[3H]-nitrendipine binding in membranes obtained from hypoxic and reoxygenated heart

We compared the binding properties of [3H]-nitrendipine in heart membranes from normal guinea-pig heart and from hypoxic or hypoxic and reoxygenated heart. The [3H]-nitrendipine binds a single class of high capacity (Bmax 667.2 +/- 105.2) with high affinity (KD 0.14 +/- 0.02) binding sites. By contr...

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Bibliographic Details

Published in:	Biochemical pharmacology Vol. 36; no. 7; p. 1059
Main Authors:	Matucci, R, Bennardini, F, Sciammarella, M L, Baccaro, C, Stendardi, I, Franconi, F, Giotti, A
Format:	Journal Article
Language:	English
Published:	England 01-04-1987
Subjects:	Aerobiosis Anaerobiosis Animals Calcium Channels Cell Membrane - metabolism Guinea Pigs Heart Ventricles - metabolism Hypoxia - metabolism Kinetics Male Microsomes - metabolism Myocardium - metabolism Nitrendipine - metabolism Receptors, Nicotinic - metabolism Xanthine Oxidase - metabolism
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