Search Results - "Scotet, Emmanuel"

Emerging Challenges of Preclinical Models of Anti-tumor Immunotherapeutic Strategies Utilizing Vγ9Vδ2 T Cells by Joalland, Noémie, Scotet, Emmanuel

“…Despite recent advances, the eradication of cancers still represents a challenge which justifies the exploration of additional therapeutic strategies such as…”
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BTN2A1, an immune checkpoint targeting Vγ9Vδ2 T cell cytotoxicity against malignant cells by Cano, Carla E., Pasero, Christine, De Gassart, Aude, Kerneur, Clement, Gabriac, Mélanie, Fullana, Marie, Granarolo, Emilie, Hoet, René, Scotet, Emmanuel, Rafia, Chirine, Herrmann, Thomas, Imbert, Caroline, Gorvel, Laurent, Vey, Norbert, Briantais, Antoine, le Floch, Anne Charlotte, Olive, Daniel

“…The anti-tumor response of Vγ9Vδ2 T cells requires the sensing of accumulated phosphoantigens (pAgs) bound intracellularly to butyrophilin 3A1 (BTN3A1). In…”
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Efficient Mitochondrial Glutamine Targeting Prevails Over Glioblastoma Metabolic Plasticity by Oizel, Kristell, Chauvin, Cynthia, Oliver, Lisa, Gratas, Catherine, Geraldo, Fanny, Jarry, Ulrich, Scotet, Emmanuel, Rabe, Marion, Alves-Guerra, Marie-Clotilde, Teusan, Raluca, Gautier, Fabien, Loussouarn, Delphine, Compan, Vincent, Martinou, Jean-Claude, Vallette, François M, Pecqueur, Claire

“…Glioblastoma (GBM) is the most common and malignant form of primary human brain tumor in adults, with an average survival at diagnosis of 18 months. Metabolism…”
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The Juxtamembrane Domain of Butyrophilin BTN3A1 Controls Phosphoantigen-Mediated Activation of Human Vγ9Vδ2 T Cells by Peigné, Cassie-Marie, Léger, Alexandra, Gesnel, Marie-Claude, Konczak, Fabienne, Olive, Daniel, Bonneville, Marc, Breathnach, Richard, Scotet, Emmanuel

“…Vγ9Vδ2 T lymphocytes are the major human peripheral γδ T cell subset, with broad reactivity against stressed human cells, including tumor cells. Vγ9Vδ2 T cells…”
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Sensing of cell stress by human γδ TCR-dependent recognition of annexin A2 by Marlin, Romain, Pappalardo, Angela, Kaminski, Hannah, Willcox, Carrie R., Pitard, Vincent, Netzer, Sonia, Khairallah, Camille, Lomenech, Anne-Marie, Harly, Christelle, Bonneville, Marc, Moreau, Jean-François, Scotet, Emmanuel, Willcox, Benjamin E., Faustin, Benjamin, Déchanet-Merville, Julie

“…Human γδ T cells comprise a first line of defense through T-cell receptor (TCR) recognition of stressed cells. However, the molecular determinants and stress…”
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Towards Deciphering the Hidden Mechanisms That Contribute to the Antigenic Activation Process of Human Vγ9Vδ2 T Cells by Boutin, Lola, Scotet, Emmanuel

“…Vγ9Vδ2 T cells represent a major unconventional γδ T cell subset located in the peripheral blood of adults in humans and several non-human primates…”
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RhoB Mediates Phosphoantigen Recognition by Vγ9Vδ2 T Cell Receptor by Sebestyen, Zsolt, Scheper, Wouter, Vyborova, Anna, Gu, Siyi, Rychnavska, Zuzana, Schiffler, Marleen, Cleven, Astrid, Chéneau, Coraline, van Noorden, Martje, Peigné, Cassie-Marie, Olive, Daniel, Lebbink, Robert Jan, Oostvogels, Rimke, Mutis, Tuna, Schuurhuis, Gerrit Jan, Adams, Erin J., Scotet, Emmanuel, Kuball, Jürgen

“…Human Vγ9Vδ2 T cells respond to tumor cells by sensing elevated levels of phosphorylated intermediates of the dysregulated mevalonate pathway, which is…”
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The antitumor activity of human Vγ9Vδ2 T cells is impaired by TGF-β through significant phenotype, transcriptomic and metabolic changes by Rafia, Chirine, Loizeau, Clément, Renoult, Ophélie, Harly, Christelle, Pecqueur, Claire, Joalland, Noémie, Scotet, Emmanuel

“…Despite significant advances, the eradication of cancer remains a clinical challenge which justifies the urgent exploration of additional therapeutic…”
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Mycobacterial Phosphatidylinositol Mannoside Is a Natural Antigen for CD1d-Restricted T Cells by Fischer, Karsten, Scotet, Emmanuel, Niemeyer, Marcus, Koebernick, Heidrun, Zerrahn, Jens, Maillet, Sophie, Hurwitz, Robert, Kursar, Mischo, Bonneville, Marc, Stefan H. E. Kaufmann, Schaible, Ulrich E., Kishimoto, Tadamitsu

“…A group of T cells recognizes glycolipids presented by molecules of the CD1 family. The CD1d-restricted natural killer T cells (NKT cells) are primarily…”
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Combined chemotherapy and allogeneic human Vγ9Vδ2 T lymphocyte-immunotherapies efficiently control the development of human epithelial ovarian cancer cells in vivo by Joalland, Noémie, Lafrance, Laura, Oullier, Thibauld, Marionneau-Lambot, Séverine, Loussouarn, Delphine, Jarry, Ulrich, Scotet, Emmanuel

