Search Results - "Schwarz, Jeanette"

Identification of ADAM12 as a Novel Basigin Sheddase by Albrechtsen, Reidar, Albrechtsen, Nicolai J Wewer, Gnosa, Sebastian, Schwarz, Jeanette, Dyrskjøt, Lars, Kveiborg, Marie

“…The transmembrane glycoprotein basigin, a member of the immunoglobulin superfamily, stimulates matrix metalloproteinase (MMP)-mediated extracellular matrix…”
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Sorting nexin 9 (SNX9) regulates levels of the transmembrane ADAM9 at the cell surface by Mygind, Kasper J., Störiko, Theresa, Freiberg, Marie L., Samsøe-Petersen, Jacob, Schwarz, Jeanette, Andersen, Olav M., Kveiborg, Marie

“…ADAM9 is an active member of the family of transmembrane ADAMs (a disintegrin and metalloproteases). It plays a role in processes such as bone formation and…”
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The role of metalloproteinase ADAM17 in regulating ICOS ligand-mediated humoral immune responses by Marczynska, Joanna, Ozga, Aleksandra, Wlodarczyk, Agnieszka, Majchrzak-Gorecka, Monika, Kulig, Paulina, Banas, Magdalena, Michalczyk-Wetula, Dominika, Majewski, Pawel, Hutloff, Andreas, Schwarz, Jeanette, Chalaris, Athena, Scheller, Jürgen, Rose-John, Stefan, Cichy, Joanna

“…Immune cells regulate cell surface receptor expression during their maturation, activation, and motility. Although many of these receptors are regulated…”
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Lipid‐Labeling Facilitates a Novel Magnetic Isolation Procedure to Characterize Pathogen‐Containing Phagosomes by Steinhäuser, Christine, Heigl, Ulrike, Tchikov, Vladimir, Schwarz, Jeanette, Gutsmann, Thomas, Seeger, Katrin, Brandenburg, Julius, Fritsch, Jürgen, Schroeder, Josef, Wiesmüller, Karl‐Heinz, Rosenkrands, Ida, Walther, Paul, Pott, Johanna, Krause, Eberhard, Ehlers, Stefan, Schneider‐Brachert, Wulf, Schütze, Stefan, Reiling, Norbert

“…Here we describe a novel approach for the isolation and biochemical characterization of pathogen‐containing compartments from primary cells: We developed a…”
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Mechanisms of site‐specific dephosphorylation and kinase opposition imposed by PP2A regulatory subunits by Kruse, Thomas, Gnosa, Sebastian Peter, Nasa, Isha, Garvanska, Dimitriya Hristoforova, Hein, Jamin B, Nguyen, Hieu, Samsøe‐Petersen, Jacob, Lopez‐Mendez, Blanca, Hertz, Emil Peter Thrane, Schwarz, Jeanette, Pena, Hanna Sofia, Nikodemus, Denise, Kveiborg, Marie, Kettenbach, Arminja N, Nilsson, Jakob

“…PP2A is an essential protein phosphatase that regulates most cellular processes through the formation of holoenzymes containing distinct regulatory B‐subunits…”
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Loss of ADAM9 expression impairs β1 integrin endocytosis, focal adhesion formation and cancer cell migration by Mygind, Kasper J, Schwarz, Jeanette, Sahgal, Pranshu, Ivaska, Johanna, Kveiborg, Marie

“…The transmembrane protease ADAM9 is frequently upregulated in human cancers, and it promotes tumour progression in mice. , ADAM9 regulates cancer cell adhesion…”
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Structural Basis for Inflammation-driven Shedding of CD163 Ectodomain and Tumor Necrosis Factor-α in Macrophages by Etzerodt, Anders, Rasmussen, Mie Rostved, Svendsen, Pia, Chalaris, Athena, Schwarz, Jeanette, Galea, Ian, Møller, Holger Jon, Moestrup, Søren Kragh

