Search Results - "Scolnick, Laura R"

Structure of a unique binuclear manganese cluster in arginase by Kanyo, Zoltan F, Scolnick, Laura R, Ash, David E, Christianson, David W

Get full text

Probing the role of the hyper-reactive histidine residue of arginase by Colleluori, Diana M., Reczkowski, Robert S., Emig, Frances A., Cama, Evis, Cox, J. David, Scolnick, Laura R., Compher, Kevin, Jude, Kevin, Han, Shoufa, Viola, Ronald E., Christianson, David W., Ash, David E.

“…Rat liver arginase (arginase I) is potently inactivated by diethyl pyrocarbonate, with a second-order rate constant of 113 M −1s −1 for the inactivation…”
Get full text

Altering the Binuclear Manganese Cluster of Arginase Diminishes Thermostability and Catalytic Function by Scolnick, Laura R, Kanyo, Zoltan F, Cavalli, R. Christopher, Ash, David E, Christianson, David W

“…Arginase is a thermostable (T m = 75 °C) binuclear manganese metalloenzyme which hydrolyzes l-arginine to form l-ornithine and urea. The three-dimensional…”
Get full text

Novel Binding Mode of Hydroxamate Inhibitors to Human Carbonic Anhydrase II by Scolnick, Laura R, Clements, Adrienne M, Liao, John, Crenshaw, Lori, Hellberg, Mark, May, Jesse, Dean, Tom R, Christianson, David W

Get full text

X-ray Crystallographic Studies of Alanine-65 Variants of Carbonic Anhydrase II Reveal the Structural Basis of Compromised Proton Transfer in Catalysis by Scolnick, Laura R, Christianson, David W

“…The three-dimensional structures of A65F, A65L, A65H, A65T, A65S, and A65G human carbonic anhydrase II (CAII) variants have been solved by X-ray…”
Get full text

Structure of a unique binuclear manganese cluster in arginase by Kanyo, Z F, Scolnick, L R, Ash, D E, Christianson, D W

“…Each individual excretes roughly 10 kg of urea per year, as a result of the hydrolysis of arginine in the final cytosolic step of the urea cycle. This reaction…”
Get full text

Molecular Basis of Hyperargininemia: Structure-Function Consequences of Mutations in Human Liver Arginase by Ash, David E., Scolnick, Laura R., Kanyo, Zoltan F., Vockley, Joseph G., Cederbaum, Stephen D., Christianson, David W.

“…Hyperargininemia is a rare autosomal recessive disorder that results from a deficiency of hepatic type I arginase. At the genetic level, this deficiency in…”
Get full text