Search Results - "Schweiger, Lutz F."

Fluorinase-Coupled Base Swaps: Synthesis of [¹⁸F]-5'-Deoxy-5'-fluorouridines by Winkler, Margit, Domarkas, Juozas, Schweiger, Lutz F, O'Hagan, David

“…Making F‐ases: One‐pot fluorination/base‐swap biotransformations were developed by coupling the fluorinase enzyme to nucleoside phosphorylases to generate…”
Get full text

An enzymatic route to 5-deoxy-5-[18F]fluoro-D-ribose, a [18F]-fluorinated sugar for PET imaging by Onega, Mayca, Domarkas, Juozas, Deng, Hai, Schweiger, Lutz F, Smith, Timothy A D, Welch, Andrew E, Plisson, Christophe, Gee, Antony D, O'Hagan, David

“…An efficient two-step, one-pot, biotransformation involving the fluorinase enzyme is described for the synthesis of 5-deoxy-5-[(18)F]fluororibose, a novel…”
Get more information

Synthesis, Radiosynthesis, and in vitro Studies on Novel Hypoxia PET Tracers Incorporating [18F]FDR by Musolino, Manuele, Fleming, Ian N., Schweiger, Lutz F., O'Hagan, David, Dall'Angelo, Sergio, Zanda, Matteo

“…We report the synthesis of five radiotracers incorporating different oxyamine spacers between the hypoxia‐reactive 2‐nitroimidazole moiety and the…”
Get full text

Last-Step Enzymatic [18F]-Fluorination of Cysteine-Tethered RGD Peptides Using Modified Barbas Linkers by Zhang, Qingzhi, Dall'Angelo, Sergio, Fleming, Ian N., Schweiger, Lutz F., Zanda, Matteo, O'Hagan, David

“…We report a last‐step fluorinase‐catalyzed [18F]‐fluorination of a cysteine‐containing RGD peptide. The peptide was attached through sulfur to a modified and…”
Get full text

[18F]-5-Fluoro-5-deoxyribose, an efficient peptide bioconjugation ligand for positron emission tomography (PET) imaging by Li, Xiang-Guo, Dall'Angelo, Sergio, Schweiger, Lutz F, Zanda, Matteo, O'Hagan, David

“…[(18)F]-5-Fluoro-5-deoxyribose ([(18)F]-FDR) conjugates much more rapidly than [(18)F]-FDG under mild reaction conditions to peptides and offers new prospects…”
Get more information

Efficient bioconjugation of 5-fluoro-5-deoxy-ribose (FDR) to RGD peptides for positron emission tomography (PET) imaging of α(v)β(3) integrin receptor by Dall'Angelo, Sergio, Zhang, Qingzhi, Fleming, Ian N, Piras, Monica, Schweiger, Lutz F, O'Hagan, David, Zanda, Matteo

“…The utility of 5-fluoro-5-deoxyribose (FDR) as an efficient bioconjugation agent for radiolabelling of the RGD peptides c(RGDfK) and c(RGDfC) is demonstrated…”
Get more information

Tumour imaging by Positron Emission Tomography using fluorinase generated 5-[18 F]fluoro-5-deoxyribose as a novel tracer by Dall'Angelo, Sergio, Bandaranayaka, Nouchali, Windhorst, Albert D, Vugts, Danielle J, van der Born, Dion, Onega, Mayca, Schweiger, Lutz F, Zanda, Matteo, O'Hagan, David

“…Abstract Introduction 5-[18 F]Fluoro-5-deoxyribose ([18 F]FDR) 3 was prepared as a novel monosaccharide radiotracer in a two-step synthesis using the…”
Get full text

Fully-automated radiosynthesis and in vitro uptake investigation of [N-methyl-¹¹C]methylene blue by Schweiger, Lutz F, Smith, Tim A D

“…Malignant melanoma is a type of skin cancer which can spread rapidly if not detected early and left untreated. Positron Emission Tomography (PET) is a powerful…”
Get full text

Decreased [18 F]fluoro-2-deoxy- d -glucose incorporation and increased glucose transport are associated with resistance to 5FU in MCF7 cells in vitro by Smith, Tim A.D, Sharma, Rituka I, Wang, Weiguang G, Welch, Andy E, Schweiger, Lutz F, Collie-Duguid, Elaina S.R

“…Abstract Introduction Tumor refractoriness to chemotherapy is frequently due to the acquisition of resistance. Resistant cells selected by exposure to…”
Get full text

18F-barbiturates are PET tracers with diagnostic potential in Alzheimer's disease by Calamai, Elisa, Dall'Angelo, Sergio, Koss, David, Domarkas, Juozas, McCarthy, Timothy J, Mingarelli, Marco, Riedel, Gernot, Schweiger, Lutz F, Welch, Andy, Platt, Bettina, Zanda, Matteo

“…Three fluoro-barbiturates were synthesised, showing in vivo sedative efficacy. One of them, [(18)F], was synthesised in radiofluorinated form. PET/CT Imaging…”
Get more information

Fluorinase‐Coupled Base Swaps: Synthesis of [18F]‐5′‐Deoxy‐5′‐fluorouridines by Winkler, Margit, Domarkas, Juozas, Schweiger, Lutz F., O'Hagan, David

“…Fluorierung und Basentausch zur Herstellung von 5′‐Desoxy‐5′‐fluornucleosiden (FDAs) lassen sich in einem Eintopfprozess ausführen, wenn man das Enzym…”
Get full text

Fluorinase‐Coupled Base Swaps: Synthesis of [ 18 F]‐5′‐Deoxy‐5′‐fluorouridines by Winkler, Margit, Domarkas, Juozas, Schweiger, Lutz F., O'Hagan, David

Get full text