“…The haptoglobin-hemoglobin receptor CD163 and proTNF-α are transmembrane macrophage proteins subjected to cleavage by the inflammation-responsive protease…”
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Circulating levels of soluble Dipeptidylpeptidase-4 are reduced in human subjects hospitalized for severe COVID-19 infections by Schlicht, Kristina, Rohmann, Nathalie, Geisler, Corinna, Hollstein, Tim, Knappe, Carina, Hartmann, Katharina, Schwarz, Jeanette, Tran, Florian, Schunk, Domagoj, Junker, Ralf, Bahmer, Thomas, Rosenstiel, Philip, Schulte, Dominik, Türk, Kathrin, Franke, Andre, Schreiber, Stefan, Laudes, Matthias

“…Dipeptidylpeptidase (DPP)-4 is a key regulator of the incretin system. For several years DPP-4 inhibitors in addition to GLP-1 analogues are of major…”
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ADAM17 is required for EGF-R-induced intestinal tumors via IL-6 trans-signaling by Schmidt, Stefanie, Schumacher, Neele, Schwarz, Jeanette, Tangermann, Simone, Kenner, Lukas, Schlederer, Michaela, Sibilia, Maria, Linder, Markus, Altendorf-Hofmann, Annelore, Knösel, Thomas, Gruber, Elisabeth S, Oberhuber, Georg, Bolik, Julia, Rehman, Ateequr, Sinha, Anupam, Lokau, Juliane, Arnold, Philipp, Cabron, Anne-Sophie, Zunke, Friederike, Becker-Pauly, Christoph, Preaudet, Adele, Nguyen, Paul, Huynh, Jennifer, Afshar-Sterle, Shoukat, Chand, Ashwini L, Westermann, Jürgen, Dempsey, Peter J, Garbers, Christoph, Schmidt-Arras, Dirk, Rosenstiel, Philip, Putoczki, Tracy, Ernst, Matthias, Rose-John, Stefan

“…Colorectal cancer is treated with antibodies blocking epidermal growth factor receptor (EGF-R), but therapeutic success is limited. EGF-R is stimulated by…”
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ADAM17 controls IL‐6 signaling by cleavage of the murine IL‐6Rα from the cell surface of leukocytes during inflammatory responses by Yan, Isabell, Schwarz, Jeanette, Lücke, Karsten, Schumacher, Neele, Schumacher, Valéa, Schmidt, Stefanie, Rabe, Björn, Saftig, Paul, Donners, Marjo, Rose‐John, Stefan, Mittrücker, Hans‐Willi, Chalaris, Athena

“…ADAM17 balances IL‐6 signaling by shedding of the murine IL‐6Rα during infection and inflammation. The cytokine IL‐6 is part of a regulatory signaling network…”
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Circulating Soluble IL-6R but Not ADAM17 Activation Drives Mononuclear Cell Migration in Tissue Inflammation by Schumacher, Neele, Schmidt, Stefanie, Schwarz, Jeanette, Dohr, Dana, Lokau, Juliane, Scheller, Jürgen, Garbers, Christoph, Chalaris, Athena, Rose-John, Stefan, Rabe, Björn

“…Neutrophil and mononuclear cell infiltration during inflammatory processes is highly regulated. The first cells at the site of infection or inflammation are…”
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Polo-like Kinase 2, a Novel ADAM17 Signaling Component, Regulates Tumor Necrosis Factor α Ectodomain Shedding by Schwarz, Jeanette, Schmidt, Stefanie, Will, Olga, Koudelka, Tomas, Köhler, Kaja, Boss, Melanie, Rabe, Björn, Tholey, Andreas, Scheller, Jürgen, Schmidt-Arras, Dirk, Schwake, Michael, Rose-John, Stefan, Chalaris, Athena

“…ADAM17 (adisintegrin and metalloprotease 17) controls pro- and anti-inflammatory signaling events by promoting ectodomain shedding of cytokine precursors and…”
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Meprin β induces activities of A disintegrin and metalloproteinases 9, 10, and 17 by specific prodomain cleavage by Wichert, Rielana, Scharfenberg, Franka, Colmorgen, Cynthia, Koudelka, Tomas, Schwarz, Jeanette, Wetzel, Sebastian, Potempa, Barbara, Potempa, Jan, Bartsch, Jörg W., Sagi, Irit, Tholey, Andreas, Saftig, Paul, Rose‐John, Stefan, Becker‐Pauly, Christoph

