Search Results - "Sckisel, Gail"

NK Cells Preferentially Target Tumor Cells with a Cancer Stem Cell Phenotype by Ames, Erik, Canter, Robert J, Grossenbacher, Steven K, Mac, Stephanie, Chen, Mingyi, Smith, Rachel C, Hagino, Takeshi, Perez-Cunningham, Jessica, Sckisel, Gail D, Urayama, Shiro, Monjazeb, Arta M, Fragoso, Ruben C, Sayers, Thomas J, Murphy, William J

“…Increasing evidence supports the hypothesis that cancer stem cells (CSCs) are resistant to antiproliferative therapies, able to repopulate tumor bulk, and seed…”
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Blocking Indolamine-2,3-Dioxygenase Rebound Immune Suppression Boosts Antitumor Effects of Radio-Immunotherapy in Murine Models and Spontaneous Canine Malignancies by Monjazeb, Arta M, Kent, Michael S, Grossenbacher, Steven K, Mall, Christine, Zamora, Anthony E, Mirsoian, Annie, Chen, Mingyi, Kol, Amir, Shiao, Stephen L, Reddy, Abhinav, Perks, Julian R, T N Culp, William, Sparger, Ellen E, Canter, Robert J, Sckisel, Gail D, Murphy, William J

“…Previous studies demonstrate that intratumoral CpG immunotherapy in combination with radiotherapy acts as an in-situ vaccine inducing antitumor immune…”
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Out-of-Sequence Signal 3 Paralyzes Primary CD4+ T-Cell-Dependent Immunity by Sckisel, Gail D., Bouchlaka, Myriam N., Monjazeb, Arta M., Crittenden, Marka, Curti, Brendan D., Wilkins, Danice E.C., Alderson, Kory A., Sungur, Can M., Ames, Erik, Mirsoian, Annie, Reddy, Abhinav, Alexander, Warren, Soulika, Athena, Blazar, Bruce R., Longo, Dan L., Wiltrout, Robert H., Murphy, William J.

“…Primary T cell activation involves the integration of three distinct signals delivered in sequence: (1) antigen recognition, (2) costimulation, and (3)…”
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Adiposity induces lethal cytokine storm after systemic administration of stimulatory immunotherapy regimens in aged mice by Mirsoian, Annie, Bouchlaka, Myriam N, Sckisel, Gail D, Chen, Mingyi, Pai, Chien-Chun Steven, Maverakis, Emanuel, Spencer, Richard G, Fishbein, Kenneth W, Siddiqui, Sana, Monjazeb, Arta M, Martin, Bronwen, Maudsley, Stuart, Hesdorffer, Charles, Ferrucci, Luigi, Longo, Dan L, Blazar, Bruce R, Wiltrout, Robert H, Taub, Dennis D, Murphy, William J

“…Aging is a contributing factor in cancer occurrence. We recently demonstrated that systemic immunotherapy (IT) administration in aged, but not young, mice…”
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Aging predisposes to acute inflammatory induced pathology after tumor immunotherapy by Bouchlaka, Myriam N, Sckisel, Gail D, Chen, Mingyi, Mirsoian, Annie, Zamora, Anthony E, Maverakis, Emanual, Wilkins, Danice E C, Alderson, Kory L, Hsiao, Hui-Hua, Weiss, Jonathan M, Monjazeb, Arta M, Hesdorffer, Charles, Ferrucci, Luigi, Longo, Dan L, Blazar, Bruce R, Wiltrout, Robert H, Redelman, Doug, Taub, Dennis D, Murphy, William J

“…Cancer commonly occurs in the elderly and immunotherapy (IT) is being increasingly applied to this population. However, the majority of preclinical mouse tumor…”
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Increased antitumor effects using IL-2 with anti-TGF-β reveals competition between mouse NK and CD8 T cells by Alvarez, Maite, Bouchlaka, Myriam N, Sckisel, Gail D, Sungur, Can M, Chen, Mingyi, Murphy, William J

