Search Results - "Schwartz Jr, S"

EMT blockage strategies: Targeting Akt dependent mechanisms for breast cancer metastatic behaviour modulation by Rafael, D, Doktorovová, S, Florindo, H F, Gener, P, Abasolo, I, Schwartz, Jr, S, Videira, M A

“…Epithelial Mesenchymal Transition (EMT) is an event where epithelial cells acquire mesenchymal-like phenotype. EMT can occur as a physiological phenomenon…”
Get more information

Transforming pathways unleashed by a HDAC2 mutation in human cancer by Ropero, S, Ballestar, E, Alaminos, M, Arango, D, Schwartz, S, Esteller, M

“…Although disruption of histone modification patterns is a common hallmark of human cancer, our knowledge of the mechanistic role of histone-modifying enzymes…”
Get full text

Frameshift mutations at mononucleotide repeats in caspase-5 and other target genes in endometrial and gastrointestinal cancer of the microsatellite mutator phenotype by SCHWARTZ, S. JR, YAMAMOTO, H, NAVARRO, M, MAESTRO, M, REVENTOS, J, PERUCHO, M

“…The majority of tumors from hereditary nonpolyposis colorectal cancer families and a subset of unselected gastrointestinal and endometrial tumors exhibit a…”
Get full text

Prognostic value of immunohistochemical expression of the c‐erbB‐2 oncoprotein in metastasic prostate cancer by Morote, Joan, de Torres, Inés, Caceres, Carme, Vallejo, Carlos, Schwartz, Simó, Reventos, Jaume

“…It is well established that the activation of proto‐oncogenes could trigger uncontrolled cell growth and cancer development. Although this correlation has…”
Get full text

KRAS and BRAF oncogenic mutations in MSS colorectal carcinoma progression by OLIVEIRA, C, VELHO, S, SCHWARTZ, S, CARNEIRO, F, SERUCA, R, MOUTINHO, C, FERREIRA, A, PRETO, A, DOMINGO, E, CAPELINHA, A. F, DUVAL, A, HAMELIN, R, MACHADOL, J. C

“…In sporadic colorectal cancer (CRC), KRAS are alternative to BRAF mutations and occur, respectively, in 30 and 10% of cases. Few reports addressed the…”
Get full text

BRAF screening as a low-cost effective strategy for simplifying HNPCC genetic testing by Domingo, E, Laiho, P, Ollikainen, M, Pinto, M, Wang, L, French, A J, Westra, J, Frebourg, T, Espín, E, Armengol, M, Hamelin, R, Yamamoto, H, Hofstra, R M W, Seruca, R, Lindblom, A, Peltomäki, P, Thibodeau, S N, Aaltonen, L A, Schwartz, S

“…Background: According to the international criteria for hereditary non-polyposis colorectal cancer (HNPCC) diagnostics, cancer patients with a family history…”
Get full text

Serrated carcinomas form a subclass of colorectal cancer with distinct molecular basis by LAIHO, P, KOKKO, A, SCHWARTZ, S, ARANGO, D, MÄKINEN, M. J, AALTONEN, L. A, VANHARANTA, S, SALOVAARA, R, SAMMALKORPI, H, JARVINEN, H, MECKLIN, J.-P, KARTTUNEN, T. J, TUPPURAINEN, K, DAVALOS, V

“…Serrated colorectal carcinomas (CRCs) are morphologically different from conventional CRCs and have been proposed to follow a distinct pathway of CRC…”
Get full text

Gains of the relative genomic content of erbB-1 and erbB-2 in prostate carcinoma and their association with metastasis by Schwartz, Jr, S, Caceres, C, Morote, J, De Torres, I, Rodriguez-Vallejo, J M, Gonzalez, J, Reventos, J

“…Prostate carcinoma (PC) is the second leading cause of cancer death in men in the western world. Although the role of oncogenes and growth factors in prostate…”
Get more information

Somatic mutations in the DNA damage-response genes ATR and CHK1 in sporadic stomach tumors with microsatellite instability by MENOYO, Anna, ALAZZOUZI, Hafid, ESPIN, Eloi, ARMENGOL, Manel, YAMAMOTO, Hiroyuki, SCHWARTZ, Simo JR

“…Maintenance of genomic stability depends on the appropriate cellular responses to DNA damage and the integrity of the DNA repair systems. We analyzed stomach…”
Get full text

Over‐expression of epidermal growth factor receptor and c‐ erbB2/neu but not of int‐2 genes in benign prostatic hyperplasia by means of semi‐quantitative PCR by Schwartz, Simó, Caceres, Carme, Morote, Joan, De Torres, Inés, M. Rodriguez‐Vallejo, José, Gonzalez, Jorge, Reventos, Jaume

“…It is well established that activation of cellular genes may trigger uncontrolled cell growth and cancer development. Previous reports suggest that the…”
Get full text

High EPHB2 mutation rate in gastric but not endometrial tumors with microsatellite instability by DAVALOS, V, DOPESO, H, LEON, L, NIESSEN, R. C, KELLER, G, DALLENBACH-HELLWEG, G, ESPIN, E, ARMENGOL, M, PLAJA, A, PERUCHO, M, IMAI, K, YAMAMOTO, H, VELHO, S, GEBERT, J. F, DIAZ-CHICO, J. C, HOFSTRA, R. M, WOERNER, S. M, SERUCA, R, SCHWARTZ, S, ARANGO, D, FERREIRA, A. M, CIRNES, L, DIAZ-CHICO, N, BILBAO, C, RAMIREZ, R, RODRIGUEZ, G, FALCON, O

