The National Institutes of Health Center for Human Immunology, Autoimmunity, and Inflammation: history and progress

The Center for Human Immunology, Autoimmunity, and Inflammation (CHI) is an exciting initiative of the NIH intramural program begun in 2009. It is uniquely trans‐NIH in support (multiple institutes) and leadership (senior scientists from several institutes who donate their time). Its goal is an in‐d...

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Bibliographic Details
Published in:	Annals of the New York Academy of Sciences Vol. 1285; no. 1; pp. 133 - 147
Main Authors:	Dickler, Howard B., McCoy, J. Philip, Nussenblatt, Robert, Perl, Shira, Schwartzberg, Pamela A., Tsang, John S., Wang, Ena, Young, Neil S.
Format:	Journal Article
Language:	English
Published:	United States Blackwell Publishing Ltd 01-05-2013 Wiley Subscription Services, Inc
Subjects:	Allergy and Immunology - history Autoimmune Diseases - history Autoimmune Diseases - pathology autoimmunity Gene expression History, 21st Century human Humans Immunology inflammation Inflammation - history Inflammation - pathology Influenza Vaccines - history Medical research National Institutes of Health (U.S.) - history National Institutes of Health (U.S.) - organization & administration United States Vaccination - history United States
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Summary:	The Center for Human Immunology, Autoimmunity, and Inflammation (CHI) is an exciting initiative of the NIH intramural program begun in 2009. It is uniquely trans‐NIH in support (multiple institutes) and leadership (senior scientists from several institutes who donate their time). Its goal is an in‐depth assessment of the human immune system using high‐throughput multiplex technologies for examination of immune cells and their products, the genome, gene expression, and epigenetic modulation obtained from individuals both before and after interventions, adding information from in‐depth clinical phenotyping, and then applying advanced biostatistical and computer modeling methods for mining these diverse data. The aim is to develop a comprehensive picture of the human “immunome” in health and disease, elucidate common pathogenic pathways in various diseases, identify and validate biomarkers that predict disease progression and responses to new interventions, and identify potential targets for new therapeutic modalities. Challenges, opportunities, and progress are detailed.
Bibliography:	istex:ED4F72398D2E080C31E0CAF67DF6B9BEC208F874 ark:/67375/WNG-FQKQKB0Q-K ArticleID:NYAS12101 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0077-8923 1749-6632
DOI:	10.1111/nyas.12101