Search Results - "Scita, G."

Modelling cancer cell budding in-vitro as a self-organised, non-equilibrium growth process by Agosti, A., Marchesi, S., Scita, G., Ciarletta, P.

“…•We performed in-vitro experiments showing the glioblastoma cell budding in monolayers.•This phase transition is studied with a theoretical model and its…”
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Retraction Note: Osteolytic bone metastasis is hampered by impinging on the interplay among autophagy, anoikis and ossification by Maroni, P., Bendinelli, P., Matteucci, E., Locatelli, A., Nakamura, T., Scita, G., Desiderio, M. A.

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Phosphorylation of SOS1 on tyrosine 1196 promotes its RAC GEF activity and contributes to BCR-ABL leukemogenesis by Gerboth, S, Frittoli, E, Palamidessi, A, Baltanas, F C, Salek, M, Rappsilber, J, Giuliani, C, Troglio, F, Rolland, Y, Pruneri, G, Kreutmair, S, Pallavicini, I, Zobel, M, Cinquanta, M, Minucci, S, Gomez, C, Santos, E, Illert, A L, Scita, G

“…Son of Sevenless 1 (SOS1) is a dual guanine nucleotide exchange factor (GEF) that activates the small GTPases RAC and RAS. Although the molecular mechanisms of…”
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Actin polymerization machinery: the finish line of signaling networks, the starting point of cellular movement by Disanza, A, Steffen, A, Hertzog, M, Frittoli, E, Rottner, K, Scita, G

“…Dynamic assembly of actin filaments generates the forces supporting cell motility. Several recent biochemical and genetic studies have revealed a plethora of…”
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Osteolytic bone metastasis is hampered by impinging on the interplay among autophagy, anoikis and ossification by Maroni, P, Bendinelli, P, Matteucci, E, Locatelli, A, Nakamura, T, Scita, G, Desiderio, M A

“…Here we show that the fate of osteolytic bone metastasis depends on the balance among autophagy, anoikis resistance and ossification, and that the hepatocyte…”
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Strength recovery after proximal humeral fractures treated with locking plate by Verdano, M. A., Baudi, P., Pellegrini, A., Lunini, E., Aliani, D., Scita, G., Schiavi, P., Costantino, C., Ceccarelli, F.

“…Purpose The aim of this study is to understand whether the isokinetic strength could be a valid objective data of functional recovery evaluating a group of…”
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Recycling of vitamin E in human low density lipoproteins by Kagan, VE, Serbinova, EA, Forte, T, Scita, G, Packer, L

“…Oxidative modification of low density lipoproteins (LDL) and their unrestricted scavenger receptor-dependent uptake is believed to account for cholesterol…”
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Understanding biological dynamics: following cells and molecules to track functions and mechanisms by Palamidessi, A., Testa, I., Frittoli, E., Barozzi, S., Garrè, M., Mazza, D., Di Fiore, P. P., Diaspro, A., Scita, G., Faretta, Mario

“…The dissection of the molecular circuitries at the base of cell life and the identification of their abnormal transformation during carcinogenesis rely on the…”
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Protein complexes regulating Arp2/3-mediated actin assembly by Stradal, Theresia EB, Scita, Giorgio

“…Key steps in regulating actin dynamics are the de novo nucleation and elongation of actin filaments, which can be catalysed by a limited number of proteins and…”
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ATR is essential for preservation of cell mechanics and nuclear integrity during interstitial migration by Kidiyoor, Gururaj Rao, Li, Qingsen, Bastianello, Giulia, Bruhn, Christopher, Giovannetti, Irene, Mohamood, Adhil, Beznoussenko, Galina V., Mironov, Alexandre, Raab, Matthew, Piel, Matthieu, Restuccia, Umberto, Matafora, Vittoria, Bachi, Angela, Barozzi, Sara, Parazzoli, Dario, Frittoli, Emanuela, Palamidessi, Andrea, Panciera, Tito, Piccolo, Stefano, Scita, Giorgio, Maiuri, Paolo, Havas, Kristina M., Zhou, Zhong-Wei, Kumar, Amit, Bartek, Jiri, Wang, Zhao-Qi, Foiani, Marco

