Search Results - "Schwartzentruber, Aurelie"

Oxidative switch drives mitophagy defects in dopaminergic parkin mutant patient neurons by Schwartzentruber, Aurelie, Boschian, Camilla, Lopes, Fernanda Martins, Myszczynska, Monika A., New, Elizabeth J., Beyrath, Julien, Smeitink, Jan, Ferraiuolo, Laura, Mortiboys, Heather

“…Mutations in PRKN are the most common cause of early onset Parkinson’s disease. Parkin is an E3 ubiquitin ligase, functioning in mitophagy. Mitochondrial…”
Get full text

Loss of IGF1R in Human Astrocytes Alters Complex I Activity and Support for Neurons by Ratcliffe, Laura E., Vázquez Villaseñor, Irina, Jennings, Luke, Heath, Paul R., Mortiboys, Heather, Schwartzentruber, Aurelie, Karyka, Evangelia, Simpson, Julie E., Ince, Paul G., Garwood, Claire J., Wharton, Stephen B.

“…•We have established a novel human astrocyte-neuron co-culture system.•Astrocytes provided contact-mediated support for neurite outgrowth.•IGF1R-impaired…”
Get full text

Deep phenotyping of peripheral tissue facilitates mechanistic disease stratification in sporadic Parkinson’s disease by Carling, Phillippa J, Mortiboys, Heather, Green, Claire, Mihaylov, Simeon, Sandor, Cynthia, Schwartzentruber, Aurelie, Taylor, Rosie, Wei, Wenbin, Hastings, Chris, Wong, Siew, Lo, Christine, Evetts, Samuel, Clemmens, Hannah, Wyles, Matthew, Willcox, Sam, Payne, Thomas, Hughes, Rachel, Ferraiuolo, Laura, Webber, Caleb, Hide, Winston, Wade-Martins, Richard, Talbot, Kevin, Hu, Michele T., Bandmann, Oliver

“…•We undertook fibroblast-based deep phenotyping in sporadic Parkinson’s disease (sPD).•We identified distinct subgroups with mitochondrial or lysosomal…”
Get full text