“…Because of increasing interest in the removal of immunosuppressive pathways in cancer, the combination of IL-2 with Abs to neutralize TGF-β, a potent…”
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Engineered IL-21 Cytokine Muteins Fused to Anti-PD-1 Antibodies Can Improve CD8+ T Cell Function and Anti-tumor Immunity by Shen, Shanling, Sckisel, Gail, Sahoo, Anupama, Lalani, Almin, Otter, Doug Den, Pearson, Josh, DeVoss, Jason, Cheng, Jay, Casey, Stephanie C, Case, Ryan, Yang, Melissa, Low, Ray, Daris, Mark, Fan, Bin, Agrawal, Neeraj J, Ali, Khaled

“…Inhibitors that block the programmed cell death-1 (PD-1) pathway can potentiate endogenous antitumor immunity and have markedly improved cancer survival rates…”
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Bystander activation and anti-tumor effects of CD8+ T cells following Interleukin-2 based immunotherapy is independent of CD4+ T cell help by Monjazeb, Arta M, Tietze, Julia K, Grossenbacher, Steven K, Hsiao, Hui-Hua, Zamora, Anthony E, Mirsoian, Annie, Koehn, Brent, Blazar, Bruce R, Weiss, Jonathan M, Wiltrout, Robert H, Sckisel, Gail D, Murphy, William J

“…We have previously demonstrated that immunotherapy combining agonistic anti-CD40 and IL-2 (IT) results in synergistic anti-tumor effects. IT induces expansion…”
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Systemic immunostimulation induces glucocorticoid-mediated thymic involution succeeded by rebound hyperplasia which is impaired in aged recipients by Collins, Craig P, Khuat, Lam T, Sckisel, Gail D, Vick, Logan V, Minnar, Christine M, Dunai, Cordelia, Le, Catherine T, Curti, Brendan D, Crittenden, Marka, Merleev, Alexander, Sheng, Michael, Chao, Nelson J, Maverakis, Emanual, Rosario, Spencer R, Monjazeb, Arta M, Blazar, Bruce R, Longo, Dan L, Canter, Robert J, Murphy, William J

“…The thymus is the central organ involved with T-cell development and the production of naïve T cells. During normal aging, the thymus undergoes marked…”
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Mechanical disruption of tumors by iron particles and magnetic field application results in increased anti-tumor immune responses by Bouchlaka, Myriam N, Sckisel, Gail D, Wilkins, Danice, Maverakis, Emanual, Monjazeb, Arta M, Fung, Maxwell, Welniak, Lisbeth, Redelman, Doug, Fuchs, Alan, Evrensel, Cahit A, Murphy, William J

“…The primary tumor represents a potential source of antigens for priming immune responses for disseminated disease. Current means of debulking tumors involves…”
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Medicago truncatula ortholog of Arabidopsis EIN2, sickle, is a negative regulator of symbiotic and pathogenic microbial associations by Varma Penmetsa, R, Uribe, Pedro, Anderson, Jonathan, Lichtenzveig, Judith, Gish, John-Charles, Nam, Young Woo, Engstrom, Eric, Xu, Kun, Sckisel, Gail, Pereira, Mariana, Baek, Jong Min, Lopez-Meyer, Melina, Long, Sharon R, Harrison, Maria J, Singh, Karam B, Kiss, Gyorgy B, Cook, Douglas R

“…The plant hormone ethylene negatively regulates bacterial infection and nodule formation in legumes in response to symbiotic rhizobia, but the molecular…”
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Differential phenotypes of memory CD4 and CD8 T cells in the spleen and peripheral tissues following immunostimulatory therapy by Sckisel, Gail D, Mirsoian, Annie, Minnar, Christine M, Crittenden, Marka, Curti, Brendan, Chen, Jane Q, Blazar, Bruce R, Borowsky, Alexander D, Monjazeb, Arta M, Murphy, William J

