Search Results - "Schwientek, Tilo"

Chemoenzymatically synthesized multimeric Tn/STn MUC1 glycopeptides elicit cancer-specific anti-MUC1 antibody responses and override tolerance by Sørensen, Anne Louise, Reis, Celso A, Tarp, Mads A, Mandel, Ulla, Ramachandran, Kavitha, Sankaranarayanan, Vasanthi, Schwientek, Tilo, Graham, Ros, Taylor-Papadimitriou, Joyce, Hollingsworth, Michael A, Burchell, Joy, Clausen, Henrik

“…The MUC1 mucin represents a prime target antigen for cancer immunotherapy because it is abundantly expressed and aberrantly glycosylated in carcinomas…”
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Identification and characterization of large galactosyltransferase gene families: galactosyltransferases for all functions by Amado, Margarida, Almeida, Raquel, Schwientek, Tilo, Clausen, Henrik

“…Enzymatic glycosylation of proteins and lipids is an abundant and important biological process. A great diversity of oligosaccharide structures and types of…”
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Differential expression proteomics of human colorectal cancer based on a syngeneic cellular model for the progression of adenoma to carcinoma by Roth, Udo, Razawi, Hanieh, Hommer, Julia, Engelmann, Katja, Schwientek, Tilo, Müller, Stefan, Baldus, Stephan E, Patsos, Georgios, Corfield, Anthony P, Paraskeva, Christos, Hanisch, Franz-Georg

“…This is the first differential expression proteomics study on a human syngeneic cellular in vitro progression model of the colorectal adenoma-to-carcinoma…”
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A serial lectin approach to the mucin-type O-glycoproteome of Drosophila melanogaster S2 cells by Schwientek, Tilo, Mandel, Ulla, Roth, Udo, Müller, Stefan, Hanisch, Franz-Georg

“…Identification of mucin‐type O‐glycosylated proteins with known functions in model organisms like Drosophila could provide keys to elucidate functions of the…”
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Chemical de-O-glycosylation of glycoproteins for application in LC-based proteomics by Hanisch, Franz-Georg, Teitz, Sebastian, Schwientek, Tilo, Müller, Stefan

“…We describe a cyclic on-column procedure for the sequential degradation of complex O-glycans on proteins or peptides by periodate oxidation of sugars and…”
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The Relative Activities of the C2GnT1 and ST3Gal-I Glycosyltransferases Determine O-Glycan Structure and Expression of a Tumor-associated Epitope on MUC1 by Dalziel, Martin, Whitehouse, Caroline, McFarlane, Ian, Brockhausen, Inka, Gschmeissner, Stephen, Schwientek, Tilo, Clausen, Henrik, Burchell, Joy M., Taylor-Papadimitriou, Joyce

“…In breast cancer, the O-glycans added to the MUC1 mucin are core 1- rather than core 2-based. We have analyzed whether competition by the glycosyltransferase,…”
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Functional Analysis of the Glucuronyltransferases GlcAT-P and GlcAT-S of Drosophila melanogaster: Distinct Activities towards the O-linked T-antigen by Breloy, Isabelle, Schwientek, Tilo, Althoff, Deborah, Holz, Marvin, Koppen, Tim, Krupa, Angelika, Hanisch, Franz-Georg

“…The Drosophila melanogaster glucuronyltransferases dGlcAT-S and dGlcAT-P were reported to be expressed ubiquitously and results of in vitro activity assays…”
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O-Glycosylation Modulates Proprotein Convertase Activation of Angiopoietin-like Protein 3 by Schjoldager, Katrine T.-B.G., Vester-Christensen, Malene B., Bennett, Eric Paul, Levery, Steven B., Schwientek, Tilo, Yin, Wu, Blixt, Ola, Clausen, Henrik

“…The angiopoietin-like protein 3 (ANGPTL3) is an important inhibitor of the endothelial and lipoprotein lipases and a promising drug target. ANGPTL3 undergoes…”
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Synthesis of Poly-N-acetyllactosamine in Core 2 Branched O-Glycans by Ujita, Minoru, McAuliffe, Joseph, Schwientek, Tilo, Almeida, Raquel, Hindsgaul, Ole, Clausen, Henrik, Fukuda, Minoru

“…Poly- N -acetyllactosamine is a unique carbohydrate composed of N -acetyllactosamine repeats and provides the backbone structure for additional modifications…”
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The Drosophila Gene brainiac Encodes a Glycosyltransferase Putatively Involved in Glycosphingolipid Synthesis by Schwientek, Tilo, Keck, Birgit, Levery, Steven B., Jensen, Mads A., Pedersen, Johannes W., Wandall, Hans H., Stroud, Mark, Cohen, Stephen M., Amado, Margarida, Clausen, Henrik

“…The Drosophila genesfringe and brainiac exhibit sequence similarities to glycosyltransferases. Drosophila and mammalian fringe homologs encode…”
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Structure elucidation of neutral, di-, tri-, and tetraglycosylceramides from High Five cells: identification of a novel (non-arthro-series) glycosphingolipid pathway by Fuller, Matthew D, Schwientek, Tilo, Wandall, Hans H, Pedersen, Johannes W, Clausen, Henrik, Levery, Steven B

“…The major neutral glycosphingolipids (GSLs) of High Five insect cells have been extracted, purified, and characterized. It was anticipated that GSLs from High…”
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Golgi Localization and in Vivo Activity of a Mammalian Glycosyltransferase (Human β1,4-Galactosyltransferase) in Yeast (∗) by Schwientek, Tilo, Narimatsu, Hisashi, Ernst, Joachim F.

