Search Results - "Schwemmle, Martin"

New Product Design: Concept, Measurement, and Consequences by Homburg, Christian, Schwemmle, Martin, Kuehnl, Christina

“…Product design is a source of competitive advantage for companies and is an important driver of company performance. Drawing on an extensive literature review…”
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Adaptation of Avian Influenza A Virus Polymerase in Mammals To Overcome the Host Species Barrier by Mänz, Benjamin, Schwemmle, Martin, Brunotte, Linda

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Within-host evolution of SARS-CoV-2 in an immunosuppressed COVID-19 patient as a source of immune escape variants by Weigang, Sebastian, Fuchs, Jonas, Zimmer, Gert, Schnepf, Daniel, Kern, Lisa, Beer, Julius, Luxenburger, Hendrik, Ankerhold, Jakob, Falcone, Valeria, Kemming, Janine, Hofmann, Maike, Thimme, Robert, Neumann-Haefelin, Christoph, Ulferts, Svenja, Grosse, Robert, Hornuss, Daniel, Tanriver, Yakup, Rieg, Siegbert, Wagner, Dirk, Huzly, Daniela, Schwemmle, Martin, Panning, Marcus, Kochs, Georg

“…The origin of SARS-CoV-2 variants of concern remains unclear. Here, we test whether intra-host virus evolution during persistent infections could be a…”
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Bats reveal the true power of influenza A virus adaptability by Ciminski, Kevin, Pfaff, Florian, Beer, Martin, Schwemmle, Martin

“…About the Authors: Kevin Ciminski Affiliations Institute of Virology, Medical Center–University of Freiburg, Freiburg, Germany, Faculty of Medicine, University…”
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Human bornavirus research: Back on track by Rubbenstroth, Dennis, Schlottau, Kore, Schwemmle, Martin, Rissland, Jürgen, Beer, Martin

“…Bornavirus infections in man have been a matter of controversial scientific debate for most of the last three decades. Because Borna disease virus 1 (BoDV-1)…”
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A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape by Hubel, Philipp, Urban, Christian, Bergant, Valter, Schneider, William M., Knauer, Barbara, Stukalov, Alexey, Scaturro, Pietro, Mann, Angelika, Brunotte, Linda, Hoffmann, Heinrich H., Schoggins, John W., Schwemmle, Martin, Mann, Matthias, Rice, Charles M., Pichlmair, Andreas

“…Interferon-stimulated genes (ISGs) form the backbone of the innate immune system and are important for limiting intra- and intercellular viral replication and…”
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Adaptive mutations in NEP compensate for defective H5N1 RNA replication in cultured human cells by Mänz, Benjamin, Brunotte, Linda, Reuther, Peter, Schwemmle, Martin

“…Infection of mammals by avian influenza viruses requires adaptive mutations to achieve high-level replication in the new host. However, the basic mechanism…”
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The Viral Nucleoprotein Determines Mx Sensitivity of Influenza A Viruses by Zimmermann, Petra, Mänz, Benjamin, Haller, Otto, Schwemmle, Martin, Kochs, Georg

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Anti-influenza A virus restriction factors that shape the human species barrier and virus evolution by Petric, Philipp Peter, Schwemmle, Martin, Graf, Laura

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Influenza A viruses escape from MxA restriction at the expense of efficient nuclear vRNP import by Götz, Veronika, Magar, Linda, Dornfeld, Dominik, Giese, Sebastian, Pohlmann, Anne, Höper, Dirk, Kong, Byung-Whi, Jans, David A., Beer, Martin, Haller, Otto, Schwemmle, Martin

“…To establish a new lineage in the human population, avian influenza A viruses (AIV) must overcome the intracellular restriction factor MxA. Partial escape from…”
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COVID-19 mRNA booster vaccine induces transient CD8+ T effector cell responses while conserving the memory pool for subsequent reactivation by Reinscheid, Matthias, Luxenburger, Hendrik, Karl, Vivien, Graeser, Anne, Giese, Sebastian, Ciminski, Kevin, Reeg, David B., Oberhardt, Valerie, Roehlen, Natascha, Lang-Meli, Julia, Heim, Kathrin, Gross, Nina, Baum, Christina, Rieg, Siegbert, Speer, Claudius, Emmerich, Florian, Breisinger, Susanne, Steinmann, Daniel, Bengsch, Bertram, Boettler, Tobias, Kochs, Georg, Schwemmle, Martin, Thimme, Robert, Neumann-Haefelin, Christoph, Hofmann, Maike

“…Immunization with two mRNA vaccine doses elicits robust spike-specific CD8 + T cell responses, but reports of waning immunity after COVID-19 vaccination prompt…”
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Lambda Interferon Renders Epithelial Cells of the Respiratory and Gastrointestinal Tracts Resistant to Viral Infections by Mordstein, Markus, Neugebauer, Eva, Ditt, Vanessa, Jessen, Birthe, Rieger, Toni, Falcone, Valeria, Sorgeloos, Frederic, Ehl, Stephan, Mayer, Daniel, Kochs, Georg, Schwemmle, Martin, Günther, Stephan, Drosten, Christian, Michiels, Thomas, Staeheli, Peter

