Search Results - "Schwendeman, Anna"

Survey of Clinical Translation of Cancer NanomedicinesLessons Learned from Successes and Failures by He, Hongliang, Liu, Lisha, Morin, Emily E, Liu, Min, Schwendeman, Anna

“…Conspectus In 1995, the year the first cancer nanomedicine, Doxil, was approved by the Food and Drug Administration (FDA), only 23 manuscripts appeared in a…”
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Chemo-photothermal therapy combination elicits anti-tumor immunity against advanced metastatic cancer by Nam, Jutaek, Son, Sejin, Ochyl, Lukasz J., Kuai, Rui, Schwendeman, Anna, Moon, James J.

“…Photothermal therapy (PTT) is a promising cancer treatment modality, but PTT generally requires direct access to the source of light irradiation, thus…”
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Overview of Humira® Biosimilars: Current European Landscape and Future Implications by Coghlan, Jill, He, Hongliang, Schwendeman, Anna S

“…Humira® (adalimumab) by AbbVie has been the top-selling biologic drug product for the last few years - reaching nearly $20 billion in annual sales in 2018…”
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High-density lipoproteins during sepsis: from bench to bedside by Tanaka, Sébastien, Couret, David, Tran-Dinh, Alexy, Duranteau, Jacques, Montravers, Philippe, Schwendeman, Anna, Meilhac, Olivier

“…High-density lipoproteins (HDLs) represent a family of particle characterized by the presence of apolipoprotein A-I (apoA-I) and by their ability to transport…”
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Injectable controlled release depots for large molecules by Schwendeman, Steven P, Shah, Ronak B, Bailey, Brittany A, Schwendeman, Anna S

“…Biodegradable, injectable depot formulations for long-term controlled drug release have improved therapy for a number of drug molecules and led to over a dozen…”
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High-Density Lipoprotein-Mimicking Nanodiscs for Chemo-immunotherapy against Glioblastoma Multiforme by Kadiyala, Padma, Li, Dan, Nuñez, Fernando M, Altshuler, David, Doherty, Robert, Kuai, Rui, Yu, Minzhi, Kamran, Neha, Edwards, Marta, Moon, James J, Lowenstein, Pedro R, Castro, Maria G, Schwendeman, Anna

“…Glioblastoma multiforme (GBM) is an aggressive primary brain tumor, for which there is no cure. Treatment effectiveness for GBM has been limited due to tumor…”
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Dual TLR agonist nanodiscs as a strong adjuvant system for vaccines and immunotherapy by Kuai, Rui, Sun, Xiaoqi, Yuan, Wenmin, Ochyl, Lukasz J., Xu, Yao, Hassani Najafabadi, Alireza, Scheetz, Lindsay, Yu, Min-Zhi, Balwani, Ishina, Schwendeman, Anna, Moon, James J.

“…Recent studies have shown that certain combinations of Toll-like receptor (TLR) agonists can induce synergistic immune activation. However, it remains…”
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Immune Implications of Cholesterol-Containing Lipid Nanoparticles by Back, Patricia Ines, Yu, Minzhi, Modaresahmadi, Shadan, Hajimirzaei, Sahelosadat, Zhang, Qisheng, Islam, Md Rakibul, Schwendeman, Anna A., La-Beck, Ninh M.

“…The majority of clinically approved nanoparticle-mediated therapeutics are lipid nanoparticles (LNPs), and most of these LNPs are liposomes containing…”
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Analytical method development and comparability study for AmBisome® and generic Amphotericin B liposomal products by Liu, Yayuan, Mei, Zihan, Mei, Ling, Tang, Jie, Yuan, Wenmin, Srinivasan, Santhanakrishnan, Ackermann, Rose, Schwendeman, Anna S.

“…[Display omitted] Liposomal Amphotericin B, known as AmBisome®, is a life-saving antifungal product that sold $407 million in 2019. AmBisome® has a rather…”
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Synthetic High-density Lipoprotein Nanodiscs for Personalized Immunotherapy Against Gliomas by Scheetz, Lindsay, Kadiyala, Padma, Sun, Xiaoqi, Son, Sejin, Hassani Najafabadi, Alireza, Aikins, Marisa, Lowenstein, Pedro R, Schwendeman, Anna, Castro, Maria G, Moon, James J

“…Gliomas are brain tumors with dismal prognoses. The standard-of-care treatments for gliomas include surgical resection, radiation, and temozolomide…”
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Reconstitution of the Cytb5-CytP450 Complex in Nanodiscs for Structural Studies using NMR Spectroscopy by Zhang, Meng, Huang, Rui, Ackermann, Rose, Im, Sang-Choul, Waskell, Lucy, Schwendeman, Anna, Ramamoorthy, Ayyalusamy

“…Cytochrome P450s (P450s) are a superfamily of enzymes responsible for the catalysis of a wide range of substrates. Dynamic interactions between full‐length…”
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Synthetic high-density lipoprotein nanoparticles delivering rapamycin for the treatment of age-related macular degeneration by Mei, Ling, Yu, Minzhi, Liu, Yayuan, Weh, Eric, Pawar, Mercy, Li, Li, Besirli, Cagri G., Schwendeman, Anna A.