“…The EPH/EFN family of receptor tyrosine kinases regulates cell adhesion and migration and has an important role in controlling cell positioning in the normal…”
Get full text

Androgen‐independent basal cell re‐epithelialization, c‐erbB‐2 mRNA expression and androgen‐dependent EGFr mRNA expression in benign prostatic hyperplasia explant cultures treated with finasteride by Schwartz, Simó, Caceres, Carme, De Torres, Inés, Morote, Joan, Rodriguez‐Vallejo, José M., Gonzalez, Jorge, Reventos, Jaume

“…We have analyzed the effects of the 5α‐reductase inhibitor, finasteride (MK906), on the mRNA expression of the epidermal growth factor receptor and c‐erbB‐2…”
Get full text

The C/C−13910 genotype of adult-type hypolactasia is associated with an increased risk of colorectal cancer in the Finnish population by Rasinperä, H, Forsblom, C, Enattah, N S, Halonen, P, Salo, K, Victorzon, M, Mecklin, J-P, Järvinen, H, Enholm, S, Sellick, G, Alazzouzi, H, Houlston, R, Robinson, J, Groop, P-H, Tomlinson, I, Schwartz, S, Aaltonen, L A, Järvelä, I

“…Background and aims: The role of nutrition in the pathogenesis of colorectal cancer is not fully understood. Milk products are an essential part of human…”
Get full text

Somatic mutations in mitochondrial DNA do not associate with nuclear microsatellite instability in gastrointestinal cancer by Schwartz, Simó, Perucho, Manuel

“…GASTROENTEROLOGY 2000;119:1806-1807…”
Get full text

Bacterial cellulose hydrogel loaded with lipid nanoparticles for localized cancer treatment by Cacicedo, M.L., Islan, G.A., León, I.E., Álvarez, V.A., Chourpa, I., Allard-Vannier, E., García-Aranda, N., Díaz-Riascos, Z.V., Fernández, Y., Schwartz, S., Abasolo, I., Castro, G.R.

“…[Display omitted] •Cationic state of the Dox in NLCs determined drug release and in vitro efficacy.•NLCs with cationic and neutral Dox were loaded into…”
Get full text

The prevalence of PIK3CA mutations in gastric and colon cancer by Velho, Sérgia, Oliveira, Carla, Ferreira, Ana, Ferreira, António Carlos, Suriano, Gianpaolo, Schwartz, Simó, Duval, Alex, Carneiro, Fátima, Machado, José Carlos, Hamelin, Richard, Seruca, Raquel

“…A wide variety of tumours show PIK3CA mutations leading to increased phosphatidylinositol-3 kinase ( PI3K) activity. We have determined the frequency of PIK3CA…”
Get full text

BRAF-V600E is not involved in the colorectal tumorigenesis of HNPCC in patients with functional MLH1 and MSH2 genes by Domingo, Enric, Niessen, Renée C, Oliveira, Carla, Alhopuro, Pia, Moutinho, Catia, Espín, Eloi, Armengol, Manel, Sijmons, Rolf H, Kleibeuker, Jan H, Seruca, Raquel, Aaltonen, Lauri A, Imai, Kohzoh, Yamamoto, Hiroyuki, Schwartz, Jr, Simó, Hofstra, Robert M W

“…Recently, it was shown that the oncogenic activation of BRAF, a member of the RAS/RAF family of kinases, by the V600E mutation is characteristic for sporadic…”
Get full text

BRAF mutations characterize colon but not gastric cancer with mismatch repair deficiency by OLIVEIRA, Carla, PINTO, Mafalda, SCHWARTZ, Simo JR, DUVAL, Alex, BRENNETOT, Caroline, DOMINGO, Enric, ESPIN, Eloi, ARMENGOL, Manel, YAMAMOTO, Hiroyuki, HAMELIN, Richard, SERUCA, Raquel

“…Genes from the RAF family are Ras-regulated kinases involved in growth cellular responses. Recently, a V599E hotspot mutation within the BRAF gene was reported…”
Get full text

Activated BRAF targets proximal colon tumors with mismatch repair deficiency and MLH1 inactivation by Domingo, Enric, Espín, Eloi, Armengol, Manel, Oliveira, Carla, Pinto, Mafalda, Duval, Alex, Brennetot, Caroline, Seruca, Raquel, Hamelin, Richard, Yamamoto, Hiroyuki, Schwartz Jr, Simó

“…BRAF, a serine/threonine kinase of the RAF family, is a downstream transducer of the RAS‐regulated MAPK pathway and signals upstream of MEK1/2 kinases…”
Get full text

Concomitant RASSF1A hypermethylation and KRAS/BRAF mutations occur preferentially in MSI sporadic colorectal cancer by OLIVEIRA, Carla, VELHO, Sérgia, DOMINGO, Enric, PRETO, Ana, HOFSTRA, Robert M. W, HAMELIN, Richard, YAMAMOTO, Hiroyuki, SERUCA, Raquel, SCHWARTZ, Simo JR

“…Methylation-associated inactivation of RASSF1A has frequently been observed in several human malignancies including sporadic colorectal and gastric cancer…”
Get full text