Search Results - "Scolari, Silvia"
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Lipid Domain Specific Recruitment of Lipophilic Nucleic Acids: A Key for Switchable Functionalization of Membranes
Published in Journal of the American Chemical Society (17-11-2010)“…Lipid domains in mammalian plasma membranes serve as platforms for specific recruitment or separation of proteins involved in various functions. Here, we have…”
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Benzothiazinones: A Novel Class of Adenosine Receptor Antagonists Structurally Unrelated to Xanthine and Adenine Derivatives
Published in Journal of medicinal chemistry (12-04-2012)“…2-(Acyl)amino-4H-3,1-benzothiazin-4-ones and related thienothiazinones were identified as structurally novel antagonists at adenosine receptors (ARs)…”
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Modulation of cell surface transport and lipid raft localization by the cytoplasmic tail of the influenza virus hemagglutinin
Published in Cellular microbiology (01-01-2016)“…Summary Viral glycoproteins are highly variable in their primary structure, but on the other hand feature a high functional conservation to fulfil their…”
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Lateral Distribution of the Transmembrane Domain of Influenza Virus Hemagglutinin Revealed by Time-resolved Fluorescence Imaging
Published in The Journal of biological chemistry (05-06-2009)“…Influenza virus hemagglutinin (HA) has been suggested to be enriched in liquid-ordered lipid domains named rafts, which represent an important step in virus…”
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Liquid-Ordered Phase Formation by Mammalian and Yeast Sterols: A Common Feature With Organizational Differences
Published in Frontiers in cell and developmental biology (12-06-2020)“…Here, biophysical properties of membranes enriched in three metabolically related sterols are analyzed both in vitro and in vivo . Unlike cholesterol and…”
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The cholesterol‐binding motif of the HIV‐1 glycoprotein gp41 regulates lateral sorting and oligomerization
Published in Cellular microbiology (01-10-2014)“…Summary Enveloped viruses often use membrane lipid rafts to assemble and bud, augment infection and spread efficiently. However, the molecular bases and…”
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FLIM-FRET and FRAP reveal association of influenza virus haemagglutinin with membrane rafts
Published in Biochemical journal (01-02-2010)“…It has been supposed that the HA (haemagglutinin) of influenza virus must be recruited to membrane rafts to perform its function in membrane fusion and virus…”
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Full-length cellular β-secretase has a trimeric subunit stoichiometry, and its sulfur-rich transmembrane interaction site modulates cytosolic copper compartmentalization
Published in The Journal of biological chemistry (11-08-2017)“…The β-secretase (BACE1) initiates processing of the amyloid precursor protein (APP) into Aβ peptides, which have been implicated as central players in the…”
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Lipid domain association of influenza virus proteins detected by dynamic fluorescence microscopy techniques
Published in Cellular microbiology (01-02-2013)“…Summary Influenza virus is thought to assemble in raft domains of the plasma membrane, but many of the conclusions were based on (controversial) Triton…”
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Cell-To-Cell Variability in Plasma Membrane Lipid Rafts
Published in Biophysical journal (29-01-2013)Get full text
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Interaction of Mammalian Seminal Plasma Protein PDC-109 with Cholesterol: Implications for a Putative CRAC Domain
Published in Biochemistry (Easton) (26-10-2010)“…Seminal plasma proteins of the fibronectin type II (Fn2) family modulate mammalian spermatogenesis by triggering the release of the lipids phosphatidylcholine…”
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Unraveling interactions of cell cycle‐regulating proteins Sic1 and B‐type cyclins in living yeast cells: a FLIM‐FRET approach
Published in The FASEB journal (01-02-2012)“…ABSTRACT Sic1, cyclin‐dependent kinase inhibitor of budding yeast, is synthesized in anaphase and largely degraded at the S‐phase onset to regulate timing of…”
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Hemagglutinin of Influenza Virus Partitions into the Nonraft Domain of Model Membranes
Published in Biophysical journal (21-07-2010)“…The HA of influenza virus is a paradigm for a transmembrane protein thought to be associated with membrane-rafts, liquid-ordered like nanodomains of the plasma…”
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The cholesterol-binding motif of the HIV-1 glycoprotein gp41 regulates lateral sorting and oligomerization: gp41 sorting and oligomerization
Published in Cellular microbiology (01-10-2014)Get full text
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Subunit composition of an energy-coupling-factor-type biotin transporter analysed in living bacteria
Published in Biochemical journal (01-11-2010)“…BioMNY, a bacterial high-affinity biotin transporter, is a member of the recently defined class of ECF (energy-coupling factor) transporters. These systems are…”
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Applications of fluorescence lifetime spectroscopy and imaging to lipid domains in vivo
Published in Methods in enzymology (01-01-2012)“…Lipid domains are part of the current description of cell membranes and their involvement in many fundamental cellular processes is currently acknowledged…”
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Sterol Properties Required for Microdomain Formation: From Model Systems to Living Yeast and Mammalian Cells
Published in Biophysical journal (31-01-2012)Get full text
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