“…Gene fusions encoding the membrane anchor region of yeast α1,2-mannosyltransferase (Mnt1p) fused to human β1,4-galactosyltransferase (Gal-Tf) were constructed…”
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O-Glycosylation Modulates Proprotein Convertase Activation of Angiopoietin-like Protein 3: POSSIBLE ROLE OF POLYPEPTIDE GalNAc-TRANSFERASE-2 IN REGULATION OF CONCENTRATIONS OF PLASMA LIPIDS by Schjoldager, Katrine T.-B.G, Vester-Christensen, Malene B, Bennett, Eric Paul, Levery, Steven B, Schwientek, Tilo, Yin, Wu, Blixt, Ola, Clausen, Henrik

“…The angiopoietin-like protein 3 (ANGPTL3) is an important inhibitor of the endothelial and lipoprotein lipases and a promising drug target. ANGPTL3 undergoes…”
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Golgi Localization in Yeast Is Mediated by the Membrane Anchor Region of Rat Liver Sialyltransferase (∗) by Schwientek, Tilo, Lorenz, Claudia, Ernst, Joachim F.

“…To investigate the function of the membrane anchor region of a mammalian glycosyltransferase in yeast we constructed a fusion gene that encodes the 34…”
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Functional Conservation of Subfamilies of Putative UDP-N-acetylgalactosamine:Polypeptide N-Acetylgalactosaminyltransferases inDrosophila, Caenorhabditis elegans, and Mammals by Schwientek, Tilo, Bennett, Eric P., Flores, Carlos, Thacker, John, Hollmann, Martin, Reis, Celso A., Behrens, Jane, Mandel, Ulla, Keck, Birgit, Schäfer, Mireille A., Haselmann, Kim, Zubarev, Roman, Roepstorff, Peter, Burchell, Joy M., Taylor-Papadimitriou, Joyce, Hollingsworth, Michael A., Clausen, Henrik

“…The completed fruit fly genome was found to contain up to 15 putative UDP-N-acetyl-α-d-galactosamine:polypeptideN-acetylgalactosaminyltransferase…”
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Control of O-Glycan Branch Formation by Schwientek, Tilo, Yeh, Jiunn-Chern, Levery, Steven B., Keck, Birgit, Merkx, Gerard, van Kessel, Ad Geurts, Fukuda, Minoru, Clausen, Henrik

“…Core 2 O-glycan branching catalyzed by UDP-N-acetyl-α-d-glucosamine: acceptor β1,6-N-acetylglucosaminyltransferases (β6GlcNAc-Ts) is an important step in…”
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A quantitative and site-specific chemoenzymatic glycosylation approach for PEGylated MUC1 peptides by Bello, Claudia, Farbiarz, Karine, Möller, Jan F., Becker, Christian F. W., Schwientek, Tilo

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Glycoproteomic Analysis of Serum from Patients with Gastric Precancerous Lesions by Gomes, Catarina, Almeida, Andreia, Ferreira, José Alexandre, Silva, Luísa, Santos-Sousa, Hugo, Pinto-de-Sousa, João, Santos, Lúcio L, Amado, Francisco, Schwientek, Tilo, Levery, Steven B, Mandel, Ulla, Clausen, Henrik, David, Leonor, Reis, Celso A, Osório, Hugo

“…Gastric cancer is preceded by a carcinogenesis pathway that includes gastritis caused by Helicobacter pylori infection, chronic atrophic gastritis that may…”
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Control of O-Glycan Branch Formation by Schwientek, Tilo, Nomoto, Mitsuharu, Levery, Steven B., Merkx, Gerard, van Kessel, Ad Geurts, Bennett, Eric P., Hollingsworth, Michael A., Clausen, Henrik

“…A novel human UDP-GlcNAc:Gal/GlcNAcβ1–3GalNAcα β1,6GlcNAc-transferase, designated C2/4GnT, was identified by BLAST analysis of expressed sequence tags…”
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A quantitative and site-specific chemoenzymatic glycosylation approach for PEGylated MUC1 peptidesElectronic supplementary information (ESI) available: Procedures for peptide synthesis and purification, analytical data, procedures for peptide enzymatic glycosylation and recovery via ethanol-ether precipitation. See DOI: 10.1039/c3sc52641k by Bello, Claudia, Farbiarz, Karine, Möller, Jan F, Becker, Christian F. W, Schwientek, Tilo

“…Full control over complex post-translational modifications (PTMs), such as O -glycosylation, is a prerequisite for testing and understanding the biological…”
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