Search Results - "Sciuto, Tracey E"

Identification of extant vertebrate Myxine glutinosa VWF: evolutionary conservation of primary hemostasis by Grant, Marianne A., Beeler, David L., Spokes, Katherine C., Chen, Junmei, Dharaneeswaran, Harita, Sciuto, Tracey E., Dvorak, Ann M., Interlandi, Gianluca, Lopez, José A., Aird, William C.

“…Hemostasis in vertebrates involves both a cellular and a protein component. Previous studies in jawless vertebrates (cyclostomes) suggest that the protein…”
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Early Actions of Anti–Vascular Endothelial Growth Factor/Vascular Endothelial Growth Factor Receptor Drugs on Angiogenic Blood Vessels by Sitohy, Basel, Chang, Sunghee, Sciuto, Tracey E., Masse, Elizabeth, Shen, Mei, Kang, Peter M., Jaminet, Shou-Ching, Benjamin, Laura E., Bhatt, Rupal S., Dvorak, Ann M., Nagy, Janice A., Dvorak, Harold F.

“…Tumors induce their heterogeneous vasculature by secreting vascular endothelial growth factor (VEGF)-A. Anti-VEGF/VEGF receptor (VEGFR) drugs treat cancer, but…”
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Vascular Permeability and Pathological Angiogenesis in Caveolin-1-Null Mice by Chang, Sung-Hee, Feng, Dian, Nagy, Janice A, Sciuto, Tracey E, Dvorak, Ann M, Dvorak, Harold F

“…Caveolin-1, the signature protein of endothelial cell caveolae, has many important functions in vascular cells. Caveolae are thought to be the transcellular…”
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A Phase Ib Trial of Personalized Neoantigen Therapy Plus Anti-PD-1 in Patients with Advanced Melanoma, Non-small Cell Lung Cancer, or Bladder Cancer by Ott, Patrick A., Hu-Lieskovan, Siwen, Chmielowski, Bartosz, Govindan, Ramaswamy, Naing, Aung, Bhardwaj, Nina, Margolin, Kim, Awad, Mark M., Hellmann, Matthew D., Lin, Jessica J., Friedlander, Terence, Bushway, Meghan E., Balogh, Kristen N., Sciuto, Tracey E., Kohler, Victoria, Turnbull, Samantha J., Besada, Rana, Curran, Riley R., Trapp, Benjamin, Scherer, Julian, Poran, Asaf, Harjanto, Dewi, Barthelme, Dominik, Ting, Ying Sonia, Dong, Jesse Z., Ware, Yvonne, Huang, Yuting, Huang, Zhengping, Wanamaker, Amy, Cleary, Lisa D., Moles, Melissa A., Manson, Kelledy, Greshock, Joel, Khondker, Zakaria S., Fritsch, Ed, Rooney, Michael S., DeMario, Mark, Gaynor, Richard B., Srinivasan, Lakshmi

“…Neoantigens arise from mutations in cancer cells and are important targets of T cell-mediated anti-tumor immunity. Here, we report the first open-label, phase…”
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Personalized neoantigen vaccine NEO-PV-01 with chemotherapy and anti-PD-1 as first-line treatment for non-squamous non-small cell lung cancer by Awad, Mark M., Govindan, Ramaswamy, Balogh, Kristen N., Spigel, David R., Garon, Edward B., Bushway, Meghan E., Poran, Asaf, Sheen, Joong Hyuk, Kohler, Victoria, Esaulova, Ekaterina, Srouji, John, Ramesh, Suchitra, Vyasamneni, Rohit, Karki, Binisha, Sciuto, Tracey E., Sethi, Himanshu, Dong, Jesse Z., Moles, Melissa A., Manson, Kelledy, Rooney, Michael S., Khondker, Zakaria S., DeMario, Mark, Gaynor, Richard B., Srinivasan, Lakshmi

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The T-cell-directed vaccine BNT162b4 encoding conserved non-spike antigens protects animals from severe SARS-CoV-2 infection by Arieta, Christina M., Xie, Yushu Joy, Rothenberg, Daniel A., Diao, Huitian, Harjanto, Dewi, Meda, Shirisha, Marquart, Krisann, Koenitzer, Byron, Sciuto, Tracey E., Lobo, Alexander, Zuiani, Adam, Krumm, Stefanie A., Cadima Couto, Carla Iris, Hein, Stephanie, Heinen, André P., Ziegenhals, Thomas, Liu-Lupo, Yunpeng, Vogel, Annette B., Srouji, John R., Fesser, Stephanie, Thanki, Kaushik, Walzer, Kerstin, Addona, Theresa A., Türeci, Özlem, Şahin, Uğur, Gaynor, Richard B., Poran, Asaf

