Search Results - "Schwarz, Juergen R"

Functional Characterization of Genetically Labeled Gonadotropes by Wen, Shuping, Schwarz, Jürgen R, Niculescu, Dragos, Dinu, Crenguta, Bauer, Christiane K, Hirdes, Wiebke, Boehm, Ulrich

“…Gonadotropes are crucial in the control of reproduction but difficult to isolate for functional analysis due to their scattered distribution in the anterior…”
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Erg potassium currents of neonatal mouse Purkinje cells exhibit fast gating kinetics and are inhibited by mGluR1 activation by Niculescu, Dragos, Hirdes, Wiebke, Hornig, Sönke, Pongs, Olaf, Schwarz, Jürgen R

“…We investigated the subthreshold properties of an erg (ether-à-go-go-related gene) K(+) current in Purkinje cells of neonatal mice. Action potentials recorded…”
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Neuroligin 1 is dynamically exchanged at postsynaptic sites by Schapitz, Inga U, Behrend, Bardo, Pechmann, Yvonne, Lappe-Siefke, Corinna, Kneussel, Silas J, Wallace, Karen E, Stempel, A Vanessa, Buck, Fritz, Grant, Seth G N, Schweizer, Michaela, Schmitz, Dietmar, Schwarz, Jürgen R, Holzbaur, Erika L F, Kneussel, Matthias

“…Neuroligins are postsynaptic cell adhesion molecules that associate with presynaptic neurexins. Both factors form a transsynaptic connection, mediate signaling…”
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The Kv7 potassium channel activator flupirtine affects clinical excitability parameters of myelinated axons in isolated rat sural nerve by Sittl, Ruth, Carr, Richard W., Schwarz, Jürgen R., Grafe, Peter

“…Flupirtine is an activator of Kv7 (KCNQ/M) potassium channels that has found clinical use as an analgesic with muscle relaxant properties. Kv7 potassium…”
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Modulation of Ca2+ entry and plasma membrane potential by human TRPM4b by Fliegert, Ralf, Glassmeier, Günter, Schmid, Frederike, Cornils, Kerstin, Genisyuerek, Selda, Harneit, Angelika, Schwarz, Jürgen R., Guse, Andreas H.

“…TRPM4b is a Ca2+‐activated, voltage‐dependent monovalent cation channel that has been shown to act as a negative regulator of Ca2+ entry and to be involved in…”
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Ancillary subunits associated with voltage-dependent K+ channels by Pongs, Olaf, Schwarz, Jürgen R

“…Since the first discovery of Kvbeta-subunits more than 15 years ago, many more ancillary Kv channel subunits were characterized, for example, KChIPs, KCNEs,…”
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Ether‐à‐go‐go K+ channels: effective modulators of neuronal excitability by Bauer, Christiane K., Schwarz, Jürgen R.

“…Mammalian ether‐à‐go‐go (EAG) channels are voltage‐gated K+ channels. They are encoded by the KCNH gene family and divided into three subfamilies, eag (Kv10),…”
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The mechanosensitive ion channel TRAAK is localized to the mammalian node of Ranvier by Brohawn, Stephen G, Wang, Weiwei, Handler, Annie, Campbell, Ernest B, Schwarz, Jürgen R, MacKinnon, Roderick

“…TRAAK is a membrane tension-activated K channel that has been associated through behavioral studies to mechanical nociception. We used specific monoclonal…”
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Functional Inhibition of Katanin Affects Synaptic Plasticity by Lombino, Franco L, Schwarz, Jürgen R, Pechmann, Yvonne, Schweizer, Michaela, Jark, Rebecca, Stange, Oliver, Glatzel, Markus, Gee, Christine E, Hausrat, Torben J, Gromova, Kira V, Kneussel, Matthias

“…Dynamic microtubules critically regulate synaptic functions, but the role of microtubule severing in these processes is barely understood. Katanin is a…”
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Spastin depletion increases tubulin polyglutamylation and impairs kinesin-mediated neuronal transport, leading to working and associative memory deficits by Lopes, André T, Hausrat, Torben J, Heisler, Frank F, Gromova, Kira V, Lombino, Franco L, Fischer, Timo, Ruschkies, Laura, Breiden, Petra, Thies, Edda, Hermans-Borgmeyer, Irm, Schweizer, Michaela, Schwarz, Jürgen R, Lohr, Christian, Kneussel, Matthias

“…Mutations in the gene encoding the microtubule-severing protein spastin (spastic paraplegia 4 [SPG4]) cause hereditary spastic paraplegia (HSP), associated…”
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Ca2+ channels in the node of Ranvier: new insights into modulation of nodal excitability by Schwarz, Jürgen R.

