Search Results - "Schweickert, Axel"

The evolution and conservation of left-right patterning mechanisms by Blum, Martin, Feistel, Kerstin, Thumberger, Thomas, Schweickert, Axel

“…Morphological asymmetry is a common feature of animal body plans, from shell coiling in snails to organ placement in humans. The signaling protein Nodal is key…”
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Bicc1 and Dicer regulate left-right patterning through post-transcriptional control of the Nodal inhibitor Dand5 by Maerker, Markus, Getwan, Maike, Dowdle, Megan E., McSheene, Jason C., Gonzalez, Vanessa, Pelliccia, José L., Hamilton, Danielle S., Yartseva, Valeria, Vejnar, Charles, Tingler, Melanie, Minegishi, Katsura, Vick, Philipp, Giraldez, Antonio J., Hamada, Hiroshi, Burdine, Rebecca D., Sheets, Michael D., Blum, Martin, Schweickert, Axel

“…Rotating cilia at the vertebrate left-right organizer (LRO) generate an asymmetric leftward flow, which is sensed by cells at the left LRO margin. Ciliary…”
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A Conserved Role of the Unconventional Myosin 1d in Laterality Determination by Tingler, Melanie, Kurz, Sabrina, Maerker, Markus, Ott, Tim, Fuhl, Franziska, Schweickert, Axel, LeBlanc-Straceski, Janine M., Noselli, Stéphane, Blum, Martin

“…Anatomical and functional asymmetries are widespread in the animal kingdom [1, 2]. In vertebrates, many visceral organs are asymmetrically placed [3]. In…”
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A secretory cell type develops alongside multiciliated cells, ionocytes and goblet cells, and provides a protective, anti-infective function in the frog embryonic mucociliary epidermis by Dubaissi, Eamon, Rousseau, Karine, Lea, Robert, Soto, Ximena, Nardeosingh, Siddarth, Schweickert, Axel, Amaya, Enrique, Thornton, David J, Papalopulu, Nancy

“…The larval epidermis of Xenopus is a bilayered epithelium, which is an excellent model system for the study of the development and function of mucosal and…”
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The Nodal Inhibitor Coco Is a Critical Target of Leftward Flow in Xenopus by Schweickert, Axel, Vick, Philipp, Getwan, Maike, Weber, Thomas, Schneider, Isabelle, Eberhardt, Melanie, Beyer, Tina, Pachur, Anke, Blum, Martin

“…Vertebrate laterality, which is manifested by asymmetrically placed organs [ 1], depends on asymmetric activation of the Nodal signaling cascade in the left…”
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Xenopus, an ideal model organism to study laterality in conjoined twins by Tisler, Matthias, Schweickert, Axel, Blum, Martin

“…Conjoined twins occur at low frequency in all vertebrates including humans. Many twins fused at the chest or abdomen display a very peculiar laterality defect:…”
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Wnt11b is involved in cilia-mediated symmetry breakage during Xenopus left-right development by Walentek, Peter, Schneider, Isabelle, Schweickert, Axel, Blum, Martin

“…Breakage of bilateral symmetry in amphibian embryos depends on the development of a ciliated epithelium at the gastrocoel roof during early neurulation. Motile…”
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dmrt2 and myf5 Link Early Somitogenesis to Left-Right Axis Determination in Xenopus laevis by Tingler, Melanie, Brugger, Amelie, Feistel, Kerstin, Schweickert, Axel

“…The vertebrate left-right axis is specified during neurulation by events occurring in a transient ciliated epithelium termed left-right organizer (LRO), which…”
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A novel serotonin-secreting cell type regulates ciliary motility in the mucociliary epidermis of Xenopus tadpoles by Walentek, Peter, Bogusch, Susanne, Thumberger, Thomas, Vick, Philipp, Dubaissi, Eamon, Beyer, Tina, Blum, Martin, Schweickert, Axel

“…The embryonic skin of Xenopus tadpoles serves as an experimental model system for mucociliary epithelia (MCE) such as the human airway epithelium. MCEs are…”
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The RNA-binding protein bicaudal C regulates polycystin 2 in the kidney by antagonizing miR-17 activity by Tran, Uyen, Zakin, Lise, Schweickert, Axel, Agrawal, Raman, Döger, Remziye, Blum, Martin, De Robertis, E M, Wessely, Oliver

