Search Results - "Scotland, Ramona S"

Sex differences in resident immune cell phenotype underlie more efficient acute inflammatory responses in female mice by Scotland, Ramona S., Stables, Melanie J., Madalli, Shimona, Watson, Peter, Gilroy, Derek W.

“…Females are protected against mortality arising from severe sepsis; however, the precise mechanisms that confer this survival advantage in females over males…”
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A Role of Matrix Metalloproteinase-8 in Atherosclerosis by Laxton, Ross C, Hu, Yanhua, Duchene, Johan, Zhang, Feng, Zhang, Zhongyi, Leung, Kit-Yi, Xiao, Qingzhong, Scotland, Ramona S, Hodgkinson, Conrad P, Smith, Katherine, Willeit, Johann, López-Otín, Carlos, Simpson, Iain A, Kiechl, Stefan, Ahluwalia, Amrita, Xu, Qingbo, Ye, Shu

“…RATIONALE:Atherosclerotic lesions express matrix metalloproteinase (MMP)8, which possesses proteolytic activity on matrix proteins particularly fibrillar…”
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Distinct endothelial pathways underlie sexual dimorphism in vascular auto‐regulation by Chan, Melissa V, Bubb, Kristen J, Noyce, Alastair, Villar, Inmaculada C, Duchene, Johan, Hobbs, Adrian J, Scotland, Ramona S, Ahluwalia, Amrita

“…BACKGROUND AND PURPOSE Pre‐menopausal females have a lower incidence of cardiovascular disease compared with age‐matched males, implying differences in the…”
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C-type natriuretic peptide in vascular physiology and disease by Scotland, Ramona S, Ahluwalia, Amrita, Hobbs, Adrian J

“…Natriuretic peptides play a critical role in coordination of fluid/electrolyte balance and vascular tone. The renal effects of circulating atrial natriuretic…”
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Antiinflammatory Activity of Soluble Guanylate Cyclase: cGMP-Dependent Down-Regulation of P-Selectin Expression and Leukocyte Recruitment by Ahluwalia, Amrita, Foster, Paul, Scotland, Ramona S., McLean, Peter G., Mathur, Anthony, Perretti, Mauro, Moncada, Salvador, Hobbs, Adrian J.

“…Nitric oxide (NO) production by the vascular endothelium maintains an essential antiinflammatory, cytoprotective influence on the blood vessel wall. A key…”
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C-Type Natriuretic Peptide Inhibits Leukocyte Recruitment and Platelet-Leukocyte Interactions via Suppression of P-Selectin Expression by Scotland, Ramona S., Cohen, Marc, Foster, Paul, Lovell, Matthew, Mathur, Anthony, Ahluwalia, Amrita, Hobbs, Adrian J., Moncada, Salvador

“…The multifaceted process of immune cell recruitment to sites of tissue injury is key to the development of an inflammatory response and involved in the…”
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Functional Reconstitution of Endothelial Nitric Oxide Synthase Reveals the Importance of Serine 1179 in Endothelium-Dependent Vasomotion by Scotland, Ramona S, Morales-Ruiz, Manuel, Chen, Yan, Yu, Jun, Rudic, Radu Daniel, Fulton, David, Gratton, Jean-Philippe, Sessa, William C

“…Phosphorylation of endothelial nitric oxide synthase (eNOS) at serine 1179 can activate the enzyme, leading to NO release. Because eNOS is important in…”
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Sexual dimorphisms in leukocyte trafficking in a mouse peritonitis model by Kay, Emma, Gomez‐Garcia, Lorena, Woodfin, Abigail, Scotland, Ramona S., Whiteford, James R.

“…Differences in inflammatory response between male and female C57BL6 mice. Sexual dimorphisms exist in the incidence and severity of many diseases, with females…”
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Toll-like receptors: Role in inflammation and therapeutic potential by Kay, Emma, Scotland, Ramona S., Whiteford, James R.

“…Inflammation is an essential process in response to injury and infection. However, under certain circumstances dis‐regulation of this process can lead to…”
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An endothelium-derived hyperpolarizing factor-like factor moderates myogenic constriction of mesenteric resistance arteries in the absence of endothelial nitric oxide synthase-derived nitric oxide by SCOTLAND, Ramona S, CHAUHAN, Sharmila, VALLANCE, Patrick J. T, AHLUWALIA, Amrita

“…Myogenic tone is an important determinant of vascular tone and blood flow in small resistance arteries of certain vascular beds. The role of the endothelium in…”
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Investigation of vascular responses in endothelial nitric oxide synthase/cyclooxygenase-1 double-knockout mice: Key role for endothelium-derived hyperpolarizing factor in the regulation of blood pressure in vivo by SCOTLAND, Ramona S, MADHANI, Melanie, CHAUHAN, Sharmila, MONCADA, Salvador, ANDRESEN, Jørgen, NILSSON, Holger, HOBBS, Adrian J, AHLUWALIA, Amrita

