Search Results - "Scoggins, Krista L"

Morphine efficacy is altered in conditional HIV-1 Tat transgenic mice by Fitting, Sylvia, Scoggins, Krista L., Xu, Ruqiang, Dever, Seth M., Knapp, Pamela E., Dewey, William L., Hauser, Kurt F.

“…Opiate abuse reportedly can exaggerate complications of human immunodeficiency virus type-1 (HIV-1) infection in the central nervous system (CNS), while opiate…”
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Design, syntheses, and pharmacological characterization of 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6α-(isoquinoline-3′-carboxamido)morphinan analogues as opioid receptor ligands by Yuan, Yunyun, Zaidi, Saheem A., Stevens, David L., Scoggins, Krista L., Mosier, Philip D., Kellogg, Glen E., Dewey, William L., Selley, Dana E., Zhang, Yan

“…[Display omitted] A series of 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6α-(isoquinoline-3′-carboxamido)morphinan (NAQ) analogues were synthesized and…”
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Design, Synthesis, and Biological Evaluation of 14-Heteroaromatic-Substituted Naltrexone Derivatives: Pharmacological Profile Switch from Mu Opioid Receptor Selectivity to Mu/Kappa Opioid Receptor Dual Selectivity by Yuan, Yunyun, Zaidi, Saheem A, Elbegdorj, Orgil, Aschenbach, Lindsey C. K, Li, Guo, Stevens, David L, Scoggins, Krista L, Dewey, William L, Selley, Dana E, Zhang, Yan

“…On the basis of a mu opioid receptor (MOR) homology model and the isosterism concept, three generations of 14-heteroaromatically substituted naltrexone…”
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Morphine Tolerance and Physical Dependence Are Altered in Conditional HIV-1 Tat Transgenic Mice by Fitting, Sylvia, Stevens, David L, Khan, Fayez A, Scoggins, Krista L, Enga, Rachel M, Beardsley, Patrick M, Knapp, Pamela E, Dewey, William L, Hauser, Kurt F

“…Despite considerable evidence that chronic opiate use selectively affects the pathophysiologic consequences of human immunodeficiency virus type 1 (HIV-1)…”
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Design, Synthesis, and Biological Evaluation of 17-Cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-[(4′-pyridyl)carboxamido]morphinan Derivatives as Peripheral Selective μ Opioid Receptor Agents by Yuan, Yunyun, Elbegdorj, Orgil, Chen, Jianyang, Akubathini, Shashidhar K, Zhang, Feng, Stevens, David L, Beletskaya, Irina O, Scoggins, Krista L, Zhang, Zhenxian, Gerk, Phillip M, Selley, Dana E, Akbarali, Hamid I, Dewey, William L, Zhang, Yan

“…Peripheral selective μ opioid receptor (MOR) antagonists could alleviate the symptoms of opioid-induced constipation (OIC) without compromising the analgesic…”
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Chronic neuropathic pain in mice reduces μ-opioid receptor-mediated G-protein activity in the thalamus by Hoot, Michelle R, Sim-Selley, Laura J, Selley, Dana E, Scoggins, Krista L, Dewey, William L

“…Abstract Neuropathic pain is a debilitating condition that is often difficult to treat using conventional pharmacological interventions and the exact…”
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6β-N-Heterocyclic substituted naltrexamine derivative NAP as a potential lead to develop peripheral mu opioid receptor selective antagonists by Yuan, Yunyun, Stevens, David L., Braithwaite, Amanda, Scoggins, Krista L., Bilsky, Edward J., Akbarali, Hamid I., Dewey, William L., Zhang, Yan

“…A 6β-N-heterocyclic substituted naltrexamine derivative, NAP, was proposed as a peripheral mu opioid receptor (MOR) selective antagonist based on the in vitro…”
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6β-N-Heterocyclic Substituted Naltrexamine Derivative BNAP: A Peripherally Selective Mixed MOR/KOR Ligand by Williams, Dwight A, Zheng, Yi, David, Bethany G, Yuan, Yunyun, Zaidi, Saheem A, Stevens, David L, Scoggins, Krista L, Selley, Dana E, Dewey, William L, Akbarali, Hamid I, Zhang, Yan

“…The 6β-N-heterocyclic naltrexamine derivative, NAP, has been demonstrated to be a peripherally selective mu opioid receptor modulator. To further improve…”
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Chronic constriction injury reduces cannabinoid receptor 1 activity in the rostral anterior cingulate cortex of mice by Hoot, Michelle R, Sim-Selley, Laura J, Poklis, Justin L, Abdullah, Rehab A, Scoggins, Krista L, Selley, Dana E, Dewey, William L

“…Abstract The present studies examined the effect of chronic neuropathic pain on cannabinoid receptor density and receptor-mediated G-protein activity within…”
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Characterization of 6α- and 6β-N-Heterocyclic Substituted Naltrexamine Derivatives as Novel Leads to Development of Mu Opioid Receptor Selective Antagonists by Yuan, Yunyun, Li, Guo, He, Hengjun, Stevens, David L., Kozak, Patrick, Scoggins, Krista L., Mitra, Pallabi, Gerk, Phillip M., Selley, Dana E., Dewey, William L., Zhang, Yan

“…As important pharmacological probes, highly selective opioid receptor antagonists are essential in opioid receptor structural characterization and opioid…”
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Design, Syntheses, and Biological Evaluation of 14-Heteroaromatic Substituted Naltrexone Derivatives: Pharmacological Profile Switch from Mu Opioid Receptor Selectivity to Mu/Kappa Opioid Receptor Dual Selectivity by Yuan, Yunyun, Zaidi, Saheem A., Elbegdorj, Orgil, Aschenbach, Lindsey C. K., Li, Guo, Stevens, David L., Scoggins, Krista L., Dewey, William L., Selley, Dana E., Zhang, Yan

“…Based on a mu opioid receptor (MOR) homology model and the “isosterism” concept, three generations of 14-heteroaromatically substituted naltrexone derivatives…”
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