“…ATR responds to mechanical stress at the nuclear envelope and mediates envelope-associated repair of aberrant topological DNA states. By combining microscopy,…”
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VE-cadherin modulates YAP intracellular localization and signalling by Giampietro, C., Disanza, A., Scita, G., Dejana, Elisabetta

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Retinol bound to cellular retinol-binding protein is a substrate for cytosolic retinoic acid synthesis by Ottonello, S, Scita, G, Mantovani, G, Cavazzini, D, Rossi, G L

“…Retinol bound to cellular retinol-binding protein (CRBP) was found to be oxidized to retinoic acid by a soluble activity from calf liver. Cytosolic retinoic…”
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Mechanism of IRSp53 inhibition and combinatorial activation by Cdc42 and downstream effectors by Kast, David J, Yang, Changsong, Disanza, Andrea, Boczkowska, Malgorzata, Madasu, Yadaiah, Scita, Giorgio, Svitkina, Tatyana, Dominguez, Roberto

“…IRSp53 is a BAR-domain protein under the control of Rho family GTPases and has crucial roles in processes such as cell motility and tumor invasiveness. In a…”
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Retinoid X Receptor-Selective Ligands Produce Malformations in Xenopus Embryos by Minucci, Saverio, Saint-Jeannet, Jean-Pierre, Toyama, Reiko, Scita, Giorgio, DeLuca, Luigi M., Taira, Masanori, Levin, Arthur A., Ozato, Keiko, Dawid, Igor B.

“…Retinoids exert pleiotropic effects on the development of vertebrates through the action of retinoic acid receptors (RAR) and retinoid X receptors (RXR). We…”
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Rab5 is a signalling GTPase involved in actin remodelling by receptor tyrosine kinases by Di Fiore, Pier Paolo, Lanzetti, Letizia, Palamidessi, Andrea, Areces, Liliana, Scita, Giorgio

“…Rab5 is a small GTPase involved in the control of intracellular trafficking, both at the level of receptor endocytosis and endosomal dynamics. The finding that…”
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Sra-1 and Nap1 link Rac to actin assembly driving lamellipodia formation by Steffen, Anika, Rottner, Klemens, Ehinger, Julia, Innocenti, Metello, Scita, Giorgio, Wehland, Jürgen, Stradal, Theresia EB

“…The Rho‐GTPase Rac1 stimulates actin remodelling at the cell periphery by relaying signals to Scar/WAVE proteins leading to activation of Arp2/3‐mediated actin…”
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Abi1 is essential for the formation and activation of a WAVE2 signalling complex by Scita, Giorgio, Innocenti, Metello, Zucconi, Adriana, Disanza, Andrea, Frittoli, Emanuela, Areces, Liliana B, Steffen, Anika, Stradal, Theresia E. B, Fiore, Pier Paolo Di, Carlier, Marie-France

“…WAVE2 belongs to a family of proteins that mediates actin reorganization by relaying signals from Rac to the Arp2/3 complex, resulting in lamellipodia…”
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Regulation of actin dynamics by WASP and WAVE family proteins by Stradal, Theresia E B, Rottner, Klemens, Disanza, Andrea, Confalonieri, Stefano, Innocenti, Metello, Scita, Giorgio

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Phosphoinositide 3-Kinase Activates Rac by Entering in a Complex with Eps8, Abi1, and Sos-1 by Innocenti, Metello, Frittoli, Emanuela, Ponzanelli, Isabella, Falck, John R., Brachmann, Saskia M., Di Fiore, Pier Paolo, Scita, Giorgio

“…Class I phosphoinositide 3-kinases (PI3Ks) are implicated in many cellular responses controlled by receptor tyrosine kinases (RTKs), including actin…”
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Abi1 regulates the activity of N-WASP and WAVE in distinct actin-based processes by Carlier, Marie-France, Scita, Giorgio, Innocenti, Metello, Gerboth, Silke, Rottner, Klemens, Lai, Frank P. L, Hertzog, Maud, Stradal, Theresia E. B, Frittoli, Emanuela, Didry, Dominique, Polo, Simona, Disanza, Andrea, Benesch, Stefanie, Fiore, Pier Paolo Di

“…Neural Wiskott-Aldrich syndrome protein (N-WASP) and WAVE are members of a family of proteins that use the Arp2/3 complex to stimulate actin assembly in…”
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