Search Results - "Science signaling"

Specificity, versatility, and control of TGF-β family signaling by Derynck, Rik, Budi, Erine H

“…Encoded in mammalian cells by 33 genes, the transforming growth factor-β (TGF-β) family of secreted, homodimeric and heterodimeric proteins controls the…”
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Signaling mechanisms of the epithelial-mesenchymal transition by Gonzalez, David M, Medici, Damian

“…The epithelial-mesenchymal transition (EMT) is an essential mechanism in embryonic development and tissue repair. EMT also contributes to the progression of…”
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Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal by Gao, Jianjiong, Aksoy, Bülent Arman, Dogrusoz, Ugur, Dresdner, Gideon, Gross, Benjamin, Sumer, S Onur, Sun, Yichao, Jacobsen, Anders, Sinha, Rileen, Larsson, Erik, Cerami, Ethan, Sander, Chris, Schultz, Nikolaus

“…The cBioPortal for Cancer Genomics (http://cbioportal.org) provides a Web resource for exploring, visualizing, and analyzing multidimensional cancer genomics…”
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TGF-β inhibits the activation and functions of NK cells by repressing the mTOR pathway by Viel, Sébastien, Marçais, Antoine, Guimaraes, Fernando Souza-Fonseca, Loftus, Roisin, Rabilloud, Jessica, Grau, Morgan, Degouve, Sophie, Djebali, Sophia, Sanlaville, Amélien, Charrier, Emily, Bienvenu, Jacques, Marie, Julien C, Caux, Christophe, Marvel, Jacqueline, Town, Liam, Huntington, Nicholas D, Bartholin, Laurent, Finlay, David, Smyth, Mark J, Walzer, Thierry

“…Transforming growth factor-β (TGF-β) is a major immunosuppressive cytokine that maintains immune homeostasis and prevents autoimmunity through its…”
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Illuminating the dark phosphoproteome by Needham, Elise J, Parker, Benjamin L, Burykin, Timur, James, David E, Humphrey, Sean J

“…Protein phosphorylation is a major regulator of protein function and biological outcomes. This was first recognized through functional biochemical experiments,…”
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High-resolution structures of the SARS-CoV-2 2'- O -methyltransferase reveal strategies for structure-based inhibitor design by Rosas-Lemus, Monica, Minasov, George, Shuvalova, Ludmilla, Inniss, Nicole L, Kiryukhina, Olga, Brunzelle, Joseph, Satchell, Karla J F

“…There are currently no antiviral therapies specific for SARS-CoV-2, the virus responsible for the global pandemic disease COVID-19. To facilitate…”
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AMPK directly activates mTORC2 to promote cell survival during acute energetic stress by Kazyken, Dubek, Magnuson, Brian, Bodur, Cagri, Acosta-Jaquez, Hugo A, Zhang, Deqiang, Tong, Xin, Barnes, Tammy M, Steinl, Gabrielle K, Patterson, Nicole E, Altheim, Christopher H, Sharma, Naveen, Inoki, Ken, Cartee, Gregory D, Bridges, Dave, Yin, Lei, Riddle, Steven M, Fingar, Diane C

“…AMP-activated protein kinase (AMPK) senses energetic stress and, in turn, promotes catabolic and suppresses anabolic metabolism coordinately to restore energy…”
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Glutamine-dependent α-ketoglutarate production regulates the balance between T helper 1 cell and regulatory T cell generation by Klysz, Dorota, Tai, Xuguang, Robert, Philippe A, Craveiro, Marco, Cretenet, Gaspard, Oburoglu, Leal, Mongellaz, Cédric, Floess, Stefan, Fritz, Vanessa, Matias, Maria I, Yong, Carmen, Surh, Natalie, Marie, Julien C, Huehn, Jochen, Zimmermann, Valérie, Kinet, Sandrina, Dardalhon, Valérie, Taylor, Naomi

“…T cell activation requires that the cell meet increased energetic and biosynthetic demands. We showed that exogenous nutrient availability regulated the…”
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Exosomes from bone marrow mesenchymal stem cells contain a microRNA that promotes dormancy in metastatic breast cancer cells by Ono, Makiko, Kosaka, Nobuyoshi, Tominaga, Naoomi, Yoshioka, Yusuke, Takeshita, Fumitaka, Takahashi, Ryou-u, Yoshida, Masayuki, Tsuda, Hitoshi, Tamura, Kenji, Ochiya, Takahiro

“…Breast cancer patients often develop metastatic disease years after resection of the primary tumor. The patients are asymptomatic because the disseminated…”
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Manifold roles of β-arrestins in GPCR signaling elucidated with siRNA and CRISPR/Cas9 by Luttrell, Louis M, Wang, Jialu, Plouffe, Bianca, Smith, Jeffrey S, Yamani, Lama, Kaur, Suneet, Jean-Charles, Pierre-Yves, Gauthier, Christophe, Lee, Mi-Hye, Pani, Biswaranjan, Kim, Jihee, Ahn, Seungkirl, Rajagopal, Sudarshan, Reiter, Eric, Bouvier, Michel, Shenoy, Sudha K, Laporte, Stéphane A, Rockman, Howard A, Lefkowitz, Robert J

