Search Results - "Schwer, B."

SIRT6 in DNA repair, metabolism and ageing by Lombard, D. B., Schwer, B., Alt, F. W., Mostoslavsky, R.

“… Ageing, or increased mortality with time, coupled with physiologic decline, is a nearly universal yet poorly understood biological phenomenon. Studies in…”
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SIRT3 regulates mitochondrial protein acetylation and intermediary metabolism by Hirschey, M D, Shimazu, T, Huang, J-Y, Schwer, B, Verdin, E

“…The sirtuins are a family of nicotinamide adenine dinucleotide (NAD(+))-dependent protein deacetylases that regulate cell survival, metabolism, and longevity…”
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A new twist on RNA helicases: DExH/D box proteins as RNPases by Schwer, Beate

“…DExH/D box proteins are required for the major transactions of RNA, including mRNA synthesis, pre-mRNA splicing, ribosome biogenesis, translation and RNA…”
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SIRT3 Regulates Mitochondrial Protein Acetylation and Intermediary Metabolism by Hirschey, M. D., Shimazu, T., Huang, J.- Y., Schwer, B., Verdin, E.

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RNA helicase dynamics in pre-mRNA splicing by Schwer, Beate, Meszaros, Tamar

“…The DExH‐box NTPase/helicase Prp22p plays two important roles in pre‐mRNA splicing. It promotes the second transesterification reaction and then catalyzes the…”
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Biochemical and genetic analysis of RNA cap guanine-N2 methyltransferases from Giardia lamblia and Schizosaccharomyces pombe by Hausmann, Stéphane, Ramirez, Alejandro, Schneider, Susanne, Schwer, Beate, Shuman, Stewart

“…RNA cap guanine-N2 methyltransferases such as Schizosaccharomyces pombe Tgs1 and Giardia lamblia Tgs2 catalyze methylation of the exocyclic N2 amine of…”
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Accelerated mRNA decay in conditional mutants of yeast mRNA capping enzyme by Schwer, B, Mao, X, Shuman, S

“…Current models of mRNA decay in yeast posit that 3′ deadenylation precedes enzymatic removal of the 5′ cap, which then exposes the naked end to 5′ exonuclease…”
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SLU7 and a novel activity, SSF1, act during the PRP16-dependent step of yeast pre-mRNA splicing by Ansari, A, Schwer, B

“…Understanding the mechanism of pre-mRNA splicing requires the characterization of all components involved. In the present study, we used the genetically and…”
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conformational rearrangement in the spliceosome is dependent on PRP16 and ATP hydrolysis by Schwer, B, Guthrie, C

“…PRP16 is an RNA-dependent ATPase that is required for the second catalytic step of pre-mRNA splicing. We have previously shown that PRP16 protein binds stably…”
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Yeast mRNA cap methyltransferase is a 50-kilodalton protein encoded by an essential gene by Mao, Xiangdong, Schwer, Beate, Shuman, Stewart

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Covalent catalysis in nucleotidyl transfer reactions: essential motifs in Saccharomyces cerevisiae RNA capping enzyme are conserved in Schizosaccharomyces pombe and viral capping enzymes and among polynucleotide ligases by Shuman, S. (Sloan-Kettering Institute, New York, NY.), Liu, Y, Schwer, B

“…Formation of the 5' cap structure of eukaryotic mRNAs occurs via transfer of GMP from GTP to the 5' terminus of the primary transcript. RNA…”
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Mutational analysis of the Saccharomyces cerevisiae ABD1 gene: cap methyltransferase activity is essential for cell growth by Mao, Xiangdong, Schwer, Beate, Shuman, Stewart

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Mutational Analysis of Yeast mRNA Capping Enzyme by Schwer, Beate, Shuman, Stewart

“…RNA guanylyltransferase (capping enzyme) catalyzes the transfer of GMP from GTP to the 5'-diphosphate end of mRNA. The capping reaction proceeds via an…”
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Effects of deletion mutations in the yeast Ces1 protein on cell growth and morphology and on high copy suppression of mutations in mRNA capping enzyme and translation initiation factor 4A by Schwer, B, Linder, P, Shuman, S

“…The homologous Saccharomyces cerevisiae genes CES1 and CES4 act as high copy suppressors of temperature-sensitive mutations of Ceg1p, the yeast mRNA capping…”
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A dominant negative mutation in a spliceosomal ATPase affects ATP hydrolysis but not binding to the spliceosome by SCHWER, B, GUTHRIE, C

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Mutations in PRP43 That Uncouple RNA-Dependent NTPase Activity and Pre-mRNA Splicing Function by Tanaka, Naoko, Schwer, Beate

“…Saccharomyces cerevisiae Prp43 is a DEAH-box RNA-dependent ATPase that catalyzes the release of excised lariat intron from the mRNA spliceosome. Previous…”
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Characterization of the NTPase, RNA-Binding, and RNA Helicase Activities of the DEAH-Box Splicing Factor Prp22 by Tanaka, Naoko, Schwer, Beate

“…The DEAH protein Prp22 is important for the second transesterification step of pre-mRNA splicing, and it is essential for releasing mature mRNA from the…”
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The Human Silent Information Regulator (Sir)2 Homologue hSIRT3 Is a Mitochondrial Nicotinamide Adenine Dinucleotide-Dependent Deacetylase by Schwer, Björn, North, Brian J., Frye, Roy A., Ott, Melanie, Verdin, Eric

“…The yeast silent information regulator (Sir)2 protein links cellular metabolism and transcriptional silencing through its nicotinamide adenine dinucleotide…”
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SIRT4 IS A MITOCHONDRIAL REGULATOR OF METABOLISM AND LIFESPAN IN DROSOPHILA MELANOGASTER by Wood, J, Schwer, B, Verdin, E, Helfand, S

“…Sirtuins are an evolutionarily conserved family of NAD+-dependent deacylases that control metabolism, stress response, genomic stability, and longevity. In…”
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Multicopy suppressors of temperature-sensitive mutations of yeast mRNA capping enzyme by Schwer, B. (Robert Wood Johnson Medical School, Piscataway, NJ.), Shuman, S

“…We have isolated three Saccharomyces cerevisiae genes - CES1, CES2, and CES3 - that, when present in high copy, suppress the ts growth defect caused by…”
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