Search Results - "Schwede, Matthew"

Taxonomy of breast cancer based on normal cell phenotype predicts outcome by Santagata, Sandro, Thakkar, Ankita, Ergonul, Ayse, Wang, Bin, Woo, Terri, Hu, Rong, Harrell, J Chuck, McNamara, George, Schwede, Matthew, Culhane, Aedin C, Kindelberger, David, Rodig, Scott, Richardson, Andrea, Schnitt, Stuart J, Tamimi, Rulla M, Ince, Tan A

“…Accurate classification is essential for understanding the pathophysiology of a disease and can inform therapeutic choices. For hematopoietic malignancies, a…”
Get full text

Profiles of Genomic Instability in High-Grade Serous Ovarian Cancer Predict Treatment Outcome by WANG, Zhigang C, JUUL BIRKBAK, Nicolai, LIU, Joyce, ETEMADMOGHADAM, Dariush, MIRON, Alexander, SALVESEN, Helga B, MITCHELL, Gillian, DEFAZIO, Anna, QUACKENBUSH, John, BERKOWITZ, Ross S, DIRK IGLEHART, J, BOWTELL, David D. L, CULHANE, Aedin C, MATULONIS, Ursula A, DRAPKIN, Ronny, FATIMA, Aquila, RUIYANG TIAN, SCHWEDE, Matthew, ALSOP, Kathryn, DANIELS, Kathryn E, HUIYING PIAO

“…High-grade serous cancer (HGSC) is the most common cancer of the ovary and is characterized by chromosomal instability. Defects in homologous recombination…”
Get full text

Proinflammatory cytokines and ARDS pulmonary edema fluid induce CD40 on human mesenchymal stromal cells-A potential mechanism for immune modulation by Wilfong, Erin M, Croze, Roxanne, Fang, Xiaohui, Schwede, Matthew, Niemi, Erene, López, Giselle Y, Lee, Jae-Woo, Nakamura, Mary C, Matthay, Michael A

“…Human mesenchymal stem/stromal cells (hMSCs) are a promising therapy for acute respiratory distress syndrome (ARDS) and other inflammatory conditions. While…”
Get full text

Web-Based Scaffolds: The Feasibility of a Constructivist Approach to Oncology Fellow Learning by Brondfield, Sam, Schwede, Matthew, Johnson, Tyler P, Arora, Shagun

“…In this 2-institution feasibility pilot, oncology fellows used and updated freely available web-based learning tools (scaffolds) in a constructivist fashion…”
Get full text

Strong correlation of downregulated genes related to synaptic transmission and mitochondria in post-mortem autism cerebral cortex by Schwede, Matthew, Nagpal, Shailender, Gandal, Michael J, Parikshak, Neelroop N, Mirnics, Karoly, Geschwind, Daniel H, Morrow, Eric M

“…Genetic studies in autism have pinpointed a heterogeneous group of loci and genes. Further, environment may be an additional factor conferring susceptibility…”
Get full text

Gene expression signature of normal cell-of-origin predicts ovarian tumor outcomes by Merritt, Melissa A, Bentink, Stefan, Schwede, Matthew, Iwanicki, Marcin P, Quackenbush, John, Woo, Terri, Agoston, Elin S, Reinhardt, Ferenc, Crum, Christopher P, Berkowitz, Ross S, Mok, Samuel C, Witt, Abigail E, Jones, Michelle A, Wang, Bin, Ince, Tan A

“…The potential role of the cell-of-origin in determining the tumor phenotype has been raised, but not adequately examined. We hypothesized that distinct…”
Get full text

Stem cell-like gene expression in ovarian cancer predicts type II subtype and prognosis by Schwede, Matthew, Spentzos, Dimitrios, Bentink, Stefan, Hofmann, Oliver, Haibe-Kains, Benjamin, Harrington, David, Quackenbush, John, Culhane, Aedín C

“…Although ovarian cancer is often initially chemotherapy-sensitive, the vast majority of tumors eventually relapse and patients die of increasingly aggressive…”
Get full text

Preparing for Clerkships: Learning to Deliver Specialty-Specific Oral Presentations by Daniel, Michelle, Heney, Ryan, Kwan, Brian, Mannino, Courtney, Williams, Claire, Macdonald, Kelly, Williams, John, Reardon, Juliann, Resnick-Ault, Daniel, Schaetzel-Hill, Terra, Cormier, Justine, Schwede, Matthew, Sangal, Rohit, Dalal, Rahul, George, Paul, Sutton, Elizabeth

“…Abstract The Association of American Medical Colleges' Entrustable Professional Activity (EPA) 6 states that “the day 1 resident should be able to concisely…”
Get full text

Acute Myeloid Leukemia with Inv(3) or t(3;3): A Clinical and Cytogenetic Characterization of 40 Patients by Moscvin, Maria, Schwede, Matthew, Mannis, Gabriel, Zhang, Tian Y.