“…Meprin β is a membrane‐bound metalloprotease involved in extracellular matrix assembly and inflammatory processes in health and disease. A disintegrin and…”
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Correction: Circulating levels of soluble Dipeptidylpeptidase-4 are reduced in human subjects hospitalized for severe COVID-19 infections by Schlicht, Kristina, Rohmann, Nathalie, Geisler, Corinna, Hollstein, Tim, Knappe, Carina, Hartmann, Katharina, Schwarz, Jeanette, Tran, Florian, Schunk, Domagoj, Junker, Ralf, Bahmer, Thomas, Rosenstiel, Philip, Schulte, Dominik, Türk, Kathrin, Franke, Andre, Schreiber, Stefan, Laudes, Matthias

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Short-term TNFα shedding is independent of cytoplasmic phosphorylation or furin cleavage of ADAM17 by Schwarz, Jeanette, Broder, Claudia, Helmstetter, Ansgard, Schmidt, Stefanie, Yan, Isabell, Müller, Miryam, Schmidt-Arras, Dirk, Becker-Pauly, Christoph, Koch-Nolte, Friedrich, Mittrücker, Hans-Willi, Rabe, Björn, Rose-John, Stefan, Chalaris, Athena

“…Proteolysis of transmembrane molecules is an irreversible post-translational modification enabling autocrine, paracrine and endocrine signaling of many…”
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Structural and Functional Analyses of the Shedding Protease ADAM17 in HoxB8-Immortalized Macrophages and Dendritic-like Cells by Cabron, Anne-Sophie, El Azzouzi, Karim, Boss, Melanie, Arnold, Philipp, Schwarz, Jeanette, Rosas, Marcela, Dobert, Jan Philipp, Pavlenko, Egor, Schumacher, Neele, Renné, Thomas, Taylor, Philip R, Linder, Stefan, Rose-John, Stefan, Zunke, Friederike

“…A disintegrin and metalloproteinase (ADAM) 17 has been implicated in many shedding processes. Major substrates of ADAM17 are TNF-α, IL-6R, and ligands of the…”
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Shedding of Endogenous Interleukin-6 Receptor (IL-6R) Is Governed by A Disintegrin and Metalloproteinase (ADAM) Proteases while a Full-length IL-6R Isoform Localizes to Circulating Microvesicles by Schumacher, Neele, Meyer, Dörte, Mauermann, Andre, von der Heyde, Jan, Wolf, Janina, Schwarz, Jeanette, Knittler, Katharina, Murphy, Gillian, Michalek, Matthias, Garbers, Christoph, Bartsch, Jörg W., Guo, Songbo, Schacher, Beate, Eickholz, Peter, Chalaris, Athena, Rose-John, Stefan, Rabe, Björn

“…Generation of the soluble interleukin-6 receptor (sIL-6R) is a prerequisite for pathogenic IL-6 trans-signaling, which constitutes a distinct signaling pathway…”
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Loss of PACS-2 delays regeneration in DSS-induced colitis but does not affect the Apc Min model of colorectal cancer by Dombernowsky, Sarah L, Schwarz, Jeanette, Samsøe-Petersen, Jacob, Albrechtsen, Reidar, Jensen, Kim B, Thomas, Gary, Kveiborg, Marie

“…PACS-2 is a multifunctional sorting protein that mediates cell homeostasis. We recently identified PACS-2 in a functional genome-wide siRNA screen for novel…”
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230: Unraveling the role of Adam17 in IL-6 trans-signaling by Schwarz, Jeanette, Yan, Isabell, Will, Olga, Saftig, Paul, Stefan-Rose-John, Mittrücker, Hans-Willi, Chalaris, Athena

“…IL-6 is a key regulator of immune responses after bacterial infection. IL-6 signaling is mediated via the receptor subunits IL-6R and gp130. The signal…”
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230 by Schwarz, Jeanette, Yan, Isabell, Will, Olga, Saftig, Paul, Stefan-Rose-John, Mittrücker, Hans-Willi, Chalaris, Athena

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