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MmTX1 and MmTX2 from coral snake venom potently modulate GABA A receptor activity by Rosso, Jean-Pierre, Schwarz, Jürgen R., Diaz-Bustamante, Marcelo, Céard, Brigitte, Gutiérrez, José M., Kneussel, Matthias, Pongs, Olaf, Bosmans, Frank, Bougis, Pierre E.

“…In this study, we report the identification of the first potent GABA A receptor-targeting toxins, to our knowledge, in snake venom, which provides a conceptual…”
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Purkinje cell hyperexcitability and depressive-like behavior in mice lacking erg3 (ether-à-go-go-related gene) K + channel subunits by Schwarz, Jürgen R, Freitag, Sandra, Pechmann, Yvonne, Hermans-Borgmeyer, Irm, Wagner, Wolfgang, Hornig, Sönke, Kneussel, Matthias

“…Potassium channels stabilize the resting potential and neuronal excitability. Among them, erg (ether-à-go-go-related gene) K channels represent a subfamily of…”
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The Kinesin KIF21B Regulates Microtubule Dynamics and Is Essential for Neuronal Morphology, Synapse Function, and Learning and Memory by Muhia, Mary, Thies, Edda, Labonté, Dorthe, Ghiretti, Amy E., Gromova, Kira V., Xompero, Francesca, Lappe-Siefke, Corinna, Hermans-Borgmeyer, Irm, Kuhl, Dietmar, Schweizer, Michaela, Ohana, Ora, Schwarz, Jürgen R., Holzbaur, Erika L.F., Kneussel, Matthias

“…The kinesin KIF21B is implicated in several human neurological disorders, including delayed cognitive development, yet it remains unclear how KIF21B…”
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Inhibition of HERG1 K+ channel protein expression decreases cell proliferation of human small cell lung cancer cells by Glassmeier, Günter, Hempel, Kathrin, Wulfsen, Iris, Bauer, Christiane K., Schumacher, Udo, Schwarz, Jürgen R.

“…HERG (human ether-à-go-go-related gene) K + currents fulfill important ionic functions in cardiac and other excitable cells. In addition, HERG channels…”
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Myosin VI Drives Clathrin-Mediated AMPA Receptor Endocytosis to Facilitate Cerebellar Long-Term Depression by Wagner, Wolfgang, Lippmann, Kristina, Heisler, Frank F., Gromova, Kira V., Lombino, Franco L., Roesler, Mona K., Pechmann, Yvonne, Hornig, Sönke, Schweizer, Michaela, Polo, Simona, Schwarz, Jürgen R., Eilers, Jens, Kneussel, Matthias

“…Myosin VI is an actin-based cytoskeletal motor implicated in various steps of membrane trafficking. Here, we investigated whether this myosin is crucial for…”
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Myosin XVI Regulates Actin Cytoskeleton Dynamics in Dendritic Spines of Purkinje Cells and Affects Presynaptic Organization by Roesler, Mona Katrin, Lombino, Franco Luis, Freitag, Sandra, Schweizer, Michaela, Hermans-Borgmeyer, Irm, Schwarz, Jürgen R, Kneussel, Matthias, Wagner, Wolfgang

“…The actin cytoskeleton is crucial for function and morphology of neuronal synapses. Moreover, altered regulation of the neuronal actin cytoskeleton has been…”
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MmTX1 and MmTX2 from coral snake venom potently modulate GABA^sub A^ receptor activity by Rosso, Jean-Pierre, Schwarz, Jürgen R, Diaz-Bustamante, Marcelo, Céard, Brigitte, Gutiérrez, José M, Kneussel, Matthias, Pongs, Olaf, Bosmans, Frank, Bougis, Pierre E

“…GABA... receptors shape synaptic transmission by modulating Cl- conductance across the cell membrane. Remarkably, animal toxins that specifically target…”
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Neuronal differentiation by indomethacin and IBMX inhibits proliferation of small cell lung cancer cells in vitro by Lange, Annika, Gustke, Heike, Glassmeier, Günter, Heine, Markus, Zangemeister-Wittke, Uwe, Schwarz, Jürgen R, Schumacher, Udo, Lange, Tobias

“…Abstract Background Small cell lung cancer (SCLC) is one of the most aggressive malignancies implying a very poor prognosis for patients even under therapy…”
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Activation of T Cell Calcium Influx by the Second Messenger ADP-ribose by Gasser, Andreas, Glassmeier, Günter, Fliegert, Ralf, Langhorst, Matthias F., Meinke, Stephan, Hein, Dörte, Krüger, Sylvia, Weber, Karin, Heiner, Inka, Oppenheimer, Norman, Schwarz, Jürgen R., Guse, Andreas H.

“…Stimulation of Jurkat T cells by high concentrations of concanavalin A (ConA) induced an elevation of the endogenous adenosine diphosphoribose (ADPR)…”
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