Search Results - "Sciulli, MG"

Pharmacodynamic interaction of naproxen with low-dose aspirin in healthy subjects by Capone, Marta L., Sciulli, Maria G., Tacconelli, Stefania, Grana, Marilena, Ricciotti, Emanuela, Renda, Giulia, Di Gregorio, Patrizia, Merciaro, Gabriele, Patrignani, Paola

“…We investigated the occurrence of pharmacodynamic interaction between low-dose aspirin and naproxen. The uncertainty of cardioprotection by naproxen has…”
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Clinical pharmacology of selective COX-2 inhibitors by Capone, M L, Tacconelli, S, Sciulli, M G, Patrignani, P

“…The discovery of cyclooxygenase (COX)-2 has provided the rationale for the development of a new class of nonsteroidal antiinflammatory drugs (NSAIDs), the…”
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Effects of acetaminophen on constitutive and inducible prostanoid biosynthesis in human blood cells by Sciulli, Maria G, Seta, Francesca, Tacconelli, Stefania, Capone, Marta L, Ricciotti, Emanuela, Pistritto, Giuseppa, Patrignani, Paola

“…Acetaminophen, an analgesic and antipyretic drug with weak antiinflammatory properties, has been suggested to act as a tissue‐selective inhibitor of…”
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The future of traditional nonsteroidal antiinflammatory drugs and cyclooxygenase-2 inhibitors in the treatment of inflammation and pain by Sciulli, Maria G, Capone, Marta L, Tacconelli, Stefania, Patrignani, Paola

“…Prostanoids act leading roles in a myriad of physiologic and pathologic processes because these autacoids participate in the amplification of biological…”
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Differential inhibition of human prostaglandin endoperoxide synthase-1 and -2 by nonsteroidal anti-inflammatory drugs by Patrignani, P, Panara, M R, Sciulli, M G, Santini, G, Renda, G, Patrono, C

“…We have evaluated the selectivity in vitro of various conventional nonsteroidal anti-inflammatory drugs (NSAIDs) and new anti-inflammatory compounds (NS-398,…”
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Clinical pharmacology of platelet, monocyte, and vascular cyclooxygenase inhibition by naproxen and low-dose aspirin in healthy subjects by CAPONE, Marta L, TACCONELLI, Stefania, SCIULLI, Maria G, GRANA, Marilena, RICCIOTTI, Emanuela, MINUZ, Pietro, DI GREGORIO, Patrizia, MERCIARO, Gabriele, PATRONO, Carlo, PATRIGNANI, Paola

“…The current controversy on the potential cardioprotective effect of naproxen prompted us to evaluate the extent and duration of platelet, monocyte, and…”
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De Novo Synthesis of Cyclooxygenase-1 Counteracts the Suppression of Platelet Thromboxane Biosynthesis by Aspirin by Evangelista, Virgilio, Manarini, Stefano, Di Santo, Angelo, Capone, Marta L, Ricciotti, Emanuela, Di Francesco, Luigia, Tacconelli, Stefania, Sacchetti, Andrea, D’Angelo, Sandra, Scilimati, Antonio, Sciulli, Maria G, Patrignani, Paola

“…Aspirin affords cardioprotection through the acetylation of serine in human cyclooxygenase-1 (COX-1) of anucleated platelets, inducing a permanent defect in…”
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Pharmacodynamic of cyclooxygenase inhibitors in humans by Capone, Marta L., Tacconelli, Stefania, Di Francesco, Luigia, Sacchetti, Andrea, Sciulli, Maria G., Patrignani, Paola

“…We provide comprehensive knowledge on the differential regulation of expression and catalysis of cyclooxygenase (COX)-1 and COX-2 in health and disease which…”
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Human pharmacology of naproxen sodium by Capone, Marta L, Tacconelli, Stefania, Sciulli, Maria G, Anzellotti, Paola, Di Francesco, Luigia, Merciaro, Gabriele, Di Gregorio, Patrizia, Patrignani, Paola

“…We compared the variability in degree and recovery from steady-state inhibition of cyclooxygenase (COX)-1 and COX-2 ex vivo and in vivo and platelet…”
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Paracetamol effectively reduces prostaglandin E 2 synthesis in brain macrophages by inhibiting enzymatic activity of cyclooxygenase but not phospholipase and prostaglandin E synthase by Greco, Anita, Ajmone‐Cat, Maria Antonietta, Nicolini, Alessia, Sciulli, Maria Gina, Minghetti, Luisa

