Search Results - "Schwieters, Charles D."

Molecular Structure of β-Amyloid Fibrils in Alzheimer’s Disease Brain Tissue by Lu, Jun-Xia, Qiang, Wei, Yau, Wai-Ming, Schwieters, Charles D., Meredith, Stephen C., Tycko, Robert

“…In vitro, β-amyloid (Aβ) peptides form polymorphic fibrils, with molecular structures that depend on growth conditions, plus various oligomeric and…”
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Xplor‐NIH for molecular structure determination from NMR and other data sources by Schwieters, Charles D., Bermejo, Guillermo A., Clore, G. Marius

“…Xplor‐NIH is a popular software package for biomolecular structure determination from nuclear magnetic resonance (NMR) and other data sources. Here, some of…”
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Conformational Ensemble of Disordered Proteins Probed by Solvent Paramagnetic Relaxation Enhancement (sPRE) by Kooshapur, Hamed, Schwieters, Charles D., Tjandra, Nico

“…Characterization of the conformational ensemble of disordered proteins is highly important for understanding protein folding and aggregation mechanisms, but…”
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Open-to-closed transition in apo maltose-binding protein observed by paramagnetic NMR by Tang, Chun, Schwieters, Charles D, Clore, G. Marius

“…Large-scale domain rearrangements in proteins have long been recognized to have a critical function in ligand binding and recognition, catalysis and…”
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Atomic-resolution structure of HIV-1 capsid tubes by magic-angle spinning NMR by Lu, Manman, Russell, Ryan W., Bryer, Alexander J., Quinn, Caitlin M., Hou, Guangjin, Zhang, Huilan, Schwieters, Charles D., Perilla, Juan R., Gronenborn, Angela M., Polenova, Tatyana

“…HIV-1 capsid plays multiple key roles in viral replication, and inhibition of capsid assembly is an attractive target for therapeutic intervention. Here, we…”
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Proline-rich domain of human ALIX contains multiple TSG101-UEV interaction sites and forms phosphorylation-mediated reversible amyloids by Elias, Ruben D., Ma, Wen, Ghirlando, Rodolfo, Schwieters, Charles D., Reddy, Vijay S., Deshmukh, Lalit

“…Proline-rich domains (PRDs) are among the most prevalent signaling modules of eukaryotes but often unexplored by biophysical techniques as their heterologous…”
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Structure and Dynamics of Full-Length HIV‑1 Capsid Protein in Solution by Deshmukh, Lalit, Schwieters, Charles D, Grishaev, Alexander, Ghirlando, Rodolfo, Baber, James L, Clore, G. Marius

“…The HIV-1 capsid protein plays a crucial role in viral infectivity, assembling into a cone that encloses the viral RNA. In the mature virion, the N-terminal…”
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Integrated NMR and cryo-EM atomic-resolution structure determination of a half-megadalton enzyme complex by Gauto, Diego F., Estrozi, Leandro F., Schwieters, Charles D., Effantin, Gregory, Macek, Pavel, Sounier, Remy, Sivertsen, Astrid C., Schmidt, Elena, Kerfah, Rime, Mas, Guillaume, Colletier, Jacques-Philippe, Güntert, Peter, Favier, Adrien, Schoehn, Guy, Schanda, Paul, Boisbouvier, Jerome

“…Atomic-resolution structure determination is crucial for understanding protein function. Cryo-EM and NMR spectroscopy both provide structural information, but…”
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Recommendations of the wwPDB NMR Validation Task Force by Montelione, Gaetano T., Nilges, Michael, Bax, Ad, Güntert, Peter, Herrmann, Torsten, Richardson, Jane S., Schwieters, Charles D., Vranken, Wim F., Vuister, Geerten W., Wishart, David S., Berman, Helen M., Kleywegt, Gerard J., Markley, John L.

“…As methods for analysis of biomolecular structure and dynamics using nuclear magnetic resonance spectroscopy (NMR) continue to advance, the resulting 3D…”
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Visualizing RNA conformational and architectural heterogeneity in solution by Ding, Jienyu, Lee, Yun-Tzai, Bhandari, Yuba, Schwieters, Charles D., Fan, Lixin, Yu, Ping, Tarosov, Sergey G., Stagno, Jason R., Ma, Buyong, Nussinov, Ruth, Rein, Alan, Zhang, Jinwei, Wang, Yun-Xing

“…RNA flexibility is reflected in its heterogeneous conformation. Through direct visualization using atomic force microscopy (AFM) and the adenosylcobalamin…”
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Outcome of the First wwPDB Hybrid/Integrative Methods Task Force Workshop by Sali, Andrej, Berman, Helen M., Schwede, Torsten, Trewhella, Jill, Kleywegt, Gerard, Burley, Stephen K., Markley, John, Nakamura, Haruki, Adams, Paul, Bonvin, Alexandre M.J.J., Chiu, Wah, Peraro, Matteo Dal, Di Maio, Frank, Ferrin, Thomas E., Grünewald, Kay, Gutmanas, Aleksandras, Henderson, Richard, Hummer, Gerhard, Iwasaki, Kenji, Johnson, Graham, Lawson, Catherine L., Meiler, Jens, Marti-Renom, Marc A., Montelione, Gaetano T., Nilges, Michael, Nussinov, Ruth, Patwardhan, Ardan, Rappsilber, Juri, Read, Randy J., Saibil, Helen, Schröder, Gunnar F., Schwieters, Charles D., Seidel, Claus A.M., Svergun, Dmitri, Topf, Maya, Ulrich, Eldon L., Velankar, Sameer, Westbrook, John D.

