Genomic reassortment of influenza A virus in North American swine, 1998–2011

Revealing the frequency and determinants of reassortment among RNA genome segments is fundamental to understanding basic aspects of the biology and evolution of the influenza virus. To estimate the extent of genomic reassortment in influenza viruses circulating in North American swine, we performed...

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Bibliographic Details
Published in:	Journal of general virology Vol. 93; no. Pt 12; pp. 2584 - 2589
Main Authors:	Nelson, Martha I, Detmer, Susan E, Wentworth, David E, Tan, Yi, Schwartzbard, Aaron, Halpin, Rebecca A
Format:	Journal Article
Language:	English
Published:	Reading Society for General Microbiology 01-12-2012
Subjects:	Animal Animals Biological and medical sciences Evolution, Molecular Fundamental and applied biological sciences. Psychology genes genetic recombination Genome, Viral Hemagglutinin Glycoproteins, Influenza Virus - genetics hemagglutinins Humans Influenza A virus Influenza A virus - classification Influenza A virus - genetics Influenza A virus - isolation & purification Microbiology Miscellaneous North America Phylogeny Reassortant Viruses - classification Reassortant Viruses - genetics Reassortant Viruses - isolation & purification RNA Short Communication sialidase Sus scrofa - virology swine Time Factors Virology North America Virus Vertebrata Influenzavirus A Mammalia Influenza A virus Swine Genomics Orthomyxoviridae Artiodactyla Veterinary Ungulata
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Summary:	Revealing the frequency and determinants of reassortment among RNA genome segments is fundamental to understanding basic aspects of the biology and evolution of the influenza virus. To estimate the extent of genomic reassortment in influenza viruses circulating in North American swine, we performed a phylogenetic analysis of 139 whole-genome viral sequences sampled during 1998–2011 and representing seven antigenically distinct viral lineages. The highest amounts of reassortment were detected between the H3 and the internal gene segments (PB2, PB1, PA, NP, M and NS), while the lowest reassortment frequencies were observed among the H1(gamma), H1pdm and neuraminidase segments, particularly N1. Less reassortment was observed among specific haemagglutinin–neuraminidase combinations that were more prevalent in swine, suggesting that some genome constellations may be evolutionarily more stable.
Bibliography:	http://handle.nal.usda.gov/10113/57685 http://dx.doi.org/10.1099/vir.0.045930-0 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1465-2099 0022-1317 1465-2099
DOI:	10.1099/vir.0.045930-0