“…Endothelium-dependent dilatation is mediated by 3 principal vasodilators: nitric oxide (NO), prostacyclin (PGI2), and endothelium-derived hyperpolarizing…”
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Vanilloid Receptor TRPV1, Sensory C-Fibers, and Vascular Autoregulation: A Novel Mechanism Involved in Myogenic Constriction by Scotland, Ramona S, Chauhan, Sharmila, Davis, Clare, De Felipe, Carmen, Hunt, Stephen, Kabir, Jahangir, Kotsonis, Peter, Oh, Uhtaek, Ahluwalia, Amrita

“…Myogenic constriction describes the innate ability of resistance arteries to constrict in response to elevations in intraluminal pressure and is a fundamental…”
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Definitive role for natriuretic peptide receptor-C in mediating the vasorelaxant activity of C-type natriuretic peptide and endothelium-derived hyperpolarising factor by VILLAR, Inmaculada C, PANAYIOTOU, Catherine M, SHERAZ, Adil, MADHANI, Melanie, SCOTLAND, Ramona S, NOBLES, Muriel, KEMP-HARPER, Barbara, AHLUWALIA, Amrita, HOBBS, Adrian J

“…C-type natriuretic peptide (CNP) has recently been suggested to represent an endothelium-derived hyperpolarising factor (EDHF) in the mammalian resistance…”
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Suppression of Endothelial P-Selectin Expression Contributes to Reduced Cell Trafficking in Females: An Effect Independent of NO and Prostacyclin by Villar, Inmaculada C, Scotland, Ramona S, Khambata, Rayomand S, Chan, Melissa, Duchene, Johan, Sampaio, Andre L, Perretti, Mauro, Hobbs, Adrian J, Ahluwalia, Amrita

“…OBJECTIVE—Sex hormones underlie the lower incidence of cardiovascular disease in premenopausal women. Vascular inflammation is involved in the pathogenesis of…”
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Sex-specific regulation of chemokine Cxcl5/6 controls neutrophil recruitment and tissue injury in acute inflammatory states by Madalli, Shimona, Beyrau, Martina, Whiteford, James, Duchene, Johan, Singh Nandhra, Inderpal, Patel, Nimesh S A, Motwani, Madhur P, Gilroy, Derek W, Thiemermann, Christoph, Nourshargh, Sussan, Scotland, Ramona S

“…Tissue infiltration by neutrophils during acute inflammatory states causes substantial tissue injury. While the magnitude of tissue neutrophil accumulation in…”
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Cell-permeable peptides improve cellular uptake and therapeutic gene delivery of replication-deficient viruses in cells and in vivo by Sessa, William C, Gratton, Jean-Philippe, Yu, Jun, Griffith, Jason W, Babbitt, Roger W, Scotland, Ramona S, Hickey, Reed, Giordano, Frank J

“…Small polybasic peptides derived from the transduction domains of certain proteins, such as the third α-helix of the Antennapedia (Antp) homeodomain, can cross…”
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Vascular natriuretic peptide receptor‐linked particulate guanylate cyclases are modulated by nitric oxide–cyclic GMP signalling by Madhani, Melanie, Scotland, Ramona S, MacAllister, Raymond J, Hobbs, Adrian J

“…The sensitivity of the particulate guanylate cyclase–cyclic guanosine‐3′,5′‐monophosphate (cGMP) system to atrial (ANP) and C‐type (CNP) natriuretic peptides…”
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Endogenous factors involved in regulation of tone of arterial vasa vasorum : implications for conduit vessel physiology by SCOTLAND, Ramona S, VALLANCE, Patrick J. T, AHLUWALIA, Amrita

“…The walls of conduit blood vessels are nourished by diffusion of oxygen from luminal blood and from the vasa vasorum. The vasa vasorum, or 'vessels of a…”
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Expression and function of recombinant S1179D endothelial nitric oxide synthase in canine cerebral arteries by AKIYAMA, Masahiko, EGUCHI, Daihiko, WEILER, Deborah, O'BRIEN, Timothy, KOVESDI, Imre, SCOTLAND, Ramona S, SESSA, William C, KATUSIC, Zvonimir S

“…Bovine endothelial nitric oxide synthase (eNOS) is phosphorylated directly by the protein kinase Akt at serine 1179. Mutation of this residue to the negatively…”
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95 by Kay, Emma, Scotland, Ramona S., Whiteford, James R.

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