“…Synthetic high-density lipoprotein (sHDL) and rapamycin (Rap) have both been shown to be potential treatments for age-related macular degeneration (AMD). The…”
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Characterization of attributes and in vitro performance of exenatide-loaded PLGA long-acting release microspheres by Li, Tinghui, Chandrashekar, Aishwarya, Beig, Avital, Walker, Jennifer, Hong, Justin K.Y., Benet, Alexander, Kang, Jukyung, Ackermann, Rose, Wang, Yan, Qin, Bin, Schwendeman, Anna S., Schwendeman, Steven P.

“…[Display omitted] Bydureon® (Bdn) is a once-weekly injectable long-acting release (LAR) product for adults with type 2 diabetes based on PLGA microspheres…”
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Efficient aqueous remote loading of peptides in poly(lactic-co-glycolic acid) by Giles, Morgan B., Hong, Justin K. Y., Liu, Yayuan, Tang, Jie, Li, Tinghui, Beig, Avital, Schwendeman, Anna, Schwendeman, Steven P.

“…Poly(lactic-co-glycolic acid) (PLGA) long-acting release depots are effective for extending the duration of action of peptide drugs. We describe efficient…”
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Collision-Induced Unfolding Reveals Stability Differences in Infliximab Therapeutics under Native and Heat Stress Conditions by Vallejo, Daniel D, Kang, Jukyung, Coghlan, Jill, Ramírez, Carolina Rojas, Polasky, Daniel A, Kurulugama, Ruwan T, Fjeldsted, John C, Schwendeman, Anna A, Ruotolo, Brandon T

“…Ion mobility-mass spectrometry (IM-MS) and collision-induced unfolding (CIU) assays of monoclonal antibody (mAb)-based biotherapeutics have proven sensitive to…”
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Designer vaccine nanodiscs for personalized cancer immunotherapy by Kuai, Rui, Ochyl, Lukasz J., Bahjat, Keith S., Schwendeman, Anna, Moon, James J.

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Characterizing release mechanisms of leuprolide acetate-loaded PLGA microspheres for IVIVC development I: In vitro evaluation by Hirota, Keiji, Doty, Amy C., Ackermann, Rose, Zhou, Jia, Olsen, Karl F., Feng, Meihua R., Wang, Yan, Choi, Stephanie, Qu, Wen, Schwendeman, Anna S., Schwendeman, Steven P.

“…Release testing of parental controlled release microspheres is an essential step in controlling quality and predicting the duration of efficacy. In the first…”
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Effect of size and pegylation of liposomes and peptide-based synthetic lipoproteins on tumor targeting by Tang, Jie, Kuai, Rui, Yuan, Wenmin, Drake, Lindsey, Moon, James J, Schwendeman, Anna

“…Abstract Synthetic high-density lipoprotein nanoparticles (sHDL) are a valuable class of nanomedicines with established animal safety profile, clinical…”
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Electrospun Azithromycin-Laden Gelatin Methacryloyl Fibers for Endodontic Infection Control by Ayoub, Afzan A, Mahmoud, Abdel H, Ribeiro, Juliana S, Daghrery, Arwa, Xu, Jinping, Fenno, J Christopher, Schwendeman, Anna, Sasaki, Hajime, Dal-Fabbro, Renan, Bottino, Marco C

“…This study was aimed at engineering photocrosslinkable azithromycin (AZ)-laden gelatin methacryloyl fibers via electrospinning to serve as a localized and…”
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The effect of phospholipid composition of reconstituted HDL on its cholesterol efflux and anti-inflammatory properties[S] by Schwendeman, Anna, Sviridov, Denis O., Yuan, Wenmin, Guo, Yanhong, Morin, Emily E., Yuan, Yue, Stonik, John, Freeman, Lita, Ossoli, Alice, Thacker, Seth, Killion, Salena, Pryor, Milton, Chen, Y.Eugene, Turner, Scott, Remaley, Alan T.

“…The goal of this study was to understand how the reconstituted HDL (rHDL) phospholipid (PL) composition affects its cholesterol efflux and anti-inflammatory…”
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