Search Results - "Sciacca, Michele F"

Phospholipids Critical Micellar Concentrations Trigger Different Mechanisms of Intrinsically Disordered Proteins Interaction with Model Membranes by Scollo, Federica, Tempra, Carmelo, Lolicato, Fabio, Sciacca, Michele F. M, Raudino, Antonio, Milardi, Danilo, La Rosa, Carmelo

“…Amyloidogenic proteins are involved in many diseases, including Alzheimer’s, Parkinson’s, and type II diabetes. These proteins are thought to be toxic for…”
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Lipid-Chaperone Hypothesis: A Common Molecular Mechanism of Membrane Disruption by Intrinsically Disordered Proteins by Sciacca, Michele F, Lolicato, Fabio, Tempra, Carmelo, Scollo, Federica, Sahoo, Bikash R, Watson, Matthew D, García-Viñuales, Sara, Milardi, Danilo, Raudino, Antonio, Lee, Jennifer C, Ramamoorthy, Ayyalusamy, La Rosa, Carmelo

“…An increasing number of human diseases has been shown to be linked to aggregation and amyloid formation by intrinsically disordered proteins (IDPs). Amylin,…”
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Phosphatidylethanolamine Enhances Amyloid Fiber-Dependent Membrane Fragmentation by Sciacca, Michele F. M, Brender, Jeffrey R, Lee, Dong-Kuk, Ramamoorthy, Ayyalusamy

“…The toxicity of amyloid-forming peptides has been hypothesized to reside in the ability of protein oligomers to interact with and disrupt the cell membrane…”
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Probing the Sources of the Apparent Irreproducibility of Amyloid Formation: Drastic Changes in Kinetics and a Switch in Mechanism Due to Micellelike Oligomer Formation at Critical Concentrations of IAPP by Brender, Jeffrey R, Krishnamoorthy, Janarthanan, Sciacca, Michele F. M, Vivekanandan, Subramanian, D’Urso, Luisa, Chen, Jennifer, La Rosa, Carmelo, Ramamoorthy, Ayyalusamy

“…The aggregation of amyloidogenic proteins is infamous for being highly chaotic, with small variations in conditions sometimes leading to large changes in…”
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Exploring the therapeutic potential of Aloin: unraveling neuroprotective and anticancer mechanisms, and strategies for enhanced stability and delivery by Zimbone, Stefania, Romanucci, Valeria, Zarrelli, Armando, Giuffrida, Maria Laura, Sciacca, Michele F. M., Lanza, Valeria, Campagna, Tiziana, Maugeri, Ludovica, Petralia, Salvatore, Consoli, Grazia Maria Letizia, Di Fabio, Giovanni, Milardi, Danilo

“…We investigate the therapeutic potential of Aloin A and Aloin B, two natural compounds derived from Aloe vera leaves, focusing on their neuroprotective and…”
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Inhibition of Aβ Amyloid Growth and Toxicity by Silybins: The Crucial Role of Stereochemistry by Sciacca, Michele. F. M, Romanucci, Valeria, Zarrelli, Armando, Monaco, Irene, Lolicato, Fabio, Spinella, Natalia, Galati, Clelia, Grasso, Giuseppe, D’Urso, Luisa, Romeo, Margherita, Diomede, Luisa, Salmona, Mario, Bongiorno, Corrado, Di Fabio, Giovanni, La Rosa, Carmelo, Milardi, Danilo

“…The self-assembling of the amyloid β (Aβ) peptide into neurotoxic aggregates is considered a central event in the pathogenesis of Alzheimer’s disease (AD)…”
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Lipid Composition-Dependent Membrane Fragmentation and Pore-Forming Mechanisms of Membrane Disruption by Pexiganan (MSI-78) by Lee, Dong-Kuk, Brender, Jeffrey R, Sciacca, Michele F. M, Krishnamoorthy, Janarthanan, Yu, Changsu, Ramamoorthy, Ayyalusamy

“…The potency and selectivity of many antimicrobial peptides (AMPs) are correlated with their ability to interact with and disrupt the bacterial cell membrane…”
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Non-selective ion channel activity of polymorphic human islet amyloid polypeptide (amylin) double channels by Zhao, Jun, Hu, Rundong, Sciacca, Michele F M, Brender, Jeffrey R, Chen, Hong, Ramamoorthy, Ayyalusamy, Zheng, Jie

“…Fundamental understanding of ion channel formation by amyloid peptides, which is strongly linked to cell toxicity, is very critical for (pre)clinical treatment…”
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The Role of Cholesterol in Driving IAPP-Membrane Interactions by Sciacca, Michele F.M., Lolicato, Fabio, Di Mauro, Giacomo, Milardi, Danilo, D’Urso, Luisa, Satriano, Cristina, Ramamoorthy, Ayyalusamy, La Rosa, Carmelo