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Packaging of the Influenza Virus Genome Is Governed by a Plastic Network of RNA- and Nucleoprotein-Mediated Interactions by Bolte, Hardin, Rosu, Miruna E, Hagelauer, Elena, García-Sastre, Adolfo, Schwemmle, Martin

“…The genome of influenza A virus is organized into eight ribonucleoproteins, each composed of a distinct RNA segment bound by the viral polymerase and…”
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Fatal Encephalitic Borna Disease Virus 1 in Solid-Organ Transplant Recipients by Schlottau, Kore, Forth, Leonie, Angstwurm, Klemens, Höper, Dirk, Zecher, Daniel, Liesche, Friederike, Hoffmann, Bernd, Kegel, Victoria, Seehofer, Daniel, Platen, Sabine, Salzberger, Bernd, Liebert, Uwe G, Niller, Hans-Helmut, Schmidt, Barbara, Matiasek, Kaspar, Riemenschneider, Markus J, Brochhausen, Christoph, Banas, Bernhard, Renders, Lutz, Moog, Philipp, Wunderlich, Silke, Seifert, Christian L, Barreiros, Ana, Rahmel, Axel, Weiss, Jutta, Tappe, Dennis, Herden, Christiane, Schmidt-Chanasit, Jonas, Schwemmle, Martin, Rubbenstroth, Dennis, Schlegel, Jürgen, Pietsch, Corinna, Hoffmann, Donata, Jantsch, Jonathan, Beer, Martin

“…Evidence of Borna disease virus 1 infection in humans is limited; in this report, donor-derived Borna virus encephalitis is shown to occur in three solid-organ…”
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Expected and Unexpected Features of the Newly Discovered Bat Influenza A-like Viruses by Ma, Wenjun, García-Sastre, Adolfo, Schwemmle, Martin

“…  [...]H17 and H18 HAs are unable to bind and hemagglutinate red blood cells and therefore are not "true" HAs. [...]we suggest that HAs from both H17 and H18…”
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The Nuclear Export Protein of H5N1 Influenza A Viruses Recruits Matrix 1 (M1) Protein to the Viral Ribonucleoprotein to Mediate Nuclear Export by Brunotte, Linda, Flies, Joe, Bolte, Hardin, Reuther, Peter, Vreede, Frank, Schwemmle, Martin

“…In influenza A virus-infected cells, replication and transcription of the viral genome occurs in the nucleus. To be packaged into viral particles at the plasma…”
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Impaired immune response drives age-dependent severity of COVID-19 by Beer, Julius, Crotta, Stefania, Breithaupt, Angele, Ohnemus, Annette, Becker, Jan, Sachs, Benedikt, Kern, Lisa, Llorian, Miriam, Ebert, Nadine, Labroussaa, Fabien, Nhu Thao, Tran Thi, Trueeb, Bettina Salome, Jores, Joerg, Thiel, Volker, Beer, Martin, Fuchs, Jonas, Kochs, Georg, Wack, Andreas, Schwemmle, Martin, Schnepf, Daniel

“…Severity of COVID-19 shows an extraordinary correlation with increasing age. We generated a mouse model for severe COVID-19 and show that the age-dependent…”
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Pre-existing immunity and vaccine history determine hemagglutinin-specific CD4 T cell and IgG response following seasonal influenza vaccination by Wild, Katharina, Smits, Maike, Killmer, Saskia, Strohmeier, Shirin, Neumann-Haefelin, Christoph, Bengsch, Bertram, Krammer, Florian, Schwemmle, Martin, Hofmann, Maike, Thimme, Robert, Zoldan, Katharina, Boettler, Tobias

“…Effectiveness of seasonal influenza vaccination varies between individuals and might be affected by vaccination history among other factors. Here we show, by…”
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Influenza A Viruses and Zoonotic Events-Are We Creating Our Own Reservoirs? by Kessler, Susanne, Harder, Timm C, Schwemmle, Martin, Ciminski, Kevin

“…Zoonotic infections of humans with influenza A viruses (IAVs) from animal reservoirs can result in severe disease in individuals and, in rare cases, lead to…”
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Pandemic influenza A viruses escape from restriction by human MxA through adaptive mutations in the nucleoprotein by Mänz, Benjamin, Dornfeld, Dominik, Götz, Veronika, Zell, Roland, Zimmermann, Petra, Haller, Otto, Kochs, Georg, Schwemmle, Martin

“…The interferon-induced dynamin-like MxA GTPase restricts the replication of influenza A viruses. We identified adaptive mutations in the nucleoprotein (NP) of…”
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