“…G protein-coupled receptors (GPCRs) use diverse mechanisms to regulate the mitogen-activated protein kinases ERK1/2. β-Arrestins (βArr1/2) are ubiquitous…”
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Targeting NOTCH activation in small cell lung cancer through LSD1 inhibition by Augert, Arnaud, Eastwood, Emily, Ibrahim, Ali H, Wu, Nan, Grunblatt, Eli, Basom, Ryan, Liggitt, Denny, Eaton, Keith D, Martins, Renato, Poirier, John T, Rudin, Charles M, Milletti, Francesca, Cheng, Wei-Yi, Mack, Fiona, MacPherson, David

“…Small cell lung cancer (SCLC) is a recalcitrant, aggressive neuroendocrine-type cancer for which little change to first-line standard-of-care treatment has…”
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Cells alter their tRNA abundance to selectively regulate protein synthesis during stress conditions by Torrent, Marc, Chalancon, Guilhem, de Groot, Natalia S, Wuster, Arthur, Madan Babu, M

“…Decoding the information in mRNA during protein synthesis relies on tRNA adaptors, the abundance of which can affect the decoding rate and translation…”
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Chronic TGF-β exposure drives stabilized EMT, tumor stemness, and cancer drug resistance with vulnerability to bitopic mTOR inhibition by Katsuno, Yoko, Meyer, Dominique Stephan, Zhang, Ziyang, Shokat, Kevan M, Akhurst, Rosemary J, Miyazono, Kohei, Derynck, Rik

“…Tumors comprise cancer stem cells (CSCs) and their heterogeneous progeny within a stromal microenvironment. In response to transforming growth factor-β…”
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Structural principles of tumor necrosis factor superfamily signaling by Vanamee, Éva S, Faustman, Denise L

“…The tumor necrosis factor (TNF) ligand and receptor superfamilies play an important role in cell proliferation, survival, and death. Stimulating or inhibiting…”
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Astrocyte-shed extracellular vesicles regulate the peripheral leukocyte response to inflammatory brain lesions by Dickens, Alex M, Tovar-Y-Romo, Luis B, Yoo, Seung-Wan, Trout, Amanda L, Bae, Mihyun, Kanmogne, Marlene, Megra, Bezawit, Williams, Dionna W, Witwer, Kennith W, Gacias, Mar, Tabatadze, Nino, Cole, Robert N, Casaccia, Patrizia, Berman, Joan W, Anthony, Daniel C, Haughey, Norman J

“…Brain injury induces a peripheral acute cytokine response that directs the transmigration of leukocytes into the brain. Because this brain-to-peripheral immune…”
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Androgen receptor inhibitor-induced "BRCAness" and PARP inhibition are synthetically lethal for castration-resistant prostate cancer by Li, Likun, Karanika, Styliani, Yang, Guang, Wang, Jiangxiang, Park, Sanghee, Broom, Bradley M, Manyam, Ganiraju C, Wu, Wenhui, Luo, Yong, Basourakos, Spyridon, Song, Jian H, Gallick, Gary E, Karantanos, Theodoros, Korentzelos, Dimitrios, Azad, Abul Kalam, Kim, Jeri, Corn, Paul G, Aparicio, Ana M, Logothetis, Christopher J, Troncoso, Patricia, Heffernan, Timothy, Toniatti, Carlo, Lee, Hyun-Sung, Lee, Ju-Seog, Zuo, Xuemei, Chang, Wenjun, Yin, Jianhua, Thompson, Timothy C

“…Cancers with loss-of-function mutations in or are deficient in the DNA damage repair pathway called homologous recombination (HR), rendering these cancers…”
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The hallmarks of cancer are also the hallmarks of wound healing by MacCarthy-Morrogh, Lucy, Martin, Paul

“…The Hanahan and Weinberg "hallmarks of cancer" papers provide a useful structure for considering the various mechanisms driving cancer progression, and the…”
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The cytosolic DNA sensor cGAS recognizes neutrophil extracellular traps by Apel, Falko, Andreeva, Liudmila, Knackstedt, Lorenz Sebastian, Streeck, Robert, Frese, Christian Karl, Goosmann, Christian, Hopfner, Karl-Peter, Zychlinsky, Arturo

“…Neutrophil extracellular traps (NETs) are structures consisting of chromatin and antimicrobial molecules that are released by neutrophils during a form of…”
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The transcription factor TFEB links mTORC1 signaling to transcriptional control of lysosome homeostasis by Roczniak-Ferguson, Agnes, Petit, Constance S, Froehlich, Florian, Qian, Sharon, Ky, Jennifer, Angarola, Brittany, Walther, Tobias C, Ferguson, Shawn M

“…Lysosomes are the major cellular site for clearance of defective organelles and digestion of internalized material. Demand on lysosomal capacity can vary…”
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Proteome-wide analysis of arginine monomethylation reveals widespread occurrence in human cells by Larsen, Sara C, Sylvestersen, Kathrine B, Mund, Andreas, Lyon, David, Mullari, Meeli, Madsen, Maria V, Daniel, Jeremy A, Jensen, Lars J, Nielsen, Michael L

“…The posttranslational modification of proteins by arginine methylation is functionally important, yet the breadth of this modification is not well…”
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