Optical devices used for image analysis of pigmented skin lesions: a proposal for quality assurance protocol using tissue-like phantoms

Different technological tools have been developed to aid in the diagnosis of pigmented skin lesions, including cameras working with conventional RGB colour systems, epiluminescence microscopy and spectrophotometric methods using visible and near infrared wavelengths. All the different procedures sho...

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Bibliographic Details
Published in:	Physics in medicine & biology Vol. 51; no. 23; p. N429
Main Authors:	Lualdi, M, Colombo, A, Carrara, M, Scienza, L, Tomatis, S, Marchesini, R
Format:	Journal Article
Language:	English
Published:	England 07-12-2006
Subjects:	Biophysical Phenomena Biophysics Humans Image Processing, Computer-Assisted Melanoma - diagnosis Nevus, Pigmented - diagnosis Optical Devices Optics and Photonics - instrumentation Phantoms, Imaging Quality Assurance, Health Care Skin Neoplasms - diagnosis Skin Pigmentation Spectrophotometry - instrumentation Spectrophotometry - standards
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Summary:	Different technological tools have been developed to aid in the diagnosis of pigmented skin lesions, including cameras working with conventional RGB colour systems, epiluminescence microscopy and spectrophotometric methods using visible and near infrared wavelengths. All the different procedures should provide in an objective and reproducible fashion quantitative measurements of the colour and shape features of a given skin mole. At present, many devices have been introduced in experimental stages for clinical diagnosis, mainly used to provide to the clinicians an objective, computer-assisted second opinion. As for any diagnostic instruments, optical devices should also be subjected to a dedicated quality assurance protocol in order to evaluate the response repeatability of each device (intra-instrument agreement) and to check the accordance among the responses of different devices (inter-instrument agreement). The aim of this study was to design a quality assurance protocol for optical devices dedicated to image analysis of pigmented skin lesions and, in case, to detect cutaneous melanoma by using suitable tissue-like phantoms as standard references that enable testing of both hardware and software components. As an example, we report the results of intra-instrument and inter-instrument agreement when the protocol was applied on a series of 30 SpectroShade instruments, a novel optical device based on multi-spectral image analysis of colour and shape features of pigmented skin lesion.
ISSN:	0031-9155
DOI:	10.1088/0031-9155/51/23/n05