“…Epidemiological studies indicate that nonsteroidal anti‐inflammatory drugs (NSAIDs) are neuroprotective, although the mechanisms underlying their beneficial…”
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Reduced thromboxane biosynthesis in carriers of toll-like receptor 4 polymorphisms in vivo by Patrignani, Paola, Di Febbo, Concetta, Tacconelli, Stefania, Moretta, Valeria, Baccante, Giovanna, Sciulli, Maria G., Ricciotti, Emanuela, Capone, Marta L., Antonucci, Ivana, Guglielmi, Maria D., Stuppia, Liborio, Porreca, Ettore

“…The recent demonstration that platelets express a functional toll-like receptor 4 (TLR4) prompted us to explore the influence of TLR4 polymorphisms (Asp299Gly…”
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Heterogeneity in the suppression of platelet cyclooxygenase-1 activity by aspirin in coronary heart disease by Sciulli, Maria G., Renda, Giulia, Capone, Marta L., Tacconelli, Stefania, Ricciotti, Emanuela, Manarini, Stefano, Evangelista, Virgilio, Rebuzzi, Antonio, Patrignani, Paola

“…Background and Objectives Complete and persistent suppression of platelet thromboxane (TX) A2 biosynthesis by aspirin is mandatory to fulfill its…”
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New insights into COX-2 biology and inhibition by Patrignani, Paola, Tacconelli, Stefania, Sciulli, Maria Gina, Capone, Marta L.

“…It is now established that prostanoids play important roles in many cellular responses and pathophysiologic processes including modulation of the inflammatory…”
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The Biochemical Selectivity of Novel COX-2 Inhibitors in Whole Blood Assays of COX-isozyme Activity by Tacconelli, Stefania, Capone, Marta L., Sciulli, Maria G., Ricciotti, Emanuela, Patrignani, Paola

“…Summary We have evaluated the biochemical selectivity of novel cyclo-oxygenase (COX)-2 inhibitors, etoricoxib, valdecoxib, DFU and DFP, vs rofecoxib and…”
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Effects of Vitamin E Supplementation on F 2 -Isoprostane and Thromboxane Biosynthesis in Healthy Cigarette Smokers by Patrignani, Paola, Panara, Maria R., Tacconelli, Stefania, Seta, Francesca, Bucciarelli, Tonino, Ciabattoni, Giovanni, Alessandrini, Paola, Mezzetti, Andrea, Santini, Giovanna, Sciulli, Maria G., Cipollone, Francesco, Davı̀, Giovanni, Gallina, Pietro, Bon, Gabriele Bittolo, Patrono, Carlo

“…Background —Increased formation of 8-iso-prostaglandin (PG) F 2α and thromboxane (TX) A 2 , potent agonists of platelet and vascular thromboxane (TH)/PGH 2…”
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COX-2 is not involved in thromboxane biosynthesis by activated human platelets by Patrignani, P, Sciulli, M G, Manarini, S, Santini, G, Cerletti, C, Evangelista, V

“…The occurrence of aspirin resistance has been inferred by the assessment of platelet aggregation ex vivo in patients with ischemic vascular syndromes taking…”
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Platelet activation in patients with colorectal cancer by Sciulli, M.G., Filabozzi, P., Tacconelli, S., Padovano, R., Ricciotti, E., Capone, M.L., Grana, M., Carnevale, V., Patrignani, P.

“…Aspirin may reduce the risk of colorectal neoplasia at doses similar to those recommended for the prevention of cardiovascular disease. Thus, we aimed to…”
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Response to "Pharmacodynamic Interaction Between Aspirin and Ibuprofen: A Plausible Mechanism of Aspirin Resistance" by Patrignani, P, Renda, G, Tacconelli, S, Capone, ML, Sacchetta, D, Santarelli, F, Sciulli, MG, Zimarino, M, Grana, M, D'Amelio, E, Zurro, M, Patrono, C, De Caterina, R

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Dose-dependent inhibition of platelet cyclooxygenase-1 and monocyte cyclooxygenase-2 by meloxicam in healthy subjects by Panara, M R, Renda, G, Sciulli, M G, Santini, G, Di Giamberardino, M, Rotondo, M T, Tacconelli, S, Seta, F, Patrono, C, Patrignani, P

“…We evaluated whether therapeutic blood levels of meloxicam are associated with selective inhibition of monocyte cyclooxygenase (COX)-2 in vitro and ex vivo…”
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The human pharmacology of monocyte cyclooxygenase 2 inhibition by cortisol and synthetic glucocorticoids by Santini, G

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