Search Results - "Schwarz, Roland"

Cancer Evolution: Mathematical Models and Computational Inference by Beerenwinkel, Niko, Schwarz, Roland F., Gerstung, Moritz, Markowetz, Florian

“…Abstract Cancer is a somatic evolutionary process characterized by the accumulation of mutations, which contribute to tumor growth, clinical progression,…”
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Spatial and temporal heterogeneity in high-grade serous ovarian cancer: a phylogenetic analysis by Schwarz, Roland F, Ng, Charlotte K Y, Cooke, Susanna L, Newman, Scott, Temple, Jillian, Piskorz, Anna M, Gale, Davina, Sayal, Karen, Murtaza, Muhammed, Baldwin, Peter J, Rosenfeld, Nitzan, Earl, Helena M, Sala, Evis, Jimenez-Linan, Mercedes, Parkinson, Christine A, Markowetz, Florian, Brenton, James D

“…The major clinical challenge in the treatment of high-grade serous ovarian cancer (HGSOC) is the development of progressive resistance to platinum-based…”
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Phylogenetic quantification of intra-tumour heterogeneity by Schwarz, Roland F, Trinh, Anne, Sipos, Botond, Brenton, James D, Goldman, Nick, Markowetz, Florian

“…Intra-tumour genetic heterogeneity is the result of ongoing evolutionary change within each cancer. The expansion of genetically distinct sub-clonal…”
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Pre-Detection and Pre-Registration Averaging of Full Wave Signals in Airborne LiDAR Bathymetry by Schwarz, Roland, Pfennigbauer, Martin

“…A well-known technique to enhance the signal to noise ratio (SNR) of repetitive signals is to average them. The coherent parts of the signal add up…”
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Improved identification of cancer mutational processes by Kaufmann, Tom L., Schwarz, Roland F.

“…Mutational signatures help to deconvolve the different processes that shape cancer genomes. A new tool now alleviates some of the persistent challenges in the…”
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SMITH: spatially constrained stochastic model for simulation of intra-tumour heterogeneity by Streck, Adam, Kaufmann, Tom L, Schwarz, Roland F

“…Abstract Motivation Simulations of cancer evolution are highly useful to study the effects of selection and mutation rates on cellular fitness. However, most…”
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Concept and Performance Evaluation of a Novel UAV-Borne Topo-Bathymetric LiDAR Sensor by Mandlburger, Gottfried, Pfennigbauer, Martin, Schwarz, Roland, Flöry, Sebastian, Nussbaumer, Lukas

“…We present the sensor concept and first performance and accuracy assessment results of a novel lightweight topo-bathymetric laser scanner designed for…”
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Extrachromosomal circular DNA drives oncogenic genome remodeling in neuroblastoma by Koche, Richard P., Rodriguez-Fos, Elias, Helmsauer, Konstantin, Burkert, Martin, MacArthur, Ian C., Maag, Jesper, Chamorro, Rocio, Munoz-Perez, Natalia, Puiggròs, Montserrat, Dorado Garcia, Heathcliff, Bei, Yi, Röefzaad, Claudia, Bardinet, Victor, Szymansky, Annabell, Winkler, Annika, Thole, Theresa, Timme, Natalie, Kasack, Katharina, Fuchs, Steffen, Klironomos, Filippos, Thiessen, Nina, Blanc, Eric, Schmelz, Karin, Künkele, Annette, Hundsdörfer, Patrick, Rosswog, Carolina, Theissen, Jessica, Beule, Dieter, Deubzer, Hedwig, Sauer, Sascha, Toedling, Joern, Fischer, Matthias, Hertwig, Falk, Schwarz, Roland F., Eggert, Angelika, Torrents, David, Schulte, Johannes H., Henssen, Anton G.

“…Extrachromosomal circularization of DNA is an important genomic feature in cancer. However, the structure, composition and genome-wide frequency of…”
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Changes in Postural Syntax Characterize Sensory Modulation and Natural Variation of C. elegans Locomotion by Schwarz, Roland F, Branicky, Robyn, Grundy, Laura J, Schafer, William R, Brown, André E X

“…Locomotion is driven by shape changes coordinated by the nervous system through time; thus, enumerating an animal's complete repertoire of shape transitions…”
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Quantitative image analysis of cellular heterogeneity in breast tumors complements genomic profiling by Yuan, Yinyin, Failmezger, Henrik, Rueda, Oscar M, Ali, H Raza, Gräf, Stefan, Chin, Suet-Feung, Schwarz, Roland F, Curtis, Christina, Dunning, Mark J, Bardwell, Helen, Johnson, Nicola, Doyle, Sarah, Turashvili, Gulisa, Provenzano, Elena, Aparicio, Sam, Caldas, Carlos, Markowetz, Florian

“…Solid tumors are heterogeneous tissues composed of a mixture of cancer and normal cells, which complicates the interpretation of their molecular profiles…”
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Depth Measurement Bias in Pulsed Airborne Laser Hydrography Induced by Chromatic Dispersion by Schwarz, Roland Kurt, Pfeifer, Norbert, Pfennigbauer, Martin, Mandlburger, Gottfried

