Search Results - "Scott, C. L."

TGFβR signalling controls CD103+CD11b+ dendritic cell development in the intestine by Bain, C. C., Montgomery, J., Scott, C. L., Kel, J. M., Girard-Madoux, M. J. H., Martens, L., Zangerle-Murray, T. F. P., Ober-Blöbaum, J., Lindenbergh-Kortleve, D., Samsom, J. N., Henri, S., Lawrence, T., Saeys, Y., Malissen, B., Dalod, M., Clausen, B. E., Mowat, A. McI

“…CD103 + CD11b + dendritic cells (DCs) are unique to the intestine, but the factors governing their differentiation are unclear. Here we show that transforming…”
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Interleukin-22 binding protein (IL-22BP) is constitutively expressed by a subset of conventional dendritic cells and is strongly induced by retinoic acid by Martin, J CJ, Bériou, G, Heslan, M, Chauvin, C, Utriainen, L, Aumeunier, A, Scott, C L, Mowat, A, Cerovic, V, Houston, S A, Leboeuf, M, Hubert, F X, Hémont, C, Merad, M, Milling, S, Josien, R

“…Interleukin-22 (IL-22) is mainly produced at barrier surfaces by T cells and innate lymphoid cells and is crucial to maintain epithelial integrity. However,…”
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Analysis of the apoptotic and therapeutic activities of histone deacetylase inhibitors by using a mouse model of B cell lymphoma by Lindemann, R.K, Newbold, A, Whitecross, K.F, Cluse, L.A, Frew, A.J, Ellis, L, Williams, S, Wiegmans, A.P, Dear, A.E, Scott, C.L, Pellegrini, M, Wei, A, Richon, V.M, Marks, Paul A, Lowe, S.W, Smyth, M.J, Johnstone, R.W

“…Histone deacetylase inhibitors (HDACi) can elicit a range of biological responses that affect tumor growth and survival, including inhibition of cell cycle…”
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Puma and to a lesser extent Noxa are suppressors of Myc-induced lymphomagenesis by Michalak, E M, Jansen, E S, Happo, L, Cragg, M S, Tai, L, Smyth, G K, Strasser, A, Adams, J M, Scott, C L

“…Evasion of apoptosis contributes importantly to c-Myc-induced tumorigenesis. The BH3-only Bcl-2 family members Puma and Noxa are critical pro-apoptotic…”
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A phase II study of pegylated-camptothecin (pegamotecan) in the treatment of locally advanced and metastatic gastric and gastro-oesophageal junction adenocarcinoma by Scott, L. C., Yao, J. C., Benson, A. B., Thomas, A. L., Falk, S., Mena, R. R., Picus, J., Wright, J., Mulcahy, M. F., Ajani, J. A., Evans, T. R. J.

“…Purpose Combination chemotherapy results in a significant survival advantage in patients with advanced gastric cancer compared to best supportive care…”
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Development of conventional dendritic cells: from common bone marrow progenitors to multiple subsets in peripheral tissues by Sichien, D, Lambrecht, B N, Guilliams, M, Scott, C L

“…Our understanding of conventional dendritic cell (cDC) development and the functional specializations of distinct subsets in the peripheral tissues has…”
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ESMO recommendations on predictive biomarker testing for homologous recombination deficiency and PARP inhibitor benefit in ovarian cancer by Miller, R.E., Leary, A., Scott, C.L., Serra, V., Lord, C.J., Bowtell, D., Chang, D.K., Garsed, D.W., Jonkers, J., Ledermann, J.A., Nik-Zainal, S., Ray-Coquard, I., Shah, S.P., Matias-Guiu, X., Swisher, E.M., Yates, L.R.

“…Homologous recombination repair deficiency (HRD) is a frequent feature of high-grade serous ovarian, fallopian tube and peritoneal carcinoma (HGSC) and is…”
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Intestinal CD103− dendritic cells migrate in lymph and prime effector T cells by Cerovic, V, Houston, S A, Scott, C L, Aumeunier, A, Yrlid, U, Mowat, A M, Milling, S W F

“…Intestinal dendritic cells (DCs) continuously migrate through lymphatics to mesenteric lymph nodes where they initiate immunity or tolerance. Recent research…”
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CCR2+CD103− intestinal dendritic cells develop from DC-committed precursors and induce interleukin-17 production by T cells by Scott, C L, Bain, C C, Wright, P B, Sichien, D, Kotarsky, K, Persson, E K, Luda, K, Guilliams, M, Lambrecht, B N, Agace, W W, Milling, S WF, Mowat, A M

“…The identification of intestinal macrophages (mφs) and dendritic cells (DCs) is a matter of intense debate. Although CD103 + mononuclear phagocytes (MPs)…”
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The development and evaluation of a nationwide training program for oncology health professionals in the provision of genetic testing for ovarian cancer patients by Gleeson, M., Kentwell, M., Meiser, B., Do, J., Nevin, S., Taylor, N., Barlow-Stewart, K., Kirk, J., James, P., Scott, C.L., Williams, R., Gamet, K., Burke, J., Murphy, M., Antill, Y.C., Pearn, A., Pachter, N., Ebzery, C., Poplawski, N., Friedlander, M., Tucker, K.M.

