Search Results - "Schweighoffer, Edina"

TLR4 signals in B lymphocytes are transduced via the B cell antigen receptor and SYK by Schweighoffer, Edina, Nys, Josquin, Vanes, Lesley, Smithers, Nicholas, Tybulewicz, Victor L J

“…Toll-like receptors (TLRs) play an important role in immune responses to pathogens by transducing signals in innate immune cells in response to microbial…”
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The BAFF Receptor Transduces Survival Signals by Co-opting the B Cell Receptor Signaling Pathway by Schweighoffer, Edina, Vanes, Lesley, Nys, Josquin, Cantrell, Doreen, McCleary, Scott, Smithers, Nicholas, Tybulewicz, Victor L.J.

“…Follicular B cell survival requires signaling from BAFFR, a receptor for BAFF and the B cell antigen receptor (BCR). This “tonic” BCR survival signal is…”
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Plasmodium -specific atypical memory B cells are short-lived activated B cells by Pérez-Mazliah, Damián, Gardner, Peter J, Schweighoffer, Edina, McLaughlin, Sarah, Hosking, Caroline, Tumwine, Irene, Davis, Randall S, Potocnik, Alexandre J, Tybulewicz, Victor Lj, Langhorne, Jean

“…A subset of atypical memory B cells accumulates in malaria and several infections, autoimmune disorders and aging in both humans and mice. It has been…”
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Dectin-2 is a Syk-coupled pattern recognition receptor crucial for Th17 responses to fungal infection by Robinson, Matthew J, Osorio, Fabiola, Rosas, Marcela, Freitas, Rui P, Schweighoffer, Edina, Gross, Olaf, Verbeek, J Sjef, Ruland, Jürgen, Tybulewicz, Victor, Brown, Gordon D, Moita, Luis Ferreira, Taylor, Philip R, Reis e Sousa, Caetano

“…Innate immune cells detect pathogens via pattern recognition receptors (PRRs), which signal for initiation of immune responses to infection. Studies with…”
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Syk-Dependent Cytokine Induction by Dectin-1 Reveals a Novel Pattern Recognition Pathway for C Type Lectins by Rogers, Neil C., Slack, Emma C., Edwards, Alexander D., Nolte, Martijn A., Schulz, Oliver, Schweighoffer, Edina, Williams, David L., Gordon, Siamon, Tybulewicz, Victor L., Brown, Gordon D., Reis e Sousa, Caetano

“…Pattern-recognition receptors (PRRs) detect molecular signatures of microbes and initiate immune responses to infection. Prototypical PRRs such as Toll-like…”
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CLEC-2 and Syk in the megakaryocytic/platelet lineage are essential for development by Finney, Brenda A., Schweighoffer, Edina, Navarro-Núñez, Leyre, Bénézech, Cecile, Barone, Francesca, Hughes, Craig E., Langan, Stacey A., Lowe, Kate L., Pollitt, Alice Y., Mourao-Sa, Diego, Sheardown, Steve, Nash, Gerard B., Smithers, Nicholas, Reis e Sousa, Caetano, Tybulewicz, Victor L.J., Watson, Steve P.

“…The C-type lectin receptor CLEC-2 signals through a pathway that is critically dependent on the tyrosine kinase Syk. We show that homozygous loss of either…”
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Restoration of pattern recognition receptor costimulation to treat chromoblastomycosis, a chronic fungal infection of the skin by Sousa, Maria da Glória, Reid, Delyth M, Schweighoffer, Edina, Tybulewicz, Victor, Ruland, Jürgen, Langhorne, Jean, Yamasaki, Sho, Taylor, Philip R, Almeida, Sandro R, Brown, Gordon D

“…Chromoblastomycosis is a chronic skin infection caused by the fungus Fonsecaea pedrosoi. Exploring the reasons underlying the chronic nature of F. pedrosoi…”
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Syk kinase is required for collaborative cytokine production induced through Dectin-1 and Toll-like receptors by Dennehy, Kevin M, Ferwerda, Gerben, Faro-Trindade, Inês, Pyż, Elwira, Willment, Janet A, Taylor, Philip R, Kerrigan, Ann, Tsoni, S. Vicky, Gordon, Siamon, Meyer-Wentrup, Friederike, Adema, Gosse J, Kullberg, Bart-Jan, Schweighoffer, Edina, Tybulewicz, Victor, Mora-Montes, Hector M, Gow, Neil A.R, Williams, David L, Netea, Mihai G, Brown, Gordon D

“…Recognition of microbial components by germ-line encoded pattern recognition receptors (PRR) initiates immune responses to infectious agents. We and others…”
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NKG2D triggers cytotoxicity in mouse NK cells lacking DAP12 or Syk family kinases by Tybulewicz, Victor L J, Di Santo, James P, Hamerman, Jessica A, Schweighoffer, Edina, Ogasawara, Kouetsu, Lanier, Lewis L, Zompi, Simona, Colucci, Francesco

