Search Results - "Schwarz, Jürgen"

Function of K2P channels in the mammalian node of Ranvier by Schwarz, Jürgen R.

“…In myelinated nerve fibres, action potentials are generated at nodes of Ranvier. These structures are located at interruptions of the myelin sheath, forming…”
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Mechanism of external K+ sensitivity of KCNQ1 channels by Abrahamyan, Astghik, Eldstrom, Jodene, Sahakyan, Harutyun, Karagulyan, Nare, Mkrtchyan, Liana, Karapetyan, Tatev, Sargsyan, Ernest, Kneussel, Matthias, Nazaryan, Karen, Schwarz, Jürgen R, Fedida, David, Vardanyan, Vitya

“…KCNQ1 voltage-gated K+ channels are involved in a wide variety of fundamental physiological processes and exhibit the unique feature of being markedly…”
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Ether‐à‐go‐go K+ channels: effective modulators of neuronal excitability by Bauer, Christiane K., Schwarz, Jürgen R.

“…Mammalian ether‐à‐go‐go (EAG) channels are voltage‐gated K+ channels. They are encoded by the KCNH gene family and divided into three subfamilies, eag (Kv10),…”
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Ancillary subunits associated with voltage-dependent K+ channels by Pongs, Olaf, Schwarz, Jürgen R

“…Since the first discovery of Kvbeta-subunits more than 15 years ago, many more ancillary Kv channel subunits were characterized, for example, KChIPs, KCNEs,…”
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The mechanosensitive ion channel TRAAK is localized to the mammalian node of Ranvier by Brohawn, Stephen G, Wang, Weiwei, Handler, Annie, Campbell, Ernest B, Schwarz, Jürgen R, MacKinnon, Roderick

“…TRAAK is a membrane tension-activated K channel that has been associated through behavioral studies to mechanical nociception. We used specific monoclonal…”
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Functional Characterization of Genetically Labeled Gonadotropes by Wen, Shuping, Schwarz, Jürgen R, Niculescu, Dragos, Dinu, Crenguta, Bauer, Christiane K, Hirdes, Wiebke, Boehm, Ulrich

“…Gonadotropes are crucial in the control of reproduction but difficult to isolate for functional analysis due to their scattered distribution in the anterior…”
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Spastin depletion increases tubulin polyglutamylation and impairs kinesin-mediated neuronal transport, leading to working and associative memory deficits by Lopes, André T, Hausrat, Torben J, Heisler, Frank F, Gromova, Kira V, Lombino, Franco L, Fischer, Timo, Ruschkies, Laura, Breiden, Petra, Thies, Edda, Hermans-Borgmeyer, Irm, Schweizer, Michaela, Schwarz, Jürgen R, Lohr, Christian, Kneussel, Matthias

“…Mutations in the gene encoding the microtubule-severing protein spastin (spastic paraplegia 4 [SPG4]) cause hereditary spastic paraplegia (HSP), associated…”
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Ca(2+) channels in the node of Ranvier: new insights into modulation of nodal excitability by Schwarz, Jürgen R

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The Kinesin KIF21B Regulates Microtubule Dynamics and Is Essential for Neuronal Morphology, Synapse Function, and Learning and Memory by Muhia, Mary, Thies, Edda, Labonté, Dorthe, Ghiretti, Amy E., Gromova, Kira V., Xompero, Francesca, Lappe-Siefke, Corinna, Hermans-Borgmeyer, Irm, Kuhl, Dietmar, Schweizer, Michaela, Ohana, Ora, Schwarz, Jürgen R., Holzbaur, Erika L.F., Kneussel, Matthias

“…The kinesin KIF21B is implicated in several human neurological disorders, including delayed cognitive development, yet it remains unclear how KIF21B…”
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The Nucleoplasmin Homolog NLP Mediates Centromere Clustering and Anchoring to the Nucleolus by Padeken, Jan, Mendiburo, María José, Chlamydas, Sarantis, Schwarz, Hans-Jürgen, Kremmer, Elisabeth, Heun, Patrick

“…Centromere clustering during interphase is a phenomenon known to occur in many different organisms and cell types, yet neither the factors involved nor their…”
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Functional Inhibition of Katanin Affects Synaptic Plasticity by Lombino, Franco L, Schwarz, Jürgen R, Pechmann, Yvonne, Schweizer, Michaela, Jark, Rebecca, Stange, Oliver, Glatzel, Markus, Gee, Christine E, Hausrat, Torben J, Gromova, Kira V, Kneussel, Matthias

“…Dynamic microtubules critically regulate synaptic functions, but the role of microtubule severing in these processes is barely understood. Katanin is a…”
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Ca2+ channels in the node of Ranvier: new insights into modulation of nodal excitability by Schwarz, Jürgen R.