“…Studies assessing immune parameters typically utilize human PBMCs or murine splenocytes to generate data that is interpreted as representative of immune…”
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Delineation of antigen-specific and antigen-nonspecific CD8+ memory T-cell responses after cytokine-based cancer immunotherapy by Tietze, Julia K., Wilkins, Danice E.C., Sckisel, Gail D., Bouchlaka, Myriam N., Alderson, Kory L., Weiss, Jonathan M., Ames, Erik, Bruhn, Kevin W., Craft, Noah, Wiltrout, Robert H., Longo, Dan L., Lanier, Lewis L., Blazar, Bruce R., Redelman, Doug, Murphy, William J.

“…Memory T cells exhibit tremendous antigen specificity within the immune system and accumulate with age. Our studies reveal an antigen-independent expansion of…”
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Repeated PD-1/PD-L1 monoclonal antibody administration induces fatal xenogeneic hypersensitivity reactions in a murine model of breast cancer by Mall, Christine, Sckisel, Gail D., Proia, David A., Mirsoian, Annie, Grossenbacher, Steven K., Pai, Chien-Chun Steven, Chen, Mingyi, Monjazeb, Arta M., Kelly, Karen, Blazar, Bruce R., Murphy, William J.

“…Monoclonal antibodies (mAbs) targeting coinhibitory molecules such as PD-1, PD-L1 and CTLA-4 are increasingly used as targets of therapeutic intervention…”
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Influenza infection results in local expansion of memory CD8+ T cells with antigen non‐specific phenotype and function by Sckisel, Gail D., Tietze, Julia K., Zamora, Anthony E., Hsiao, Hua‐Hui, Priest, Stephen O., Wilkins, Danice E. C., Lanier, Louis L., Blazar, Bruce R., Baumgarth, Nicole, Murphy, William J.

“…Summary Primary viral infections induce activation of CD8+ T cells responsible for effective resistance. We sought to characterize the nature of the CD8+ T…”
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Late administration of murine CTLA-4 blockade prolongs CD8-mediated anti-tumor effects following stimulatory cancer immunotherapy by Sckisel, Gail D., Mirsoian, Annie, Bouchlaka, Myriam N., Tietze, Julia K., Chen, Mingyi, Blazar, Bruce R., Murphy, William J.

“…We have demonstrated that immunostimulatory therapies such as interleukin-2 (IL-2) and anti-CD40 (αCD40) can be combined to deliver synergistic anti-tumor…”
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Immunoediting and antigen loss: overcoming the achilles heel of immunotherapy with antigen non-specific therapies by Monjazeb, Arta Monir, Zamora, Anthony E, Grossenbacher, Steven K, Mirsoian, Annie, Sckisel, Gail D, Murphy, William J

“…Cancer immunotherapy has emerged as a mainstream therapy option in the battle against cancer. Pre-clinical data demonstrates the ability of immunotherapy to…”
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The role of antigen-specific and non-specific immunotherapy in the treatment of cancer by Monjazeb, Arta M, Hsiao, Hui-Hua, Sckisel, Gail D, Murphy, William J

“…Immunotherapy in the treatment of cancer is increasing, particularly with the recent FDA approval of sipuleucel-T and ipilimumab. The efficacy of anti-tumor…”
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Specificity may be overrated in cancer immunotherapy: Getting to know the nonspecific side of memory T Cells by Sckisel, Gail D., Murphy, William J.

“…For a long time, cancer immunotherapy has focused on the induction of tumor-specific T cell-mediated immune responses. Now, a mounting body of evidence…”
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Monoclonal antibody therapies targeting immune checkpoints induce fatal anaphylactic reactions in a murine model of breast cancer by Mall, Christine, Sckisel, Gail D, Mirsoian, Annie, Grossenbacher, Steven K, Murphy, William J

“…Co-inhibitory molecules such as PD1, PD-L1 and CTLA-4 are being increasingly used as targets of therapeutic intervention against cancer. The use of monoclonal…”
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