“…BRCA1/2 mutation status has increasing relevance for ovarian cancer treatments, making traditional coordination of genetic testing by genetic services…”
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Prioritizing therapeutic targets using patient-derived xenograft models by Lodhia, K.A., Hadley, A.M., Haluska, P., Scott, C.L.

“…Effective systemic treatment of cancer relies on the delivery of agents with optimal therapeutic potential. The molecular age of medicine has provided genomic…”
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Neuropsychological dysfunction in depression: the relationship to regional cerebral blood flow by Dolan, R J, Bench, C J, Brown, R G, Scott, L C, Frackowiak, R S

“…The relationship between neuropsychological test performance and regional cerebral blood flow (rCBF) was examined in 29 patients meeting Research Diagnostic…”
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Lymph-borne CD8α+ dendritic cells are uniquely able to cross-prime CD8+ T cells with antigen acquired from intestinal epithelial cells by Cerovic, V, Houston, S A, Westlund, J, Utriainen, L, Davison, E S, Scott, C L, Bain, C C, Joeris, T, Agace, W W, Kroczek, R A, Mowat, A M, Yrlid, U, Milling, S WF

“…Cross-presentation of cellular antigens is crucial for priming CD8 + T cells, and generating immunity to intracellular pathogens—particularly viruses. It is…”
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Regional cerebral blood flow abnormalities in depressed patients with cognitive impairment by Dolan, R J, Bench, C J, Brown, R G, Scott, L C, Friston, K J, Frackowiak, R S

“…Depression with cognitive impairment, so called depressive pseudodementia, is commonly mistaken for a neurodegenerative dementia. Using positron emission…”
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Reassessment of interactions between hematopoietic receptors using common beta-chain and interleukin-3–specific receptor beta-chain–null cells: no evidence of functional interactions with receptors for erythropoietin, granulocyte colony-stimulating factor, or stem cell factor by Scott, Clare L., Robb, Lorraine, Papaevangeliou, Bette, Mansfield, Rachel, Nicola, Nicos A., Begley, C. Glenn

“…Mice lacking both the gene encoding the shared receptor for granulocyte macrophage–colony-stimulating factor (GM-CSF), interleukin-3 (IL-3), and IL-5 common…”
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The primordial follicle reserve is not renewed after chemical or γ-irradiation mediated depletion by Kerr, J B, Brogan, L, Myers, M, Hutt, K J, Mladenovska, T, Ricardo, S, Hamza, K, Scott, C L, Strasser, A, Findlay, J K

“…Reports indicate that germ-line stem cells present in adult mice can rapidly generate new oocytes and contribute to the primordial follicle reserve following…”
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Evidence that cyclic AMP phosphodiesterase inhibitors suppress TNFα generation from human monocytes by interacting with a ‘low‐affinity’ phosphodiesterase 4 conformer by Souness, John E., Griffin, Miriam, Maslen, Christopher, Ebsworth, Karen, Scott, Lisa C., Pollock, Kenneth, Palfreyman, Malcolm N., Karlsson, Jan‐Anders

“…1 We have investigated the inhibitory effects of RP 73401 (piclamilast) and rolipram against human monocyte cyclic AMP‐specific phosphodiesterase (PDE4) in…”
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Cognitive function in depression: its relationship to the presence and severity of intellectual decline by Brown, R G, Scott, L C, Bench, C J, Dolan, R J

“…Cognitive dysfunction is an integral feature of depression, in some cases of sufficient severity to warrant a diagnosis of dementia. There has been little…”
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The impact of single agent PD-1 or PD-L1 inhibition on advanced endometrial cancers: meta-analysis by Kok, P.-S., Antill, Y.C., Scott, C.L., Lee, C.K.

“…Immune checkpoint inhibitor (ICI) therapy is an emerging option for advanced endometrial cancer (EC). Mismatch repair (MMR) status is widely regarded as a…”
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The anatomy of melancholia--focal abnormalities of cerebral blood flow in major depression by Bench, C J, Friston, K J, Brown, R G, Scott, L C, Frackowiak, R S, Dolan, R J

“…Using positron emission tomography (PET) and 15Oxygen, regional cerebral blood flow (rCBF) was measured in 33 patients with primary depression, 10 of whom had…”
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