“…T cell responses play an important role in protection against beta-coronavirus infections, including SARS-CoV-2, where they associate with decreased COVID-19…”
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Mesenchymal Stem Cells Transmigrate Between and Directly Through Tumor Necrosis Factor-α-Activated Endothelial Cells Via Both Leukocyte-Like and Novel Mechanisms by Teo, Grace S. L., Ankrum, James A., Martinelli, Roberta, Boetto, Sarah E., Simms, Kayla, Sciuto, Tracey E., Dvorak, Ann M., Karp, Jeffrey M., Carman, Christopher V.

“…Systemically administered adult mesenchymal stem cells (MSCs), which are being explored in clinical trials to treat inflammatory disease, exhibit the critical…”
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Probing the biomechanical contribution of the endothelium to lymphocyte migration: diapedesis by the path of least resistance by Martinelli, Roberta, Zeiger, Adam S, Whitfield, Matthew, Sciuto, Tracey E, Dvorak, Ann, Van Vliet, Krystyn J, Greenwood, John, Carman, Christopher V

“…Immune cell trafficking requires the frequent breaching of the endothelial barrier either directly through individual cells ('transcellular' route) or through…”
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TM4SF1: a tetraspanin-like protein necessary for nanopodia formation and endothelial cell migration by ZUKAUSKAS, Andrew, MERLEY, Anne, DAN LI, ANG, Lay-Hong, SCIUTO, Tracey E, SALMAN, Samantha, DVORAK, Ann M, DVORAK, Harold F, SHIH JAMINET, Shou-Ching

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Antigen recognition is facilitated by invadosome-like protrusions formed by memory/effector T cells by Sage, Peter T, Varghese, Laya M, Martinelli, Roberta, Sciuto, Tracey E, Kamei, Masataka, Dvorak, Ann M, Springer, Timothy A, Sharpe, Arlene H, Carman, Christopher V

“…Adaptive immunity requires that T cells efficiently scan diverse cell surfaces to identify cognate Ag. However, the basic cellular mechanisms remain unclear…”
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ICAM-1 regulates neutrophil adhesion and transcellular migration of TNF-α-activated vascular endothelium under flow by Yang, Lin, Froio, Richard M., Sciuto, Tracey E., Dvorak, Ann M., Alon, Ronen, Luscinskas, Francis W.

“…In vivo, leukocyte transendothelial migration (TEM) occurs at endothelial cell junctions (paracellular) and nonjunctional (transcellular) locations, whereas in…”
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Transcellular Diapedesis Is Initiated by Invasive Podosomes by Carman, Christopher V., Sage, Peter T., Sciuto, Tracey E., de la Fuente, Miguel A., Geha, Raif S., Ochs, Hans D., Dvorak, Harold F., Dvorak, Ann M., Springer, Timothy A.

“…Diapedesis is critical for immune system function and inflammatory responses. This occurs by migration of blood leukocytes either directly through individual…”
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TM4SF1: a new vascular therapeutic target in cancer by Lin, Chi-Iou, Merley, Anne, Sciuto, Tracey E., Li, Dan, Dvorak, Ann M., Melero-Martin, Juan M., Dvorak, Harold F., Jaminet, Shou-Ching S.

“…Transmembrane-4 L -six family member-1 (TM4SF1) is a small plasma membrane glycoprotein that regulates cell motility and proliferation. TM4SF1 is an attractive…”
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Revealing the role of phospholipase Cβ3 in the regulation of VEGF-induced vascular permeability by Hoeppner, Luke H., Phoenix, Kathryn N., Clark, Karl J., Bhattacharya, Resham, Gong, Xun, Sciuto, Tracey E., Vohra, Pawan, Suresh, Sandip, Bhattacharya, Santanu, Dvorak, Ann M., Ekker, Stephen C., Dvorak, Harold F., Claffey, Kevin P., Mukhopadhyay, Debabrata

“…VEGF induces vascular permeability (VP) in ischemic diseases and cancer, leading to many pathophysiological consequences. The molecular mechanisms by which…”
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Intracellular distribution of TM4SF1 and internalization of TM4SF1-antibody complex in vascular endothelial cells by Sciuto, Tracey E., Merley, Anne, Lin, Chi-Iou, Richardson, Douglas, Liu, Yu, Li, Dan, Dvorak, Ann M., Dvorak, Harold F., Jaminet, Shou-Ching S.

