene expression patterns through epigenetic mechanisms that may persist through generations. However, it is less…”
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