“…Background: Acute myeloid leukemia (AML) with inv(3) or t(3;3) is an extremely aggressive and rare subtype of AML. Leukemogenesis in inv(3) AML is in part due…”
Get full text

Online scaffolds: A constructivist approach to oncology fellow learning by Brondfield, Sam, Schwede, Matthew, Johnson, Tyler Paul, Arora, Shagun

“…11010 Background: Oncology is a vast and fast-paced field. Fellows must expend significant effort to learn and stay updated. Up-to-date learning tools covering…”
Get full text

Optimizing hematology/oncology (H/O) curricula for internal medicine (IM) residents: A two-institution Delphi survey by Silverstein, Jordyn, Huppert, Laura Ann, Schwede, Matthew, Goglin, Sarah, Johnson, Tyler Paul, Babik, Jennifer, Brondfield, Sam

“…9033 Background: Although H/O topics are essential for primary care physicians, internists and subspecialists, the H/O curriculum is not standardized across IM…”
Get full text

Diagnosis and management of neutrophilic myeloid neoplasms by Schwede, Matthew, Gotlib, Jason, Shomali, William

Get full text

The Shifting Prognosis of FLT3 Mutations in Acute Myeloid Leukemia in the Era of Targeted Therapy: A Real-World Study Using Large-Scale Electronic Health Record Data by Schwede, Matthew, Rodriguez, Gladys, Henry, Solomon, Wood, Douglas, Mannis, Gabriel, Majeti, Ravindra, Chen, Jonathan, Bendavid, Eran, Zhang, Tian Y.

“…Background: Mutations in FLT3 occur in 20-30% of acute myeloid leukemia (AML), and their prognostic implications have varied over time with improved…”
Get full text

Analysis of Treatment Patterns and Outcomes in Patients Ages 60-74 in the Post-Venetoclax Era by St. Martin, Emma C, Schwede, Matthew, Fakhri, Bita, Gotlib, Jason, Liedtke, Michaela, Shomali, William, Zhang, Tian Y., Mannis, Gabriel

“…Introduction Clear standards of care exist for patients with AML under the age of 60 who are eligible for intensive chemotherapy (IC), as well as for patients…”
Get full text

Heterogeneous Definitions of Secondary Acute Myeloid Leukemia (AML) Yield Distinct Outcomes in Response to First-Line Treatment with Hypomethylating Agents (HMA) and Venetoclax (Ven) by Tan, Irena, Schwede, Matthew, Phan, Paul, Yin, Raymond, Zhang, Tian Y, Mannis, Gabriel N.

“…Background: The combination of HMA and venetoclax is now standard of care for patients with AML who are not candidates for intensive chemotherapy. Elderly…”
Get full text

Harnessing Artificial Intelligence for Risk Stratification in Acute Myeloid Leukemia (AML): Evaluating the Utility of Longitudinal Electronic Health Record (EHR) Data Via Graph Neural Networks by Sinha, Riya, Schwede, Matthew, Viggiano, Ben, Kuo, David, Henry, Solomon, Wood, Douglas, Mannis, Gabriel, Majeti, Ravindra, Chen, Jonathan, Zhang, Tian Y.

“…Background: AML is a life-threatening disease, and to determine which patients need allogeneic stem cell transplantation, hematologists risk-stratify each…”
Get full text

Development of Circulating Tumor DNA (ctDNA) for Molecular Measurable Residual Disease (MRD) in Acute Myeloid Leukemia (AML) by Gunaratne, Ruwan, Zhou, Crystal, Tai, Jesse W., Schwede, Matthew, Tanaka, Kailee, Alkaitis, Matthew, Yin, Raymond, Sworder, Brian J., Mannis, Gabriel, Majeti, Ravindra, Khodadoust, Michael S., Kurtz, David M., Zhang, Tian Y.

“…Introduction: Despite advances in therapeutic options, the majority of AML patients experience relapsed or refractory disease. Standard-of-care (SOC) methods…”
Get full text

Graph-based clinical recommender: Predicting specialists procedure orders using graph representation learning by Fouladvand, Sajjad, Gomez, Federico Reyes, Nilforoshan, Hamed, Schwede, Matthew, Noshad, Morteza, Jee, Olivia, You, Jiaxuan, Sosic, Rok, Leskovec, Jure, Chen, Jonathan

“…To determine whether graph neural network based models of electronic health records can predict specialty consultation care needs for endocrinology and…”
Get full text

Mutation order in acute myeloid leukemia identifies uncommon patterns of evolution and illuminates phenotypic heterogeneity by Schwede, Matthew, Jahn, Katharina, Kuipers, Jack, Miles, Linde A., Bowman, Robert L., Robinson, Troy, Furudate, Ken, Uryu, Hidetaka, Tanaka, Tomoyuki, Sasaki, Yuya, Ediriwickrema, Asiri, Benard, Brooks, Gentles, Andrew J., Levine, Ross, Beerenwinkel, Niko, Takahashi, Koichi, Majeti, Ravindra

“…Acute myeloid leukemia (AML) has a poor prognosis and a heterogeneous mutation landscape. Although common mutations are well-studied, little research has…”
Get full text

The Impact of Stroma Admixture on Molecular Subtypes and Prognostic Gene Signatures in Serous Ovarian Cancer by Schwede, Matthew, Waldron, Levi, Mok, Samuel C, Wei, Wei, Basunia, Azfar, Merritt, Melissa A, Mitsiades, Constantine S, Parmigiani, Giovanni, Harrington, David P, Quackenbush, John, Birrer, Michael J, Culhane, Aedín C

“…Recent efforts to improve outcomes for high-grade serous ovarian cancer, a leading cause of cancer death in women, have focused on identifying molecular…”
Get full text