“…The RNA-binding protein Bicaudal C is an important regulator of embryonic development in C. elegans, Drosophila and Xenopus. In mouse, bicaudal C (Bicc1)…”
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Xenopus, an ideal model system to study vertebrate left‐right asymmetry by Blum, Martin, Beyer, Tina, Weber, Thomas, Vick, Philipp, Andre, Philipp, Bitzer, Eva, Schweickert, Axel

“…Vertebrate organ laterality is manifested by the asymmetric morphogenesis and placement of inner organs. Asymmetric induction of the Nodal signaling cascade in…”
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Cilia are required for asymmetric nodal induction in the sea urchin embryo by Tisler, Matthias, Wetzel, Franziska, Mantino, Sabrina, Kremnyov, Stanislav, Thumberger, Thomas, Schweickert, Axel, Blum, Martin, Vick, Philipp

“…Left-right (LR) organ asymmetries are a common feature of metazoan animals. In many cases, laterality is established by a conserved asymmetric Nodal signaling…”
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Flow on the right side of the gastrocoel roof plate is dispensable for symmetry breakage in the frog Xenopus laevis by Vick, Philipp, Schweickert, Axel, Weber, Thomas, Eberhardt, Melanie, Mencl, Stine, Shcherbakov, Denis, Beyer, Tina, Blum, Martin

“…Leftward flow of extracellular fluid breaks the bilateral symmetry of most vertebrate embryos, manifested by the ensuing asymmetric induction of Nodal…”
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The ion channel polycystin-2 is required for left-right axis determination in mice by Pennekamp, Petra, Karcher, Christina, Fischer, Anja, Schweickert, Axel, Skryabin, Boris, Horst, Jürgen, Blum, Martin, Dworniczak, Bernd

“…Generation of laterality depends on a pathway which involves the asymmetrically expressed genes nodal, Ebaf, Leftb, and Pitx2. In mouse, node monocilia are…”
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Calponin 2 Acts As an Effector of Noncanonical Wnt-Mediated Cell Polarization during Neural Crest Cell Migration by Ulmer, Bärbel, Hagenlocher, Cathrin, Schmalholz, Silke, Kurz, Sabrina, Schweickert, Axel, Kohl, Ayelet, Roth, Lee, Sela-Donenfeld, Dalit, Blum, Martin

“…Neural crest cells (NCCs) migrate throughout the embryo to differentiate into cell types of all germ layers. Initial directed NCC emigration relies on planar…”
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Symmetry breakage in the frog Xenopus: Role of Rab11 and the ventral-right blastomere by Tingler, Melanie, Ott, Tim, Tözser, Janos, Kurz, Sabrina, Getwan, Maike, Tisler, Matthias, Schweickert, Axel, Blum, Martin

“…Summary Vertebrates display asymmetric arrangements of inner organs such as heart and stomach. The Nodal signaling cascade in the left lateral plate mesoderm…”
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Vertebrate Left-Right Asymmetry: What Can Nodal Cascade Gene Expression Patterns Tell Us? by Schweickert, Axel, Ott, Tim, Kurz, Sabrina, Tingler, Melanie, Maerker, Markus, Fuhl, Franziska, Blum, Martin

“…Laterality of inner organs is a wide-spread characteristic of vertebrates and beyond. It is ultimately controlled by the left-asymmetric activation of the…”
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An Early Function of Polycystin-2 for Left-Right Organizer Induction in Xenopus by Vick, Philipp, Kreis, Jennifer, Schneider, Isabelle, Tingler, Melanie, Getwan, Maike, Thumberger, Thomas, Beyer, Tina, Schweickert, Axel, Blum, Martin

“…Nodal signaling controls asymmetric organ placement during vertebrate embryogenesis. Nodal is induced by a leftward fluid flow at the ciliated left-right…”
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ATP4a Is Required for Wnt-Dependent Foxj1 Expression and Leftward Flow in Xenopus Left-Right Development by Walentek, Peter, Beyer, Tina, Thumberger, Thomas, Schweickert, Axel, Blum, Martin

“…Most vertebrate embryos break symmetry by a cilia-driven leftward flow during neurulation. In the frog Xenopus asymmetric expression of the ion pump ATP4a was…”
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Ciliation and gene expression distinguish between node and posterior notochord in the mammalian embryo by Blum, Martin, Andre, Philipp, Muders, Kerstin, Schweickert, Axel, Fischer, Anja, Bitzer, Eva, Bogusch, Susanne, Beyer, Tina, van Straaten, Henny W.M., Viebahn, Christoph

“…The mammalian node, the functional equivalent of the frog dorsal blastoporal lip (Spemann's organizer), was originally described by Viktor Hensen in 1876 in…”
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