“…In contrast to topographic laser scanning, laser hydrography must take into account the presence of two media. A pulsed laser beam, which enters the water from…”
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MEDICC2: whole-genome doubling aware copy-number phylogenies for cancer evolution by Kaufmann, Tom L, Petkovic, Marina, Watkins, Thomas B K, Colliver, Emma C, Laskina, Sofya, Thapa, Nisha, Minussi, Darlan C, Navin, Nicholas, Swanton, Charles, Van Loo, Peter, Haase, Kerstin, Tarabichi, Maxime, Schwarz, Roland F

“…Aneuploidy, chromosomal instability, somatic copy-number alterations, and whole-genome doubling (WGD) play key roles in cancer evolution and provide…”
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Mitogen‐activated protein kinase activity drives cell trajectories in colorectal cancer by Uhlitz, Florian, Bischoff, Philip, Peidli, Stefan, Sieber, Anja, Trinks, Alexandra, Lüthen, Mareen, Obermayer, Benedikt, Blanc, Eric, Ruchiy, Yana, Sell, Thomas, Mamlouk, Soulafa, Arsie, Roberto, Wei, Tzu‐Ting, Klotz‐Noack, Kathleen, Schwarz, Roland F, Sawitzki, Birgit, Kamphues, Carsten, Beule, Dieter, Landthaler, Markus, Sers, Christine, Horst, David, Blüthgen, Nils, Morkel, Markus

“…In colorectal cancer, oncogenic mutations transform a hierarchically organized and homeostatic epithelium into invasive cancer tissue lacking visible…”
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Spontaneous single-nucleotide substitutions and microsatellite mutations have distinct distributions of fitness effects by Plavskin, Yevgeniy, de Biase, Maria Stella, Ziv, Naomi, Janská, Libuše, Zhu, Yuan O, Hall, David W, Schwarz, Roland F, Tranchina, Daniel, Siegal, Mark L

“…The fitness effects of new mutations determine key properties of evolutionary processes. Beneficial mutations drive evolution, yet selection is also shaped by…”
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Retraction: A Temperature‐, pH‐ and Voltage‐Responsive Nanogate with a Remarkably High Factor of Change in Ion Currents due to ON/OFF Switching by Dettori, Riccardo, Yang, Quan, Achenie, Luke E. K., Schwarz, Roland D.

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Refphase: Multi-sample phasing reveals haplotype-specific copy number heterogeneity by Watkins, Thomas B K, Colliver, Emma C, Huska, Matthew R, Kaufmann, Tom L, Lim, Emilia L, Duncan, Cody B, Haase, Kerstin, Van Loo, Peter, Swanton, Charles, McGranahan, Nicholas, Schwarz, Roland F

“…Most computational methods that infer somatic copy number alterations (SCNAs) from bulk sequencing of DNA analyse tumour samples individually. However, the…”
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Virulence evolution of the human pathogen Neisseria meningitidis by recombination in the core and accessory genome by Joseph, Biju, Schwarz, Roland F, Linke, Burkhard, Blom, Jochen, Becker, Anke, Claus, Heike, Goesmann, Alexander, Frosch, Matthias, Müller, Tobias, Vogel, Ulrich, Schoen, Christoph

“…Neisseria meningitidis is a naturally transformable, facultative pathogen colonizing the human nasopharynx. Here, we analyze on a genome-wide level the impact…”
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GAMIBHEAR: whole-genome haplotype reconstruction from Genome Architecture Mapping data by Markowski, Julia, Kempfer, Rieke, Kukalev, Alexander, Irastorza-Azcarate, Ibai, Loof, Gesa, Kehr, Birte, Pombo, Ana, Rahmann, Sven, Schwarz, Roland F

“…Abstract Motivation Genome Architecture Mapping (GAM) was recently introduced as a digestion- and ligation-free method to detect chromatin conformation…”
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Pervasive structural heterogeneity rewires glioblastoma chromosomes to sustain patient-specific transcriptional programs by Xie, Ting, Danieli-Mackay, Adi, Buccarelli, Mariachiara, Barbieri, Mariano, Papadionysiou, Ioanna, D’Alessandris, Q. Giorgio, Robens, Claudia, Übelmesser, Nadine, Vinchure, Omkar Suhas, Lauretti, Liverana, Fotia, Giorgio, Schwarz, Roland F., Wang, Xiaotao, Ricci-Vitiani, Lucia, Gopalakrishnan, Jay, Pallini, Roberto, Papantonis, Argyris

“…Glioblastoma multiforme (GBM) encompasses brain malignancies marked by phenotypic and transcriptional heterogeneity thought to render these tumors aggressive,…”
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Entirely noninvasive outcome prediction in central nervous system lymphomas using circulating tumor DNA by Heger, Jan-Michel, Mattlener, Julia, Schneider, Jessica, Gödel, Philipp, Sieg, Noëlle, Ullrich, Fabian, Lewis, Richard, Bucaciuc-Mracica, Teodora, Schwarz, Roland F., Rueß, Daniel, Ruge, Maximilian I., Montesinos-Rongen, Manuel, Deckert, Martina, Blau, Tobias, Kutsch, Nadine, Balke-Want, Hyatt, Weiss, Jonathan, Becker, Kerstin, Reinhardt, H. Christian, Hallek, Michael, Borchmann, Peter, von Tresckow, Bastian, Borchmann, Sven

“…•Tumor-agnostic ctDNA sequencing in CNSL is feasible and allows for detection of PRD.•We propose the molecular prognostic index for CNSL, a model integrating…”
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