“…Transmembrane-4 L-six family member-1 (TM4SF1) is a small plasma membrane-associated glycoprotein that is highly and selectively expressed on the plasma…”
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TM4SF1: a tetraspanin-like protein necessary for nanopodia formation and endothelial cell migration by Zukauskas, Andrew, Merley, Anne, Li, Dan, Ang, Lay-Hong, Sciuto, Tracey E., Salman, Samantha, Dvorak, Ann M., Dvorak, Harold F., Jaminet, Shou-Ching Shih

“…Transmembrane-4-L-six-family-1 (TM4SF1) is a tetraspanin-like membrane protein that is highly and selectively expressed by cultured endothelial cells (EC) and,…”
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Adoptive transfer of mast cells does not enhance the impaired survival of Kit(W)/Kit(W-v) mice in a model of low dose intraperitoneal infection with bioluminescent Salmonella typhimurium by Chatterjea, Devavani, Burns-Guydish, Stacy M, Sciuto, Tracey E, Dvorak, Ann, Contag, Christopher H, Galli, Stephen J

“…Mast cells are important effector cells in IgE-associated immune responses, but also can contribute to host defense in certain examples of bacterial infection…”
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Abstract 73: A personal neoantigen vaccine NEO-PV-01 in combination with chemotherapy and pembrolizumab induces broad de novo immune responses in first-line non-squamous NSCLC: Associations with clinical outcomes by Awad, Mark M., Govindan, Ramaswamy, Spigel, David R., Garon, Edward B., Kohler, Victoria, Vyasamneni, Rohit, Ramesh, Suchitra, Sciuto, Tracey E., Moles, Melissa A., Tepper, Jennifer, Wanamaker, Amy, Khondkar, Zakaria S., Srouji, John, Dong, Jesse Z., Balogh, Kristen N., Poran, Asaf, Bushway, Meghan E., DeMario, Mark, Gaynor, Richard B., Srinivasan, Lakshmi

“…Abstract Background: Neoantigens arising from mutations in cancer cell DNA are important targets for T cell-mediated anti-tumor immunity. NEO-PV-01 is a…”
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Abstract 5006: Comprehensive gene expression analysis of the tumor microenvironment in patients with advanced cancer treated with a personalized neoantigen vaccine, NEO-PV-01, in combination with anti-PD1 by Bushway, Meghan E., Ting, Ying Sonia, Besada, Rana H., Sciuto, Tracey E., Prabhakara, Jasmina, Scherer, Julian, Balogh, Kristen N., Lamb, April, Kaplan, Jennifer A., Cleary, Lisa D., Moles, Melissa A., Church, Sarah E., Ren, Yuqi, Ren, Xing, Gaynor, Richard B., Goldstein, Matthew J., Brail, Les H., Greshock, Joel, Srinivasan, Lakshmi

“…Abstract Background: Neoantigens arise from DNA mutations in cancer cells and are important targets for T cell mediated anti-tumor immunity. NEO-PV-01 is a…”
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Abstract 942: The personalized vaccine, NEO-PV-01 with anti-PD1, induces neoantigen-specific de novo immune responses in patients with advanced metastatic melanoma: Association with clinical outcomes by Hu-Lieskovan, Siwen, Ott, Patrick A., Naing, Aung, Besada, Rana H., Gates, Samantha J., Kohler, Victoria R., Curran, Riley R., Bushway, Meghan E., Scherer, Julian, Balogh, Kristen N., Sciuto, Tracey E., Ting, Ying S., Rooney, Michael S., Harjanto, Dewi, Huang, Zhengping, Huang, Yuting, Ware, Yvonne, Lamb, April, Cleary, Lisa D., Moles, Melissa A., Gaynor, Richard B., Goldstein, Matthew J., Brail, Les H., Greshock, Joel, Srinivasan, Lakshmi

“…Abstract Background: Neoantigens arise from DNA mutations in cancer cells and are important targets for T cell mediated anti-tumor immunity. NEO-PV-01 is a…”
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