“…Structures of biomolecular systems are increasingly computed by integrative modeling that relies on varied types of experimental data and theoretical…”
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A Small Number of Residues Can Determine if Linker Histones Are Bound On or Off Dyad in the Chromatosome by Zhou, Bing-Rui, Feng, Hanqiao, Ghirlando, Rodolfo, Li, Shipeng, Schwieters, Charles D., Bai, Yawen

“…Linker histones bind to the nucleosome and regulate the structure and function of chromatin. We have previously shown that the globular domains of chicken H5…”
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The amyloid structure of mouse RIPK3 (receptor interacting protein kinase 3) in cell necroptosis by Wu, Xia-lian, Hu, Hong, Dong, Xing-qi, Zhang, Jing, Wang, Jian, Schwieters, Charles D., Liu, Jing, Wu, Guo-xiang, Li, Bing, Lin, Jing-yu, Wang, Hua-yi, Lu, Jun-xia

“…RIPK3 amyloid complex plays crucial roles during TNF-induced necroptosis and in response to immune defense in both human and mouse. Here, we have structurally…”
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Using small angle solution scattering data in Xplor-NIH structure calculations by Schwieters, Charles D, Clore, G Marius

“…This contribution describes the use of small and wide angle X-ray and small angle neutron scattering for biomolecular structure calculation using the program…”
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Structure of alpha-synuclein fibrils derived from human Lewy body dementia tissue by Dhavale, Dhruva D., Barclay, Alexander M., Borcik, Collin G., Basore, Katherine, Berthold, Deborah A., Gordon, Isabelle R., Liu, Jialu, Milchberg, Moses H., O’Shea, Jennifer Y., Rau, Michael J., Smith, Zachary, Sen, Soumyo, Summers, Brock, Smith, John, Warmuth, Owen A., Perrin, Richard J., Perlmutter, Joel S., Chen, Qian, Fitzpatrick, James A. J., Schwieters, Charles D., Tajkhorshid, Emad, Rienstra, Chad M., Kotzbauer, Paul T.

“…The defining feature of Parkinson disease (PD) and Lewy body dementia (LBD) is the accumulation of alpha-synuclein (Asyn) fibrils in Lewy bodies and Lewy…”
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Structural Studies of Amyloid Fibrils by Paramagnetic Solid-State Nuclear Magnetic Resonance Spectroscopy by Theint, Theint, Xia, Yongjie, Nadaud, Philippe S, Mukhopadhyay, Dwaipayan, Schwieters, Charles D, Surewicz, Krystyna, Surewicz, Witold K, Jaroniec, Christopher P

“…Application of paramagnetic solid-state NMR to amyloids is demonstrated, using Y145Stop human prion protein modified with nitroxide spin-label or EDTA-Cu2+…”
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pH-triggered, activated-state conformations of the influenza hemagglutinin fusion peptide revealed by NMR by Lorieau, Justin L, Louis, John M, Schwieters, Charles D, Bax, Adriaan

“…The highly conserved first 23 residues of the influenza hemagglutinin HA2 subunit constitute the fusion domain, which plays a pivotal role in fusing viral and…”
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Improving NMR Structures of RNA by Bermejo, Guillermo A., Clore, G. Marius, Schwieters, Charles D.

“…Here, we show that modern solution nuclear magnetic resonance (NMR) structures of RNA exhibit more steric clashes and conformational ambiguities than their…”
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Structure-guided bifunctional molecules hit a DEUBAD-lacking hRpn13 species upregulated in multiple myeloma by Lu, Xiuxiu, Sabbasani, Venkata R., Osei-Amponsa, Vasty, Evans, Christine N., King, Julianna C., Tarasov, Sergey G., Dyba, Marzena, Das, Sudipto, Chan, King C., Schwieters, Charles D., Choudhari, Sulbha, Fromont, Caroline, Zhao, Yongmei, Tran, Bao, Chen, Xiang, Matsuo, Hiroshi, Andresson, Thorkell, Chari, Raj, Swenson, Rolf E., Tarasova, Nadya I., Walters, Kylie J.

“…Proteasome substrate receptor hRpn13 is a promising anti-cancer target. By integrated in silico and biophysical screening, we identified a chemical scaffold…”
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Direct Investigation of Slow Correlated Dynamics in Proteins via Dipolar Interactions by Fenwick, R. Bryn, Schwieters, Charles D, Vögeli, Beat

“…The synchronization of native state motions as they transition between microstates influences catalysis kinetics, mediates allosteric interactions, and reduces…”
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