“…Our knowledge of the molecular events underlying type 2 diabetes mellitus—a protein conformational disease characterized by the aggregation of islet amyloid…”
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Trehalose Conjugates of Silybin as Prodrugs for Targeting Toxic Aβ Aggregates by García-Viñuales, Sara, Ahmed, Rashik, Sciacca, Michele F. M, Lanza, Valeria, Giuffrida, Maria Laura, Zimbone, Stefania, Romanucci, Valeria, Zarrelli, Armando, Bongiorno, Corrado, Spinella, Natalia, Galati, Clelia, Di Fabio, Giovanni, Melacini, Giuseppe, Milardi, Danilo

“…Alzheimer’s disease (AD) is linked to the abnormal accumulation of amyloid β peptide (Aβ) aggregates in the brain. Silybin B, a natural compound extracted from…”
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role of aromatic side-chains in amyloid growth and membrane interaction of the islet amyloid polypeptide fragment LANFLVH by Milardi, Danilo, Sciacca, Michele F. M, Pappalardo, Matteo, Grasso, Domenico M, La Rosa, Carmelo

“…Human islet amyloid polypeptide (hIAPP) is known to misfold and aggregate into amyloid deposits that may be found in pancreatic tissues of patients affected by…”
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Cations as Switches of Amyloid-Mediated Membrane Disruption Mechanisms: Calcium and IAPP by Sciacca, Michele F.M., Milardi, Danilo, Messina, Grazia M.L., Marletta, Giovanni, Brender, Jeffrey R., Ramamoorthy, Ayyalusamy, La Rosa, Carmelo

“…Disruption of the integrity of the plasma membrane by amyloidogenic proteins is linked to the pathogenesis of a number of common age-related diseases. Although…”
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Amyloid-Mediated Mechanisms of Membrane Disruption by Sciacca, Michele F. M., La Rosa, Carmelo, Milardi, Danilo

“…Protein aggregation and amyloid formation are pathogenic events underlying the development of an increasingly large number of human diseases named…”
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Membrane Interactions and Conformational Preferences of Human and Avian Prion N-Terminal Tandem Repeats: The Role of Copper(II) Ions, pH, and Membrane Mimicking Environments by Di Natale, Giuseppe, Pappalardo, Giuseppe, Milardi, Danilo, Sciacca, Michele F. M, Attanasio, Francesco, La Mendola, Diego, Rizzarelli, Enrico

“…The flexible N-terminal domain of the prion protein (PrPc) is believed to play a pivotal role in both trafficking of the protein through the cell membrane and…”
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Amyloid growth and membrane damage: Current themes and emerging perspectives from theory and experiments on Aβ and hIAPP by Sciacca, Michele F.M., Tempra, Carmelo, Scollo, Federica, Milardi, Danilo, La Rosa, Carmelo

“…Alzheimer's Disease (AD) and Type 2 diabetes mellitus (T2DM) are two incurable diseases both hallmarked by an abnormal deposition of the amyloidogenic peptides…”
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The Ionophoric Activity of a Pro-Apoptotic VEGF165 Fragment on HUVEC Cells by Zimbone, Stefania, Santoro, Anna M, La Mendola, Diego, Giacomelli, Chiara, Trincavelli, Maria L, Tomasello, Marianna F, Milardi, Danilo, García-Viñuales, Sara, Sciacca, Michele F M, Martini, Claudia, Grasso, Giulia

“…Copper plays an important role as a regulator in many pathologies involving the angiogenesis process. In cancerogenesis, tumor progression, and angiogenic…”
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Two-Step Mechanism of Membrane Disruption by Aβ through Membrane Fragmentation and Pore Formation by Sciacca, Michele F.M., Kotler, Samuel A., Brender, Jeffrey R., Chen, Jennifer, Lee, Dong-kuk, Ramamoorthy, Ayyalusamy

“…Disruption of cell membranes by Aβ is believed to be one of the key components of Aβ toxicity. However, the mechanism by which this occurs is not fully…”
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Critical micellar concentration determination of pure phospholipids and lipid-raft and their mixtures with cholesterol by Serravalle, Sofia, Pisano, Martina, Sciacca, Michele F M, Salamone, Nancy, Sicali, Luciano, Mazzara, Giuseppe, Costa, Luca, La Rosa, Carmelo

“…Phospholipids in biological membranes establish a chemical equilibrium between free phospholipids in the aqueous phase (CMC) and self-assembled phospholipids…”
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Self-Assembling Pathway of HiApp Fibrils within Lipid Bilayers by Scalisi, Silvia, Sciacca, Michele F.M, Zhavnerko, Genady, Grasso, Domenico M, Marletta, Giovanni, La Rosa, Carmelo

“…A combination of atomic force microscopy, quartz crystal microbalance and fluorescence spectroscopy shed light on the mechanism of interaction of hIAPP with…”
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Tau/Aβ chimera peptides: A Thioflavin-T and MALDI-TOF study of Aβ amyloidosis in the presence of Cu(II) or Zn(II) ions and total lipid brain extract (TLBE) vesicles by Sciacca, Michele F.M., Di Natale, Giuseppe, Milardi, Danilo, Pappalardo, Giuseppe

“…Two bifunctional chimera peptides modulate Amyloid-β fibrillogenic ability at the membrane interface made up with Total Lipid Brain Extract (TLBE) components…”
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