Search Results - "Schwarzschild, Michael"

The epidemiology of Parkinson's disease: risk factors and prevention by Ascherio, Alberto, Prof, Schwarzschild, Michael A, Prof

“…Summary Since 2006, several longitudinal studies have assessed environmental or behavioural factors that seem to modify the risk of developing Parkinson's…”
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Urate as a Marker of Risk and Progression of Neurodegenerative Disease by Paganoni, Sabrina, Schwarzschild, Michael A.

“…Urate is a naturally occurring antioxidant whose levels are associated with reduced risk of developing Parkinson’s disease (PD) and Alzheimer’s disease. Urate…”
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Targeting urate to reduce oxidative stress in Parkinson disease by Crotty, Grace F., Ascherio, Alberto, Schwarzschild, Michael A.

“…Oxidative stress has been implicated as a core contributor to the initiation and progression of multiple neurological diseases. Genetic and environmental…”
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Metagenomics of the Gut Microbiome in Parkinson's Disease: Prodromal Changes by Palacios, Natalia, Wilkinson, Jeremy, Bjornevik, Kjetil, Schwarzschild, Michael A., McIver, Lauren, Ascherio, Alberto, Huttenhower, Curtis

“…Objective Prior studies on the gut microbiome in Parkinson's disease (PD) have yielded conflicting results, and few studies have focused on prodromal…”
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Prospective study of plasma urate and risk of Parkinson disease in men and women by Gao, Xiang, OʼReilly, Éilis J, Schwarzschild, Michael A, Ascherio, Alberto

“…OBJECTIVE:To examine whether higher plasma urate concentrations are associated with a lower risk of developing Parkinson disease (PD) and whether there is a…”
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What to Test in Parkinson Disease Prevention Trials?: Repurposed, Low-Risk, and Gene-Targeted Drugs by Crotty, Grace F., Schwarzschild, Michael A.

“…Despite the sound epidemiologic and basic science rationales underpinning numerous “disease modification” trials in manifest Parkinson disease (PD), none has…”
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Approaches to Disease Modification for Parkinson’s Disease: Clinical Trials and Lessons Learned by Hung, Albert Y., Schwarzschild, Michael A.

“…Despite many clinical trials over the last three decades, the goal of demonstrating that a treatment slows the progression of Parkinson’s disease (PD) remains…”
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Chasing Protection in Parkinson's Disease: Does Exercise Reduce Risk and Progression? by Crotty, Grace F, Schwarzschild, Michael A

“…Exercise may be the most commonly offered yet least consistently followed therapeutic advice for people with Parkinson's disease (PD). Epidemiological studies…”
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Use of ibuprofen and risk of Parkinson disease by XIANG GAO, HONGLEI CHEN, SCHWARZSCHILD, Michael A, ASCHERIO, Alberto

“…Neuroinflammation may contribute to the pathogenesis of Parkinson disease (PD). Use of nonsteroidal anti-inflammatory drugs (NSAID) in general, and possibly…”
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LRRK2‐Targeting Therapies March Through the Valley of Death by West, Andrew B., Schwarzschild, Michael A.

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Intake of Flavonoids and Flavonoid-Rich Foods and Mortality Risk Among Individuals With Parkinson Disease: A Prospective Cohort Study by Zhang, Xinyuan, Molsberry, Samantha A., Yeh, Tian-Shin, Cassidy, Aedin, Schwarzschild, Michael A., Ascherio, Alberto, Gao, Xiang

“…Although flavonoids have the potential to exert neuroprotective benefits, evidence of their role in improving survival rates among individuals with Parkinson…”
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The sirtuin-2 inhibitor AK7 is neuroprotective in models of Parkinson's disease but not amyotrophic lateral sclerosis and cerebral ischemia by Chen, Xiqun, Wales, Pauline, Quinti, Luisa, Zuo, Fuxing, Moniot, Sébastien, Herisson, Fanny, Rauf, Nazifa Abdul, Wang, Hua, Silverman, Richard B, Ayata, Cenk, Maxwell, Michelle M, Steegborn, Clemens, Schwarzschild, Michael A, Outeiro, Tiago F, Kazantsev, Aleksey G

“…Sirtuin deacetylases regulate diverse cellular pathways and influence disease processes. Our previous studies identified the brain-enriched sirtuin-2 (SIRT2)…”
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Physical activity and prodromal features of Parkinson disease by Hughes, Katherine C., Gao, Xiang, Molsberry, Samantha, Valeri, Linda, Schwarzschild, Michael A., Ascherio, Alberto

“…OBJECTIVETo investigate the relationship between physical activity and prodromal features of Parkinson disease that often precede the clinical diagnosis…”
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Adenosine A2A receptor gene disruption protects in an [alpha]-synuclein model of Parkinson's disease by Kachroo, Anil, Schwarzschild, Michael A

“…To investigate the putative interaction between chronic exposure to adenosine receptor antagonist caffeine and genetic influences on Parkinson's disease (PD),…”
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Clearing the Smoke: What Protects Smokers from Parkinson's Disease? by Rose, Kenneth N., Schwarzschild, Michael A., Gomperts, Stephen N.

“…The link between smoking and a lower risk of Parkinson's disease (PD) is one of the strongest environmental or lifestyle associations in neuroepidemiology…”
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Effect of Urate-Elevating Inosine on Progression of Early Parkinson Disease—Reply by Macklin, Eric A, Ascherio, Alberto, Schwarzschild, Michael A

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Probable Parasomnias and Mortality: A Prospective Study in US Men by Zhang, Xinyuan, Molsberry, Samantha A., Pavlova, Milena, Schwarzschild, Michael A., Ascherio, Alberto, Gao, Xiang

“…To examine the association between parasomnias, including rapid eye movement sleep behavior disorder (RBD) and sleep walking (SW), and mortality risk in a…”
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Caffeine and risk of Parkinson's disease in a large cohort of men and women by Palacios, Natalia, Gao, Xiang, McCullough, Marjorie L., Schwarzschild, Michael A., Shah, Roma, Gapstur, Susan, Ascherio, Alberto

“…Caffeine consumption has been associated with a reduced risk of Parkinson's disease (PD). The association is strong and consistent in men, but uncertain in…”
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Path to Parkinson Disease Prevention: Conclusion and Outlook by Berg, Daniela, Crotty, Grace F., Keavney, Jessi L., Schwarzschild, Michael A., Simuni, Tanya, Tanner, Caroline

“…Tremendous progress in our understanding of the pathophysiology and clinical manifestations of the prodromal phase of Parkinson disease (PD) offers a unique…”
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Lifestyle and Parkinson's disease progression by Ascherio, Alberto, Schwarzschild, Michael A.

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