“…In activated mouse natural killer (NK) cells, the NKG2D receptor associates with two intracellular adaptors, DAP10 and DAP12, which trigger phosphatidyl…”
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A Critical Role for Syk Protein Tyrosine Kinase in Fc Receptor-Mediated Antigen Presentation and Induction of Dendritic Cell Maturation by Sedlik, Christine, Orbach, Daniel, Veron, Philippe, Schweighoffer, Edina, Colucci, Francesco, Gamberale, Romina, Ioan-Facsinay, Andrea, Verbeek, Sjef, Ricciardi-Castagnoli, Paola, Bonnerot, Christian, Tybulewicz, Victor L. J, Di Santo, James, Amigorena, Sebastian

“…Dendritic cells (DCs) are the only APCs capable of initiating adaptive immune responses. The initiation of immune responses requires that DCs 1) internalize…”
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Redundant role for Zap70 in B cell development and activation by Fallah-Arani, Farnaz, Schweighoffer, Edina, Vanes, Lesley, Tybulewicz, Victor L.J

“…Expression of the Syk family tyrosine kinase Zap70 is strongly correlated with poor clinical outcome in chronic lymphocytic leukemia, the most common human…”
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Natural cytotoxicity uncoupled from the Syk and ZAP-70 intracellular kinases by Vivier, Eric, Tomasello, Elena, Colucci, Francesco, Schweighoffer, Edina, Turner, Martin, Tybulewicz, Victor L. J, Ortaldo, John R, Di Santo, James P

“…The intracellular signals that trigger natural cytotoxicity have not been clearly determined. The Syk and ZAP-70 tyrosine kinases are essential for cellular…”
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Interaction of Linker for Activation of T Cells with Multiple Adapter Proteins in Platelets Activated by the Glycoprotein VI-selective Ligand, Convulxin by Asazuma, Naoki, Wilde, Jonathan I., Berlanga, Oscar, Leduc, Mireille, Leo, Albrecht, Schweighoffer, Edina, Tybulewicz, Victor, Bon, Cassian, Liu, Stan K., McGlade, C. Jane, Schraven, Burkhart, Watson, Steve P.

“…The snake venom toxin convulxin activates platelets through the collagen receptor glycoprotein VI (GPVI)/Fc receptor γ-chain (FcR γ-chain) complex leading to…”
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BAFF signaling in health and disease by Schweighoffer, Edina, Tybulewicz, Victor LJ

“…BAFF is a critical cytokine supporting the survival of mature naïve B cells, acting through the BAFFR receptor. Recent studies show that BAFF and BAFFR are…”
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Signalling for B cell survival by Schweighoffer, Edina, Tybulewicz, Victor LJ

“…The number of mature B cells is carefully controlled by signalling from receptors that support B cell survival. The best studied of these are the B cell…”
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Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence by Poeck, Hendrik, Tschopp, Jürg, Tardivel, Aubry, Gross, Olaf, Dostert, Catherine, Schweighoffer, Edina, Tybulewicz, Victor, Mocsai, Attila, Bscheider, Michael, Ruland, Jürgen, Hannesschläger, Nicole, Hartmann, Gunther, Endres, Stefan

“…Fungal infections represent a serious threat, particularly in immunocompromised patients. Interleukin-1 (IL-1 ) is a key pro-inflammatory factor in innate…”
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Phosphorylation of the adaptor ASC acts as a molecular switch that controls the formation of speck-like aggregates and inflammasome activity by Hara, Hideki, Tsuchiya, Kohsuke, Kawamura, Ikuo, Fang, Rendong, Hernandez-Cuellar, Eduardo, Shen, Yanna, Mizuguchi, Junichiro, Schweighoffer, Edina, Tybulewicz, Victor, Mitsuyama, Masao

“…The adaptor ASC is required for caspase-1 activation via the NLRP3 and AIM2 inflammasomes. Mitsuyama and colleagues show that signaling dependent on the…”
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Critical requirement for BCR, BAFF, and BAFFR in memory B cell survival by Müller-Winkler, Jennifer, Mitter, Richard, Rappe, Julie C F, Vanes, Lesley, Schweighoffer, Edina, Mohammadi, Hamid, Wack, Andreas, Tybulewicz, Victor L J

“…Memory B cells (MBCs) are long-lived cells that form a critical part of immunological memory, providing rapid antibody responses to recurring infections…”
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Regulatory T Cells Inhibit Dendritic Cells by Lymphocyte Activation Gene-3 Engagement of MHC Class II by Liang, Bitao, Workman, Craig, Lee, Janine, Chew, Claude, Dale, Benjamin M, Colonna, Lucrezia, Flores, Marcella, Li, Nianyu, Schweighoffer, Edina, Greenberg, Steven, Tybulewicz, Victor, Vignali, Dario, Clynes, Raphael

“…Lymphocyte activation gene-3 (LAG-3) is a CD4-related transmembrane protein expressed by regulatory T cells that binds MHC II on APCs. It is shown in this…”
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Syk-Dependent Cytokine Induction by Dectin-1 Reveals a Novel Pattern Recognition Pathway for C Type Lectins by Rogers, Neil C., Slack, Emma C., Edwards, Alexander D., Nolte, Martijn A., Schulz, Oliver, Schweighoffer, Edina, Williams, David L., Gordon, Siamon, Tybulewicz, Victor L., Brown, Gordon D., Reis e Sousa, Caetano

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