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Myosin VI Drives Clathrin-Mediated AMPA Receptor Endocytosis to Facilitate Cerebellar Long-Term Depression by Wagner, Wolfgang, Lippmann, Kristina, Heisler, Frank F., Gromova, Kira V., Lombino, Franco L., Roesler, Mona K., Pechmann, Yvonne, Hornig, Sönke, Schweizer, Michaela, Polo, Simona, Schwarz, Jürgen R., Eilers, Jens, Kneussel, Matthias

“…Myosin VI is an actin-based cytoskeletal motor implicated in various steps of membrane trafficking. Here, we investigated whether this myosin is crucial for…”
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MmTX1 and MmTX2 from coral snake venom potently modulate GABA A receptor activity by Rosso, Jean-Pierre, Schwarz, Jürgen R., Diaz-Bustamante, Marcelo, Céard, Brigitte, Gutiérrez, José M., Kneussel, Matthias, Pongs, Olaf, Bosmans, Frank, Bougis, Pierre E.

“…Significance In this study, we report the identification of the first potent GABA A receptor-targeting toxins, to our knowledge, in snake venom, which provides…”
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Costs and benefits of preventive strategies to reduce pesticide use by Jovanka Saltzmann, Isabella Karpinski, Bettina Klocke, Jürgen Schwarz, Sandra Rajmis, Hella Kehlenbeck

“…Plant pests, diseases and weeds threaten agricultural crops and require control methods. However, the largely used pesticides are associated with undesirable…”
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Purkinje cell hyperexcitability and depressive-like behavior in mice lacking erg3 (ether-à-go-go-related gene) K + channel subunits by Schwarz, Jürgen R, Freitag, Sandra, Pechmann, Yvonne, Hermans-Borgmeyer, Irm, Wagner, Wolfgang, Hornig, Sönke, Kneussel, Matthias

“…Potassium channels stabilize the resting potential and neuronal excitability. Among them, erg (ether-à-go-go-related gene) K channels represent a subfamily of…”
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Inhibition of HERG1 K+ channel protein expression decreases cell proliferation of human small cell lung cancer cells by Glassmeier, Günter, Hempel, Kathrin, Wulfsen, Iris, Bauer, Christiane K., Schumacher, Udo, Schwarz, Jürgen R.

“…HERG (human ether-à-go-go-related gene) K + currents fulfill important ionic functions in cardiac and other excitable cells. In addition, HERG channels…”
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Myosin XVI Regulates Actin Cytoskeleton Dynamics in Dendritic Spines of Purkinje Cells and Affects Presynaptic Organization by Roesler, Mona Katrin, Lombino, Franco Luis, Freitag, Sandra, Schweizer, Michaela, Hermans-Borgmeyer, Irm, Schwarz, Jürgen R, Kneussel, Matthias, Wagner, Wolfgang

“…The actin cytoskeleton is crucial for function and morphology of neuronal synapses. Moreover, altered regulation of the neuronal actin cytoskeleton has been…”
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Erg potassium currents of neonatal mouse Purkinje cells exhibit fast gating kinetics and are inhibited by mGluR1 activation by Niculescu, Dragos, Hirdes, Wiebke, Hornig, Sönke, Pongs, Olaf, Schwarz, Jürgen R

“…We investigated the subthreshold properties of an erg (ether-à-go-go-related gene) K(+) current in Purkinje cells of neonatal mice. Action potentials recorded…”
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Muskelin regulates actin-dependent synaptic changes and intrinsic brain activity relevant to behavioral and cognitive processes by Muhia, Mary, YuanXiang, PingAn, Sedlacik, Jan, Schwarz, Jürgen R., Heisler, Frank F., Gromova, Kira V., Thies, Edda, Breiden, Petra, Pechmann, Yvonne, Kreutz, Michael R., Kneussel, Matthias

“…Muskelin (Mkln1) is implicated in neuronal function, regulating plasma membrane receptor trafficking. However, its influence on intrinsic brain activity and…”
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