Search Results - "Schwarz, Daniel M. C."

Temperature-jump solution X-ray scattering reveals distinct motions in a dynamic enzyme by Thompson, Michael C., Barad, Benjamin A., Wolff, Alexander M., Sun Cho, Hyun, Schotte, Friedrich, Schwarz, Daniel M. C., Anfinrud, Philip, Fraser, James S.

“…Correlated motions of proteins are critical to function, but these features are difficult to resolve using traditional structure determination techniques…”
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Hsp70 and Hsp40 inhibit an inter-domain interaction necessary for transcriptional activity in the androgen receptor by Eftekharzadeh, Bahareh, Banduseela, Varuna C., Chiesa, Giulio, Martínez-Cristóbal, Paula, Rauch, Jennifer N., Nath, Samir R., Schwarz, Daniel M. C., Shao, Hao, Marin-Argany, Marta, Di Sanza, Claudio, Giorgetti, Elisa, Yu, Zhigang, Pierattelli, Roberta, Felli, Isabella C., Brun-Heath, Isabelle, García, Jesús, Nebreda, Ángel R., Gestwicki, Jason E., Lieberman, Andrew P., Salvatella, Xavier

“…Molecular chaperones such as Hsp40 and Hsp70 hold the androgen receptor (AR) in an inactive conformation. They are released in the presence of androgens,…”
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Revisiting the “Art of the Chemical Probe” by Schwarz, Daniel M. C, Gestwicki, Jason E

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A Phosphoramidate Strategy Enables Membrane Permeability of a Non-nucleotide Inhibitor of the Prolyl Isomerase Pin1 by Schwarz, Daniel M. C, Williams, Sarah K, Dillenburg, Maxwell, Wagner, Carston R, Gestwicki, Jason E

“…The membrane permeability of nucleotide-based drugs, such as sofosbuvir (Sovaldi), requires installation of phosphate-caging groups. One strategy, termed…”
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Design, Synthesis, and Evaluation of Nonretinoid Retinol Binding Protein 4 Antagonists for the Potential Treatment of Atrophic Age-Related Macular Degeneration and Stargardt Disease by Cioffi, Christopher L, Dobri, Nicoleta, Freeman, Emily E, Conlon, Michael P, Chen, Ping, Stafford, Douglas G, Schwarz, Daniel M. C, Golden, Kathy C, Zhu, Lei, Kitchen, Douglas B, Barnes, Keith D, Racz, Boglarka, Qin, Qiong, Michelotti, Enrique, Cywin, Charles L, Martin, William H, Pearson, Paul G, Johnson, Graham, Petrukhin, Konstantin

“…Accumulation of lipofuscin in the retina is associated with pathogenesis of atrophic age-related macular degeneration and Stargardt disease. Lipofuscin…”
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Bicyclic [3.3.0]-Octahydrocyclopenta[c]pyrrolo Antagonists of Retinol Binding Protein 4: Potential Treatment of Atrophic Age-Related Macular Degeneration and Stargardt Disease by Cioffi, Christopher L, Racz, Boglarka, Freeman, Emily E, Conlon, Michael P, Chen, Ping, Stafford, Douglas G, Schwarz, Daniel M. C, Zhu, Lei, Kitchen, Douglas B, Barnes, Keith D, Dobri, Nicoleta, Michelotti, Enrique, Cywin, Charles L, Martin, William H, Pearson, Paul G, Johnson, Graham, Petrukhin, Konstantin

“…Antagonists of retinol-binding protein 4 (RBP4) impede ocular uptake of serum all-trans retinol (1) and have been shown to reduce cytotoxic bisretinoid…”
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Robust Sequence Determinants of α‑Synuclein Toxicity in Yeast Implicate Membrane Binding by Newberry, Robert W, Arhar, Taylor, Costello, Jean, Hartoularos, George C, Maxwell, Alison M, Naing, Zun Zar Chi, Pittman, Maureen, Reddy, Nishith R, Schwarz, Daniel M. C, Wassarman, Douglas R, Wu, Taia S, Barrero, Daniel, Caggiano, Christa, Catching, Adam, Cavazos, Taylor B, Estes, Laurel S, Faust, Bryan, Fink, Elissa A, Goldman, Miriam A, Gomez, Yessica K, Gordon, M. Grace, Gunsalus, Laura M, Hoppe, Nick, Jaime-Garza, Maru, Johnson, Matthew C, Jones, Matthew G, Kung, Andrew F, Lopez, Kyle E, Lumpe, Jared, Martyn, Calla, McCarthy, Elizabeth E, Miller-Vedam, Lakshmi E, Navarro, Erik J, Palar, Aji, Pellegrino, Jenna, Saylor, Wren, Stephens, Christina A, Strickland, Jack, Torosyan, Hayarpi, Wankowicz, Stephanie A, Wong, Daniel R, Wong, Garrett, Redding, Sy, Chow, Eric D, DeGrado, William F, Kampmann, Martin

“…Protein conformations are shaped by cellular environments, but how environmental changes alter the conformational landscapes of specific proteins in vivo…”
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Author Correction: Hsp70 and Hsp40 inhibit an inter-domain interaction necessary for transcriptional activity in the androgen receptor by Eftekharzadeh, Bahareh, Banduseela, Varuna C., Chiesa, Giulio, Martínez-Cristóbal, Paula, Rauch, Jennifer N., Nath, Samir R., Schwarz, Daniel M. C., Shao, Hao, Marin-Argany, Marta, Di Sanza, Claudio, Giorgetti, Elisa, Yu, Zhigang, Pierattelli, Roberta, Felli, Isabella C., Brun-Heath, Isabelle, García, Jesús, Nebreda, Ángel R., Gestwicki, Jason E., Lieberman, Andrew P., Salvatella, Xavier

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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Inhibitors of heat shock protein 70 (Hsp70) with enhanced metabolic stability reduce tau levels by Shao, Hao, Li, Xiaokai, Hayashi, Shigenari, Bertron, Jeanette L., Schwarz, Daniel M.C., Tang, Benjamin C., Gestwicki, Jason E.

“…[Display omitted] •Two series of YM-08 analogs were designed to remove metabolic liabilities.•Optimization resulted in JG-23, which is 12-fold more…”
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