“…Epithelial ovarian cancer (EOC) represents 5% of human gynecologic cancers in the world, is heterogeneous and highly invasive with a dismal prognosis (5…”
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Full restoration of Brucella-infected dendritic cell functionality through Vγ9Vδ2 T helper type 1 crosstalk by Ni, Ming, Martire, Delphine, Scotet, Emmanuel, Bonneville, Marc, Sanchez, Francoise, Lafont, Virginie

“…Vγ9Vδ2 T cells play an important role in the immune response to infectious agents but the mechanisms contributing to this immune process remain to be better…”
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Increased antitumor efficacy of PD-1-deficient melanoma-specific human lymphocytes by Marotte, Lucine, Simon, Sylvain, Vignard, Virginie, Dupre, Emilie, Gantier, Malika, Cruard, Jonathan, Alberge, Jean-Baptiste, Hussong, Melanie, Deleine, Cecile, Heslan, Jean-Marie, Shaffer, Jonathan, Beauvais, Tiffany, Gaschet, Joelle, Scotet, Emmanuel, Fradin, Delphine, Jarry, Anne, Nguyen, Tuan, Labarriere, Nathalie

“…BackgroundGenome editing offers unique perspectives for optimizing the functional properties of T cells for adoptive cell transfer purposes. So far, PDCD1…”
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Impact on early outcomes and immune reconstitution of high-dose post-transplant cyclophosphamide vs anti-thymocyte globulin after reduced intensity conditioning peripheral blood stem cell allogeneic transplantation by Retière, Christelle, Willem, Catherine, Guillaume, Thierry, Vié, Henri, Gautreau-Rolland, Laetitia, Scotet, Emmanuel, Saulquin, Xavier, Gagne, Katia, Béné, Marie C, Imbert, Berthe-Marie, Clemenceau, Beatrice, Peterlin, Pierre, Garnier, Alice, Chevallier, Patrice

“…We have compared prospectively the outcome and immune reconstitution of patients receiving either post-transplant cyclophosphamide (PTCY) ( = 30) or…”
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Development of Predictive Value of Urinary Cytokine Profile Induced During Intravesical Bacillus Calmette-Guérin Instillations for Bladder Cancer by Rigaud, Jérôme, Leger, Alexandra, Devilder, Marie-Claire, Bouchot, Olivier, Bonneville, Marc, Scotet, Emmanuel

“…Micro-Abstract We describe a local reaction to intravesical bacillus Calmette-Guérin (BCG) instillations for the treatment of bladder cancer, with different…”
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CD4 engagement by CD1d potentiates activation of CD4+ invariant NKT cells by Thedrez, Aurelie, de Lalla, Claudia, Allain, Sophie, Zaccagnino, Luca, Sidobre, Stephane, Garavaglia, Claudio, Borsellino, Giovanna, Dellabona, Paolo, Bonneville, Marc, Scotet, Emmanuel, Casorati, Giulia

“…The CD4 coreceptor is crucial in the activation of major histocompatibility complex (MHC) class II restricted CD4 + T lymphocytes by binding the same MHC class…”
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A novel HLA-B18 restricted CD8+ T cell epitope is efficiently cross-presented by dendritic cells from soluble tumor antigen by Zhao, Rona Y, Mifsud, Nicole A, Xiao, Kun, Chan, Kok-Fei, Oveissi, Sara, Jackson, Heather M, Dimopoulos, Nektaria, Guillaume, Philippe, Knights, Ashley J, Lowen, Tamara, Robson, Neil C, Russell, Sarah E, Scotet, Emmanuel, Davis, Ian D, Maraskovsky, Eugene, Cebon, Jonathan, Luescher, Immanuel F, Chen, Weisan

“…NY-ESO-1 has been a major target of many immunotherapy trials because it is expressed by various cancers and is highly immunogenic. In this study, we have…”
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Human V gamma 9V delta 2 T cells: promising new leads for immunotherapy of infections and tumors by Bonneville, Marc, Scotet, Emmanuel

“…V gamma 9V delta 2 T cells, a major human peripheral gamma delta T-cell subset, react in vitro against a wide array of microbial agents and tumor cells. This…”
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Human Vγ9Vδ2 T cells: promising new leads for immunotherapy of infections and tumors by Bonneville, Marc, Scotet, Emmanuel

“…Vγ9Vδ2 T cells, a major human peripheral γδ T-cell subset, react in vitro against a wide array of microbial agents and tumor cells. This broad reactivity…”
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Beyond CAR T cells: Engineered Vγ9Vδ2 T cells to fight solid tumors by Rafia, Chirine, Harly, Christelle, Scotet, Emmanuel

“…Despite recent significant progress in cancer immunotherapies based on adoptive cell transfer(s)(ACT), the eradication of cancers still represents a major…”
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The Intracellular B30.2 Domain of Butyrophilin 3A1 Binds Phosphoantigens to Mediate Activation of Human V gamma 9V delta 2 T Cells by Sandstrom, Andrew, Peigne, Cassie-Marie, Leger, Alexandra, Crooks, James E, Konczak, Fabienne, Gesnel, Marie-Claude, Breathnach, Richard, Bonneville, Marc, Scotet, Emmanuel, Adams, Erin J

“…In humans, V gamma 9V delta 2 T cells detect tumor cells and microbial infections, including , through recognition of small pyrophosphate containing organic…”
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